Major Research Areas (basic and human research)
• Xenobiotics (endocrine disruptors) and chronic diseases
• Molecular mechanisms of xenobiotics and role of nuclear receptors
• Therapeutic potential of fibroblast growth factor 19 against muscle wasting
Major scientifc discoveries
1 Ruzzin, J., et al. Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect 118, 465-471 (2010).
2 Ibrahim, M.M., et al. Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. PLoS One 6, e25170 (2011).
3 Gauthier, M.S., et al. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. J Clin Endocrinol Metab 99, E1061-1066 (2014).
4 Benoit, B., et al. Fibroblast growth factor 19 regulates skeletal muscle mass and protects from muscle wasting. Nature Medicine 23:990-996 (2017).
INVITED TALKS (major conferences)
Organiske miljøgifter og sykelig overvekt.Invited by the Norwegian Academy of Science and Letters (October 2014).
Impacts of endocrine disruptors on insulin resistance in obese individuals.Invited by the French Society of Endocrinology, Lyon, France (October 2014).
Organic Pollutants and Type 2 Diabetes.The 50th Annual Meeting of the European Association for the Study of Diabetes (EASD), Vienne, Austria (September 2014).
Linking POPs to the metabolically healthy and abnormal obese phenotype.The Gordon Research Seminar in Environmental Endocrine Disruptors, Lucca, Italy (May 2014).
Health Impacts of PersistentOrganic PollutantsPresent in Farmed Salmon: From Cells to Humans.The Norwegian Society of Pharmacology and Toxicology, Beitostølen, Norway (January 2014).
Persistent Organic Pollutantsand Metabolic Diseases.The7thCopenhagen Workshop on Endocrine Disruptors, Copenhagen, Denmark(2013).
Contribution of Persistent Organic Pollutants to Obesity and Insulin Resistance Syndrome.The Norwegian Society of Pharmacology and Toxicology, Beitostølen, Norway (2012).
Mixture of Persistent Organic Pollutants, Insulin Resistance and Obesity.Environmental Pollution Conference. Norwegian Climate and Pollution Agency and Research Council of Norway, Oslo, Norway (2012).
Environmental Pollutants: The Dark Side of The Food.The 24thSpring Congress of the Korean Diabetes Association, Gwangju, Republic of Korea (2011).
- 2018. Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals. NMCD. Nutrition Metabolism and Cardiovascular Diseases. 1-8.
- 2017. Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nature Medicine. 990-996.
- 2016. Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum. Journal of Chromatography A. 88-98.
- 2014. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. Journal of Clinical Endocrinology and Metabolism. E1061-E1066.
- 2012. Public health concern behind the exposure to persistent organic pollutants and the risk of metabolic diseases. BMC Public Health. 8 pages.
- 2012. Metabolic impacts of high dietary exposure to persistent organic pollutants in mice. Toxicology Letters. 8-15.
- 2011. Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats. Metabolism: Clinical and Experimental. 1122-1130.
- 2011. Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice. PLOS ONE. e25170.
- 2010. Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome. Environmental Health Perspectives. 465-471.
- 2014. Environmental pollutants: Downgrading the fish food stock affects chronic disease risk. Journal of Internal Medicine. 240-242.
- 2012. The secret story of fish: decreasing nutritional value due to pollution? British Journal of Nutrition. 397-399.
- 2017. Miljøgifter i kosten handler om mer enn fisk. Tidsskrift for Den norske legeforening. 973-974.
- 2015. Parma consensus statement on metabolic disruptors. Environmental health. 7 pages.
- 2017. Er miljøgifter i norsk kosthold skadelig for barn? Tidsskrift for Den norske legeforening. 295-297.
- 2015. Comment on "Contaminant levels in Norwegian farmed Atlantic salmon (Salmo salar) in the 13-year period from 1999 to 2011" by Nøstbakken et al. Environment International. 98-99.
- 2012. Reconsidering metabolic diseases: The impacts of persistent organic pollutants. 1-3.
Most Relevant Publications
Dusanov S, Ruzzin J, Kiviranta H, Klemsdal T O, Retterstøl L, Rantakokko P, Airaksinen R, Djurovic S, Tonstad S: Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals. Nutrition, Metabolism & Cardiovascular Diseases, 2018. Mar 13. pii: S0939-4753(18)30094-2. doi: 10.1016/j.numecd.2018.03.004
Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C, Monternier P-A, Durieux A-C, Freyssenet D, Lefai E, Vidal H, Ruzzin J: Fibroblast growth factor 19 regulates skeletal muscle mass and protects from muscle wasting. Nature Medicine 23(8):990-996, 2017.
D Geng, I E Jogsten, J Dunstan, J Hagberg, J Ruzzin, R Rabasa-Lhoret and B van Bavel. Atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS) for the analysis of persistent organic pollutants regulated by the Stockholm Convention in human serum. Journal of Chromatography A 1453:88-98, 2016.
JJ Heindel, FS vom Saal, B Blumberg, P Bovolin, G Calamandrei, G Ceresini, BA Cohn, E Fabbri, L Gioiosa, C Kassotis, J Legler, M La Merrill, L Rizzir, R Machtinger, A Mantovani, MA Mendez, L Montanini, L Molteni, SC Nagel, S Parmigiani, G Panzica, S Paterlini, V Pomatto, J Ruzzin, G Sartor, TT Schug, ME Street, A Suvorov, R Volpi, RT Zoeller, P Palanza. Parma consensus statement on metabolic disruptors. Environmental Health 20(14):54, 2015.
M-S Gauthier, R Rabasa-Lhoret, D Prud'homme, A Karelis, D Geng, B van Bavel, and J Ruzzin. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. The Journal of Clinical Endocrinology and Metabolism 99(6):E1061-6, 2014.
DR Jacobs Jr, J Ruzzin, and DH Lee. Environmental pollutants: downgrading the fish food stock affects chronic disease risk. Journal of Internal Medicine 276(3):240-2, 2014.
J Ruzzin Chapter 6. Mechanistic basis for elevation in risk of diabetes caused by persistent organic pollutant. (2013) Published in ”Effects of persistent and bioactive organic pollutants on human health”. Edited by David O. Carpenter. John Wiley & Sons.
MM Ibrahim, E Fjære, EJ Lock, H Amlund, L Frøyland, N Jessen, S Lund, H Vidal, and J Ruzzin. Metabolic impacts of high dietary exposure to persistent organic pollutants in mice. Toxicology Letters, 215:8-15, 2012.
J Ruzzin, DH Lee, DO Carpenter, and D Jacobs Jr. Reconsidering metabolic diseases: the impacts of persistent organic pollutants. Atherosclerosis 224:1-3, 2012.
MM Ibrahim, E Fjære, EJ Lock, D Naville, H Amlund, E Meugnier, B Le Magueresse Battistoni, L Frøyland, L Madsen, N Jessen, S Lund, H Vidal, and J Ruzzin. Chronic consumption of diet with farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. PLoS ONE 6(9): e25170, 2011.
J Ruzzin, R Petersen, E Meugnier, L Madsen, EJ Lock, H Lillefosse, T Ma, S Pesenti, S Sonne, TT Marstrand, MK Malde, ZY Du, C Chavey, L Fajas, AK Lundebye, CL Brand, H Vidal, K Kristiansen, L Frøyland. Persistent organic pollutant exposure leads to insulin resistance syndrome. Environmental Health Perspectives 118:465-71, 2010.
On-going research activities
Role of Xenobiotics in Metabolic Diseases: A Translational Approach. Principal Investigator. Financed by Research Council of Norway (RCN) -FRIMEDBIO programme
Previous research activities
Signaling impairments GeNerated by Endocrine Disruptors. Principal investigator. Financed by RCN (2013-2016).
Searching the origin of the insulin resistance syndrome. Principal investigator. Financed by RCN (2011-2013).
Role of marine food to fight metabolic syndrome: evaluating the benefits and risks. Principal investigator. Financed by RCN (2009-2012).
Salmon oil and contaminants: impacts on insulin sensitivity and metabolic diseases. Principal investigator. Financed by RCN (2008-2011).