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University of Bergen
Jørn Vegard Sagen's picture

Jørn Vegard Sagen

Professor
Department of Clinical Science
Hormone Laboratory Research Group
  • E-mailJorn.Sagen@uib.no
  • Phone+47 55 97 43 96
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2022). Study protocol: Prevalence of low energy availability and its relation to health and performance among female football players. BMJ Open sport & exercise medicine. 1-5.
  • Show author(s) (2022). Reference Curves for Pediatric Endocrinology: Leveraging Biomarker Z-Scores for Clinical Classifications. Journal of Clinical Endocrinology and Metabolism (JCEM). 2004-2015.
  • Show author(s) (2022). MRI adipose tissue segmentation and quantification in R (RAdipoSeg). Diabetology and Metabolic Syndrome. 1-8.
  • Show author(s) (2021). The Female Menstrual Cycles Effect on Strength and Power Parameters in High-Level Female Team Athletes. Frontiers in Physiology.
  • Show author(s) (2021). Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients. Journal of Clinical Endocrinology and Metabolism (JCEM). 1368-1374.
  • Show author(s) (2021). Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes. 680-695.
  • Show author(s) (2021). Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study. PLOS ONE. 1-14.
  • Show author(s) (2021). Impact of overweight on glucose homeostasis in MODY2 and MODY3. Diabetic Medicine. 3 pages.
  • Show author(s) (2021). Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children. Journal of the Endocrine Society (JES). 1-8.
  • Show author(s) (2020). Testicular Ultrasound to Stratify Hormone References in a Cross-Sectional Norwegian Study of Male Puberty . Journal of Clinical Endocrinology and Metabolism (JCEM). 1888-1898.
  • Show author(s) (2020). Obesity and COVID-19: The two sides of the coin. Obesity Facts. 1-9.
  • Show author(s) (2020). Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty. Journal of Clinical Endocrinology and Metabolism (JCEM). e4886-e4895.
  • Show author(s) (2020). European Association for the Study of Obesity Position Statement on the Global COVID-19 Pandemic. Obesity Facts. 292-296.
  • Show author(s) (2020). COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. Scientific Reports. 1-11.
  • Show author(s) (2020). An ultrasensitive routine LC-MS/MS method for estradiol and estrone in the clinically relevant sub-picomolar range. Journal of the Endocrine Society (JES). 1-15.
  • Show author(s) (2019). The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
  • Show author(s) (2019). The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
  • Show author(s) (2019). Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Journal of Clinical Endocrinology and Metabolism (JCEM). 27 pages.
  • Show author(s) (2019). Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
  • Show author(s) (2019). Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. Nature Communications. 1-10.
  • Show author(s) (2019). Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.
  • Show author(s) (2018). The short cosyntropin test revisited: new normal reference range using LC-MS/MS. Journal of Clinical Endocrinology and Metabolism (JCEM). 1696-1703.
  • Show author(s) (2018). Serum levels of leptin and adiponectin are not associated with disease activity or treatment response in multiple sclerosis. Journal of Neuroimmunology. 73-77.
  • Show author(s) (2018). LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. Toxicology in Vitro. 332-341.
  • Show author(s) (2018). IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity.
  • Show author(s) (2018). Adrenal Venous Sampling for Assessment of Autonomous Cortisol Secretion. Journal of Clinical Endocrinology and Metabolism (JCEM). 4553-4560.
  • Show author(s) (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology. 57-70.
  • Show author(s) (2017). Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 85-99.
  • Show author(s) (2017). The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes. Diabetes Research and Clinical Practice. 142-149.
  • Show author(s) (2017). Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population. Hormone and Metabolic Research. 838-846.
  • Show author(s) (2016). The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. Molecular and Cellular Endocrinology. 92-101.
  • Show author(s) (2016). Nedsatt følsomhet for thyreoideahormon. Tidsskrift for Den norske legeforening. 618-622.
  • Show author(s) (2016). Clinical reappraisal of SHORT syndrome with PIK3R1 mutations: Toward recommendation for molecular testing and management. Clinical Genetics. 501-506.
  • Show author(s) (2015). Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). Scientific Reports.
  • Show author(s) (2015). Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells. BBA - Molecular Cell Research. 2383-2391.
  • Show author(s) (2015). Body mass index influence interferon-beta treatment response in multiple sclerosis. Journal of Neuroimmunology. 92-97.
  • Show author(s) (2014). Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
  • Show author(s) (2014). GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 55-65.
  • Show author(s) (2014). COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
  • Show author(s) (2013). cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 1513-1527.
  • Show author(s) (2013). SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling. American Journal of Human Genetics. 150-157.
  • Show author(s) (2013). Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Molecular Endocrinology. 366-380.
  • Show author(s) (2013). Monogenetic diabetes mellitus in Norway :. Norsk Epidemiologi. 55-60.
  • Show author(s) (2013). Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 10 pages.
  • Show author(s) (2012). The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.
  • Show author(s) (2012). Ablation of Steroid Receptor Coactivator-3 Resembles the Human CACT Metabolic Myopathy. Cell Metabolism. 752-763.
  • Show author(s) (2010). cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1013-1019.
  • Show author(s) (2010). Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 12 pages.
  • Show author(s) (2010). Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. Proceedings of the National Academy of Sciences of the United States of America. 11122-11127.
  • Show author(s) (2008). Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 4336-4345.
  • Show author(s) (2008). Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Pediatric Diabetes. 442-449.
  • Show author(s) (2007). Management of neonatal and infancy-onset diabetes mellitus. Endocrine Development. 94-105.
  • Show author(s) (2006). Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics. 54-62.
  • Show author(s) (2006). From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes. 1713-1722.
  • Show author(s) (2006). A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. Diabetes. 1899-1903.
  • Show author(s) (2005). Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1 alpha mutation carriers. Diabetic Medicine. 406-409.
  • Show author(s) (2005). Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 2968-2972.
  • Show author(s) (2005). Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. Diabetic Medicine. 1012-1015.
  • Show author(s) (2004). Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2 - Patient characteristics and initial response to sulfonylurea therapy. Diabetes. 2713-2718.
  • Show author(s) (2004). A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA (Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation. 86-92.
  • Show author(s) (2003). Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway. Diabetes. 2854-2860.
  • Show author(s) (2003). Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway. Journal of Clinical Endocrinology and Metabolism (JCEM). 920-931.
  • Show author(s) (2003). Hepatocyte nuclear factor- 1 alpha gene mutations and diabetes in Norway. Journal of Clinical Endocrinology and Metabolism (JCEM). 920-931.
  • Show author(s) (2003). Enlarged nephrons and severe non-diabetic nephropathy in hepatocyte nuclear factor (HNF)-1 beta mutation carriers. Kidney International. 793-800.
  • Show author(s) (2003). Enlarged nephrons and severe non-diabetic nephropathy in hepatocyte nuclear factor (HNF)-1 beta mutation carriers. Kidney International. 793-800.
  • Show author(s) (2002). Reduced prevalence of late-diabetic complications in MODY3 with early diagnosis. Diabetic Medicine. 697-703.
  • Show author(s) (1998). Ikke-insulinkrevende diabetes mellitus hos barn og unge voksne. Tidsskrift for Den norske legeforening. 1054-1057.
Lecture
  • Show author(s) (2019). Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity .
Academic lecture
  • Show author(s) (2021). Epigenetic control of adipogenesis by Irx3.
  • Show author(s) (2019). Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
  • Show author(s) (2018). Amino acid metabolism in adipocytes.
  • Show author(s) (2012). Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism.
  • Show author(s) (2012). Integrative genomics links homeobox transcription factors to intra-abdominal obesity.
  • Show author(s) (2007). Overvekt og Diabetes.
  • Show author(s) (2007). Nyheter innen MODY-forskningen.
  • Show author(s) (2007). Management of Neonatal and Infancy-onset Diabetes.
  • Show author(s) (2004). Bevart sulfonylurea-indusert insulinsekresjon ved MODY3.
  • Show author(s) (2004). Baseline and glucose entrained insulin oscillations in MODY3.
  • Show author(s) (1998). Mody 3 i en norsk familie.
  • Show author(s) (1998). MODY3 in a Norwegian family with severe diabetic eye complications.
Short communication
  • Show author(s) (2022). Vektreduserende medisiner – for hvem, hvordan, hvor lenge? Tidsskrift for Den norske legeforening.
Masters thesis
  • Show author(s) (2006). Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha.
Popular scientific article
  • Show author(s) (2003). Klinisk molekylærmedisin (4): Koblingsanalyser. Pediatrisk Endokrinologi. 34-38.
Feature article
  • Show author(s) (1998). Hyperexacitability to sulphonylurea in MODY3. Diabetologia. 607-608.
Doctoral dissertation
  • Show author(s) (2015). Function and regulation of Steroid Receptor Coactivator 2. Transcriptional regulation of cellular metabolism.
  • Show author(s) (2005). Clinical and molecular aspects of monogenic diabetes mellitus.
Academic chapter/article/Conference paper
  • Show author(s) (2011). Sykdomslære. 55 pages.
  • Show author(s) (2011). Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 pages.
  • Show author(s) (2011). Fysisk aktivitet. 11 pages.
  • Show author(s) (2008). MODY5 due to mutations in TCF2 (HNF-1ß): The clinical spectrum with special reference to urogenital malformations. 7 pages.
Abstract
  • Show author(s) (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 1 pages.
  • Show author(s) (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. S429-S429.
Poster
  • Show author(s) (2019). Adipocyte amino acid metabolism in obesity-related metabolic diseases .
  • Show author(s) (2018). Irx5 regulates body weight via amyloid precursor protein (App) and mitochondrial respiration in adipocytes.
  • Show author(s) (2018). Irx5 regulates body weight via amyloid precursor protein and mitochondrial respiration in adipocytes.
  • Show author(s) (2018). Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
  • Show author(s) (2016). Repression of liver SRC-2 by metformin inhibits glucose, lipid and cholesterol biosynthesis.
  • Show author(s) (2016). PKA downregulates glucose-6phosphatase Expression through RORα and SRC2.
  • Show author(s) (2014). Steroid receptor coactivators during short-term estrogen deprivation.
  • Show author(s) (2014). Role of homeobox transcription factors IRX3 and IRX5 in mitochondrial development and activity in adipose tissue.
  • Show author(s) (2014). A moderate energy-restricted very-high-fat diet reduces fat mass and improves metabolic health in abdominally obese middle-aged men.
  • Show author(s) (2013). Role of homeobox transcription factor IRX5 in obesity and metabolic health.
  • Show author(s) (2013). Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice.
  • Show author(s) (2012). Candidate genes for fat regain after weight cycling in mice.
  • Show author(s) (2012). CDKN1A associates with fat regain after weight cycling in mice.
  • Show author(s) (2011). The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss.
  • Show author(s) (2011). Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue.
  • Show author(s) (2010). Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity.
  • Show author(s) (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss.
  • Show author(s) (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery.
  • Show author(s) (2008). cAMP/PKA Exerts Differential Effects on GRIP1- and PGC-1α-Mediated HNF-4α Transcriptional Activity in HepG2 and COS-1 Cells.
  • Show author(s) (2008). cAMP Regulates Nuclear Receptor Coactivator GRIP1–Mediated Coactivation of HNF-4alpha in HepG2 Cells.
  • Show author(s) (2007). Regulation of HNF-4alpha transcriptional activity by the coactivators GRIP1 and PGC-1alpha.
Academic literature review
  • Show author(s) (2011). Nuclear hormone receptors – a family of hormone dependent transcriptional regulators. Klinisk Biokemi i Norden. 30-35.
Article in business/trade/industry journal
  • Show author(s) (2022). Liquid biopsies and patient-reported outcome measures for integrative monitoring of patients with early-stage breast cancer: a study protocol for the longitudinal observational Prospective Breast Cancer Biobanking (PBCB) study. BMJ Open.

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