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  • E-mailJorn.Sagen@uib.no
  • Phone+47 55 97 43 96
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • 2020. Obesity and COVID-19: The two sides of the coin. Obesity Facts. 1-9.
  • 2019. The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
  • 2019. The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
  • 2019. Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Journal of Clinical Endocrinology and Metabolism. 27 pages.
  • 2019. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
  • 2019. Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. Nature Communications. 1-10.
  • 2019. Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.
  • 2018. The short cosyntropin test revisited: new normal reference range using LC-MS/MS. Journal of Clinical Endocrinology and Metabolism. 1696-1703.
  • 2018. Serum levels of leptin and adiponectin are not associated with disease activity or treatment response in multiple sclerosis. Journal of Neuroimmunology. 73-77.
  • 2018. LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. Toxicology in Vitro. 332-341.
  • 2018. IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity.
  • 2018. Adrenal Venous Sampling for Assessment of Autonomous Cortisol Secretion. Journal of Clinical Endocrinology and Metabolism. 4553-4560.
  • 2018. A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology. 57-70.
  • 2017. Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 85-99.
  • 2017. The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes. Diabetes Research and Clinical Practice. 142-149.
  • 2017. Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population. Hormone and Metabolic Research. 838-846.
  • 2016. The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. Molecular and Cellular Endocrinology. 92-101.
  • 2016. Nedsatt følsomhet for thyreoideahormon. Tidsskrift for Den norske legeforening. 618-622.
  • 2016. Clinical reappraisal of SHORT syndrome with PIK3R1 mutations: Toward recommendation for molecular testing and management. Clinical Genetics. 501-506.
  • 2015. Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). Scientific Reports.
  • 2015. Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells. BBA - Molecular Cell Research. 2383-2391.
  • 2015. Body mass index influence interferon-beta treatment response in multiple sclerosis. Journal of Neuroimmunology. 92-97.
  • 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
  • 2014. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 55-65.
  • 2014. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
  • 2013. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 1513-1527.
  • 2013. SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling. American Journal of Human Genetics. 150-157.
  • 2013. Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Molecular Endocrinology. 366-380.
  • 2013. Monogenetic diabetes mellitus in Norway :. Norsk Epidemiologi. 55-60.
  • 2013. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 10 pages.
  • 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.
  • 2012. Ablation of Steroid Receptor Coactivator-3 Resembles the Human CACT Metabolic Myopathy. Cell Metabolism. 752-763.
  • 2010. cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1013-1019.
  • 2010. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 12 pages.
  • 2010. Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. Proceedings of the National Academy of Sciences of the United States of America. 11122-11127.
  • 2008. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 4336-4345.
  • 2008. Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Pediatric Diabetes. 442-449.
  • 2007. Management of neonatal and infancy-onset diabetes mellitus. Endocrine Development. 94-105.
  • 2006. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics. 54-62.
  • 2006. From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes. 1713-1722.
  • 2006. A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. Diabetes. 1899-1903.
  • 2005. Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1 alpha mutation carriers. Diabetic Medicine. 406-409.
  • 2005. Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 2968-2972.
  • 2005. Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. Diabetic Medicine. 1012-1015.
  • 2004. Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2 - Patient characteristics and initial response to sulfonylurea therapy. Diabetes. 2713-2718.
  • 2004. A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA (Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation. 86-92.
  • 2003. Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway. Diabetes. 2854-2860.
  • 2003. Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway. Journal of Clinical Endocrinology and Metabolism. 920-931.
  • 2003. Hepatocyte nuclear factor- 1 alpha gene mutations and diabetes in Norway. Journal of Clinical Endocrinology and Metabolism. 920-931.
  • 2003. Enlarged nephrons and severe non-diabetic nephropathy in hepatocyte nuclear factor (HNF)-1 beta mutation carriers. Kidney International. 793-800.
  • 2003. Enlarged nephrons and severe non-diabetic nephropathy in hepatocyte nuclear factor (HNF)-1 beta mutation carriers. Kidney International. 793-800.
  • 2002. Reduced prevalence of late-diabetic complications in MODY3 with early diagnosis. Diabetic Medicine. 697-703.
  • 1998. Ikke-insulinkrevende diabetes mellitus hos barn og unge voksne. Tidsskrift for Den norske legeforening. 1054-1057.
Lecture
  • 2019. Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity .
Academic lecture
  • 2019. Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
  • 2018. Amino acid metabolism in adipocytes.
  • 2012. Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism.
  • 2012. Integrative genomics links homeobox transcription factors to intra-abdominal obesity.
  • 2007. Overvekt og Diabetes.
  • 2007. Nyheter innen MODY-forskningen.
  • 2007. Management of Neonatal and Infancy-onset Diabetes.
  • 2004. Bevart sulfonylurea-indusert insulinsekresjon ved MODY3.
  • 2004. Baseline and glucose entrained insulin oscillations in MODY3.
  • 1998. Mody 3 i en norsk familie.
  • 1998. MODY3 in a Norwegian family with severe diabetic eye complications.
Masters thesis
  • 2006. Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha.
Popular scientific article
  • 2003. Klinisk molekylærmedisin (4): Koblingsanalyser. Pediatrisk Endokrinologi. 34-38.
Feature article
  • 1998. Hyperexacitability to sulphonylurea in MODY3. Diabetologia. 607-608.
Doctoral dissertation
  • 2015. Function and regulation of Steroid Receptor Coactivator 2. Transcriptional regulation of cellular metabolism.
  • 2005. Clinical and molecular aspects of monogenic diabetes mellitus.
Academic chapter/article/Conference paper
  • 2011. Sykdomslære. 55 pages.
  • 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 pages.
  • 2011. Fysisk aktivitet. 11 pages.
  • 2008. MODY5 due to mutations in TCF2 (HNF-1ß): The clinical spectrum with special reference to urogenital malformations. 7 pages.
Abstract
  • 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 1 pages.
  • 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. S429-S429.
Poster
  • 2019. Adipocyte amino acid metabolism in obesity-related metabolic diseases .
  • 2018. Irx5 regulates body weight via amyloid precursor protein (App) and mitochondrial respiration in adipocytes.
  • 2018. Irx5 regulates body weight via amyloid precursor protein and mitochondrial respiration in adipocytes.
  • 2018. Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
  • 2016. Repression of liver SRC-2 by metformin inhibits glucose, lipid and cholesterol biosynthesis.
  • 2016. PKA downregulates glucose-6phosphatase Expression through RORα and SRC2.
  • 2014. Steroid receptor coactivators during short-term estrogen deprivation.
  • 2014. Role of homeobox transcription factors IRX3 and IRX5 in mitochondrial development and activity in adipose tissue.
  • 2014. A moderate energy-restricted very-high-fat diet reduces fat mass and improves metabolic health in abdominally obese middle-aged men.
  • 2013. Role of homeobox transcription factor IRX5 in obesity and metabolic health.
  • 2013. Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice.
  • 2012. Candidate genes for fat regain after weight cycling in mice.
  • 2012. CDKN1A associates with fat regain after weight cycling in mice.
  • 2011. The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss.
  • 2011. Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue.
  • 2010. Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity.
  • 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss.
  • 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery.
  • 2008. cAMP/PKA Exerts Differential Effects on GRIP1- and PGC-1α-Mediated HNF-4α Transcriptional Activity in HepG2 and COS-1 Cells.
  • 2008. cAMP Regulates Nuclear Receptor Coactivator GRIP1–Mediated Coactivation of HNF-4alpha in HepG2 Cells.
  • 2007. Regulation of HNF-4alpha transcriptional activity by the coactivators GRIP1 and PGC-1alpha.
Academic literature review
  • 2011. Nuclear hormone receptors – a family of hormone dependent transcriptional regulators. 30-35.

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