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Jian Wang

Professor
  • E-mailJian.Wang@uib.no
  • Phone+47 55 58 63 46
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Ding, Kaikai; Ji, Jianxiong; Zhang, Xin; Huang, Bin; Chen, Anjing; Zhang, Di; Li, Xingang; Wang, Xinyu; Wang, Jian. 2019. RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation. Oncogene. doi: 10.1038/s41388-019-0888-1
  • Feng, Zichao; Zhou, Wenjing; Wang, Jiwei; Qi, Qichao; Han, Mingzhi; Kong, Yang; Hu, Yaotian; Zhang, Yulin; Chen, Anbin; Huang, Bin; Zhang, Di; Li, Wenjie; Zhang, Qing; Bjerkvig, Rolf; Wang, Jian; Thorsen, Frits; Li, Xingang. 2019. Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma. Journal of Cellular and Molecular Medicine. doi: 10.1111/jcmm.14840
  • Han, Mingzhi; Wang, Shuai; Yang, Ning; Wang, Xu; Zhao, Wenbo; Sdik Saed, Halala; Daubon, Thomas; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian. 2019. Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma. EMBO Molecular Medicine. doi: 10.15252/emmm.201910924
  • Han, Mingzhi; Wang, Shuai; Zhao, Wen-Bo; Ni, Shi-Lei; Yang, Ning; Kong, Yang; Huang, Bin; Chen, An-Jing; Li, Xin-Gang; Wang, Jian; Wang, Dong-Hai. 2019. Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma. EBioMedicine. 43: 159-170. doi: 10.1016/j.ebiom.2019.04.002
  • Ji, Jianxiong; Ding, Kaikai; Luo, Tao; Xu, Ran; Zhang, Xin; Huang, Bin; Chen, An-Jing; Zhang, Di; Miletic, Hrvoje; Bjerkvig, Rolf; Thorsen, Frits; Wang, Jian; Li, Xingang. 2019. PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. Oncogene. 1-15. doi: 10.1038/s41388-019-1050-9
  • Ji, Jianxiong; Xu, Ran; Ding, Kaikai; Bao, Guoqing; Zhang, Xin; Huang, Bin; Wang, Xinyu; Martinez, Aurora; Wang, Xiuying; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Xiang, Lei; Han, Bo; Chen, Anjing; Li, Xingang; Wang, Jian. 2019. Long Noncoding RNA SChLAP1 Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-?B Signaling. Clinical Cancer Research. 25: 6868-6881. doi: 10.1158/1078-0432.CCR-19-0747
  • Kong, Yang; Feng, Zichao; Chen, Anjing; Qi, Qichao; Han, Mingzhi; Wang, Shuai; Zhang, Yulin; Zhang, Xin; Yang, Ning; Wang, Jiwei; Huang, Bin; Zhang, Qing; Xiang, Guo; Li, Wenjie; Zhang, Di; Wang, Jian; Li, Xingang. 2019. The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma. Frontiers in Oncology. 9. doi: 10.3389/fonc.2019.00942
  • Li, Haoyuan; Zhang, Yanming; Liu, Shangming; Li, Fengpeng; Wang, Benlin; Wang, Jianjie; Cao, Lanfang; Xia, Tongliang; Yao, Qingyu; Chen, Haijun; Zhang, Yulin; Zhu, Xiaodong; Li, Yang; Li, Gang; Wang, Jian; Li, Xingang; Ni, Shilei. 2019. Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia. Stem Cells. 37: 504-515. doi: 10.1002/stem.2968
  • Guo, Xiaofan; Qiu, Wei; Wang, Jian; Liu, Qinglin; Qian, Mingyu; Wang, Shaobo; Zhang, Zongpu; Gao, Xiao; Chen, Zihang; Guo, Qindong; Xu, Jianye; Xue, Hao; Li, Gang. 2018. Glioma exosomes mediate the expansion and function of myeloid‐derived suppressor cells through microRNA‐29a/Hbp1 and microRNA‐92a/Prkar1a pathways. International Journal of Cancer. 144: 3111-3126. doi: 10.1002/ijc.32052
  • Han, Mingzhi; Xu, Ran; Wang, Shuai; Yang, Ning; Ni, Shilei; Zhang, Qing; Xu, Yangyang; Zhang, Xin; Zhang, Chao; Wei, Yuzhen; Ji, Jianxiong; Huang, Bin; Zhang, Di; Chen, Anjing; Li, Wenjie; Bjerkvig, Rolf; Li, Xingang; Wang, Jian. 2018. Six-Transmembrane Epithelial Antigen of Prostate 3 Predicts Poor Prognosis and Promotes Glioblastoma Growth and Invasion. Neoplasia. 20: 543-554. doi: 10.1016/j.neo.2018.04.002
  • Ji, Jianxiong; Xu, Ran; Zhang, Xin; Han, Mingzhi; Xu, Yangyang; Wei, Yuzhen; Ding, Kaikai; Wang, Shuai; Huang, Bin; Chen, Anjing; Zhang, Di; Jiang, Zheng; Xu, Shuo; Zhang, Qing; Li, Wenjie; Ni, Shilei; Wang, Jian; Li, Xingang. 2018. Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ article. Cell Death & Disease. 9. doi: 10.1038/s41419-018-0548-3
  • Johannessen, Tor-Christian Aase; Hasan-Olive, Md Mahdi; Zhu, Huaiyang; Denisova, Oxana V.; Grudic, Amra; Latif, Md Abdul; Sdik Saed, Halala; Varughese, Jobin K.; Røsland, Gro Vatne; Yang, Ning; Sundstrøm, Terje; Nordal, Anne Birgitte Thomas; Tronstad, Karl Johan; Wang, Jian; Lund-Johansen, Morten; Simonsen, Anne; Janji, Bassam; Westermarck, Jutta; Bjerkvig, Rolf; Prestegarden, Lars. 2018. Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. International Journal of Cancer. 144: 1735-1745. Published 2018-10-05. doi: 10.1002/ijc.31912
  • Wang, Jiwei; Qi, Qichao; Zhou, Wenjing; Feng, Zichao; Huang, Bin; Chen, Anjing; Zhang, Di; Li, Wenjie; Zhang, Qing; Jiang, Zheng; Bjerkvig, Rolf; Prestegarden, Lars; Thorsen, Frits; Wang, Xinyu; Li, Xingang; Wang, Jian. 2018. Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. Autophagy. 14: 2007-2022. doi: 10.1080/15548627.2018.1501133
  • Zhang, Xin; Ding, Kaikai; Wang, Jian; Li, Xingang; Zhao, Peng. 2018. Chemoresistance caused by the microenvironment of glioblastoma and the corresponding solutions. Biomedicine and Pharmacotherapy. 109: 39-46. doi: 10.1016/j.biopha.2018.10.063
  • Zhang, Xin; Wang, Jian; Li, Xingang; Wang, Donghai. 2018. Lysosomes contribute to radioresistance in cancer. Cancer Letters. 439: 39-46. doi: 10.1016/j.canlet.2018.08.029
  • Zhang, Xin; Wang, Xuehai; Xu, Ran; Ji, Jianxiong; Xu, Yangyang; Han, Mingzhi; Wei, Yuzhen; Huang, Bin; Chen, Anjing; Zhang, Qing; Li, Wenjie; Wang, Jian; Li, Xingang; Qiu, Chen. 2018. YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma. Journal of Translational Medicine. 16:79: 1-11. doi: 10.1186/s12967-018-1451-5
  • Zhou, Wenjing; Wang, Jiwei; Qi, Qichao; Feng, Zichao; Huang, Bin; Chen, Anjing; Zhang, Di; Li, Wenjie; Zhang, Qing; Bjerkvig, Rolf; Li, Xingang; Wang, Jian. 2018. Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway. Cancer Medicine. 7: 4729-4748. doi: 10.1002/cam4.1720
  • Guo, Xing; Xu, Shugang; Gao, Xiao; Wang, Jian; Xue, Hao; Chen, Zihang; Zhang, Jinsen; Guo, Xiaofan; Qian, Mingyu; Qiu, Wei; Li, Gang. 2017. Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells. OncoTarget. 8: 80358-80372. doi: 10.18632/oncotarget.18673
  • Han, Ming-Zhi; Bin, Huang; Chen, An-Jing; Xin, Zhang; Xu, Ran; Wang, Jian; Li, Xin-Gang. 2017. High expression of RAB43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas. Oncology Reports. 37: 903-912. doi: 10.3892/or.2017.5349
  • Han, Ming-Zhi; Xu, Ran; Xu, Yang-Yang; Zhang, Xin; Ni, Shi-Lei; Huang, Bin; Chen, An-Jing; Wei, Yu-Zhen; Wang, Shuai; Li, Wen-Jie; Zhang, Qing; Li, Gang; Li, Xin-Gang; Wang, Jian. 2017. TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas. Journal of Experimental & Clinical Cancer Research. 36. doi: 10.1186/s13046-017-0619-9
  • Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille Kayitesi; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind. 2017. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 17:108: 1-13. doi: 10.1186/s12885-017-3109-8
  • Xia, Tongliang; Huang, Bin; Ni, Shilei; Gao, Lei; Wang, Jiangang; Wang, Jian; Chen, Anjing; Zhu, Shaowei; Wang, Benlin; Li, Gang; Zhu, Shugan; Li, Xingang. 2017. The combination of db-cAMP and ChABC with poly(propylene carbonate) microfibers promote axonal regenerative sprouting and functional recovery after spinal cord hemisection injury. Biomedicine and Pharmacotherapy. 86: 354-362. doi: 10.1016/j.biopha.2016.12.045
  • Xu, Ran; Han, Mingzhi; Xu, Yangyang; Zhang, Xin; Zhang, Chao; Zhang, Di; Ji, Jianxiong; Wei, Yuzhen; Wang, Shuai; Huang, Bin; Chen, Aanjing; Zhang, Qing; Li, Wenjie; Sun, Tao; Wang, Feng; Li, Xingang; Wang, Jian. 2017. Coiled-coil domain containing 109B is a HIF1?-regulated gene critical for progression of human gliomas. Journal of Translational Medicine. 15. doi: 10.1186/s12967-017-1266-9
  • Xu, Ran; Ji, Jianxiong; Zhang, Xin; Han, Mingzhi; Zhang, Chao; Xu, Yangyang; Wei, Yuzhen; Wang, Shuai; Huang, Bin; Chen, Anjing; Zhang, Di; Zhang, Qing; Li, Wenjie; Wang, Jian; Li, Xingang. 2017. PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT. Journal of Experimental & Clinical Cancer Research. 36:193: 1-17. doi: 10.1186/s13046-017-0665-3
  • Xu, Yangyang; Zhang, Lin; Wei, Yuzhen; Zhang, Xin; Xu, Ran; Han, Mingzhi; Huang, Bing; Chen, Anjing; Li, Wenjie; Zhang, Qing; Li, Gang; Wang, Jian; Zhao, Peng; Li, Xingang. 2017. Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion. OncoTarget. 8: 23401-23413. doi: 10.18632/oncotarget.15581
  • Yang, Ruowen; Wang, Jian; Zhang, Tianyu; He, Shengping. 2017. Change in the relationship between the Australian summer monsoon circulation and boreal summer precipitation over Central China in the late 1990s. Meteorology and atmospheric physics (Print). 1-9. doi: 10.1007/s00703-017-0556-3
  • Zhang, Chao; Zhang, Xin; Xu, Ran; Huang, Bin; Chen, An-Jing; Li, Chao; Wang, Jian; Li, Xin-Gang. 2017. TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion. Journal of Experimental & Clinical Cancer Research. 36. doi: 10.1186/s13046-017-0628-8
  • Zhang, Xin; Huang, Qibing; Wang, Xuehai; Xu, Yangyang; Xu, Ran; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qui, Chen; Sun, Tao; Wang, Feng; Li, Xingang; Wang, Jian; Zhao, Peng; Wang, Xinyu. 2017. Bufalin enhances radiosensitivity of glioblastoma by suppressing mitochondrial function and DNA damage repair. Biomedicine and Pharmacotherapy. 94: 627-635. doi: 10.1016/j.biopha.2017.07.136
  • Zhang, Xin; Xu, Ran; Zhang, Chao; Xu, Yangyang; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qiu, Chen; Thorsen, Frits; Prestegarden, Lars; Bjerkvig, Rolf; Wang, Jian; Li, Xingang. 2017. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. Journal of Experimental & Clinical Cancer Research. 36:118: 1-13. doi: 10.1186/s13046-017-0588-z
  • Zhao, Peng; Chen, Anjing; Qi, Qichao; Zhou, Wenjing; Feng, Zichao; Wang, Jiwei; Yang, Ning; Li, Xingang; Wang, Jian; Huang, Qibing; Huang, Bin. 2017. Impact of VEGFA polymorphisms on glioma risk in Chinese. OncoTarget. 8: 83712-83722. doi: 10.18632/oncotarget.19380
  • Zhao, Peng; Feng, Zichao; Qi, Qichao; Huang, Bin; Chen, Anjing; Li, Xingang; Wang, Xinyu; Wang, Jian. 2017. Increased NG2 AND SOX2 expression is associated with high-grade choroid plexus tumors. Oncology Letters. 14: 1802-1806. doi: 10.3892/ol.2017.6326
  • Zhu, Huaiyang; Leiss, Lina Wik; Yang, Ning; Rygh, Cecilie Brekke; Mitra, Siddharta S.; Cheshier, Samuel H.; Weissman, Irving L.; Huang, Bin; Miletic, Hrvoje; Bjerkvig, Rolf; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2017. Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy. OncoTarget. 8: 12145-12157. doi: 10.18632/oncotarget.14553
  • Chen, Weiliang; Xia, Tongliang; Wang, Donghai; Huang, Bin; Zhao, Peng; Wang, Jian; Qu, Xun; Li, Xingang. 2016. Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14. OncoTarget. 7: 62425-62438. doi: 10.18632/oncotarget.11515
  • Guo, Xiaofan; Xue, Hao; Shao, Qianqian; Wang, Jian; Guo, Xing; Chen, Xi; Zhang, Jinsen; Xu, Shugang; Li, Tong; Zhang, Ping; Gao, Xiao; Qiu, Wei; Liu, Qinglin; Li, Gang. 2016. Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR. OncoTarget. 7: 80521-80542. doi: 10.18632/oncotarget.11825
  • Liu, Ming; Wang, Jian; Huang, Bin; Chen, Anjing; Li, Xingang. 2016. Oleuropein inhibits the proliferation and invasion of glioma cells via suppression of the AKT signaling pathway. Oncology Reports. 36: 2009-2016. doi: 10.3892/or.2016.4978
  • Liu, Ming; Wang, Jiwei; Qi, Qichao; Huang, Bin; Chen, Anjing; Li, Xingang; Wang, Jian. 2016. Nitidine chloride inhibits the malignant behavior of human glioblastoma cells by targeting the PI3K/AKT/mTOR signaling pathway. Oncology Reports. 36: 2160-2168. doi: 10.3892/or.2016.4998
  • Qi, Qichao; Wang, Jiwei; Huang, Bin; Chen, Anjing; Li, Gang; Li, Xingang; Wang, Jian. 2016. Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type. OncoTarget. 7: 38775-38784. doi: 10.18632/oncotarget.9608
  • Wang, Benlin; Li, Haoyuan; Yao, Qingyu; Zhang, Yulin; Zhu, Xiaodong; Xia, Tongliang; Wang, Jian; Li, Gang; Li, Xingang; Ni, Shilei. 2016. Local in vitro delivery of rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment. Biomedicine and Pharmacotherapy. 83: 1345-1352. doi: 10.1016/j.biopha.2016.08.033
  • Wang, Jiwei; Qi, Qichao; Feng, Zichao; Zhang, Xin; Huang, Bin; Chen, Anjing; Prestegarden, Lars; Li, Xingang; Wang, Jian. 2016. Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. OncoTarget. 7: 66944-66958. doi: 10.18632/oncotarget.11396
  • Xiong, Yu; Gao, Xusheng; Zhu, Huaiyang; Ding, Caihong; Wang, Jian. 2016. Role of medical thoracoscopy in the treatment of tuberculous pleural effusion. Journal of Thoracic Disease. 8: 52-60. doi: 10.3978/j.issn.2072-1439.2016.01.34
  • Xue, Hao; Zhang, Jinsen; Guo, Xing; Wang, Jian; Li, Jiangbing; Gao, Xiao; Guo, Xiaofan; Li, Tong; Xu, Shugang; Zhang, Ping; Liu, Qinglin; Li, Gang. 2016. CREBRF is a potent tumor suppressor of glioblastoma by blocking hypoxia-induced autophagy via the CREB3/ATG5 pathway. International Journal of Oncology. 49: 519-528. doi: 10.3892/ijo.2016.3576
  • Zhang, Chao; Chen, Wenliang; Zhang, Xin; Huang, Bin; Chen, Aanjing; He, Ying; Wang, Jian; Li, Xingang. 2016. Galunisertib inhibits glioma vasculogenic mimicry formation induced by astrocytes. Scientific Reports. 6:23056. doi: 10.1038/srep23056
  • Sleire, Linda; Skeie, Bente Sandvei; Netland, Inger Anne; Førde, Hilde Elise Sundøy; Dodoo, Ernest; Selheim, Frode; Leiss, Lina Wik; Heggdal, Jan Ingemann; Pedersen, Paal-Henning; Wang, Jian; Enger, Per Øyvind. 2015. Drug repurposing: Sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc<sup>-</sup>, leading to glutathione depletion. Oncogene. 34: 5951-5959. doi: 10.1038/onc.2015.60
  • Brekke, Cecilie; Wang, Jian; Thuen, Marte; Gras Navarro, Andrea; Huuse-Røneid, Else Marie; Thorsen, Frits Alan; Poli, Aurélie; Zimmer, Jacques; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLOS ONE. 9. doi: 10.1371/journal.pone.0108414
  • Jarzabek, Monika A.; Amberger-Murphy, Verena; Callanan, John J.; Gao, Cherry; Zagozdzon, Agnieszka M.; Shiels, Liam; Wang, Jian; Ligon, Keith L.; Rich, Benjamin E.; Dicker, Patrick; Gallagher, William M.; Prehn, Jochen H.M.; Byrne, Annette T. 2014. Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. British Journal of Cancer. 111: 2275-2286. doi: 10.1038/bjc.2014.529
  • Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; Jacobsen, Hege; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian. 2014. Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. European Journal of Cancer. 50: 3262-3270. doi: 10.1016/j.ejca.2014.09.010
  • Rygh, Cecilie Brekke; Wang, Jian; Thuen, Marte; Navarro, Andrea Gras; Huuse, Else Marie; Thorsen, Frits; Poli, Aurélie; Zimmer, J.; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. PLOS ONE. 9. 12 pages. Published 2014-09-30. doi: 10.1371
  • Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina Wik; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2014. A novel GFP nude rat model to investigate tumor-stroma interactions. Cancer Cell International. 14:541. doi: 10.1186/s12935-014-0146-0
  • Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina Wik; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2014. A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma. Journal of Translational Medicine. 12:278. doi: 10.1186/s12967-014-0278-y
  • Jacobsen, Hege; Sleire, Linda; Wang, Jian; Netland, Inger Anne; Mutlu, Ercan; Førde, Hilde Elise Sundøy; Pedersen, Paal-Henning; Gullberg, Donald; Enger, Per Øyvind. 2013. Establishment of a novel dsRed NOD/Scid mouse strain to investigate the host and tumor cell compartments. Cancer Investigation. 31: 221-230. doi: 10.3109/07357907.2013.780075
  • Klink, Barbara; Miletic, Hrvoje; Stieber, Daniel; Huszthy, Peter Csaba; Jaime Alberto Campos, Valenzuela; Balss, Jörg; Wang, Jian; Schubert, Manja; Sakariassen, Per Øystein; Sundstrøm, Terje; Torsvik, Anja; Aarhus, Mads; Mahesparan, Rupavathana; von Deimling, Andreas; Kaderali, Lars; Niclou, Simone P; Schröck, Evelin; Bjerkvig, Rolf; Nigro, Janice Marie. 2013. A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. PLOS ONE. 8: e59773. doi: 10.1371/journal.pone.0059773
  • Poli, Aurélie; Wang, Jian; Domingues, Olivia; Planaguma, Jesus; Yan, Tao; Brekke, Cecilie; Skaftnesmo, Kai Ove; Thorsen, Frits Alan; McCormack, Emmet; Hentges, François; Pedersen, Paal-Henning; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha. 2013. Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. OncoTarget. 4: 1527-1546.
  • Skeie, Bente Sandvei; Wang, Jian; Dodoo, Ernest; Heggdal, Jan Ingemann; Grønli, Janne; Sleire, Linda; Bragstad, Sidsel Marit; Ganz, Jeremy Christopher; Chekenya, Martha; Mørk, Sverre; Pedersen, Paal-Henning; Enger, Per Øyvind. 2013. Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model. Biomedical research. 2013. 9 pages. doi: 10.1155/2013/139674
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Rosland, Gunnar Alm; Wang, Jian; Huszthy, Peter; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Nigro, Janice; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mork, Stian; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Neuro-Oncology. 15: 6-6. doi: 10.1007/s00401-013-1101-1
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Røsland, Gro Vatne; Wang, Jian; Huszthy, Peter Csaba; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Brekkå, Narve; Moen, Ingrid; Nigro, Janice Marie; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mørk, Sverre; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathologica. 125: 683-698. doi: 10.1007/s00401-013-1101-1
  • Brekke, Cecilie; Thuen, Marte; Poli, Aurélie; Wang, Jian; Lokka, Guro; Huuse, Else Marie; Thorsen, Frits Alan; Enger, Per Øyvind; Chekenya, Martha. 2012. Early MRI findings of targeting the NG2 proteoglycan in GBM. The FASEB Journal. 26. 1 pages.
  • Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug. 2012. Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation. BMC Cancer. 12. 10 pages. doi: 10.1186/1471-2407-12-21
  • Viel, Thomas; Talasila, Krishna Mukharji; Monfared, Parisa; Wang, Jian; Jikeli, Jan F.; Waerzeggers, Yannic; Neumaier, Bernd; Backes, Heiko; Brekkå, Narve; Thorsen, Frits Alan; Stieber, Daniel; Niclou, Simone P; Winkeler, Alexandra; Tavitian, Bertrand; Hoehn, Mathias; Bjerkvig, Rolf; Miletic, Hrvoje; Jacobs, Andreas Hans. 2012. Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. Journal of Nuclear Medicine. 53: 1135-1145. doi: 10.2967/jnumed.111.101659
  • Willingham, Stephen B.; Volkmer, Jens-Peter; Gentles, Andrew J.; Sahoo, Debashis; Dalerba, Piero; Mitra, Siddharta S.; Wang, Jian; Contreras-Trujillo, Humberto; Martin, Robin; Cohen, Justin D.; Lovelace, Patricia; Scheeren, Ferenc A.; Chao, Mark P.; Weiskopf, Kipp; Tang, Chad; Volkmer, Anne Kathrin; Naik, Tejaswitha J.; Storm, Theresa A.; Mosley, Adriane R.; Edris, Badreddin; Schmid, Sersina M.; Sun, Chris K.; Chua, Mei-Sze; Murillo, Oihana; Rajendran, Pradeep; Cha, Adriel C.; Chin, Robert K.; Kim, Dongkyoon; Adorno, Maddalena; Raveh, Tal; Tseng, Diane; Jaiswal, Siddhartha; Enger, Per Øyvind; Steinberg, Gary K.; Li, Gordon; So, Samuel K.; Majeti, Ravindra; Harsh, Griffith R.; van de Rijn, Matt; Teng, Nelson N.H.; Sunwoo, John B.; Alizadeh, Ash A.; Clarke, Michael F; Weissman, Irving L. 2012. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proceedings of the National Academy of Sciences of the United States of America. 109: 6662-6667. doi: 10.1073/pnas.1121623109
  • Jacobsen, Hege; Dicko, Aly; Wang, Jian; Storli, Kristian Eeg; Leh, Sabine; Thorsen, Frits Alan; Pavlin, Tina; Sondenaa, Karl; Gullberg, Donald; Bjerkvig, Rolf; Enger, Per Øyvind. 2011. Separate analysis of the cancer and stroma cell populations from orthotopically implanted tumor biopsies in eGFP scid mice. Clinical and Experimental Metastasis. 28: 203-203.
  • Keunen, Olivier; Johansson, Mikael; Oudin, Anaîs; Sanzey, Morgane; Rahim, Siti A. Abdul; Fack, Fred; Thorsen, Frits Alan; Taxt, Torfinn; Bartos, Michael; Jirík, Radovan; Miletic, Hrvoje; Wang, Jian; Stieber, Daniel; Stuhr, Linda Elin Birkhaug; Moen, Ingrid; Brekke, Cecilie; Bjerkvig, Rolf; Niclou, Simone P. 2011. Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 108: 3749-3754. doi: 10.1073/pnas.1014480108
  • Wang, Jian; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Miletic, Hrvoje; Hovland, Randi; Mørk, Sverre; Bjerkvig, Rolf; Tiron, Crina Elena; McCormack, Emmet Martin; Micklem, David Robert; Lorens, James; Immervoll, Heike; Thorsen, Frits Alan. 2011. A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathology and Applied Neurobiology. 37: 189-205. doi: 10.1111/j.1365-2990.2010.01119.x
  • Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike; Skaftnesmo, Kai Ove; Planaguma, Jesus; Reed, Rolf K.; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Brekke, Cecilie; Chekenya, Martha. 2011. Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. PLOS ONE. 6. 14 pages. doi: 10.1371/journal.pone.0023062
  • Yan, Tao; Skaftnesmo, Kai Ove; Leiss, Lina Wik; Sleire, Linda; Wang, Jian; Li, XinGang; Enger, Per Øyvind. 2011. Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide. BMC Cancer. 20. doi: 10.1186/1471-2407-11-524
  • Chekenya, Martha; Wang, Jian; Poli, A; Thuen, Marte; Brekke, Cecilie; Thorsen, Frits Alan; Zimmer, J; Enger, Per Øyvind. 2010. THERAPEUTIC TARGETING OF THE NG2 PROTEOGLYCAN WITH MAB 9.2.27 AND ADOPTIVELY TRANSFERRED NK CELLS LYSES HUMAN GLIOBLASTOMA MULTIFORME IN VIVO. Neuro-Oncology. 12: 9-9.
  • Goplen, Dorota; Bougnaud, Sébastien; Rajcevic, Uros; Bøe, Stig Ove; Skaftnesmo, Kai Ove; Voges, Jurgen; Enger, Per Øyvind; Wang, Jian; Tysnes, Berit Bølge; Lærum, Ole Didrik; Niclou, Simone P; Bjerkvig, Rolf. 2010. alpha B-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells. American Journal of Pathology. 177: 1618-1628. doi: 10.2353/ajpath.2010.090063
  • Huszthy, Peter Csaba; Immervoll, Heike; Wang, Jian; Goplen, Dorota; Miletic, Hrvoje; Eide, Geir Egil; Bjerkvig, Rolf. 2010. Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment. Gene Therapy. 17: 202-216. doi: 10.1038/gt.2009.130
  • Keunen, Oliver; Johansson, M; Oudin, A; Sanzey, M; Rahim, SABA; Fack, F; Thorsen, F; Taxt, Torfinn; Wang, Jian; Bjerkvig, Rolf; Niclou, SP. 2010. ANTI-ANGIOGENIC TREATMENT IN A CLINICALLY RELEVANT GLIOBLASTOMA MODEL REDUCES BLOOD FLOW AND INCREASES TUMOR CELL INVASION. Neuro-Oncology. 12: 20-20.
  • Liang, Xiao; Labeed, FH; Abdallat, R; Johannessen, Anne Chr.; Tsinkalovsky, Oleg; Wang, Jian; Costea, Daniela Elena. 2010. Rapid adherence to collagen IV enriches for tumour initiating cells. European Journal of Cancer. 8: 124-124.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Sleire, Linda; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Yan, Tao; Askland, Lasse Haugen; Persson, Andreas; Sakariassen, Per Øystein; Enger, Per Øyvind. 2010. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Research. 70: 4274-4279. doi: 10.1158/0008-5472.CAN-09-3904
  • Sleire, Linda; Wang, Jian; Heggdal, Jan; Pedersen, Paal-Henning; Enger, Per Øyvind. 2010. SULFASALAZINE SENSITIZES GLIOBLASTOMA CELLS TO RADIATION TREATMENT. Neuro-Oncology. 12: 109-109.
  • Johannessen, Tor-Christian Aase; Wang, Jian; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Enger, Per Øyvind; Petersen, Kjell; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjerkvig, Rolf; Tysnes, Berit Bølge. 2009. Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype. Neuropathology and Applied Neurobiology. 35: 380-393. doi: 10.1111/j.1365-2990.2009.01008.x
  • Niclou, SP; Johansson, Mikael; Keunen, O; Wang, Jian; Thorsen, Frits Alan; Bjerkvig, Rolf. 2009. PHENOTYPIC AND PHYSIOLOGIC EFFECTS OF BEVACIZUMAB IN A HIGHLY INFILTRATIVE AND ANGIOGENIC HUMAN GLIOBLASTOMA MODEL. Neuro-Oncology. 11: 906-906.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Askland, L; Persson, A; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Hovland, Randi; Enger, Per Øyvind. 2009. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. Neuro-Oncology. 11: 917-917.
  • Rajcevic, U; Peterson, K; Knol, Jaco C; Loos, Maarten; Bougnaud, Sébastien; Miletic, Hrvoje; Wang, Jian; Bjerkvig, Rolf; Jimenez, Connie R; Niclou, SP. 2009. MOLECULAR VARIATIONS IN TUMOR-HOST INTERACTIONS BETWEEN INVASIVE AND ANGIOGENIC PHENOTYPE IN HIGH-GRADE GLIOMAS. Neuro-Oncology. 11: 961-961.
  • Rajcevic, Uros; Petersen, Kjell; Knol, Jaco C; Loos, Maarten; Bougnaud, Sébastien; Klychnikov, Oleg; Li, Kan Wa; Pham, Thang V; Wang, Jian; Miletic, Hrvoje; Peng, Zhao; Bjerkvig, Rolf; Jimenez, Connie R; Niclou, Simone P. 2009. iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Molecular & Cellular Proteomics. 8: 2595-2612. doi: 10.1074/mcp.M900124-MCP200
  • Thulin, Asa; Ringvall, Maria; Dimberg, Anna; Kårehed, Karin; Väisänen, Timo; Väisänen, Marja-Riitta; Hamad, Osama; Wang, Jian; Bjerkvig, Rolf; Nilsson, Bo; Pihlajaniemi, Taina; Akerud, Helena; Pietras, Kristian; Jahnen-Dechent, Wilhelm; Siegbahn, Agneta; Olsson, Anna Karin. 2009. Activated Platelets Provide a Functional Microenvironment for the Antiangiogenic Fragment of Histidine-Rich Glycoprotein. Molecular Cancer Research. 7: 1792-1802. doi: 10.1158/1541-7786.MCR-09-0094
  • Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekka, N; Li, X; Mork, S; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. PHENOTYPIC MODULATION OF EXPERIMENTAL GLIOMAS: PROGRESSION FROM GLIOMATOSIS CEREBRI-LIKE LESIONS TO GLIOBLASTOMA. Neuro-Oncology. 11: 897-897.
  • Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekkå, Narve; Li, X; Zhao, P; Mørk, Sverre; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer. 9. doi: 10.1186/1471-2407-9-465
  • Wang, Jian; Tsinkalovsky, Oleg; Svendsen, Agnete; Prestegarden, Lars; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. Neuro-Oncology. 11: 221-222.
  • Wang, Jian; Tsinkalovsky, Oleg; Zhao, P; Prestegarden, L; Li, X; Cormark, E; Gjertsen, Bjørn Tore; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. TARGETING THE TUMOR STROMA: A NOVEL THERAPEUTIC STRATEGY BASED ON SEPARATE ANALYSIS OF THE MALIGNANT AND STROMAL CELL COMPARTMENTS IN BRAIN TUMORS. Neuro-Oncology. 11: 965-965.
  • Chekenya, Martha; Krakstad, Camilla; Svendsen, Agnete; Netland, Inger Anne; Staalesen, Vidar; Tysnes, Berit Bølge; Selheim, Frode; Wang, Jian; Sakariassen, Per Øystein; Sandal, Tone; Lønning, Per Eystein; Flatmark, Torgeir; Enger, Per Øyvind; Bjerkvig, Rolf; Sioud, M; Stallcup, William B. 2008. The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 27: 5182-5194. doi: 10.1038/onc.2008.157
  • Huszthy, Peter Csaba; Goplen, Dorota; Thorsen, Frits Alan; Immervoll, Heike; Wang, Jian; Gutermann, Anja; Miletic, Hrvoje; Bjerkvig, Rolf. 2008. Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Clinical Cancer Research. 14: 1571-1580. doi: 10.1158/1078-0432.CCR-07-2000
  • Huszthy, Peter Csaba; Wang, Jian; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2008. Human glioblastoma tissue engraftment in immunocompetent rodent hosts. Neuro-Oncology. 10: 815-815. doi: 10.1215/15228517-2008-051
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Lasse, A; Andreas, P; Oystein, SP; Skaftnesmo, KO; Randi, H; Enger, Per Øyvind. 2008. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. Neuro-Oncology. 10: 778-778.
  • Thorsen, Frits Alan; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Wang, Jian; Miletic, Hrvoje; Bjerkvig, Rolf. 2008. DEVELOPMENT OF A NEW BRAIN METASTASES MODEL IN IMMUNODEFICIENT ANIMALS. Neuro-Oncology. 10: 854-854.
  • Thorsen, Frits Alan; Jirak, Daniel; Wang, Jian; Sykova, Eva; Bjerkvig, Rolf; Enger, Per Øyvind; van der Kogel, Albert; Hajek, Milan. 2008. Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in Biomedicine. 21: 830-838. Published 2008-10-21. doi: 10.1002/nbm.1263
  • Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg; Immervoll, Heike; Bøe, Stig Ove; Svendsen, Agnete; Prestegarden, Lars; Røsland, Gro Vatne; Thorsen, Frits Alan; Stuhr, Linda Elin Birkhaug; Molven, Anders; Bjerkvig, Rolf; Enger, Per Øyvind. 2008. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 122: 761-768. doi: 10.1002/ijc.23130
  • Thorsen, Frits Alan; Enger, Per Øyvind; Wang, Jian; Bjerkvig, Rolf; Pedersen, PH. 2007. Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. Journal of Neuro-Oncology. 82: 1-10. doi: 10.1007/s11060-006-9240-z
  • Goplen, Dorota; Wang, Jian; Enger, Per Øyvind; Tysnes, Berit Bølge; Terzis, A. Jorge A.; Lærum, Ole Didrik; Bjerkvig, Rolf. 2006. Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Research. 66: 9895-9902. doi: 10.1158/0008-5472.CAN-05-4589
  • Piepoli, Tiziana; Jakupoglu, Cemile; Gu, Wenli; Lualdi, Elena; Suarez-Merino, Blanca; Poliani, Pietro L.; Cattaneo, Maria Grazia; Ortino, Barbara; Goplen, Dorota; Wang, Jian; Mola, Rosa; Inverardi, Francesca; Frassoni, Carolina; Bjerkvig, Rolf; Steinlein, Ortrud; Vicentini, Lucia M.; Brüstle, Oliver; Finocchiaro, Gaetano. 2006. Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1. Neuro-Oncology. 8: 96-108. doi: 10.1215/15228517-2005-006
  • Sakariassen, Per Øystein; Prestegarden, Lars; Wang, Jian; Skaftnesmo, Kai Ove; Mahesparan, Rupavathana; Molthoff, Carla; Sminia, Peter; Sundlisæter, Eirik; Misra, Anjan; Tysnes, Berit Bølge; Chekenya, Martha; Peters, Hans; Lende, Gabriel; Kalland, Karl-Henning; Øyan, Anne Margrete; Petersen, Kjell; Jonassen, Inge; van der Kogel, Albert; Feuerstein, Burt G.; Terzis, A. Jorge A.; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 16466-16471. doi: 10.1073/pnas.0607668103
  • Sundlisæter, Eirik; Wang, Jian; Sakariassen, Per Øystein; Marie, Michael Bruno Eric; Mathisen, Juan Robbie; Karlsen, Bård-Ove; Prestegarden, Lars; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Primary glioma spheroids maintain tumourogenicity and essential phenotypic traits after cryopreservation. Neuropathology and Applied Neurobiology. 32: 419-427. doi: 10.1111/j.1365-2990.2006.00744.x
  • Goplen, Dorota; Wang, Jian; Tysnes, Berit Bølge; Terzis, A. Jorge A.; Lærum, Ole Didrik; Bjerkvig, Rolf. 2005. Bacitracin inhibits glioma cell migration and invasion in vitro. Neuro-Oncology. 7: 357-357.
  • Enger, Per Øyvind; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Wang, Jian; Sundlisæter, Eirik; Prestegarden, Lars; Misra, Anjan; Tysnes, Berit Bølge; Chekenya, Martha; Feuerstein, Burt G.; Terzis, A. Jorge A.; Bjerkvig, Rolf. 2004. Angiogenesis-independent growth by brain tumor cells exhibiting cancer stem cell properties. Neuro-Oncology. 6: 309-309.
  • Sakariassen, Per Øystein; Prestegarden, Lars; Wang, Jian; Terzis, A. Jorge A.; Bjerkvig, Rolf; Enger, Per Øyvind. 2004. Forced differentiation suppresses the proliferative rate of cancer cells in brain tumours. Neuro-Oncology. 6.
Reports and theses
  • Wang, Jian. 2008. Xenografted brain tumors for modelling glioma biology – a study of brain tumor initiating cells and phenotypic modulation in gliomas.

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