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    HIB - Thormøhlens gate 55
    5006 Bergen
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    Postboks 7803
    5020 Bergen

The research of Ivar Hordvik is focused on components of the adaptive immune system in fish. A long term goal is to broaden the spectrum of well characterized molecules and develop molecular tools that can be used to study immune responses during experiments with vaccines and pathogens in fish.

After teleost fish made a separate branch on the phylogenetic tree significant differences have been introduced between fish and mammals, both with respect to primary sequence of corresponding molecules, and the introduction of new molecules by gene duplications. An example of this is the evolution of the immunoglobulins: Whereas IgM has been evolutionarily stable and maintained the primordial structure in all jawed vertebrates the IgD gene has been evolutionarily labile and has been subjected to many internal duplications and deletions. A newly discovered gene, encoding an isotype named IgT/IgZ appears to be specific for teleost fish. On the other hand, IgG, IgE, and IgA are isotypes present in mammals, but not in fish.

Several findings the last years have shown that studies of the immune system in fish still offers surprises. It is plausible to assume that improved knowledge on the function and ontogeny of immune components in fish will aid experimental design of future vaccination trials and interpretation of results. Delivery of vaccines across mucosal surfaces of fish would obviously be an advantage and boost the profitability of the aquaculture industry. Development of new reagents for identification of immune cells and for monitoring immune responses is also an issue which has been addressed by vaccine companies as well as many researchers.

Cloning and expression analysis of Atlantic halibut (Hippoglossus hippoglossus) CD3 genes
Author(s): Overgard, AC; Hordvik, I; Nerland, AH, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 27   Issue: 6   Pages: 707-713   Published: 2009

 

CD4 homologues in Atlantic salmon
Author(s): Moore, LJ; Dijkstra, JM; Koppang, EO, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 26   Issue: 1   Pages: 10-18   Published: 2009

 

Identification and characterization of a novel intraepithelial lymphoid tissue in the gills of Atlantic salmon
Author(s): Haugarvoll, E; Bjerkas, I; Nowak, BF, et al.
Source: JOURNAL OF ANATOMY   Volume: 213   Issue: 2   Pages: 202-209   Published: 2008

 

Characterization of the CD3 zeta, CD3 gamma delta and CD3 epsilon subunits of the T cell receptor complex in Atlantic salmon
Author(s): Liu, Y; Moore, L; Koppang, EO, et al.
Source: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   Volume: 32   Issue: 1   Pages: 26-35   Published: 2008

 

FABP3 and FABP10 in Atlantic salmon (Salmo salar L.) - General effects of dietary fatty acid composition and life cycle variations
Author(s): Jordal, AEO; Hordvik, I; Pelsers, M, et al.
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY   Volume: 145   Issue: 2   Pages: 147-158   Published: OCT 2006

 

Myosin heavy chain mRNA expression correlates higher with muscle protein accretion than growth in Atlantic salmon, Salmo salar
Author(s): Hevroy, EM; Jordal, AEO; Hordvik, I, et al.
Source: AQUACULTURE   Volume: 252   Issue: 2-4   Pages: 453-461   Published: MAR 10 2006

 

Identification and characterization of a second CD4-like gene in teleost fish
Author(s): Dijkstra, JM; Somamoto, T; Moore, L, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 43   Issue: 5   Pages: 410-419   Published: FEB 2006

 

MHC class II+ cells in the gills of Atlantic salmon (Salmo salar L.) affected by amoebic gill disease
Author(s): Morrison, RN; Koppang, EO; Hordvik, I, et al.
Source: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY   Volume: 109   Issue: 3-4   Pages: 297-303   Published: FEB 15 2006

 

Allergy to fish parvalbumins: Studies on the cross-reactivity of allergens from 9 commonly consumed fish
Author(s): Van Do, T; Elsayed, S; Florvaag, E, et al.
Source: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Volume: 116   Issue: 6   Pages: 1314-1320   Published: DEC 2005

 

Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon
Author(s): Olsvik, PA; Lie, KK; Jordal, AEO, et al.
Source: BMC MOLECULAR BIOLOGY   Volume: 6   Article Number: 21   Published: NOV 17 2005

 

Characterisation of salmon and trout CD8 alpha and CD8 beta
Author(s): Moore, LJ; Somamoto, T; Lie, KK, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 42   Issue: 10   Pages: 1225-1234   Published: JUN 2005

 

Characterization of parvalbumin, the major allergen in Alaska pollack, and comparison with codfish Allergen M
Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 42   Issue: 3   Pages: 345-353   Published: FEB 2005

 

The ontogeny of MHC class I expression in rainbow trout (Oncorhynchus mykiss)
Author(s): Fischer, U; Dijkstra, JM; Kollner, B, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 18   Issue: 1   Pages: 49-60   Published: JAN 2005

 

Vaccine-associated granulomatous inflammation and melanin accumulation in Atlantic salmon, Salmo salar L., white muscle
Author(s): Koppang, EO; Haugarvoll, E; Hordvik, I, et al.
Source: JOURNAL OF FISH DISEASES   Volume: 28   Issue: 1   Pages: 13-22   Published: JAN 2005

 

Structure and organization of the T cell receptor alpha chain genes in Atlantic salmon
Author(s): Hordvik, I; Torvund, J; Moore, L, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 41   Issue: 5   Pages: 553-559   Published: JUL 2004

 

Granulomatous uveitis associated with vaccination in the Atlantic salmon
Author(s): Koppang, EO; Haugarvoll, E; Hordvik, I, et al.
Source: VETERINARY PATHOLOGY   Volume: 41   Issue: 2   Pages: 122-130   Published: MAR 2004

 

Vaccination induces major histocompatibility complex class II expression in the Atlantic salmon eye
Author(s): Koppang, EO; Bjerkas, E; Bjerkas, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 58   Issue: 1   Pages: 9-14   Published: JUL 2003

 

The major allergen (parvalbumin) of codfish is encoded by at least two isotypic genes: cDNA cloning, expression and antibody binding of the recombinant allergens
Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 39   Issue: 10   Pages: 595-602   Published: JAN 2003

 

Analysis of two IgM isotypes in Atlantic salmon and brown trout
Author(s): Hordvik, I; Berven, FS; Solem, ST, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 39   Issue: 5-6   Pages: 313-321   Published: OCT 2002

 

Identification of a novel immunoglobulin delta transcript and comparative analysis of the genes encoding IgD in Atlantic salmon and Atlantic halibut
Author(s): Hordvik, I
Source: MOLECULAR IMMUNOLOGY   Volume: 39   Issue: 1-2   Pages: 85-91   Published: SEP 2002

 

Diversity of the immunoglobulin heavy chain in the Atlantic salmon (Salmo salar L.) is contributed by genes from two parallel IgH isoloci.
Author(s): Solem, ST; Hordvik, I; Killie, JEA, et al.
Source: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   Volume: 25   Issue: 5-6   Pages: 403-417   Published: JUN-JUL 2001

 

Presence of IgM in cutaneous mucus, but not in gut mucus of Atlantic salmon, Salmo salar. Serum IgM is rapidly degraded when added to gut mucus
Author(s): Hatten, F; Fredriksen, A; Hordvik, I, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 11   Issue: 3   Pages: 257-268   Published: APR 2001

 

Expression and analysis of recombinant salmon parvalbumin, the major allergen in atlantic salmon (Salmo salar)
Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 50   Issue: 6   Pages: 619-625   Published: 1999

 

Molecular cloning and phylogenetic analysis of the Atlantic salmon immunoglobulin D gene
Author(s): Hordvik, I; Thevarajan, J; Samdal, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 50   Issue: 2   Pages: 202-210   Published: AUG 1999

 

The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae
Author(s): Krossoy, B; Hordvik, I; Nilsen, F, et al.
Source: JOURNAL OF VIROLOGY   Volume: 73   Issue: 3   Pages: 2136-2142   Published: MAR 1999

 

The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes
Author(s): Hordvik, I
Source: IMMUNOLOGICAL REVIEWS   Volume: 166   Pages: 153-157   Published: DEC 1998

 

Molecular phylogeny of microsporidians with particular reference to species that infect the muscles of fish
Author(s): Nilsen, F; Endresen, C; Hordvik, I
Source: JOURNAL OF EUKARYOTIC MICROBIOLOGY   Volume: 45   Issue: 5   Pages: 535-543   Published: SEP-OCT 1998

 

Structure and organization of the immunoglobulin M heavy chain genes in Atlantic salmon, Salmo salar
Author(s): Hordvik, I; Lindstrom, CD; Voie, AM, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 34   Issue: 8-9   Pages: 631-639   Published: JUN 1997

 

Cloning of T-cell antigen receptor beta chain cDNAs from Atlantic salmon (Salmo salar)
Author(s): Hordvik, I; Jacob, ALJ; Charlemagne, J, et al.
Source: IMMUNOGENETICS   Volume: 45   Issue: 1   Pages: 9-14   Published: 1996

 

Cloning of two distinct cDNAs encoding parvalbumin, the major allergen of Atlantic salmon (Salmo salar)
Author(s): Lindstrom, CDV; VanDo, T; Hordvik, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 44   Issue: 4   Pages: 335-344   Published: OCT 1996

 

Immune genes of the Atlantic salmon, Salmo salar L.: Application of modern molecular genetic techniques to the study of antibodies and major histocompatibility complex antigens
Author(s): Hordvik, I.
Source: Aquaculture and Fisheries Management   Volume: 25   Issue: 1   Pages: 47-53   Published: 1994

 

Haploid gynogenesis: A powerful strategy for linkage analysis in fish
Author(s): Lie, O.; Slettan, A.; Lingaas, F., et al.
Source: Animal Biotechnology   Volume: 5   Issue: 1   Pages: 33-45   Published: 1994

 

MOLECULAR-CLONING OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I CDNAS FROM ATLANTIC SALMON (SALMO-SALAR)
Author(s): GRIMHOLT, U; HORDVIK, I; FOSSE, VM, et al.
Source: IMMUNOGENETICS   Volume: 37   Issue: 6   Pages: 469-473   Published: FEB 1993

 

CLONING AND SEQUENCE-ANALYSIS OF CDNAS ENCODING THE MHC CLASS-II BETA-CHAIN IN ATLANTIC SALMON (SALMO-SALAR)
Author(s): HORDVIK, I; GRIMHOLT, U; FOSSE, VM, et al.
Source: IMMUNOGENETICS   Volume: 37   Issue: 6   Pages: 437-441   Published: FEB 1993

 

CLONING AND SEQUENCE-ANALYSIS OF 2 ISOTYPIC IGM HEAVY-CHAIN GENES FROM ATLANTIC SALMON, SALMO-SALAR L
Author(s): HORDVIK, I; VOIE, AM; GLETTE, J, et al.
Source: EUROPEAN JOURNAL OF IMMUNOLOGY   Volume: 22   Issue: 11   Pages: 2957-2962   Published: NOV 1992