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Jarl Underhaug

Associate Professor, Manager of the Norwegian NMR Platform

Structural biology

Academic article
  • Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly; Ødegaard-Fougner, Øyvind; Strømland, Øyvind; Martin, Stephen R.; De Marco, Valeria; Christodoulou, Evangelos; Teigen, Knut; Isaksson, Johan; Underhaug, Jarl; Reuter, Nathalie; Aalen, Reidunn B.; Aasland, Rein; Halskau, Øyvind. 2020. The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. The FEBS Journal. 1-23.
  • Steinsholm, Silje; Oterhals, Åge; Underhaug, Jarl; Måge, Ingrid; Malmendal, Anders; Aspevik, Tone. 2020. Sensory Assessment of Fish and Chicken Protein Hydrolysates. Evaluation of NMR Metabolomics Profiling as a New Prediction Tool. Journal of Agricultural and Food Chemistry. 3881-3890.
  • Wekre, Marie Emilie; Kåsin, Karoline; Underhaug, Jarl; Holmelid, Bjarte; Jordheim, Monica. 2019. Quantification of polyphenols in seaweeds: A case study of Ulva intestinalis. Antioxidants. 1-15.
  • Ralte, Lalrempuia; Underhaug, Jarl; Törnroos, Karl Wilhelm; Le Roux, Erwan. 2019. Anionic hafnium species: an active catalytic intermediate for the coupling of epoxides with CO2? . Chemical Communications. 7227- 7230.
  • Bustad, Helene J.; Toska, Karen; Schmitt, Caroline; Vorland, Marta; Skjærven, Lars; Kallio, Juha Pekka; Simonin, Sylvie; Lettéron, Philippe; Underhaug, Jarl; Sandberg, Sverre; Martinez, Aurora. 2019. A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria. Molecular Therapy.
  • Yuste-Checa, Patricia; Brasil, Sandra; Gamez, Alejandra; Underhaug, Jarl; Desviat, Lourdes Ruiz; Ugarte, Magdalena; Pérez-Cerdá, Celia; Martinez, Aurora; Pérez, Belén. 2017. Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG. Human Mutation. 160-168.
  • Brasil, Sandra; Briso-Montiano, Álvaro; Gamez, Alejandra; Underhaug, Jarl; Flydal, Marte Innselset; Desviat, Lourdes R.; Merinero, Begoña; Ugarte, Magdalena; Martinez, Aurora; Pérez, Belén. 2017. New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type. Biochimica et Biophysica Acta - Molecular Basis of Disease. 640-648.
  • Urbaneja, María A.; Skjærven, Lars; Aubi Catevilla, Oscar; Underhaug, Jarl; López, David J.; Arregi, Igor; Alonso-Mariño, Marián; Cuevas, Andoni; Rodríguez, José A.; Martinez, Aurora; Bañuelos, Sonia. 2017. Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia. Scientific Reports.
  • Wettstein, Sara; Underhaug, Jarl; Perez, Belen; Marsden, Brian D.; Yue, Wyatt W.; Martinez, Aurora; Blau, Nenad. 2015. Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria. European Journal of Human Genetics. 302-309.
  • Koldsø, Heidi; Andersen, Ole Juul; Nikolajsen, Camilla Lund; Scavenius, Carsten; Sørensen, Charlotte S.; Underhaug, Jarl; Runager, Kasper; Nielsen, Niels Chr.; Enghild, Jan J.; Schiøtt, Birgit. 2015. Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β‑Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants. Biochemistry. 5546-5556.
  • Hole, Magnus; Underhaug, Jarl; Diez, Hector; Ying, Ming; Røhr, Åsmund Kjendseth; Jorge Finnigan, Ana; Fernàndez-Castillo, Noèlia; García-Cazorla, Angels; Andersson, K. Kristoffer; Teigen, Knut; Martinez, Aurora. 2015. Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms. Biochimica et Biophysica Acta - Proteins and Proteomics. 1078-1089.
  • Aubi Catevilla, Oscar; Flydal, Marte Innselset; Zheng, Huaixin; Skjærven, Lars; Rekand, Illimar; Leiros, Hanna-Kirsti S.; Haug, Bengt Erik; Cianciotto, Nicholas P.; Martinez, Aurora; Underhaug, Jarl. 2015. Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila. Journal of Medicinal Chemistry. 8402-8412.
  • Martin, Ianire; Underhaug, Jarl; Celaya, Garbiñe; Moro, Fernando; Teigen, Knut; Martinez, Aurora; Muga, Arturo. 2013. Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. Journal of Medicinal Chemistry. 7177-7189.
  • Jorge Finnigan, Ana; Brasil, Sandra; Underhaug, Jarl; Ruiz-Sala, Pedro; Amerinero, Begoña; Banerjee, Ruma; Desviat, Lourdes R.; Ugarte, Magdalena; Martinez, Aurora; Pérez, Belén. 2013. Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type. Human Molecular Genetics. 3680-3689.
  • Underhaug, Jarl; Koldsø, Heidi; Runager, Kasper; Nielsen, Jakob Toudahl; Sørensen, Charlotte S; Kristensen, Torsten; Otzen, Daniel Erik; Karring, Henrik; Malmendal, Anders; Schiøtt, Birgit; Enghild, Jan J; Nielsen, Niels Chr. 2013. Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization. Biochimica et Biophysica Acta - Proteins and Proteomics. 2812-2822.
  • Bustad, Helene J.; Skjærven, Lars; Ying, Ming; Halskau jr, Øyvind; Baumann, Anne; Rodriguez-Larrea, David; Costas, Miguel; Underhaug, Jarl; Sanchez-Ruiz, Jose Manuel; Martinez, Aurora. 2012. The peripheral binding of 14-3-3gamma to membranes involves isoform-specific histidine residues. PLOS ONE.
  • Kulminskaya, Natalia V.; Pedersen, Marie Ø.; Bjerring, Morten; Underhaug, Jarl; Miller, Mette; Frigaard, Niels-Ulrik; Nielsen, Jakob T.; Nielsen, Niels Chr. 2012. In situ solid-state NMR spectroscopy of protein in heterogeneous membranes: the baseplate antenna complex of chlorobaculum tepidum. Angewandte Chemie International Edition. 6891-6895.
  • Havukainen, Heli; Underhaug, Jarl; Wolschin, Florian; Amdam, Gro Vang; Halskau jr, Øyvind. 2012. A vitellogenin polyserine cleavage site: highly disordered conformation protected from proteolysis by phosphorylation. Journal of Experimental Biology. 1837-1846.
  • Johannessen, Helene Bustad; Underhaug, Jarl; Halskau jr, Øyvind; Martinez, Aurora. 2011. The binding of 14-3-3 gamma to membranes studied by intrinsic fluorescence spectroscopy. FEBS Letters. 1163-1168.
  • Halskau jr, Øyvind; Perez-Jimenez, Raul; Ibarra-Molero, Beatriz; Underhaug, Jarl; Muñoz, Victor; Martinez, Aurora; Sanchez-Ruiz, Jose Manuel. 2008. Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics. Proceedings of the National Academy of Sciences of the United States of America. 8625-8630.
  • Halskau, Øyvind; Underhaug, Jarl; Frøystein, Nils Åge; Martinez, Aurora. 2005. Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity. Journal of Molecular Biology. 1072-1086.
Lecture
  • Steinsholm, Silje; Oterhals, Åge; Underhaug, Jarl; Måge, Ingrid; Malmendal, Anders; Aspevik, Tone. 2019. Application of nuclear magnetic resonance (NMR) to assess the development of flavor attributes during enzymatic protein hydrolysis.
Academic lecture
  • Ytre-Arne, Mari; Underhaug, Jarl; Cornaciu, Irina; Hoffmann, Guillaume; Martinez, Aurora; Bowler, Matthew; Leonard, Gordon; Marquez, Jose Antonia; Bjørås, Magnar; Dalhus, Bjørn. 2015. Experimental structures of human 8-oxoguanine glycosylase 1 in complex with novel inhibitors.
Interview
  • Valle, Marius; Kvalheim, Olav Martin; Underhaug, Jarl. 2017. NMR-spektroskopi - Disse maskinene har potensial til å revolusjonere helsen din.
Abstract
  • Jorge-Finnigan, A; Underhaug, Jarl; Desviat, Lourdes R.; Martinez, Aurora; Ugarte, Magdalena; Perez, Belen. 2010. POTENTIAL PHARMACOLOGYCAL CHAPERONE THERAPY FOR ISOLATED METHYLMALONIC ACIDURIA cbIB TYPE. Journal of Inherited Metabolic Disease. S40-S40.
  • Bustad, Helene J.; Rønneseth, Eva; Toska, Karen; Underhaug, Jarl; Martinez, Aurora; Sandberg, Sverre. 2010. Characterization of the molecular basis of acute intermittent porphyria. The FEBS Journal. 76-76.
  • Johannessen, Helene Bustad; Rxnneseth, E; Underhaug, Jarl; Skjærven, Lars; Toska, Karen; Martinez, Aurora; Sandberg, Sverre. 2010. CHARACTERIZATION OF THE MOLECULAR BASIS OF ACUTE INTERMITTENT PORPHYRIA. Journal of Inherited Metabolic Disease. S177-S177.
Errata
  • Hole, Magnus; Underhaug, Jarl; Diez, Hector; Ying, Ming; Røhr, Åsmund Kjendseth; Jorge-Finnigan, Ana; Fernàndez-Castillo, Noèlia; Garcia-Cazorla, Àngels; Kristoffer Andersson, K.; Teigen, Knut; Martinez, Aurora. 2016. Erratum: Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms (Biochimica et Biophysica Acta - Proteins and Proteomics (2015) 1854:9 (1078-1089) DOI: 10.1016/j.bbapap.2015.04.030). Biochimica et Biophysica Acta - Proteins and Proteomics. 317.
Academic literature review
  • Hole, Magnus; Jorge Finnigan, Ana; Underhaug, Jarl; Teigen, Knut; Martinez, Aurora. 2016. Pharmacological chaperones that protect Tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms. 1515-1526.
  • Underhaug, Jarl; Aubi, Oscar; Martinez, Aurora. 2012. Phenylalanine hydroxylase misfolding and pharmacological chaperones. 2534-2545.

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