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Jennifer Gjerde

Postdoctoral fellow
  • E-mailJennifer.Gjerde@uib.no
  • Phone+47 55 97 43 98
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Johansson, Harriet; Aristarco, Valentina; Gandini, Sara; Gjerde, Jennifer; Macis, Debora; Guerrieri-Gonzaga, Aliana; Serrano, Davide; Lazzeroni, Matteo; Rajasekaran, Agnita; Williard, Clark V.; Mellgren, Gunnar; DeCensi, Andrea; Bonanni, Bernardo. 2019. Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. The Pharmacogenomics Journal. 1-8.
  • Helland, Thomas; Hagen, Kari Britt; Haugstøyl, Martha Eimstad; Kvaløy, Jan Terje; Lunde, Siri; Lode, Kirsten; Lind, Ragna Anne; Gripsrud, Birgitta Haga; Jonsdottir, Kristin; Gjerde, Jennifer; Bifulco, Ersilia; Hustad, Simon Steinar; Jonassen, Janne; Aas, Turid; Lende, Tone Hoel; Lien, Ernst Asbjørn; Janssen, Emiel; Søiland, Håvard; Mellgren, Gunnar. 2019. Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. Breast Cancer Research and Treatment. 185-195.
  • Johansson, Harriet; Gandini, Sara; Serrano, Davide; Gjerde, Jennifer; Lattanzi, Monia; Macis, Debora; Guerrieri-Gonzaga, Aliana; Aristarco, Valentina; Mellgren, Gunnar; Lien, Ernst Asbjørn; Decensi, Andrea; Bonanni, Bernardo. 2016. A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. Breast Cancer Research and Treatment. 97-108.
  • Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N; Fenne, Ingvild Sveinsgjerd; Skartveit, Linn; Drangevåg, Andreas; Bozickovic, Olivera; Flågeng, Marianne Hauglid; Søiland, Håvard; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2015. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLOS ONE. 19 pages.
  • Flågeng, Marianne Hauglid; Knappskog, Stian; Gjerde, Jennifer; Lønning, Per Eystein; Mellgren, Gunnar. 2015. Estrogens correlate with PELP1 expression in ER positive breast cancer. PLOS ONE. 12 pages.
  • Bjørndal, Bodil; Strand, Elin; Gjerde, Jennifer; Bohov, Pavol; Svardal, Asbjørn M.; Diehl, Bernd W.K.; Innis, Sheila M.; Berger, Alvin; Berge, Rolf Kristian. 2014. Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults. Lipids in Health and Disease.
  • Hagen, Kari Britt; Aas, Turid; Lode, Kirsten; Gjerde, Jennifer; Lien, Ernst Asbjørn; Kvaløy, Jan Terje; Lash, Timothy L; Søiland, Håvard; Lind, Ragna Anne. 2014. Illness uncertainty in breast cancer patients: Validation of the 5-item short form of the Mishel Uncertainty in Illness Scale. European Journal of Oncology Nursing. 1-7.
  • Lien, Ernst Asbjørn; Søiland, Håvard; Lundgren, Steinar; Aas, Turid; Steen, Vidar Martin; Mellgren, Gunnar; Gjerde, Jennifer. 2013. Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. Breast Cancer Research and Treatment. 243-248.
  • Methlie, Paal; Dankel, Simon E Nitter; Myhra, Tone Sæterdal; Christensen, Bjørn Jostein; Gjerde, Jennifer; Fadnes, Dag Jone Stokke; Våge, Villy; Løvås, Kristian; Mellgren, Gunnar. 2013. Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 2495-2503.
  • Serrano, Davide; Lazzeroni, Matteo; Gandini, Sara; Macis, Debora; Johansson, Harriet; Gjerde, Jennifer; Lien, Ernst Asbjørn; Feroce, Irene; Pruneri, Giancarlo; Sandri, Maria T; Bassi, Fabio; Brenelli, Fabricio; Luini, Alberto; Cazzaniga, Massimiliano; Varricchio, Clara; Guerrieri-Gonzaga, Aliana; Decensi, Andrea; Bonanni, Bernardo. 2013. A randomized phase II presurgical trial of weekly low-dose tamoxifen versus raloxifene versus placebo in premenopausal women with estrogen receptor-positive breast cancer. Breast Cancer Research. 11 pages.
  • Gjerde, Jennifer; Gandini, Sara; Guerrieri-Gonzaga, Aliana; Moi, Line Leonore Haugan; Aristarco, Valentina; Mellgren, Gunnar; Decensi, Andrea; Lien, Ernst Asbjørn. 2012. Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. Breast Cancer Research and Treatment. 693-700.
  • Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer; Nielsen, Hans Jørgen; Solsvik, Margit Hildershavn; Haugen, Christine; Christensen, Bjørn Jostein; Hoang, Tuyen; Fadnes, Dag Jone Stokke; Busch, Christian; Våge, Villy; Sagen, Jørn V.; Mellgren, Gunnar. 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gjerde, Jennifer; Madsen, Andre Greger; Røst, Therese Halvorsen; Gudbrandsen, Oddrun Anita; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2012. Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. BMC Cancer. 12 pages.
  • Ahern, Thomas P.; Christensen, Mariann; Cronin-Fenton, Deirdre P.; Lunetta, Kathryn L.; Søiland, Håvard; Gjerde, Jennifer; Garne, Jens Peter; Rosenberg, Carol L.; Silliman, Rebecca A.; Sørensen, Henrik Toft; Lash, Timothy L.; Hamilton-Dutoit, Stephen. 2011. Functional polymorphisms in UDP-glucuronosyltransferases and recurrence in tamoxifen-treated breast cancer survivors. Cancer Epidemiology, Biomarkers and Prevention. 1937-1943.
  • Serrano, Davide; Lazzeroni, Matteo; Zambon, Carlo–Federico; Macis, Debora; Maisonneuve, Patrick; Johansson, Harriet Ann; Guerrieri-Gonzaga, Aliana; Plebani, Mario; Basso, Daniela; Gjerde, Jennifer; Mellgren, Gunnar; Rotmensz, Nicole; Decensi, Andrea; Bonanni, Bernardo. 2011. Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. The Pharmacogenomics Journal. 100-107.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gandini, Sara; Guerrieri-Gonzaga, Aliana; Bonanni, Bernardo; Lazzeroni, Matteo; Gjerde, Jennifer; Lien, Ernst Asbjørn; De Censi, Andrea; Mellgren, Gunnar. 2010. Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. Clinical Cancer Research. 2176-2186.
  • Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2010. Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer. 13 pages.
  • Karimian, Elham; Chagin, Andrei S; Gjerde, Jennifer Fernandez; Heino, Terhi; Lien, Ernst Asbjørn; Ohlsson, Claes; Sävendahl, Lars. 2008. Tamoxifen impairs both longitudinal and cortical bone growth in young male rats. Journal of Bone and Mineral Research. 1267-1277.
  • Gjerde, Jennifer Fernandez; Hauglid, M; Breilid, Harald; Lundgren, S.; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2008. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Annals of Oncology. 56-61.
  • Decensi, Andrea; Gandini, Sara; Serrano, Davide; Cazzaniga, Massimiliano; Pizzamiglio, Maria; Maffini, Fausto; Pelosi, Giuseppe; Daldoss, Christina; Omodei, Umberto; Johansson, Harriet; Macis, Debora; Lazzeroni, Matteo; Penotti, Mauro; Sironi, Laura; Moroni, Simona; Bianco, Vanda; Rondanina, Gabriella; Gjerde, Jennifer Fernandez; Guerrieri-Gonzaga, Aliana; Bonanni, Bernardo. 2007. Randomized dose-ranging trial of tamoxifen at low doses in hormone replacement therapy users. Journal of Clinical Oncology. 4201-4209.
  • Gjerde, Jennifer; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, H; Hauglid, M; Varhaug, Jan Erik; Mellgren, G; Steen, VM; Lønning, Per Eystein; Lien, Ernst A. 2007. A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. Breast Cancer Research and Treatment. S144-S144.
  • Schjøtt, Jan; Gjerde, Jennifer; Kisanga, Elton Richard; Lien, Ernst Asbjørn. 2006. Pretreatment with tamoxifen does not change acute epirubicin cardiotoxicity in rats. Basic & Clinical Pharmacology & Toxicology. 231-234.
  • Kisanga, Elton Richard; Moi, Line Leonore Haugan; Gjerde, Jennifer; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. Journal of Steroid Biochemistry and Molecular Biology. 489-498.
  • Gjerde, Jennifer Fernandez; Kisanga, Elton Richard; Hauglid, Marianne; Holm, Pål Ivar; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A. 6-14.
  • Kisanga, Elton Richard; Gjerde, Jennifer; Guerrieri-gonzaga, Aliana; Pigatto, Francesca; Pesci - feltri, Adriana; Robertson, Chris; Serrano, Davide; Pelosi, Giuseppe; Decensi, Andrea; Lien, Ernst Asbjørn. 2004. Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in randomized preoperative trial. Clinical Cancer Research. 2336-2343.
  • Kisanga, Elton Richard; Gjerde, Jennifer; Schjøtt, Jan; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2003. Tamoxifen administration and metabolism in nude mice and nude rats. Journal of Steroid Biochemistry and Molecular Biology. 361-367.
Academic lecture
  • Gjerde, Jennifer. 2010. Estrogen Receptor degradation.
  • Gjerde, Jennifer Fernandez; Lien, Ernst Asbjørn. 2005. Distribution of tamoxifen in serum and breast cancer tissue and its effects on sex hormone-binding globulin (SHBG).
Reader opinion piece
  • Søiland, Håvard; Hagen, Kari Britt; Gjerde, Jennifer; Lende, Tone Hoel; Lien, Ernst Asbjørn. 2013. Breaking away: High fracture rates may merit a new trial of adjuvant endocrine therapy in Scandinavian breast cancer patients. Acta Oncologica. 861-U216.
Masters thesis
  • Aursland, Johannes. 2010. CYP2C19 single nucleotide polymorphisms And their effects on the metabolism of Tamoxifen in breast cancer patients.
Doctoral dissertation
  • Gjerde, Jennifer. 2008. Tamoxifen treatment of breast cancer: Pharmacogenetics and therapeutic drug monitoring.
Academic chapter/article/Conference paper
  • Aas, Grete Hansen; Strand, Elin; Gjerde, Jennifer; Røsvik, Anne Synnøve; Sæbø, Per Christian; Bjørndal, Bodil. 2018. Effect of Whey and Herring Roe Protein administered as a supplement to young healthy adults – A pilot study.
  • Gjerde, Jennifer; Moi, Line Leonore Haugan; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2012. Tamoxifen metabolism and biological activity. 22 pages.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Fenne, Ingvild Sveinsgjerd; Gjerde, Jennifer; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer. 18 pages.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Hoang, Tuyen; Gjerde, Jennifer; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 pages.
Abstract
  • Lien, Ernst Asbjørn; Søiland, Håvard; Gjerde, Jennifer. 2013. Associations between tamoxifen and age during steady state tamoxifen treatment of postmenopausal women with breast cancer. Experimental and clinical endocrinology & diabetes. 1 pages.
  • Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2010. Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism. European Journal of Cancer. 60-60.
  • Gjerde, Jennifer Fernandez; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, Harald; Hauglid, M; Varhaug, EJ; Steen, Vidar Martin; Lonning, PE; Lien, Ernst Asbjørn. 2008. A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. Breast Cancer Research and Treatment. 592-592.
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2007. Effect of CYP2D6 and SULT1A1 genotypes on the serum concentration of 4-hydroxytamoxifen and 4-hydroxy-N-demethyltamoxifen during steady state treatment of breast cancer patients. Breast. S15-S15.
  • Gjerde, Jennifer Fernandez; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, Harald; Hauglid, Marianne; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lønning, Per Eystein; Lien, Ernst Asbjørn. 2007. A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. Breast Cancer Research and Treatment.
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2005. Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. Breast Cancer Research and Treatment. S236-S237.
Poster
  • Lunde, Siri; Helland, Thomas; Jonassen, Janne; Martha, Haugstøyl; Austdal, Marie; Lode, Kirsten; Hagen, Kari-Britt; Gripsrud, Birgitta Haga; Lind, Ragna Anne; Gjerde, Jennifer; Lende, Tone Hoel; Gilje, Bjørnar; Aas, Turid; Jonsdottir, Kristin; Kroksveen, Ann Cathrine; Erdal, Bjørg; Vevle, Sissel; Sagen, Jørn-Vegard; Oltedal, Satu; Nordgård, Oddmund; Tjensvoll, Kjersti; Lash, Timothy; Kvaløy, Jan Terje; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard; Lien, Ernst Asbjørn. 2018. A prospective, longitudinal, breast cancer biobank (PBCB) in western Norway.
  • Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer; Nielsen, Hans Jørgen; Solsvik, Margit Hildershavn; Haugen, Christine; Christensen, Bjørn Jostein; Hoang, Tuyen; Busch, Christian; Fadnes, Dag Jone Stokke; Våge, Villy; Sagen, Jørn V.; Mellgren, Gunnar. 2011. The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss.
  • Gjerde, Jennifer; Guerrieri-gonzaga, Aliana; Flågeng, Marianne Hauglid; Gandini, Sara; Haugan Moi, Line; Bonanni, Bernardo; Macis, Debora; Johansson, Harriet; Decensi, Andrea; Mellgren, Gunnar; Lien, Ernst A. 2010. The influence of tamoxifen treatment on the expression levels of liver receptor homolog (LHR-1).
  • Flågeng, Marianne Hauglid; Moi, Line Leonore Haugan; Gandini, Sara; Guerrieri Gonzaga, Aliana; Bonanni, Bernardo; Lazzeroni, Matteo; Gjerde, Jennifer; Lien, Ernst Asbjørn; Decensi, Andrea; Mellgren, Gunnar. 2010. Expression of Steroid Receptor Coactivators and HER-2/neu in normal and malignant breast tissue in controls and tamoxifen treated patients.
  • Gjerde, Jennifer; Geisler, Jurgen; Lundgren, Steinar; Ekse, D.; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst A. 2010. Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism.
  • Gjerde, Jennifer; Guerrieri-Gonzaga, Aliana; Bonanni, Bernardo; Gandini, Sara; Macis, Debora; Mellgren, Gunnar; De Censi, Andrea; Lien, Ernst A. 2010. Distribution of tamoxifen and five metabolites into normal and malignant human breast cancer tissue during conventional and low dose treatment.
  • Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Lønning, Per Eystein; Lien, Ernst Asbjørn. 2009. Relations between FSH, SHBG and tamoxifen metabolism during steady state tamoxifen treatment.
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2007. Effect of CYP2D6 and SULT1A1 Genotypes on the serum concentration of 4-OHtamoxifen and 4-OH-N-Demethyltamoxifen during steady state treatment of breast cancer patients.
  • Gjerde, Jennifer; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, H; Hauglid, M; Varhaug, Jan Erik; Mellgren, G; Steen, VM; Lønning, Per Eystein; Lien, Ernst A. 2007. A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment.
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2005. Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients.
  • Gjerde, Jennifer; Hauglid, M; Breilid, H; Lundgren, Steinar; Varhaug, JE; Kisanga, ER; Mellgren, G; Steen, VM; Lien, Ernst A. 2005. Relationship between CYP2D6 and SULT1A1 genotype and serum concentration of tamoxifen and its metabolites during steady state treatment in breast cancer patients.
  • Moi, Line Leonore Haugan; Kisanga, Elton Richard; Gjerde, Jennifer; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Effects of low-dose tamoxifen treatment on expression of drug-metabolising enzymes in rat liver in relation to administration route.
  • Moi, Line Leonore Haugan; Kisanga, Elton Richard; Gjerde, Jennifer; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2004. Tamoxifen metabolism and induction of hepatic drug-metabolizing enzymes in nude rats.
  • Gjerde, Jennifer; Lien, Ernst Asbjørn. 2004. Quantification of serum tamoxifen and metabolites by liquid chromatography-tandem mass spectrometry.
  • Kisanga, Elton Richard; Gjerde, Jennifer Fernandez; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2002. Tamoxifen metabolism in immunocompromised rats and mice.

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