Jan Inge Øvrebø's picture
Mari Bergsvåg

Jan Inge Øvrebø

  • E-mailjan.ovrebo@uib.no
  • Visitor Address
    HIB - Thormøhlens gt. 55
  • Postal Address
    Postboks 7803
    5020 Bergen

O. dioica displays an unique system of cell cycle regulation that are poorly understood, because previous research on cell cycle have focussed on a single nuclei within its own cytoplasm, while in this model we can study cell cycle regulation of multiple nuclei, both meiotic and endocycling, sharing a common cytoplasm, as seen in the coenocyst. Cell cycle in O. dioica is also unique in its way of development because most cells switch from rapid mitotic division to endoreduplication around the event of tail shift. O. dioica is also an important organism when viewed at the light of evolution, because it is the closest evolutionary relative to the vertebrates, and is therefore an important model organism in the field biology. In addition to presenting a unique environment for cell cycle studies and its evolutionary importance, it has many other abilities that make it an excellent model organism. O. dioica is successfully maintained in culture and have a short life cycle of 6 days at 15°C (Bouquet, 2009), and is therefore an excellent model organism for developmental studies. It is also transparent which makes it easy to observe internal organs when used for in situ experiments. Another advantage of using O. dioica as a model organism is the fact that the genome of O. dioica has been fully sequenced, which makes genetic studies easier by far.

Academic article
  • Show author(s) (2022). Translational control of E2f1 regulates the Drosophila cell cycle. Proceedings of the National Academy of Sciences of the United States of America.
  • Show author(s) (2022). Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos. Frontiers in Cell and Developmental Biology. 18 pages.
  • Show author(s) (2022). Cell growth and the cell cycle: New insights about persistent questions. Bioessays.
  • Show author(s) (2017). The Functional roles of the MDM2 splice variants P2-MDM2-10 and MDM2-∆5 in breast cancer cells. Translational Oncology. 806-817.
  • Show author(s) (2017). Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells. BMC Cell Biology. 1-9.
  • Show author(s) (2016). Identification of a novel leptin receptor duplicate in Atlantic salmon: Expression analyses in different life stages and in response to feeding status. General and Comparative Endocrinology. 108-119.
  • Show author(s) (2015). Functional specialization of chordate cdk1 paralogs during oogenic meiosis. Cell Cycle. 880-893.
  • Show author(s) (2012). Expansion of cyclin D and CDK1 paralogs in Oikopleura dioica, a chordate employing diverse cell cycle variants. Molecular Biology and Evolution (MBE). 487-502.
Doctoral dissertation
  • Show author(s) (2014). Cell cycle regulation of Oikopleura dioica.
Academic literature review
  • Show author(s) (2018). Polyploidy in tissue homeostasis and regeneration. Development.
Article in business/trade/industry journal
  • Show author(s) (2021). The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1. PNAS.

More information in national current research information system (CRIStin)


Study of cell cycle regulation within the female gonad of Oikopleura dioica

MSc in Molecular biology