Janne Grønli

Department of Biological and Medical Psychology

E-mailJanne.Gronli@uib.no
Phone+47 55 58 60 03
Visitor Address
Jonas Liesvei 91

5009 Bergen

Room
9th floor, Bygg for biologiske basalfag (BBB)
Postal Address
Postboks 7807

5020 Bergen

My current research focuses on the relationship between stress (across the life span), disturbances in sleep and circadian rhythms (like working nights or changes in hours with daylight) and health (mentally and physically). The research highlights how circadian rhythms modulate physiology and behaviour, as well as how disrupting them in animal models can produce physiological and behavioral abnormalities that change an animal's susceptibility to further environmental or psychological stress.

I also have a current research focus on the consequences on exposure to - or blocking - blue light. Blue light affects activation level in the healthy young population and some patients with psychiatric disorders may be vulnerable to such energy-riched light.

It is hoped that these animal models and clinical trials will provide an understanding of how dysregulation of the body's timing interact to produce changes in behavior and physiology, and will potentially lead to new clinical interventions to alleviate some of the physical and mental health consequences of our modern lifestyles.

Research interests:

The regulation and function of sleep
The relationship between sleep, circadian rhythms, stress and brain function
- How can stress influence the sleep; quality, regulation and function
- How can stress influence circadian rhythms
- The influence of stress on behavior
- Consequences of stress on the neurobiology
Consequences of simulated shiftwork on sleep, circadian rhythms, biological clocks and metabolism
How light influence wakefulness and sleep
- e-reading before bedtime
- blocking blue light as additive treatment for mania
- blocking blue light as treatment to ease sleep disturbances during pregnancy
- consequences of short day versus long day

Methods:

Polysomnography (PSG)
Actigraphy
Radar
Circadian rhythms
Light laboratory
Blue-blocking glasses
Simulated shift work, in men and rodents
Animal models of depression
Behavioral tests in rodents

Nobel prize for the function of circadian rhythms
Podcast in Norwegian from 13:17, NRK Kuriøs.

Is there a connection between sleep, circadian rhythms and depression?
A conversation with Trond Viggo Torgersen and me.
Podcast in Norwegian, NRK Kroppen

Several Utøya-survivors suffered from sleep disturbances two years after the terror attack
Web article in Norwegian at forskning.no

Sleep - elegantly designed for us to be awake
Chronicle in Norwegian, Bergens Tidende

Do dogs dream?
NRK Newton. TV program in Norwegian from 16:07

Reading from a tablet before bed may affect sleep quality
Interview in English. Reuters Health

Course coordinator:

Biological psychology PROPSY303
Sleep, circadian rhythms and behavior PSYK115
Circadian rhythms and sleep their role in mental and physical health, safety and productivity (NRSN summer school 2017)
Polysomnography (PSG) - scoring of sleep and sleep related events; beginners and advanced level

Some topics that I teach:

The regulation of sleep and circadian rhythms
Sleep, sleep disturbances and mental health
Chronobiological treatment of psychiatric diseases
The use of actigraphy and PSG
The interpretation of actogram and hypnogram
Endocrinology
Immunology
Psychoendocrinology/psychoimmunology
Sexual reproduction and differentiation

Here you can find my list of publications in PubMed

Academic article

Show author(s) (2022). Sleep homeostasis and night work: a polysomnographic study of daytime sleep following three consecutive simulated night shifts. Nature and Science of Sleep. 243-254.
Show author(s) (2022). Evening light environments can be designed to consolidate and increase the duration of REM-sleep. Scientific Reports. 10 pages.
Show author(s) (2022). Bright light exposure during simulated night work improves cognitive flexibility. Chronobiology International. 948-963.
Show author(s) (2022). A randomized controlled trial on the effects of blue-blocking glasses compared to partial blue-blockers on sleep outcomes in the third trimester of pregnancy. PLOS ONE. 18 pages.

Show author(s) (2021). Time-of-Day Effects in Resting-State Functional Magnetic Resonance Imaging: Changes in Effective Connectivity and Blood Oxygenation Level Dependent Signal. Brain Connectivity. 515-523.
Show author(s) (2021). Sleep, evening light exposure and perceived stress in healthy nulliparous women in the third trimester of pregnancy. PLOS ONE. 1-17.
Show author(s) (2021). In the twilight zone: An epidemiological study of sleep-related hallucinations. Comprehensive Psychiatry. 1-6.
Show author(s) (2021). Effect of dietary nitrate supplementation on sleep in chronic obstructive pulmonary disease patients. Nature and Science of Sleep. 435-446.
Show author(s) (2021). A randomized controlled trial on the effect of blue-blocking glasses compared to partial blue-blockers on melatonin profile among nulliparous women in third trimester of the pregnancy. Neurobiology of Sleep and Circadian Rhythms.

Show author(s) (2020). Seksuelle overgrep i barndommen og arbeidsuførhet i voksen alder – Funn fra et norsk befolkningsutvalg. Tidsskrift for Norsk Psykologforening. 260-271.
Show author(s) (2020). Role of nocturnal light intensity on adaptation to three consecutive night shifts: a counterbalanced crossover study. Occupational and Environmental Medicine. 249-255.
Show author(s) (2020). Predictors and correlates of lifetime and persistent non-suicidal self-injury and suicide attempts among adult survivors of childhood sexual abuse. European Journal of Psychotraumatology. 14 pages.
Show author(s) (2020). Longitudinal Relationships between Perceived Social Support and Symptom Outcomes: Findings from a sample of Adult Survivors of Childhood Sexual Abuse. International Journal of Child Abuse & Neglect. 16 pages.
Show author(s) (2020). Faktorer som henger sammen med økt risiko for arbeidsuførhet blant personer utsatt for seksuelle overgrep i barndommen. Tidsskrift for Norsk Psykologforening. 348-359.
Show author(s) (2020). Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. Scientific Reports.
Show author(s) (2020). Blue-enriched white light improves performance but not subjective alertness and circadian adaptation during three consecutive simulated night shifts. Frontiers in Psychology. 1-16.
Show author(s) (2020). Alerting and Circadian Effects of Short-Wavelength vs. Long-Wavelength Narrow-Bandwidth Light during a Simulated Night Shift. Clocks & Sleep. 502-522.

Show author(s) (2019). Validation of peripheral arterial tonometry as tool for sleep assessment in chronic obstructive pulmonary disease. Scientific Reports. 1-8.
Show author(s) (2019). Insomnia symptom trajectories among adult survivors of childhood sexual abuse: A longitudinal study. International Journal of Child Abuse & Neglect. 263-276.

Show author(s) (2018). State-dependent modulation of visual evoked potentials in a rodent genetic model of electroencephalographic instability. Frontiers in Systems Neuroscience.
Show author(s) (2018). Sleep deprivation and hallucinations. A qualitative study of military personnel. Military Psychology. 430-436.
Show author(s) (2018). Mathematical modeling of sleep state dynamics in a rodent model of shift work. Neurobiology of Sleep and Circadian Rhythms. 37-51.
Show author(s) (2018). Can night shift workers benefit from light exposure? Journal of Physiology.
Show author(s) (2018). A pilot study of impulse radio ultra wideband radar technology as a new tool for sleep assessment. Journal of Clinical Sleep Medicine (JCSM). 1249-1254.

Show author(s) (2017). Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study. International Journal of Child Abuse & Neglect. 280-293.
Show author(s) (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 1-12.
Show author(s) (2017). Life threat and sleep disturbances in adolescents: a two-year follow-up of survivors from the 2011 Utøya, Norway, terror attack. Journal of Traumatic Stress. 219-228.
Show author(s) (2017). Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse. International Journal of Child Abuse & Neglect. 99-111.

Show author(s) (2016). Sleep homeostatic and waking behavioral phenotypes in Egr3-deficient mice associated with serotonin receptor 5-Ht2 deficits. Sleep. 2189-2199.
Show author(s) (2016). Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. Nutrients. 1-13.
Show author(s) (2016). Reading from an iPad or from a book in bed: the impact on human sleep. A randomized controlled crossover trial. Sleep Medicine. 86-92.
Show author(s) (2016). Prescription trajectories and effect of total hip arthroplasty on the use of analgesics, hypnotics, antidepressants, and anxiolytics: Results from a population of total hip arthroplasty patients. Pain. 643-651.
Show author(s) (2016). Mild daily stressors in adulthood may counteract behavioural effects after constant presence of mother during early life. Physiology and Behavior. 313-321.
Show author(s) (2016). Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells. Journal of Gene Medicine. 234-243.
Show author(s) (2016). Langvarig taushet om seksuelle overgrep : prediktorer og korrelater hos voksne som opplevde seksuelle overgrep som barn. Tidsskrift for Norsk Psykologforening. 889-899.
Show author(s) (2016). Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. Translational Psychiatry.
Show author(s) (2016). How perceived pain influence sleep and mood more than the reverse: A novel, exploratory study with patients awaiting total hip arthroplasty. Frontiers in Psychology. 11 pages.
Show author(s) (2016). Blue-blocking glasses as additive treatment for mania: A randomized placebo-controlled trial. Bipolar Disorders. 221-232.
Show author(s) (2016). Beta EEG reflects sensory processing in active wakefulness and homeostatic sleep drive in quiet wakefulness. Journal of Sleep Research. 257-268.
Show author(s) (2016). A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms. 48-63.

Show author(s) (2014). Prevalence and correlates of insomnia and excessive sleepiness in adults with obstructive sleep apnea symptoms. Perceptual and Motor Skills. 571-586.
Show author(s) (2014). Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations. Chronobiology International. 252-264.
Show author(s) (2014). Effects of social defeat on sleep and behaviour: Importance of the confrontational behaviour. Physiology and Behavior. 54-63.
Show author(s) (2014). Blocking blue light during mania - markedly increased regularity of sleep and rapid improvement of symptoms: A case report. Bipolar Disorders. 894-898.

Show author(s) (2013). Shift-related sleep problems vary according to work schedule. Occupational and Environmental Medicine. 238-245.
Show author(s) (2013). Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model. Biomedical Research. 9 pages.
Show author(s) (2013). Early and later life stress alter brain activity and sleep in rats. PLOS ONE.

Show author(s) (2012). Sleep in older chronic pain patients: a comparative polysomnographic study. The Clinical Journal of Pain. 277-283.
Show author(s) (2012). Shift work disorder in nurses - assessment, prevalence and related health problems. PLOS ONE. 9 pages.
Show author(s) (2012). Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behavioural Brain Research. 251-262.
Show author(s) (2012). Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress. Physiology and Behavior. 1058-1066.
Show author(s) (2012). Long-term effects of footshock and social defeat on anxiety-like behaviours in rats: Relationships to pre-stressor plasma corticosterone concentration. Stress. 658-670.
Show author(s) (2012). Insomnia, nightmare frequency, and nightmare distress in victims of sexual abuse: the role of perceived social support and abuse characteristics. Journal of Interpersonal Violence. 1827-1843.
Show author(s) (2012). English title: The prevalence of sexual abuse in a Norwegian representative population sample. . Tidsskrift for Norsk Psykologforening. 950-957.
Show author(s) (2012). A reliability and validity study of the Bergen shift work sleep questionnaire in nurses working three-shift rotations. Chronobiology International. 937-946.

Show author(s) (2011). Transient changes in frontal alpha asymmetry as a measure of emotional and physical distress during sleep. Brain Research. 234-249.

Show author(s) (2010). Prevalence of different parasomnias in the general population. Sleep Medicine. 1031-1034.
Show author(s) (2010). Dyremodeller for søvn og stress - implikasjoner for mentale lidelser. SØVN. 8-10.

Show author(s) (2008). The effect of a REM sleep deprivation procedure on different aspects of memory function in humans. Psychophysiology. 309-317.
Show author(s) (2008). Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta Physiologica. 89-97.
Show author(s) (2008). A double exposure to social defeat induces sub-chronic effects on sleep and open field dehaviour in rats. Physiology and Behavior. 553-561.

Show author(s) (2007). Increased extracellular 5-HT but no change of sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleous of rats . Acta Physiologica.
Show author(s) (2007). Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. - A microdialysis study in an animal model of depression. Behavioural Brain Research. 42-51.

Show author(s) (2006). The effect of GABA(A) antagonist bicuculline on dorsal raphe nucleus and frontal cortex extracellular serotonin: A window on SWS and REM sleep modulation. Pharmacology, Biochemistry and Behavior.
Show author(s) (2006). SOV:no: Nasjonalt Kompetansesenter for Søvnsykdommer. Medisinsk informasjon. 28-29.
Show author(s) (2006). Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration. Psychopharmacology. 335-346.
Show author(s) (2006). Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, Biochemistry and Behavior. 842-849.

Show author(s) (2005). Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions. Physiology and Behavior. 571-577.

Show author(s) (2004). Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Research. 2105-2112.

Show author(s) (2002). Effects of sleep deprivation on extracellular serotonin in the hippocampus and frontal cortex of the rat. Neuroscience. 323-330.

Show author(s) (2001). The selective 5-HT 1A receptor antagonist p-MPPI antagonizes sleep-waking and behavioural effects of 8-OH-DPAT in rats. Behavioural Brain Research. 181-187.
Show author(s) (2001). Sleep and waking following microdialysis perfusion of the selective 5-HT 1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat. Brain Research. 122-130.

Show author(s) (1998). On-line detection of extracellular levels of serotonin in dosal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neuroscience. 807-814.
Show author(s) (1998). On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving ra. Neuroscience. 807-814.

Lecture

Show author(s) (2013). Chronic stress, sleep and the protein factory.

Popular scientific lecture

Show author(s) (2000). A single dose of the adenosine A1 antagonist 8-cyclopentyl-theofylline (CPT) increases hippocampal serotonin during waking in rats as measured by microdialysis.

Show author(s) (1997). Virksomheten innen kolloid- og overflatekjemi i Bergen.
Show author(s) (1997). Sleep/waking effects of methiothepin, a non-selective 5-HT antagonist, perfused in dorsal raphe nucleus in rats. Microdialysis combined with polygr recording.
Show author(s) (1997). Selvassosiasjon av alkoholder i modellolje.
Show author(s) (1997). Extracellular 5-HT levels in dorsal raphe over the sleep/wake cycle: a microdialysis study in the freely moving rat.

Academic lecture

Show author(s) (2022). Reversal learning and working memory scanning task performance improve with bright light exposure during simulated night work: a counterbalanced crossover study.

Show author(s) (2019). Effects of Different Light Intensities on Adaptation to Simulated Night Shifts: A Randomized Counterbalanced Crossover Study.

Show author(s) (2018). Funn fra prosjektet 'Akutt stress på en hjerne I utvikling'.

Show author(s) (2016). What does shift work do to sleep, circadian function and regulation of metabolism? Controlled studies with a rodent model.
Show author(s) (2016). The relation between sleep, circadian rhythms, depression and brain function.
Show author(s) (2016). Sleep homeostatic and waking behavioral phenotypes in Egr3-deficient mice associated with serotonin receptor 5-HT2 deficits.
Show author(s) (2016). Simulated night work disrupts circadian rhythmicity and hypothalamic clock gene expression in a rat model.
Show author(s) (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats.
Show author(s) (2016). Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.

Show author(s) (2015). Night work - disturbances in sleep and circadian rhythm parameters. An animal model.

Show author(s) (2013). Hypothermia after chronic mild stress exposure in rats with ahistory of postnatal maternal separation.
Show author(s) (2013). Early and later life stress in rats. Effects on sleep EEG and circadian rhythmicity.

Show author(s) (2012). Sleep and circadian rhythms after early life stress.
Show author(s) (2012). Chronic stress and sleep regulation.

Show author(s) (2011). Shift work disorder in nurses.
Show author(s) (2011). Shift work disorder - operationalization, prevalence and related health outcome in nurses.
Show author(s) (2011). Lower brain activity during sleep and wakefullnes; induced by exposure to long maternal separation and chronic mild stress in rats.
Show author(s) (2011). Lifetime consequences of maternal separation - behavior, sleep, circadian rhythms and brain activity.
Show author(s) (2011). Experiences with the 4ET transmitters in telemetric measurement of EEG, EMG, body temperature and motor activity in male rats exposed to early and later life stress.
Show author(s) (2011). Eearly and later life stress lower brain activity during sleep and wakefulness.
Show author(s) (2011). Early and later life stress leads to a lower brain activity during sleep and wakefulness in rats.
Show author(s) (2011). Chronic mild stress potentiates a lower brain activity during sleep and wakefulness in rats exposed to long maternal separation.

Show author(s) (2010). Sleep in older patients - A comparative polysomnographic study.
Show author(s) (2010). Early Life Stress and the effect on circadian rhythmicity. The mother - infant relationship in rats as model.
Show author(s) (2010). Altered body temperature and depression-like symptoms following early and later life stress in rats.

Show author(s) (2009). Stress and depression: preclinical models with focus on sleep.
Show author(s) (2009). Rhythms, sleep and biology after maternal separations. The mother – infant relationship.

Show author(s) (2007). The effect of GABAA antagonist bicucilline on dorsal raphe nucleus and frontal cortex extracellular serotonin: a window on SWS and REM sleep modulation.
Show author(s) (2007). Serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study over the sleep/wake cycle in an animal model of depression.
Show author(s) (2007). "Modest changes in sleep and behaviour in rats exposed to social defeat".

Show author(s) (2000). Microdialysis perfusion of a 5-HT1A receptor antagonist in dorsal raphe nucleus change 5-HT levels in sleep and waking.
Show author(s) (2000). Dialysis perfusion of a 5-HT1A receptor antagonist in dorsal raphe nucleus increases 5-HT levels in sleep and waking.

Show author(s) (1999). The effect of a selective 5-HT1A antagonist on waking levels of serotonin in hippocampus in rats.

Show author(s) (1998). Perfusion by microdialysis of a 5-HT1A receptor antagonist in dorsal raphe nucleus increases 5-HT levels in sleep and waking.

Editorial

Show author(s) (2022). Scientists Against War: A Plea to World Leaders for Better Governance. Sleep and Vigilance.

Show author(s) (2016). The impact of e-reading on sleep. Sleep Medicine. 109-110.

Research groups

Bergen Stress and Sleep Group, BSSG