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  • E-mailJanne.Molnes@uib.no
  • Phone+47 55 97 52 77
  • Visitor Address
    Children's clinic, 3. etg.
    Room 
    3008
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Sagen, Jørn V.; Bjørkhaug, Lise; Haukanes, Bjørn Ivar; Grevle, Louise; Molnes, Janne; Nedrebø, Bjørn Gunnar; Søvik, Oddmund; Njølstad, Pål Rasmus; Johansson, Stefan; Molven, Anders. 2017. The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes. Diabetes Research and Clinical Practice. 142-149.
  • Johansson, Bente Berg; Irgens, Henrik Underthun; Molnes, Janne; Sztromwasser, Pawel Szymon; Aukrust, Ingvild; Juliusson, Petur Benedikt; Søvik, Oddmund; Levy, Shawn; Skrivarhaug, Torild; Joner, Geir; Molven, Anders; Johansson, Stefan; Njølstad, Pål Rasmus. 2017. Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry. Diabetologia. 625-635.
  • Najmi, Laeya Abdoli; Aukrust, Ingvild; Flannick, Jason; Molnes, Janne; Burtt, Noël; Molven, Anders; Groop, Leif; Altshuler, David; Johansson, Stefan; Bjørkhaug, Lise; Njølstad, Pål Rasmus. 2017. Functional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population. Diabetes. 335-346.
  • Negahdar, Maria; Aukrust, Ingvild; Molnes, Janne; Solheim, Marie Holm; Johansson, Bente Berg; Sagen, Jørn V.; Dahl-Jørgensen, Knut; Kulkarni, Rohit Rajesh; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2014. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 55-65.
  • Aukrust, Ingvild; Bjørkhaug, Lise; Negahdar, Maria; Molnes, Janne; Johansson, Bente Berg; Müller, Yvonne; Haas, Wilhelm; Gygi, Steven P.; Søvik, Oddmund; Flatmark, Torgeir; Kulkarni, Rohit N; Njølstad, Pål Rasmus. 2013. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. Journal of Biological Chemistry. 5951-5962.
  • Irgens, Henrik Underthun; Molnes, Janne; Johansson, Bente Berg; Ringdal, Monika; Skrivarhaug, Torild; Undlien, Dag Erik; Søvik, Oddmund; Joner, Geir; Molven, Anders; Njølstad, Pål Rasmus. 2013. Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. Diabetologia. 1512-1519.
  • Søvik, Oddmund; Irgens, Henrik Underthun; Molnes, Janne; Sagen, Jørn V.; Bjørkhaug, Lise; Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus. 2013. Monogenetic diabetes mellitus in Norway :. Norsk Epidemiologi. 55-60.
  • Jahnavi, S; Poovazhagi, V; Mohan, V; Bodhini, D; Raghupathy, P; Amutha, A; Suresh Kumar, P; Adhikari, P; Shriraam, M; Kaur, T; Das, AK; Molnes, Janne; Njølstad, Pål Rasmus; Unnikrishnan, R; Radha, V. 2013. Clinical and molecular characterization of neonatal diabetes and monogenic syndromic diabetes in Asian Indian children. Clinical Genetics. 439-445.
  • Flannick, Jason; Beer, Nicola L.; Bick, Alexander G.; Agarwala, Vineeta; Molnes, Janne; Gupta, Namrata; Burtt, Noël P.; Florez, Jose C.; Meigs, James B.; Taylor, Herman; Lyssenko, Valeriya; Irgens, Henrik Underthun; Fox, Erwin; Burslem, Frank; Johansson, Stefan; Brosnan, M. Julia; Trimmer, Jeff K.; Newton-Cheh, Christopher; Tuomi, Tiinamaija; Molven, Anders; Wilson, James G.; O'Donnell, Christopher J.; Kathiresan, Sekar; Hirschhorn, Joel N.; Njølstad, Pål Rasmus; Rolph, Tim; Seidman, Jonathan G.; Gabriel, Stacey; Cox, David R.; Seidman, Christine E.; Groop, Leif; Altshuler, David. 2013. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nature Genetics. 1380-1385.
  • Elbarbary, Nancy S.; Tjora, Erling; Molnes, Janne; Lie, Benedicte Alexandra; Habib, Mohammad A.; Salem, Mona A.; Njølstad, Pål Rasmus. 2013. An Egyptian family with H syndrome due to a novel mutation in SLC29A3 illustrating overlapping features with pigmented hypertrichotic dermatosis with insulin-dependent diabetes and Faisalabad histiocytosis. Pediatric Diabetes. 466-472.
  • Eifes, Serge; Chudasama, Kishan Kumar; Molnes, Janne; Wagner, Kerstin; Hoang, Tuyen; Schierloh, Ulrike; Rocour-Brumioul, Danielle; Johansson, Stefan; Njølstad, Pål Rasmus; de Beaufort, Carine. 2013. A novel GATA6 mutation in a child with congenital heart malformation and neonatal diabetes. Clinical Case Reports. 86-90.
  • Gonc, E. Nazli; Ozturk, Burcu Bulum; Haldorsen, Ingfrid S.; Molnes, Janne; Immervoll, Heike ; Ræder, Helge; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2012. HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease. Pediatric Diabetes. e1-e5.
  • Negahdar, Maria; Aukrust, Ingvild; Johansson, Bente Berg; Molnes, Janne; Molven, Anders; Matschinsky, Franz M.; Søvik, Oddmund; Kulkarni, Rohit N; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2012. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1705-1715.
  • Johansson, Stefan; Irgens, Henrik Underthun; Chudasama, Kishankumar; Molnes, Janne; Aerts, Jan; Roque, Francisco; Jonassen, Inge; Levy, Shawn; Lima, Kari; Knappskog, Per; Bell, Graeme I.; Molven, Anders; Njølstad, Pål Rasmus. 2012. Exome sequencing and genetic testing for MODY. PLOS ONE. 8 pages.
  • Molnes, Janne; Teigen, Knut; Aukrust, Ingvild; Bjørkhaug, Lise; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus. 2011. Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. The FEBS Journal. 2372-2386.
  • Sagen, Jørn V.; Bjørkhaug, Lise; Molnes, Janne; Ræder, Helge; Grevle, Louise; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2008. Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Pediatric Diabetes. 442-449.
  • Molnes, Janne; Bjørkhaug, Lise; Søvik, Oddmund; Njølstad, Pål Rasmus; Flatmark, Torgeir. 2008. Catalytic activation of human glucokinase by substrate binding - residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions. The FEBS Journal. 2467-2481.
  • Bjørkhaug, Lise; Molnes, Janne; Søvik, Oddmund; Njølstad, Pål Rasmus; Flatmark, Torgeir. 2007. Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation. Journal of Biological Chemistry. 22757-22764.
  • Tammaro, Paolo; Girard, Christophe; Molnes, Janne; Njølstad, Pål Rasmus; Ashcroft, Frances M. 2005. Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions. EMBO Journal. 2318-2330.
  • Sagen, Jørn V.; Ræder, Helge; Hathout, Eba; Gudmundsson, K; Bævre, H; Abuelo, D; Phornphutkul, C; Molnes, Janne; Bell, GI; Gloyn, AL; Hattersley, AT; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2004. Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2 - Patient characteristics and initial response to sulfonylurea therapy. Diabetes. 2713-2718.
  • Gloyn, AL; Pearson, ER; Antcliff, JF; Proks, P; Bruining, GJ; Slingerland, AS; Howard, N; Srinivasan, S; Silva, JMCL; Molnes, Janne; Edghill, EL; Frayling, TM; Temple, IK; Mackay, D; Shield, JPH; Sumnik, Z; van Rhijn, A; Wales, JKH; Clark, P; Gorman, S; Aisenberg, J; Ellard, S; Njølstad, Pål Rasmus; Ashcroft, FM; Hattersley, AT. 2004. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. New England Journal of Medicine. 1838-1849.
  • Njølstad, Pål Rasmus; Sagen, Jørn; Bjørkhaug, Lise; Odili, Stella; Shehadeh, Naim; Bakry, Doua; Sarici, S. Umit; Alpay, Faruk; Molnes, Janne; Molven, Anders; Søvik, Oddmund; Matschinsky, Franz M. 2003. Permanent neonatal diabetes mellitus due to glucokinase deficiency- an inborn error of the glucose-insulin signalling pathway. Diabetes. 2854-2860.
  • Njølstad, Pål Rasmus; Sagen, Jørn V.; Bjørkhaug, Lise; Odili, Stella; Shehadeh, Naim; Bakry, Doua; Sarici, U; Alpay, Faruk; Molnes, Janne; Molven, Anders; Søvik, Oddmund; Matschinsky, Franz M. 2003. Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway. Diabetes. 2854-2860.
Academic lecture
  • Kaci, Alba; Aukrust, Ingvild; Njølstad, Pål Rasmus; Bjørkhaug, Lise; Svalastoga, Pernille; Molnes, Janne. 2019. Functional characterization of diabetes gene variants is important for precision medicine .
  • Haaheim, Lars Reinhardt; Cox, RJ; Molnes, Janne; Nakkestad, Hanne Linda; Ibsen, M. W. 1997. Plasmacute - A diagnostic tool for influenza?
Thesis at a second degree level
  • Molnes, Janne. 1998. Antigenic drift in the HA1 domain of influenza A(H3N2) strains isolated in Norway in 1992-6 and relationship to vaccine and reference viruses.
  • Molnes, Janne. 1997. Antigenic drift in the HA<SUB>1</SUB> domain of influenza A(H3N2) strains isolated in Norway in 1992-6 and relationship to vaccine and reference viruses.
Doctoral dissertation
  • Molnes, Janne. 2012. Human pancreatic glucokinase; Structural and physico-chemical studies related to catalytic activation, kinetic cooperativity and GCK-diabetes.
Abstract
  • Tammaro, P; Girard, C; Molnes, Janne; Njølstad, Pål Rasmus; Ashcroft, F. 2005. Two novel Kir6.2 mutations affecting the ATP sensitivity of the K-ATP channel are the cause of Permanent Neonatal Diabetes. Biophysical Journal. 285A-285A.
Poster
  • Kaci, Alba; Aukrust, Ingvild; Bjørkhaug, Lise; Svalastoga, Pernille; Molnes, Janne; Njølstad, Pål Rasmus. 2019. Functional characterization of HNF1A variants identified in Norwegian MODY diabetes registry can implement precision medicine in diabetes clinics.
  • Bjørkhaug, Lise; Aukrust, Ingvild; Kaci, Alba; Molnes, Janne; Torsvik, Janniche; Irgens, Henrik Underthun; Johansson, Bente Berg; Njølstad, Pål Rasmus. 2018. Functional characterization of HNF1A variants identified in Norwegian diabetes registries can be important for precision medicine in diabetes clinics.
  • Njølstad, Pål Rasmus; Dahl-Jørgensen, Knut; Sarici, U; Bjørkhaug, L; Molnes, Janne; Molven, Anders; Søvik, Oddmund; Matschinsky, FM. 2002. Mild diabetes or permanent neonatal diabetes: Localization of glukoinase mutations linked to severity of phenotype.
  • Njølstad, Pål Rasmus; Dahl-Jørgensen, Knut; Sarici, U; Bjørkhaug, L; Odili, S; Molnes, Janne; Molven, Anders; Søvik, Oddmund; Matschinsky, FM. 2002. Mild diabetes or permanent neonatal diabetes: Localization of glucoinase mutations linked to severity of phenotype.

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