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Jian Wang

Professor
  • E-mailJian.Wang@uib.no
  • Phone+47 55 58 63 46
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2021). miR-6858 plays a key role in the process of melatonin inhibition of the malignant biological behavior of glioma. Journal of clinical neuroscience. 137-146.
  • Show author(s) (2021). Nicotinamide riboside and metformin ameliorate mitophagy defect in induced pluripotent stem cell-derived astrocytes with POLG mutations. Frontiers in Cell and Developmental Biology. 1-20.
  • Show author(s) (2020). Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib. ACS Chemical Neuroscience. 1337-1346.
  • Show author(s) (2020). Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. . American Journal of Cancer Research. 545-563.
  • Show author(s) (2020). TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα. . Cell Death and Differentiation. 367-381.
  • Show author(s) (2020). LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM. Frontiers in Oncology. 1-10.
  • Show author(s) (2020). Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis. . Frontiers in Immunology.
  • Show author(s) (2020). Glioblastoma Therapy Using Codelivery of Cisplatin and Glutathione Peroxidase Targeting siRNA from Iron Oxide Nanoparticles. ACS Applied Materials & Interfaces.
  • Show author(s) (2020). Disulfiram, a ferroptosis inducer, triggers lysosomal membrane permeabilization by up-regulating ros in glioblastoma. OncoTargets and Therapy. 10631-10640.
  • Show author(s) (2019). Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma. EMBO Molecular Medicine.
  • Show author(s) (2019). The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma. Frontiers in Oncology.
  • Show author(s) (2019). Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma. Journal of Cellular and Molecular Medicine.
  • Show author(s) (2019). RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation. Oncogene.
  • Show author(s) (2019). PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. Oncogene. 1-15.
  • Show author(s) (2019). Melatonin enhances proliferation and modulates differentiation of neural stem cells via autophagy in hyperglycemia. Stem Cells. 504-515.
  • Show author(s) (2019). Long Noncoding RNA SChLAP1 Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-kappa B Signaling. Clinical Cancer Research. 6868-6881.
  • Show author(s) (2019). Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling. Brain. 512-530.
  • Show author(s) (2019). Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma. EBioMedicine. 159-170.
  • Show author(s) (2019). Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways. Oncogene. 428-442.
  • Show author(s) (2018). YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma. Journal of Translational Medicine. 1-11.
  • Show author(s) (2018). Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. International Journal of Cancer. 1735-1745.
  • Show author(s) (2018). Six-Transmembrane Epithelial Antigen of Prostate 3 Predicts Poor Prognosis and Promotes Glioblastoma Growth and Invasion. Neoplasia. 543-554.
  • Show author(s) (2018). Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway. Cancer Medicine. 4729-4748.
  • Show author(s) (2018). Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. Autophagy. 2007-2022.
  • Show author(s) (2018). Glioma exosomes mediate the expansion and function of myeloid‐derived suppressor cells through microRNA‐29a/Hbp1 and microRNA‐92a/Prkar1a pathways. International Journal of Cancer. 3111-3126.
  • Show author(s) (2018). Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ article. Cell Death & Disease.
  • Show author(s) (2017). Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 1-13.
  • Show author(s) (2017). Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. Journal of Experimental & Clinical Cancer Research. 1-13.
  • Show author(s) (2017). The combination of db-cAMP and ChABC with poly(propylene carbonate) microfibers promote axonal regenerative sprouting and functional recovery after spinal cord hemisection injury. Biomedicine and Pharmacotherapy. 354-362.
  • Show author(s) (2017). TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion. Journal of Experimental & Clinical Cancer Research.
  • Show author(s) (2017). TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas. Journal of Experimental & Clinical Cancer Research.
  • Show author(s) (2017). Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy. OncoTarget. 12145-12157.
  • Show author(s) (2017). Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion. OncoTarget. 23401-23413.
  • Show author(s) (2017). PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT. Journal of Experimental & Clinical Cancer Research. 1-17.
  • Show author(s) (2017). Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells. OncoTarget. 80358-80372.
  • Show author(s) (2017). Increased NG2 AND SOX2 expression is associated with high-grade choroid plexus tumors. Oncology Letters. 1802-1806.
  • Show author(s) (2017). Impact of VEGFA polymorphisms on glioma risk in Chinese. OncoTarget. 83712-83722.
  • Show author(s) (2017). High expression of RAB43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas. Oncology Reports. 903-912.
  • Show author(s) (2017). Coiled-coil domain containing 109B is a HIF1?-regulated gene critical for progression of human gliomas. Journal of Translational Medicine.
  • Show author(s) (2017). Change in the relationship between the Australian summer monsoon circulation and boreal summer precipitation over Central China in the late 1990s. Meteorology and atmospheric physics (Print). 1-9.
  • Show author(s) (2017). Bufalin enhances radiosensitivity of glioblastoma by suppressing mitochondrial function and DNA damage repair. Biomedicine and Pharmacotherapy. 627-635.
  • Show author(s) (2016). Role of medical thoracoscopy in the treatment of tuberculous pleural effusion. Journal of Thoracic Disease. 52-60.
  • Show author(s) (2016). Oleuropein inhibits the proliferation and invasion of glioma cells via suppression of the AKT signaling pathway. Oncology Reports. 2009-2016.
  • Show author(s) (2016). Nitidine chloride inhibits the malignant behavior of human glioblastoma cells by targeting the PI3K/AKT/mTOR signaling pathway. Oncology Reports. 2160-2168.
  • Show author(s) (2016). Local in vitro delivery of rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment. Biomedicine and Pharmacotherapy. 1345-1352.
  • Show author(s) (2016). Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR. OncoTarget. 80521-80542.
  • Show author(s) (2016). Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14. OncoTarget. 62425-62438.
  • Show author(s) (2016). Galunisertib inhibits glioma vasculogenic mimicry formation induced by astrocytes. Scientific Reports.
  • Show author(s) (2016). CREBRF is a potent tumor suppressor of glioblastoma by blocking hypoxia-induced autophagy via the CREB3/ATG5 pathway. International Journal of Oncology. 519-528.
  • Show author(s) (2016). Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. OncoTarget. 66944-66958.
  • Show author(s) (2016). Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type. OncoTarget. 38775-38784.
  • Show author(s) (2015). Drug repurposing: Sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc<sup>-</sup>, leading to glutathione depletion. Oncogene. 5951-5959.
  • Show author(s) (2014). Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. European Journal of Cancer. 3262-3270.
  • Show author(s) (2014). Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. British Journal of Cancer. 2275-2286.
  • Show author(s) (2014). Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLOS ONE.
  • Show author(s) (2014). Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. PLOS ONE. 12 pages.
  • Show author(s) (2014). A novel GFP nude rat model to investigate tumor-stroma interactions. Cancer Cell International.
  • Show author(s) (2014). A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma. Journal of Translational Medicine.
  • Show author(s) (2013). Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. OncoTarget. 1527-1546.
  • Show author(s) (2013). Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model. Biomedical Research. 9 pages.
  • Show author(s) (2013). Establishment of a novel dsRed NOD/Scid mouse strain to investigate the host and tumor cell compartments. Cancer Investigation. 221-230.
  • Show author(s) (2013). EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathologica. 683-698.
  • Show author(s) (2013). A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. PLOS ONE. e59773.
  • Show author(s) (2012). The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proceedings of the National Academy of Sciences of the United States of America. 6662-6667.
  • Show author(s) (2012). Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation. BMC Cancer. 10 pages.
  • Show author(s) (2012). Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. Journal of Nuclear Medicine. 1135-1145.
  • Show author(s) (2011). Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. PLOS ONE. 14 pages.
  • Show author(s) (2011). Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide. BMC Cancer.
  • Show author(s) (2011). Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 3749-3754.
  • Show author(s) (2011). A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathology and Applied Neurobiology. 189-205.
  • Show author(s) (2010). alpha B-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells. American Journal of Pathology. 1618-1628.
  • Show author(s) (2010). Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Research. 4274-4279.
  • Show author(s) (2010). Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment. Gene Therapy. 202-216.
  • Show author(s) (2009). iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Molecular & Cellular Proteomics. 2595-2612.
  • Show author(s) (2009). Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype. Neuropathology and Applied Neurobiology. 380-393.
  • Show author(s) (2009). Activated Platelets Provide a Functional Microenvironment for the Antiangiogenic Fragment of Histidine-Rich Glycoprotein. Molecular Cancer Research. 1792-1802.
  • Show author(s) (2009). A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer.
  • Show author(s) (2008). Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in Biomedicine. 830-838.
  • Show author(s) (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 5182-5194.
  • Show author(s) (2008). Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Clinical Cancer Research. 1571-1580.
  • Show author(s) (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 761-768.
  • Show author(s) (2007). Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. Journal of Neuro-Oncology. 1-10.
  • Show author(s) (2006). Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Research. 9895-9902.
  • Show author(s) (2006). Primary glioma spheroids maintain tumourogenicity and essential phenotypic traits after cryopreservation. Neuropathology and Applied Neurobiology. 419-427.
  • Show author(s) (2006). Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1. Neuro-Oncology. 96-108.
  • Show author(s) (2006). Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 16466-16471.
Masters thesis
  • Show author(s) (2021). Development of 3D in vitro Interaction Models for the Evaluation and Treatment of Brain Metastases.
Doctoral dissertation
  • Show author(s) (2016). Experimental modeling and therapeutic strategies in glioblastoma.
  • Show author(s) (2008). Xenografted brain tumors for modelling glioma biology – a study of brain tumor initiating cells and phenotypic modulation in gliomas.
Abstract
  • Show author(s) (2013). EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Neuro-Oncology. 6-6.
  • Show author(s) (2012). Early MRI findings of targeting the NG2 proteoglycan in GBM. The FASEB Journal. 1 pages.
  • Show author(s) (2011). Separate analysis of the cancer and stroma cell populations from orthotopically implanted tumor biopsies in eGFP scid mice. Clinical and Experimental Metastasis. 203-203.
  • Show author(s) (2010). THERAPEUTIC TARGETING OF THE NG2 PROTEOGLYCAN WITH MAB 9.2.27 AND ADOPTIVELY TRANSFERRED NK CELLS LYSES HUMAN GLIOBLASTOMA MULTIFORME IN VIVO. Neuro-Oncology. 9-9.
  • Show author(s) (2010). SULFASALAZINE SENSITIZES GLIOBLASTOMA CELLS TO RADIATION TREATMENT. Neuro-Oncology. 109-109.
  • Show author(s) (2010). Rapid adherence to collagen IV enriches for tumour initiating cells. European Journal of Cancer. 124-124.
  • Show author(s) (2010). ANTI-ANGIOGENIC TREATMENT IN A CLINICALLY RELEVANT GLIOBLASTOMA MODEL REDUCES BLOOD FLOW AND INCREASES TUMOR CELL INVASION. Neuro-Oncology. 20-20.
  • Show author(s) (2009). Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. Neuro-Oncology. 221-222.
  • Show author(s) (2009). TARGETING THE TUMOR STROMA: A NOVEL THERAPEUTIC STRATEGY BASED ON SEPARATE ANALYSIS OF THE MALIGNANT AND STROMAL CELL COMPARTMENTS IN BRAIN TUMORS. Neuro-Oncology. 965-965.
  • Show author(s) (2009). PHENOTYPIC MODULATION OF EXPERIMENTAL GLIOMAS: PROGRESSION FROM GLIOMATOSIS CEREBRI-LIKE LESIONS TO GLIOBLASTOMA. Neuro-Oncology. 897-897.
  • Show author(s) (2009). PHENOTYPIC AND PHYSIOLOGIC EFFECTS OF BEVACIZUMAB IN A HIGHLY INFILTRATIVE AND ANGIOGENIC HUMAN GLIOBLASTOMA MODEL. Neuro-Oncology. 906-906.
  • Show author(s) (2009). MOLECULAR VARIATIONS IN TUMOR-HOST INTERACTIONS BETWEEN INVASIVE AND ANGIOGENIC PHENOTYPE IN HIGH-GRADE GLIOMAS. Neuro-Oncology. 961-961.
  • Show author(s) (2009). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. Neuro-Oncology. 917-917.
  • Show author(s) (2008). Human glioblastoma tissue engraftment in immunocompetent rodent hosts. Neuro-Oncology. 815-815.
  • Show author(s) (2008). DEVELOPMENT OF A NEW BRAIN METASTASES MODEL IN IMMUNODEFICIENT ANIMALS. Neuro-Oncology. 854-854.
  • Show author(s) (2008). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. Neuro-Oncology. 778-778.
  • Show author(s) (2005). Bacitracin inhibits glioma cell migration and invasion in vitro. Neuro-Oncology. 357-357.
  • Show author(s) (2004). Forced differentiation suppresses the proliferative rate of cancer cells in brain tumours. Neuro-Oncology.
  • Show author(s) (2004). Angiogenesis-independent growth by brain tumor cells exhibiting cancer stem cell properties. Neuro-Oncology. 309-309.
Poster
  • Show author(s) (2009). Highly infiltrative brain tumors show reduced chemosensitivity associated with a stem cell-like phenotype.
Academic literature review
  • Show author(s) (2018). Lysosomes contribute to radioresistance in cancer. Cancer Letters. 39-46.
  • Show author(s) (2018). Chemoresistance caused by the microenvironment of glioblastoma and the corresponding solutions. Biomedicine and Pharmacotherapy. 39-46.

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