Ivar Hordvik

Emeritus

E-mailivar.hordvik@uib.no
Phone+47 55 58 45 38
Visitor Address
HIB - Thormøhlens gate 55

5006 Bergen
Postal Address
Postboks 7803

5020 Bergen

Research
Publications

The research of Ivar Hordvik is focused on components of the adaptive immune system in fish. A long term goal is to broaden the spectrum of well characterized molecules and develop molecular tools that can be used to study immune responses during experiments with vaccines and pathogens in fish.

After teleost fish made a separate branch on the phylogenetic tree significant differences have been introduced between fish and mammals, both with respect to primary sequence of corresponding molecules, and the introduction of new molecules by gene duplications. An example of this is the evolution of the immunoglobulins: Whereas IgM has been evolutionarily stable and maintained the primordial structure in all jawed vertebrates the IgD gene has been evolutionarily labile and has been subjected to many internal duplications and deletions. A newly discovered gene, encoding an isotype named IgT/IgZ appears to be specific for teleost fish. On the other hand, IgG, IgE, and IgA are isotypes present in mammals, but not in fish.

Several findings the last years have shown that studies of the immune system in fish still offers surprises. It is plausible to assume that improved knowledge on the function and ontogeny of immune components in fish will aid experimental design of future vaccination trials and interpretation of results. Delivery of vaccines across mucosal surfaces of fish would obviously be an advantage and boost the profitability of the aquaculture industry. Development of new reagents for identification of immune cells and for monitoring immune responses is also an issue which has been addressed by vaccine companies as well as many researchers.

Academic article

Show author(s) (2023). The thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelled. Frontiers in Immunology. 19 pages.
Show author(s) (2023). The Distribution of IgT mRNA<sup>+</sup> Cells in the Gut of the Atlantic Salmon (Salmo salar L.). Animals. 16 pages.

Show author(s) (2022). The teleost polymeric Ig receptor counterpart in ballan wrasse (Labrus bergylta) differs from pIgR in higher vertebrates. Veterinary Immunology and Immunopathology. 14 pages.

Show author(s) (2019). Intramuscular vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) induces inflammatory reactions and local immunoglobulin M production at the vaccine administration site. Journal of Fish Diseases. 1731-1743.
Show author(s) (2019). Analysis of immunoglobulin and T cell receptor gene expression in ballan wrasse (Labrus bergylta) revealed an extraordinarily high IgM expression in the gut. Fish and Shellfish Immunology. 650-658.
Show author(s) (2019). A teleost structural analogue to the avian bursa of Fabricius. Journal of Anatomy. 1-11.

Show author(s) (2018). T cell receptor alpha chain genes in the teleost Ballan wrasse (Labrus bergylta) are subjected to somatic hypermutation. Frontiers in Immunology. 1-11.
Show author(s) (2018). Ectopic epithelial cell clusters in salmonid intestine are associated with inflammation. Journal of Fish Diseases. 1031-1040.

Show author(s) (2017). Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of Fish Diseases. 613-623.
Show author(s) (2017). The interbranchial lymphoid tissue likely contributes to immune tolerance and defense in the gills of Atlantic salmon. Developmental and Comparative Immunology. 247-254.
Show author(s) (2017). Studies on the antibody response and side effects after intramuscular and intraperitoneal injection of Atlantic lumpfish (Cyclopterus lumpus L.) with different oil-based vaccines. Journal of Fish Diseases. 1805-1813.

Show author(s) (2016). Coronary changes in the Atlantic salmon Salmo salar L: characterization and impact of dietary fatty acid compositions. Journal of Fish Diseases. 41-54.
Show author(s) (2016). Characterization of IgM in Norwegian cleaner fish (lumpfish and wrasses). Fish and Shellfish Immunology. 9-17.

Show author(s) (2015). The interbranchial lymphoid tissue of Atlantic Salmon (Salmo salar L) extends as a diffuse mucosal lymphoid tissue throughout the trailing edge of the gill filament. Journal of morphology. 1075-1088.
Show author(s) (2015). Immunoglobulin Isotypes in Atlantic Salmon, Salmo Salar. Biomolecules. 166-177.

Show author(s) (2014). Transcriptional characterization of the T cell population within the salmonid interbranchial lymphoid tissue. Journal of Immunology. 3463-3469.
Show author(s) (2014). Immune parameters in the intestine of wild and reared unvaccinated and vaccinated Atlantic salmon (Salmo salar L.). Developmental and Comparative Immunology. 6-16.

Show author(s) (2013). Comparative cardiac pathological changes of Atlantic salmon (Salmo salar L.) affected with heart and skeletal muscle inflammation (HSMI), cardiomyopathy syndrome (CMS) and pancreas disease (PD). Veterinary Immunology and Immunopathology. 49-62.
Show author(s) (2013). Comparative analysis of IgM sub-variants in salmonid fish and identification of a residue in mu 3 which is essential for MAb4C10 reactivity. Fish and Shellfish Immunology. 667-672.

Show author(s) (2012). Pigment-producing granulomatous myopathy in Atlantic salmon: A novel inflammatory response. Fish and Shellfish Immunology. 277-285.
Show author(s) (2012). Characterization of myocardial lesions associated with cardiomyopathy syndrome in Atlantic salmon, Salmo salar L., using laser capture microdissection. Journal of Fish Diseases. 907-916.
Show author(s) (2012). Cardiac pathological changes of Atlantic salmon (Salmo salar L.) affected with heart and skeletal muscle inflammation (HSMI). Fish and Shellfish Immunology. 305-315.

Show author(s) (2011). Molecular cloning of IgT from Atlantic salmon, and analysis of the relative expression of tau, mu, and delta in different tissues. Veterinary Immunology and Immunopathology. 17-26.
Show author(s) (2011). Gene expression analyses of immune responses in Atlantic salmon during early stages of infection by salmon louse (Lepeophtheirus salmonis) revealed bi-phasic responses coinciding with the copepod-chalimus transition. BMC Genomics. 17 pages.
Show author(s) (2011). Analysis of polymeric immunoglobulin receptor- and CD300-like molecules from Atlantic salmon. Molecular Immunology. 462-473.
Show author(s) (2011). A monoclonal antibody distinguishes between two IgM heavy chain isotypes in Atlantic salmon and brown trout: Protein characterization, 3D modeling and epitope mapping. Molecular Immunology.

Show author(s) (2010). Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue. Journal of Anatomy. 728-739.

Show author(s) (2009). Cloning and expression analysis of Atlantic halibut (Hippoglossus hippoglossus) CD3 genes. Fish and Shellfish Immunology. 707-713.
Show author(s) (2009). CD4 homologues in Atlantic salmon. Fish and Shellfish Immunology. 10-18.
Show author(s) (2009). CD4 homologues in Atlantic salmon. Fish and Shellfish Immunology. 10-18.

Show author(s) (2008). Identification and characterization of a novel intraepithelial lymphoid tissue in the gills of Atlantic salmon. Journal of Anatomy. 202-209.
Show author(s) (2008). Identification and characterization of a novel intraepithelial lymphoid tissue in the gills of Atlantic salmon. Journal of Anatomy. 202-209.
Show author(s) (2008). Characterization of the CD3f, CD3cd and CD3e subunits of the T cell receptor complex in Atlantic salmon. Developmental and Comparative Immunology. 26-35.
Show author(s) (2008). Characterization of the CD3 zeta, CD3 gamma delta and CD3 epsilon subunits of the T cell receptor complex in Atlantic salmon. Developmental and Comparative Immunology. 26-35.

Show author(s) (2006). Myosin heavy chain mRNA expression correlates higher with muscle protein accretion than growth in Atlantic salmon, Salmo salar. Aquaculture. 453-461.
Show author(s) (2006). MHC class ll+ cells in the gills of Atlantic salmon ( Salmo salar L.) affected by amoebic gill disease. Veterinary Immunology and Immunopathology. 297-303.
Show author(s) (2006). MHC class II+ cells in the gills of Atlantic salmon (Salmo salar L.) affected by amoebic gill disease. Veterinary Immunology and Immunopathology. 297-303.
Show author(s) (2006). Identification and characterization of a second CD4-like gene in teleost fish. Molecular Immunology. 410-419.

Show author(s) (2005). Vaccine-associated granulomatous inflammation and melanin accumulation in Atlantic salmon, Salmo salar L., white muscle. Journal of Fish Diseases.
Show author(s) (2005). Vaccine-associated granulomatous inflammation and melanin accumulation in Atlantic salmon, Salmo salar L., white muscle. Journal of Fish Diseases. 13-22.
Show author(s) (2005). The ontogeny of MHC class I expression in rainbow trout (Oncorhynchus mykiss). Fish and Shellfish Immunology. 49-60.
Show author(s) (2005). The ontogeny of MHC class I expression in rainbow trout (Oncorhynchus mykiss). Fish and Shellfish Immunology. 49-60.
Show author(s) (2005). Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon. BMC Molecular Biology. 1-9.
Show author(s) (2005). Characterization of parvalbumin, the major allergen in Alaska pollack, and comparison with codfish Allergen M. Molecular Immunology. 345-353.
Show author(s) (2005). Characterisation of salmon and trout CD8 alpha and CD8 beta. Molecular Immunology.
Show author(s) (2005). Allergy to fish parvalbumins: Studies on the cross-reactivity of allergens from 9 commonly consumed fish. Journal of Allergy and Clinical Immunology. 1314-1320.

Show author(s) (2004). Structure and organization of the T cell receptor alpha chain genes in Atlantic salmon. Molecular Immunology. 553-559.
Show author(s) (2004). Granulomatous uveitis associated with vaccination in the Atlantic salmon. Veterinary pathology. 122-130.
Show author(s) (2004). Granulomatous uveitis associated with vaccination in the Atlantic salmon. Veterinary pathology. 122-130.

Show author(s) (2003). Vaccination induces major histocompatibility complex class II expression in the Atlantic salmon eye. Scandinavian Journal of Immunology. 9-14.
Show author(s) (2003). Vaccination Induces Major Histocompatibility Complex Class II Expression in the Atlantic Salmon Eye. Scandinavian Journal of Immunology. 9-14.
Show author(s) (2003). Production of rabbit antisera against recombinant MHC class II beta chain and identification of immunoreactive cells in Atlantic salmon (Salmo salar). Fish and Shellfish Immunology. 115-132.
Show author(s) (2003). Production of rabbit antisera against recombinant MHC class II B chain and identification of immunoreactive cells in Atlantic salmon (Salmo salar). Fish and Shellfish Immunology. 115-132.

Show author(s) (2002). Karakterisering av immungener hos fisk. Litt historikk, status og fremtidsutsikter. Fiskehelse.
Show author(s) (2002). Identification of a novel immunoglobulin δ transcript and comparative analysis of the genes encoding IgD in Atlantic salmon and Atlantic halibut. Molecular Immunology. 85-91.
Show author(s) (2002). Analysis of two IgM isotypes in Atlantic salmon and brown trout. Molecular Immunology. 313-321.

Show author(s) (2001). Presence of IgM in cutaneous mucus, but not in gut mucus of Atlantic salmon, Salmo salar. Serum IgM is rapidly degraded when added to gut mucus. Fish and Shellfish Immunology. 257-268.
Show author(s) (2001). Diversity of the immunoglobulin heavy chain in the Atlantic salmon (Salmo salar L.) is contributed by genes from two parallel IgH isoloci. Developmental and Comparative Immunology. 403-417.

Show author(s) (1999). The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae. Journal of Virology. 2136-2142.
Show author(s) (1999). Molecular cloning and phylogenetic analysis of the Atlantic salmon Immunoglobulin D gene. Scandinavian Journal of Immunology. 202-210.
Show author(s) (1999). Expression and analysis of recombinant salmon parvalbumin, the major allergen in Atlantic salmon (Salmo salar). ?. 619-625.
Show author(s) (1999). Expression and analysis of recombinant salmon parvalbumin, the major allergen in Atlantic salmon (Salmo salar). Scandinavian Journal of Immunology. 619-625.

Show author(s) (1998). The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes. Immunological Reviews. 153-157.
Show author(s) (1998). Molecular phylogeny of mcrosoridians with particular reference to species that infect the muscles of fish. Journal of Eukaryotic Microbiology. 535-543.

Show author(s) (1997). Structure and organization of the immunoglobulin M heavy chain genes in Atlantic salmon, Salmo salar. Molecular Immunology. 631-639.

Show author(s) (1996). Cloning of two distinct cDNAs encoding parvalbumin, the major allergen of Atlantic salmon (Salmo salar). Scandinavian Journal of Immunology. 335-344.
Show author(s) (1996). Cloning of two distinct cDNA encoding parvalbumin, the major allergen of Atlantic salmon (Salmo salar). Allergy. European Journal of Allergy and Clinical Immunology. 139.
Show author(s) (1996). Cloning of T-cell antigen receptor beta chain cDNAs from Atlantic salmon (Salmo salar). Immunogenetics. 9-14.
Show author(s) (1996). Avl og sykdomsresistens. Norsk Fiskeoppdrett. 25-27.

Show author(s) (1994). Immune genes of the Atlantic salmon. Application of modern genetic techniques to the study of antibodies and MHC antigens from Atlantic salmon. Aquaculture and Fisheries Management. 47-53.
Show author(s) (1994). Haploid gynogenesis. A powerful strategy for linkage analysis in fish. Animal Biotechnology.

Show author(s) (1993). Molecular cloning of major histocompability complex class I cDNAs from Atlantic salmon (Salmo salar). Immunogenetics. S. 469-473.
Show author(s) (1993). Cloning and sequence analysis of cDNAs encoding the MHC class II beta chain in Atlantic salmon (Salmo salar). Immunogenetics. 437-441.

Show author(s) (1992). The zebrafish homeobox gene Hox(zf-114): primary structure, expression pattern and evolutionary aspects. International Journal of Developmental Biology. 229-237.
Show author(s) (1992). Cloning and sequence analysis of two isotopic IgM heavy chain genes from Atlantic salmon, Salmo salar L. European Journal of Immunology. 2957-2962.

Academic lecture

Show author(s) (2019). Intramuscular vaccination of Atlantic lumpfish induces inflammation and local IgM production.
Show author(s) (2019). Distribution of different populations of T cells and B cells in the interbranchial lymphoid tissue (ILT) of salmon.
Show author(s) (2019). Characterization and development of focal red and melanised changes in the Atlantic salmon.

Show author(s) (2017). Intramuscular injection of oil-based vaccines in Atlantic lumpfish (Cyclopterus lumpus L.) – a possible route of administration or not? Emphasis on fish welfare and immune response .
Show author(s) (2017). Intramuscular injection of oil-based vaccines in Atlantic lumpfish (Cyclopterus lumpus L.) – a possible route of administration or not?

Show author(s) (2011). Tarmkreft hos laksefisk er assosiert med betennelse.

Show author(s) (2003). Analysis of IgD expression in Atlantic salmon.

Show author(s) (2002). Detection of MHC class II positive cells in the Atlantic salmon (Salmo salar).
Show author(s) (2002). Detection of MHC class II positive cells in the Atlantic salmon (Salmo salar).

Show author(s) (2001). Identification of IgD heavy chain RNA splice variants in Atlantic salmon, Salmo salar.
Show author(s) (2001). Analyse av immunoglobulin D uttrykking hos laks.

Show author(s) (2000). IgM and IgD heavy chain subvariants in Atlantic salmon and brown trout, related to ancestral tetraploidy.

Show author(s) (1993). Two isotypic IgM heavy chain genes of the Atlantic salmon.
Show author(s) (1993). MHC polymorphism in Atlantic salmon.

Reader opinion piece

Show author(s) (2011). Ville reinsdyr trives best. Bergens Tidende. 28-28.

Thesis at a second degree level

Show author(s) (2007). Deteksjon av IgM-positive celler i blodutstryk fra kveite (Hippoglossus hippoglossus L.): in situ hybridisering med to typer prober.

Show author(s) (2004). Expression of two fragments from the atlantic salmon major histocompability class 1α chain in E.coli, utilizing two different.
Show author(s) (2004). Analyse av IgM- og IgD-genuttrykking i ulike vev hos atlantisk laks (Salmo salar L.).