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Jérôme Ruzzin

Researcher
  • E-mailJerome.Ruzzin@uib.no
  • Phone+47 55 58 43 79
  • Visitor Address
    3. etasje Høyteknologisenteret, Bioblokka, Thormøhlensgate 55, 5008 Bergen
    Bergen
    Room 
    Rom 325C1/326C1
  • Postal Address
    Postboks 7803
    5020 Bergen

Major Research Areas (basic and human research)

• Xenobiotics (endocrine disruptors) and chronic diseases

• Molecular mechanisms of xenobiotics and role of nuclear receptors  

• Therapeutic potential of fibroblast growth factor 19 against muscle wasting 

 

Major scientifc discoveries

1 Ruzzin, J., et al. Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect 118, 465-471 (2010).

2 Ibrahim, M.M., et al. Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. PLoS One 6, e25170 (2011).

3 Gauthier, M.S., et al. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. J Clin Endocrinol Metab 99, E1061-1066 (2014).

4 Benoit, B., et al. Fibroblast growth factor 19 regulates skeletal muscle mass and protects from muscle wasting. Nature Medicine 23:990-996 (2017).

INVITED TALKS  (major conferences)

Organiske miljøgifter og sykelig overvekt.Invited by the Norwegian Academy of Science and Letters (October 2014). 

Impacts of endocrine disruptors on insulin resistance in obese individuals.Invited by the French Society of Endocrinology, Lyon, France (October 2014).

Organic Pollutants and Type 2 Diabetes.The 50th Annual Meeting of the European Association for the Study of Diabetes (EASD), Vienne, Austria (September 2014). 

Linking POPs to the metabolically healthy and abnormal obese phenotype.The Gordon Research Seminar in Environmental Endocrine Disruptors, Lucca, Italy (May 2014).

Health Impacts of PersistentOrganic PollutantsPresent in Farmed Salmon: From Cells to Humans.The Norwegian Society of Pharmacology and Toxicology, Beitostølen, Norway (January 2014). 

Persistent Organic Pollutantsand Metabolic Diseases.The7thCopenhagen Workshop on Endocrine Disruptors, Copenhagen, Denmark(2013).

Contribution of Persistent Organic Pollutants to Obesity and Insulin Resistance Syndrome.The Norwegian Society of Pharmacology and Toxicology, Beitostølen, Norway (2012). 

Mixture of Persistent Organic Pollutants, Insulin Resistance and Obesity.Environmental Pollution Conference. Norwegian Climate and Pollution Agency and Research Council of Norway, Oslo, Norway (2012). 

Environmental Pollutants: The Dark Side of The Food.The 24thSpring Congress of the Korean Diabetes Association, Gwangju, Republic of Korea (2011).

BIO206 Organ Toxicology

BIO316 Selected topics in environmental toxicology

BIO101 Organismal Biology

MOL200 Metabolism: Reactions, Regulations and Compartmentalization 

 

Journal articles
  • Dusanov, Sasa; Ruzzin, Jérôme; Kiviranta, Hannu; Klemsdal, Tor Ole; Retterstøl, Lars; Rantakokko, Panu; Airaksinen, Riikka; Djurovic, Srdjan; Tonstad, Serena. 2018. Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals. NMCD. Nutrition Metabolism and Cardiovascular Diseases. 1-8. doi: 10.1016/j.numecd.2018.03.004
  • Benoit, Berengère; Meugnier, Emmanuelle; Castelli, Martina Galatea; Chanon, Stéphanie; Vieille-Marchiset, Aurélie; Durand, Christine; Bendridi, Nadia; Pesenti, Sandra; Monternier, Pierre-Axel; Durieux, Anne-Cécile; Freyssenet, Damien; Rieusset, Jennifer; Lefai, Etienne; Vidal, Hubert; Ruzzin, Jérôme. 2017. Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nature Medicine. 23: 990-996. doi: 10.1038/nm.4363
  • Bolann, Bjørn Johan; Huber, Sandra; Ruzzin, Jérôme; Brox, Jan; Huitfeldt, Henrik; Monsen, Anne Lise Bjørke. 2017. Miljøgifter i kosten handler om mer enn fisk. Tidsskrift for Den norske legeforening. 137: 973-974. doi: 10.4045/tidsskr.17.0521
  • Bolann, Bjørn Johan; Huber, Sandra; Ruzzin, Jérôme; Brox, Jan; Huitfeldt, Henrik; Monsen, Anne Lise Bjørke. 2017. Er miljøgifter i norsk kosthold skadelig for barn? Tidsskrift for Den norske legeforening. 137: 295-297. doi: 10.4045/tidsskr.16.0978
  • Geng, Dawei; Jogsten, Ingrid Ericson; Dunstan, Jody; Hagberg, Jessika; Wang, Thanh; Ruzzin, Jérôme; Rabasa-Lhoret, Rémi; Bavel, Bert Van. 2016. Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum. Journal of Chromatography A. 1453: 88-98. doi: 10.1016/j.chroma.2016.05.030
  • Heindel, Jerold J.; Vom Saal, Frederick S.; Blumberg, Bruce; Bovolin, Patrizia; Calamandrei, Gemma; Ceresini, Graziano; Cohn, Barbara A.; Fabbri, Elena; Gioiosa, Laura; Kassotis, Christopher; Legler, Juliette; La Merrill, Michele; Rizzir, Laura; Machtinger, Ronit; Mantovani, Alberto; Mendez, Michelle A.; Montanini, Luisa; Molteni, Laura; Nagel, Susan C.; Parmigiani, Stefano; Panzica, Giancarlo; Paterlini, Silvia; Pomatto, Valentina; Ruzzin, Jérôme; Sartor, Giorgio; Schug, Thaddeus T.; Street, Maria E.; Suvorov, Alexander; Volpi, Riccardo; Zoeller, R. Thomas; Palanza, Paola. 2015. Parma consensus statement on metabolic disruptors. Environmental health. 14:19. 7 pages. doi: 10.1186/s12940-015-0042-7
  • Ruzzin, Jérôme; Bethune, Claudette; Goksøyr, Anders; Hylland, Ketil; Lee, Duk Hee; Jacobs, David R; Carpenter, David O. 2015. Comment on "Contaminant levels in Norwegian farmed Atlantic salmon (Salmo salar) in the 13-year period from 1999 to 2011" by Nøstbakken et al. Environment International. 80: 98-99. doi: 10.1016/j.envint.2015.01.003
  • Gauthier, Marie-Soleil; Rabasa-Lhoret, Rémi Rabasa; Prud'homme, Denis; Karelis, Antony D.; Geng, Dawei; van Bavel, Bert; Ruzzin, Jérôme. 2014. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. Journal of Clinical Endocrinology and Metabolism. 99: E1061-E1066. doi: 10.1210/jc.2013-3935
  • Jacobs, David R. Jr.; Ruzzin, Jérôme; Lee, Duk Hee. 2014. Environmental pollutants: Downgrading the fish food stock affects chronic disease risk. Journal of Internal Medicine. 276: 240-242. doi: 10.1111/joim.12205
  • Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Frøyland, Livar; Jessen, Niels; Lund, Sten; Vidalf, Hubert; Ruzzin, Jérôme. 2012. Metabolic impacts of high dietary exposure to persistent organic pollutants in mice. Toxicology Letters. 215: 8-15. doi: 10.1016/j.toxlet.2012.09.022
  • Ruzzin, Jérôme. 2012. Public health concern behind the exposure to persistent organic pollutants and the risk of metabolic diseases. BMC Public Health. 12. 8 pages. doi: 10.1186/1471-2458-12-298
  • Ruzzin, Jérôme; Jacobs, David. 2012. The secret story of fish: decreasing nutritional value due to pollution? British Journal of Nutrition. 108: 397-399. doi: 10.1017/S0007114512002048
  • Ruzzin, Jérôme; Lee, Duk-Hee; Carpenter, David O.; Jacobs, David. 2012. Reconsidering metabolic diseases: The impacts of persistent organic pollutants. Atherosclerosis. 224: 1-3. doi: 10.1016/j.atherosclerosis.2012.02.039
  • Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Naville, Danielle; Amlund, Heidi; Meugnier, Emmanuelle; Battistoni, Brigitte Le; Frøyland, Livar; Madsen, Lise; Jessen, Niels; Lund, Sten; Vidal, Hubert; Ruzzin, Jérôme. 2011. Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice. PLOS ONE. 6: e25170. doi: 10.1371/journal.pone.0025170
  • Pilon, Geneviève; Ruzzin, Jérôme; Rioux, Laurie Eve; Lavigne, Charles; White, Philip J.; Frøyland, Livar; Jacques, Hélène; Bryl, Piotr; Beaulieu, Lucie; Marette, André. 2011. Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats. Metabolism: Clinical and Experimental. 60: 1122-1130. doi: 10.1016/j.metabol.2010.12.005
  • Ruzzin, Jérôme; Petersen, Rasmus; Meugnier, Emmanuelle; Madsen, Lise; LOCK, ERIK-JAN; Lillefosse, Haldis Haukås; Ma, Tao; Pesenti, Sandra; Sonne, Si Brask; Marstrand, Troels Torben; Malde, Marian Kjellevold; DU, ZHEN-YU; Chavey, Carine; Fajas, Lluis; Lundebye-Haldorsen, Anne Katrine; Brand, Christian Lehn; Vidal, Hubert; Kristiansen, Karsten; Frøyland, Livar. 2010. Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome. Environmental Health Perspectives. 118: 465-471. doi: 10.1289/ehp.0901321

More information in national current research information system (CRIStin)

Most Relevant Publications

Dusanov S, Ruzzin J, Kiviranta H, Klemsdal T O, Retterstøl L, Rantakokko P, Airaksinen R, Djurovic S, Tonstad S: Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals. Nutrition, Metabolism & Cardiovascular Diseases, 2018. Mar 13. pii: S0939-4753(18)30094-2. doi: 10.1016/j.numecd.2018.03.004

Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C, Monternier P-A, Durieux A-C, Freyssenet D, Lefai E, Vidal H, Ruzzin J: Fibroblast growth factor 19 regulates skeletal muscle mass and protects from muscle wasting. Nature Medicine 23(8):990-996, 2017.

D Geng, I E Jogsten, J Dunstan, J Hagberg, J Ruzzin, R Rabasa-Lhoret and B van Bavel. Atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS) for the analysis of persistent organic pollutants regulated by the Stockholm Convention in human serum. Journal of Chromatography A 1453:88-98, 2016.

JJ Heindel, FS vom Saal, B Blumberg, P Bovolin, G Calamandrei, G Ceresini, BA Cohn, E Fabbri, L Gioiosa, C Kassotis, J Legler, M La Merrill, L Rizzir, R Machtinger, A Mantovani, MA Mendez, L Montanini, L Molteni, SC Nagel, S Parmigiani, G Panzica, S Paterlini, V Pomatto, J Ruzzin, G Sartor, TT Schug, ME Street, A Suvorov, R Volpi, RT Zoeller, P Palanza. Parma consensus statement on metabolic disruptors. Environmental Health 20(14):54, 2015.

M-S Gauthier, R Rabasa-Lhoret, D Prud'homme, A Karelis, D Geng, B van Bavel, and J Ruzzin. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. The Journal of Clinical Endocrinology and Metabolism 99(6):E1061-6, 2014.

DR Jacobs Jr, J Ruzzin, and DH Lee. Environmental pollutants: downgrading the fish food stock affects chronic disease risk. Journal of Internal Medicine 276(3):240-2, 2014.

J Ruzzin Chapter 6. Mechanistic basis for elevation in risk of diabetes caused by persistent organic pollutant. (2013) Published in ”Effects of persistent and bioactive organic pollutants on human health”. Edited by David O. Carpenter. John Wiley & Sons.

MM Ibrahim, E Fjære, EJ Lock, H Amlund, L Frøyland, N Jessen, S Lund, H Vidal, and J Ruzzin. Metabolic impacts of high dietary exposure to persistent organic pollutants in mice. Toxicology Letters, 215:8-15, 2012.

J Ruzzin, DH Lee, DO Carpenter, and D Jacobs Jr. Reconsidering metabolic diseases: the impacts of persistent organic pollutants. Atherosclerosis 224:1-3, 2012.

MM Ibrahim, E Fjære, EJ Lock, D Naville, H Amlund, E Meugnier, B Le Magueresse Battistoni, L Frøyland, L Madsen, N Jessen, S Lund, H Vidal, and J Ruzzin. Chronic consumption of diet with farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. PLoS ONE 6(9): e25170, 2011.

J Ruzzin, R Petersen, E Meugnier, L Madsen, EJ Lock, H Lillefosse, T Ma, S Pesenti, S Sonne, TT Marstrand, MK Malde, ZY Du, C Chavey, L Fajas, AK Lundebye, CL Brand, H Vidal, K Kristiansen, L Frøyland. Persistent organic pollutant exposure leads to insulin resistance syndrome. Environmental Health Perspectives 118:465-71, 2010.

On-going research activities 

Role of Xenobiotics in Metabolic Diseases: A Translational Approach. Principal Investigator. Financed by Research Council of Norway (RCN) -FRIMEDBIO programme

Previous research activities 

Signaling impairments GeNerated by Endocrine Disruptors. Principal investigator. Financed by RCN (2013-2016).

Searching the origin of the insulin resistance syndrome. Principal investigator. Financed by RCN (2011-2013).

Role of marine food to fight metabolic syndrome: evaluating the benefits and risks. Principal investigator. Financed by RCN (2009-2012).

Salmon oil and contaminants: impacts on insulin sensitivity and metabolic diseases. Principal investigator. Financed by RCN (2008-2011).

Research groups