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Jaakko Saraste

Professor
  • E-mailJaakko.Saraste@uib.no
  • Phone+47 55 58 63 29
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

Jaakko received his PhD at the University of Helsinki, Finland. He did his postdoctoral work at Yale University School of Medicine, USA. From 1987-1992 he worked as a group leader at Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm. From 1993-1998 he worked as a Research Fellow at the Department of Biochemistry and Molecular Biology. In 1998 he took up a position as a Professor at the Department of Anatomy and Cell Biology.
His group is working on the functional organisation of the intermediate compartment, a membrane system operating between the endoplasmic reticulum and the Golgi complex.

Journal articles
  • Saraste, Jaakko; Prydz, Kristian. 2019. A New Look at the Functional Organization of the Golgi Ribbon. Frontiers in Cell and Developmental Biology. 7. doi: 10.3389/fcell.2019.00171
  • Saraste, Jaakko; Marie, Michaël Bruno Eric. 2018. Intermediate compartment (IC): from pre-Golgi vacuoles to a semi-autonomous membrane system. Histochemistry and Cell Biology. 150: 407-430. doi: 10.1007/s00418-018-1717-2
  • Aukrust, Ingvild; Rosenberg, Linn Andersen; Ankerud, Mia Madeleine; Bertelsen, Vibeke; Hollås, Hanne; Saraste, Jaakko; Grindheim, Ann Kari; Vedeler, Anni. 2017. Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes. FEBS Open Bio. 7: 160-173. doi: 10.1002/2211-5463.12173
  • Grindheim, Ann Kari; Saraste, Jaakko; Vedeler, Anni. 2017. Protein phosphorylation and its role in the regulation of Annexin A2 function. Biochimica et Biophysica Acta - General Subjects. 1861: 2515-2529. doi: 10.1016/j.bbagen.2017.08.024
  • Jorge Finnigan, Ana; Kleppe, Rune; K C, Kunwar Jung; Ying, Ming; Marie, Michael Bruno Eric; Rios Mondragon, Ivan; Salvatore, Michael F; Saraste, Jaakko; Martinez, Aurora. 2017. Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. Journal of Biological Chemistry. 292: 14092-14107. doi: 10.1074/jbc.M116.762344
  • Leandro, João; Saraste, Jaakko; Leandro, Paula; Flatmark, Torgeir. 2017. PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain. FEBS Open Bio. 7: 195-203. doi: 10.1002/2211-5463.12175
  • Grindheim, Ann Kari; Hollås, Hanne; Raddum, Aase Merethe; Saraste, Jaakko; Vedeler, Anni. 2016. Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. Journal of Cell Science. 129: 314-328. doi: 10.1242/jcs.173195
  • Christensen, Anne Elisabeth; Bruland, Ove; Vedeler, Anni; Saraste, Jaakko; Schönheit, Jürgen; Bredrup, Cecilie; Knappskog, Per; Rødahl, Eyvind. 2015. Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin. Investigative Ophthalmology and Visual Science. 56: 2909-2915. doi: 10.1167/iovs.14-16014
  • Grindheim, Ann Kari; Hollås, Hanne; Ramirez, Juan; Saraste, Jaakko; Trave, Gilles Michel; Vedeler, Anni. 2014. Effect of serine phosphorylation and ser25 phospho-mimicking mutations on nuclear localisation and ligand interactions of annexin A2. Journal of Molecular Biology. 426: 2486-2499. doi: 10.1016/j.jmb.2014.04.019
  • Torsvik, Janniche; Johansson, Bente Berg; Dalva, Monica; Marie, Michael Bruno Eric; Fjeld, Karianne; Johansson, Stefan; Bjørkøy, Geir; Saraste, Jaakko; Njølstad, Pål Rasmus; Molven, Anders. 2014. Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction. Journal of Biological Chemistry. 289: 29097-29111. doi: 10.1074/jbc.M114.574244
  • Molven, Anders; Torsvik, Janniche; Johansson, Bente Berg; Marie, Michael Bruno Eric; Fjeld, Karianne; Johansson, Stefan; Saraste, Jaakko; Njølstad, Pål Rasmus. 2013. Cellular re-uptake of secreted carboxyl-ester lipase protein in CEL-MODY, a syndrome of diabetes and pancreatic exocrine dysfunction. Diabetologia. 56: S152-S152.
  • Prydz, Kristian; Tveit, Heidi; Vedeler, Anni; Saraste, Jaakko. 2013. Arrivals and departures at the plasma membrane: direct and indirect transport routes. Cell and Tissue Research. 352: 5-20. doi: 10.1007/s00441-012-1409-5
  • Leandro, João; Saraste, Jaakko; Leandro, Paula; Flatmark, Torgeir. 2012. Self-association of the regulatory domain of human phenylalanine hydroxylase: contribution to the protein instability. The FEBS Journal. 279: 465-465. doi: 10.1111/j.1742-4658.2010.08705.x
  • Marie, Michael Bruno Eric; Dale, Hege Avsnes; Kouprina, Nina; Saraste, Jaakko. 2012. Division of the intermediate compartment at the onset of mitosis provides a mechanism for Golgi inheritance. Journal of Cell Science. 125: 5403-5416. doi: 10.1242/jcs.108100
  • Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise; Vesterhus, Mette; Ragvin, Anja; Tjora, Erling; Fjeld, Karianne; Hoem, Dag; Johansson, Stefan; Ræder, Helge; Lindquist, Susanne; Hernell, Olle; Cnop, Miriam; Saraste, Jaakko; Flatmark, Torgeir; Molven, Anders; Njølstad, Pål Rasmus. 2011. Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 286: 34593-34605. doi: 10.1074/jbc.M111.222679
  • Leandro, João; Saraste, Jaakko; Leandro, Paula; Flatmark, Torgeir. 2011. The G46S-hPAH mutant protein: A model to study the rescue of aggregation-prone PKU mutations by chaperones. Molecular Genetics and Metabolism. 104: S40-S44. doi: 10.1016/j.ymgme.2011.07.024
  • Leandro, João; Simonsen, Nina; Saraste, Jaakko; Leandro, Paula; Flatmark, Torgeir. 2011. Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1812: 106-120. doi: 10.1016/j.bbadis.2010.09.015
  • Marie, Michael Bruno Eric; Dale, Hege Avsnes; Sannerud, Ragna Raymonde T.; Saraste, Jaakko. 2009. The Function of the Intermediate Compartment in Pre-Golgi Trafficking Involves its Stable Connection with the Centrosome. Molecular Biology of the Cell. 20: 4458-4470. doi: 10.1091/mbc.E08-12-1229
  • Saraste, Jaakko; Dale, Hege Avsnes; Bazzocco, Sarah; Marie, Michael Bruno Eric. 2009. Emerging new roles of the pre-Golgi intermediate compartment in biosynthetic-secretory trafficking. FEBS Letters. 583: 3804-3810. doi: 10.1016/j.febslet.2009.10.084
  • Marie, Michael Bruno Eric; Sannerud, Ragna Raymonde T.; Dale, Hege Avsnes; Saraste, Jaakko. 2008. Take the 'A' train: on fast tracks to the cell surface. Cellular and Molecular Life Sciences (CMLS). 65: 2859-2874. doi: 10.1007/s00018-008-8355-0
  • Torsvik, Janniche; Johansson, Bente Berg; Johansson, Stefan; Saraste, Jaakko; Njølstad, Pål Rasmus; Molven, Anders. 2008. Pancreatic exocrine dysfunction in diabetes: functional characterisation of the carboxyl-ester lipase gene. Diabetologia. 51: S123-S124. doi: 10.1007/s00125-008-1117-6
  • Saraste, Jaakko; Goud, Bruno. 2007. Functional symmetry of endomembranes. Molecular Biology of the Cell. 18: 1430-1436. doi: 10.1091/mbc.E06-10-0933
  • Sannerud, Ragna Raymonde T.; Marie, Michael Bruno Eric; Nizak, Clement; Dale, Hege Avsnes; Pernet-Gallay, Karin; Perez, Franck; Goud, Bruno; Saraste, Jaakko. 2006. Rab1 defines a novel pathway connecting the pre-Golgi intermediate compartment with the cell periphery. Molecular Biology of the Cell. 17: 1514-1526. doi: 10.1091/mbc.E05-08-0792
  • Palokangas, H.; Ying, Ming; Väänänen, K.; Saraste, Jaakko. 1998. Retrograde transport from the pre-Golgi intermediate compartment and the Golgi complex is affected by the vacuolar H -ATPase inhibitor bafilomycin. Molecular Biology of the Cell. 9: 3561-3578.
  • Saraste, Jaakko. 1998. Ongoing controversy: How are proteins transported through the Golgi complex? NBS-nytt. 22. 10-11..
  • Jäntti, J; Saraste, Jaakko; Kuismanen, E. 1997. Protein segregation in peripheral 15ºC intermediates in response to caffeine treatment. European Journal of Cell Biology. 74: 150-164.
  • Rahkila, P; Väänänen, K; Saraste, Jaakko; Metsikkö, K. 1997. Endoplasmic reticulum to Golgi trafficking in multi-nucleated skeletal muscle fibers. Experimental Cell Research. 234: 452-464.
  • Jantti, J.; Saraste, Jaakko; Kuismanen, E. 1996. Differential redistribution of marker proteins of the er-golgi interface in response to the caffeine-induces transport block. Molecular Biology of the Cell. 6: 1680.
  • Lahtinen, U.; Hellman, U.; Wernstedt, C.; Saraste, Jaakko; Pettersson, R.F. 1996. Molecular cloning and expression of a 58-kDa cis-Golgi and intermediate compartment protein. Journal of Biological Chemistry. 271: 4031-4037.
  • Saraste, Jaakko. 1996. Selective movement of pre-golgi and cis-golgi membranes to developing neurites and growth cones in ngf-treated pc12 cells. Molecular Biology of the Cell. 6: 1679.
  • Saraste, Jaakko; Lahtinen, U.; Goud, B. 1996. Localization of the small gtp-binding protein rab1p to early compartments of the secretory pathway. Journal of Cell Science. 108: 1541-1552.
  • Sariola, M.; Saraste, Jaakko; Kuismanen, E. 1996. Communication of post-golgi elements with early Endocytic pathwayregulation of endoproteolytic cleavage of semliki forest virus-p62 precursor. Journal of Cell Science. 108: 2465-2475.
  • Tonn, J-C; Haugland, Hans Kristian; Saraste, Jaakko; Roosen, K; Lærum, Ole Didrik. 1996. Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines. Journal of Neurosurgery. 82: 1035-1043.
  • Tonn, J.-C.; Haugland, Hans Kristian; Saraste, Jaakko; Roosen, K.; Lærum, Ole Didrik. 1996. Differential-effects of vincristine and phenytoin on the proliferation, migration and invasion of human glioma cell-lines. Journal of Neurosurgery. 82: 1035-1043.
Book sections
  • Sannerud, Ragna Raymonde T.; Marie, Michael Bruno Eric; Hansen, Bodil; Saraste, Jaakko. 2008. Use of polarized PC12 cells to monitor protein localization in the early biosynthetic pathway. Part II. Mammalian Cells Ch. 19, pages 253-265. In:
    • Vancura, Ales. 2008. Membrane Trafficking. Humana Press. 408 pages. ISBN: 978-1-58829-925-3.

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