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University of Bergen
Kari Espolin Fladmark's picture

Kari Espolin Fladmark

Professor
Department of Biological Sciences (BIO)
  • E-mailKari.Fladmark@uib.no
  • Phone+47 55 58 45 14
  • Visitor Address
    Thormøhlensgt. 53 A/B
  • Postal Address
    Postboks 7803
    5020 Bergen
Journal articles
  • Edson, Amanda Jayne; Hushagen, Helena A.; Frøyset, Ann Kristin; Elda, Inga; Khan, Essa Ahsan; Di Stefano, Antonio; Fladmark, Kari Espolin. 2019. Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson’s Disease-Related Protein DJ-1. Molecular Neurobiology. 1-17. doi: 10.1007/s12035-019-01667-w
  • Frøyset, Ann Kristin; Edson, Amanda Jayne; Gharbi, Naouel; Khan, Essa A.; Dondorp, Daniel; Bai, Qing; Tiraboschi, Ettore; Suster, Maximiliano; Connolly, Joanne B.; Burton, Edward A.; Fladmark, Kari Espolin. 2018. Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo. Redox Biology. 16: 237-247. doi: 10.1016/j.redox.2018.02.010
  • Lombardo, Giusy; Dentelli, Patrizia; Togliatto, Gabriele; Rosso, Arturo; Fladmark, Kari Espolin; Camussi, Giovanni; Brizzi, Maria Felice. 2018. The protein cargo of endothelial cell-derived extracellular vesicles released in response to IL-3 identifies the Wnt signaling pathway as a relevant mediator of inflammation. Journal of Extracellular Vesicles. doi: 10.1080/20013078.2018.1461450
  • Egea, Javier; Fabregat, Isabel; Frapart, Yves M.; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G.; Lopez, Manuela G.; Olaso-Gonzalez, Gloria; Petry, Andreas; Schulz, Rainer; Vina, Jose; Winyard, Paul; Abbas, Kahina; Ademowo, Opeyemi S.; Afonso, Catarina B.; Andreadou, Ioanna; Antelmann, Haike; Antunes, Fernando; Aslan, Mutay; Barbosa, Rui M.; Belousov, Vsevolod; Berndt, Carsten; Bernlohr, David; Bertran, Esther; Bindoli, Alberto; Bottari, Serge P.; Brito, Paula M.; Carrara, Guia; Casas, Ana I.; Chatzi, Afroditi; Chondrogianni, Niki; Conrad, Marcus; Cooke, Marcus S.; Costa, João G.; Cuadrado, Antonio; My-Chan Dang, Pham; De Smet, Barbara; Debelec-Butuner, Bilge; Dias, Irundika H.K.; Dunn, Joe Dan; Edson, Amanda Jayne; El Assar, Mariam; El-Benna, Jamel; Ferdinandy, Péter; Fernandes, Ana S.; Fladmark, Kari Espolin; Förstermann, Ulrich; Giniatullin, Rashid; Giricz, Zoltán; Görbe, Anikó; Griffiths, Helen; Hampl, Vaclav; Hanf, Alina; Herget, Jan; Hernansanz-Agustin, Pablo; Hillion, Melanie; Huang, Jingjing; Ilikay, Serap; Jansen-Dürr, Pidder; Jaquet, Vincent; Joles, Jaap A.; Kalyanaraman, Balaraman; Kaminskyy, Danylo; Karbaschi, Mahsa; Kleanthous, Marina; Klotz, Lars-Oliver; Korac, Bato; Korkmaz, Kemal Sami; Koziel, Rafal; Kračun, Damir; Krause, Karl-Heinz; Křen, Vladimir; Krieg, Thomas; Laranjinha, João; Lazou, Antigone; Li, Huige; Martinez-Ruiz, Antonio; McBean, Gethin J.; Meredith, Stuart P.; Messens, Joris; Miguel, Verónica; Mikhed, Yuliya; Milisav, Irina; Milković, Lidija; Miranda-Vizuete, Antonio; Mojović, Miloš; Monsalve, María; Mouthuy, Pierre-Alexis; Mulvey, John; Münzel, Thomas; Muzykantov, Vladimir; Nguyen, Isabel T.N.; Oelze, Matthias; Oliveira, Nuno G.; Palmeira, Carlos M.; Papaevgeniou, Nikoletta; Pavićević, Aleksandra; Pedre, Brandán; Peyrot, Fabienne; Phylactides, Marios; Pircalabioru, Gratiela G.; Pitt, Andrew R.; Poulsen, Henrik E.; Prieto, Ignacio; Rigobello, Maria Pia; Robledinos-Antón, Natalia; Rodríguez-Mañas, Leocadio; Rolo, Anabela P.; Rousset, Francis; Ruskovska, Tatjana; Saraiva, Nuno; Sasson, Shlomo; Schröder, Katrin; Semen, Khrystyna; Seredenina, Tamara; Shakirzyanova, Anastasia; Smith, Geoffrey L.; Soldati, Thierry; Sousa, Bebiana C.; Spickett, Corinne M.; Stancic, Ana; Stasia, Marie José; Steinbrenner, Holger; Stepanić, Višnja; Steven, Sebastian; Tokatlidis, Kostas; Tuncay, Erkan; Turan, Belma; Ursini, Fulvio; Vacek, Jan; Vajnerova, Olga; Valentová, Kateřina; Van Breusegem, Frank; Varisli, Lokman; Veal, Elizabeth A.; Yalçın, A. Suha; Yelisyeyeva, Olha; Žarković, Neven; Zatloukalova, Martina; Zielonka, Jacek; Touyz, Rhian M.; Papapetropoulos, Andreas; Grune, Tilman; Lamas, Santiago; Schmidt, Harald H.H.W.; Di Lisa, Fabio; Daiber, Andreas. 2017. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology. 13: 94-162. doi: 10.1016/j.redox.2017.05.007
  • Frøyset, Ann Kristin; Khan, Essa Ahsan; Fladmark, Kari Espolin. 2016. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Scientific Reports. 6:29631. doi: 10.1038/srep29631
  • Hjørnevik, Linda Veka; Frøyset, Ann Kristin; Grønset, Toril Anne; Rungruangsak-Torrissen, Krisna; Fladmark, Kari Espolin. 2015. Algal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometry. Marine Drugs. 13: 7390-7402. doi: 10.3390/md13127072
  • Pajares, Marta; Jiménez-Moreno, Natalia; Dias, Irundika H.K.; Debelec, Bilge; Vucetic, Milica; Fladmark, Kari Espolin; Basaga, Huveyda; Ribaric, Samo; Milisav, Irina; Cuadrado, Antonio. 2015. Redox control of protein degradation. Redox Biology. 6: 409-420. doi: 10.1016/j.redox.2015.07.003
  • Ree, Rasmus Moen; Myklebust, Line Merethe; Thiel, Puja; Foyn, Håvard; Fladmark, Kari Espolin; Arnesen, Thomas. 2015. The N-terminal acetyltransferase Naa10 is essential for zebrafish development. Bioscience Reports. 35:00249. 10 pages. doi: 10.1042/BSR20150168
  • Kamil, Atif; Raae, Arnt Johan; Fjelldal, Per Gunnar; Koppang, Erling Olaf; Fladmark, Kari Espolin; Hordvik, Ivar. 2013. Comparative analysis of IgM sub-variants in salmonid fish and identification of a residue in mu 3 which is essential for MAb4C10 reactivity. Fish and Shellfish Immunology. 34: 667-672. doi: 10.1016/j.fsi.2012.12.006
  • Opsahl, Jill Anette; Ljostveit, Sonja; Saunders, Threrese Solstad; Risa, Kristin; Roepstorff, Peter; Fladmark, Kari Espolin. 2013. Identification of dynamic changes in proteins associated with the cellular cytoskeleton after exposure to okadaic acid. Marine Drugs. 11: 1763-1782. doi: 10.3390/md11061763
  • Hjørnevik, Linda Veka; Fismen, Lise; Young, Fiona M; Solstad, Terese; Fladmark, Kari Espolin. 2012. Nodularin exposure induces SOD1 phosphorylation and disrupts SOD1 co-localization with actin filaments. Toxins. 4: 1482-1499. doi: 10.3390/toxins4121482
  • Oveland, Eystein; Wergeland, Line; Hovland, Randi; Lorens, James; Gjertsen, Bjørn Tore; Fladmark, Kari Espolin. 2012. Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. Cell Biology and Toxicology. 28: 201-212. doi: 10.1007/s10565-012-9216-z
  • de Vareilles, Mahut; Conceição, Luis E.C.; Gomez Requeni, Pedro; Kousoulaki, Katerina; Richard, Nadège; Rodrigues, Pedro M.; Fladmark, Kari Espolin; Rønnestad, Ivar. 2012. Dietary lysine imbalance affects muscle proteome in zebrafish (Danio rerio): a comparative 2D-DIGE study. Marine Biotechnology. 14: 643-654. doi: 10.1007/s10126-012-9462-3
  • de Vareilles, Mahut; Richard, Nadège; Gavaia, Paulo J.; Silva, Tomé S.; Cordeiro, Odete; Guerreiro, Inês; Yúfera, Manuel; Batista, Irineu; Pires, Carla; Pousao-Ferreira, Pedro; Rodrigues, Pedro M.; Rønnestad, Ivar; Fladmark, Kari Espolin; Conceição, Luís E.C. 2012. Impact of dietary protein hydrolysates on skeleton quality and proteome in Diplodus sargus larvae. Journal of Applied Ichthyology. 28: 477-487. doi: 10.1111/j.1439-0426.2012.01986.x
  • Opsahl, Jill Anette; Hjørnevik, Linda Veka; Bull, Vibeke Hervik; Fismen, Lise; Frøyset, Ann Kristin; Gromyko, Darina; Solstad, Therese; Fladmark, Kari Espolin. 2010. Increased interaction between DJ-1 and the Mi-2/nucleosome remodelling and deacetylase complex during cellular stress. Proteomics. 10: 1494-1504. doi: 10.1002/pmic.200900586
  • Herfindal, Lars; Kasprzykowski, Franciszek; Schwede, Frank; Lankiewicz, Leszek; Fladmark, Kari Espolin; Lukomska, Joanna; Wahlsten, Matti; Sivonen, Kaarina; Grzonka, Zbigniew; Jastorff, Bernd; Doskeland, Stein Ove. 2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 52: 5758-5762. doi: 10.1021/jm900502e
  • Kellmann, Ralf; Schaffner, Carlos António Markus; Grønset, Toril Anne; Satake, Masayuki; Ziegler, Mathias; Fladmark, Kari Espolin. 2009. Proteomic response of human neuroblastoma cells to azaspiracid-1. Journal of Proteomics. 72: 695-707. doi: 10.1016/j.jprot.2009.02.008
  • Oveland, Eystein; Gjertsen, Bjørn Tore; Wergeland, Line; Selheim, Frode; Fladmark, Kari Espolin; Hovland, Randi. 2009. Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Leukemia Research. 33: 276-287. doi: 10.1016/j.leukres.2008.06.029
  • Solstad, Therese; Bull, Vibeke Hervik; Breivik, Lars Ertesvåg; Fladmark, Kari Espolin. 2008. Identification of protein interaction partners by immunoprecipitation: Possible pitfalls and false positives. Experimental and Clinical Hepatology. 4: 16-22.
  • Solstad, Therese; Fismen, Lise; Garberg, Hilde Kristin; Fladmark, Kari Espolin. 2008. Identification of a novel phosphorylation site of acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes. Experimental Cell Research. 314: 2141-2149. doi: 10.1016/j.yexcr.2008.03.014
  • Målen, Hiwa; Berven, Frode; Fladmark, Kari Espolin; Wiker, Harald G. 2007. Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics. 7: 1702-1718. doi: 10.1002/pmic.200600853
  • Brøgger, Jan Christian; Fladmark, Kari Espolin. 2006. Proteomic tissue imaging for rapid brain biomarker discovery. European Journal of Neurology. 13: 42-42.
  • Krakstad, Camilla; Herfindal, Lars; Gjertsen, Bjørn Tore; Bøe, Roald; Vintermyr, Olav Karsten; Fladmark, Kari Espolin; Doskeland, Stein Ove. 2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 13: 1191-1202. doi: 10.1038/sj.cdd.4401798
  • Oveland, Eystein; Fladmark, Kari Espolin; Wergeland, Line; Gjertsen, Bjørn Tore; Hovland, Randi. 2006. Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies. Current Pharmaceutical Biotechnology. 7: 185-198. doi: 10.2174/138920106777549696
  • Solstad, Therese; Fladmark, Kari Espolin. 2006. Algal toxins as guidance to identify phosphoproteins with key roles in apoptotic cell death. Current Pharmaceutical Biotechnology. 7: 209-215. doi: 10.2174/138920106777549704
  • Gausdal, Gro; Gjertsen, Bjørn Tore; Fladmark, Kari Espolin; Demol, H.; Vandekerckhove, Joel; Døskeland, Stein Ove. 2004. Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia. 18: 1989-1996.
  • Fladmark, Kari Espolin. 2003. PROBE-nasjonal plattform i proteomikk. NBS-nytt. 2: 23-24.
  • Grav, Hans J; Tronstad, Karl J.; Gudbrandsen, Oddrun A.; Berge, Kjetil; Fladmark, Kari E.; Martinsen, Tom C.; Waldum, Helge; Wergedahl, Hege; Berge, Rolf K. 2003. Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling protein 2 (UCP-2) expression. Journal of Biological Chemistry. 278: 30525-30533.
  • Grav, Hans J; Tronstad, Karl Johan; Gudbrandsen, Oddrun; Berge, Kjetil; Fladmark, Kari Espolin; Martinsen, Tom C; Waldum, Helge; Wergedahl, Hege; Berge, Rolf Kristian. 2003. Changed Energy State and Increased Mitochondrial B-Oxidation Rate in Liver of Rats Associated with Lowered Proton Electrochemical Potential and Stimulated Uncoupling Protein 2 (UCP-2) Expression. Journal of Biological Chemistry. 278: 30525-30533.
  • Fladmark, Kari Espolin; Brustugun, Odd Terje; Mellgren, Gunnar; Krakstad, Camilla; Bøe, Roald; Vintermyr, Olav Karsten; Schulman, Howard; Døskeland, Stein Ove. 2002. Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. Journal of Biological Chemistry. 277: 2804-2811.
  • Fladmark, Kari Espolin; Birkeland, Magne. 2001. Biologisk baserte blåskjelltester (BBB). Fiskehelse. 2. 26-33.
  • Mankiewicz, J; Tarczynska, M; Fladmark, Kari Espolin; Døskeland, Stein Ove; Walter, Z; Zalewski, M. 2001. Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environmental Toxicology. 16: 225-233.
  • Mankiewitcz, J; Walter, Z; Tarczynska, M; Zalewski, M; Fladmark, Kari Espolin; Døskeland, Stein Ove. 2001. Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. International Journal of Occupational Medicine and Environmental Health. 13: 335-344.
  • Serres, Margrethe Hauge; Fladmark, Kari Espolin; Døskeland, Stein Ove. 2000. An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon. 38: 347-360.
  • Fladmark, Kari Espolin; Brustugun, Odd Terje; Hovland, Randi; Bøe, Ragnar; Gjertsen, Bjørn Tore; Zhivotovsky, B; Døskeland, Stein Ove. 1999. Ultrarapid apoptosis inducted by phosphatase inhibitors. Cell Death Differ. Cell Death and Differentiation. 6: 1099-1108.
  • Jensen, PH; Fladmark, Kari Espolin; Gjertsen, Bjørn Tore; Vintermyr, Olav Karsten. 1999. Caspase I related protease inhibition retards the execution of okadaic acid and camptothecin induced apoptosis and PAI-2 selective cleavage, but not commitment to cell death in HL-60 cells. British Journal of Cancer. 79: 1685-1691.
  • Serres, Margrethe Hauge; Fladmark, Kari Espolin; Døskeland, Stein Ove. 1999. An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon. 38: 347-360.
  • Brustugun, Odd Terje; Fladmark, Kari Espolin; Døskeland, Stein Ove; Orrenius, S.; Zhivotovsky, B. 1998. Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation. 5: 660-668.
  • Fladmark, Kari Espolin; Serres, Margrethe Hauge; Larsen, Nina Lied; Yasumoto, T.; Aune, T.; Døskeland, Stein Ove. 1998. Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon. 36: 1101-1114.
  • Fladmark, Kari Espolin; Gjertsen, Bjørn Tore; Døskeland, Stein Ove; Vintermyr, Olav Karsten. 1997. Fas/APO-1 (CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP. Biochemical and Biophysical Research Communications - BBRC. 232: 20-25.
  • Fladmark, Kari Espolin; Gjertsen, Bjørn Tore; Molven, Anders; Mellgren, Gunnar; Vintermyr, Olav Karsten; Døskeland, Stein Ove. 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 25: 847-855.
  • Zom, M; Fladmark, Kari Espolin; Øgreid, D.; Jastorff, B; Døskeland, SO; Dostman, WRG. 1995. Ala%3%3%5 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I. FEBS Letters. 362: 291-294.
  • Zorn, M; Fladmark, Kari Espolin; Øgreid, D.; Jastorff, B; Døskeland, SO; Dostmann, WRG. 1995. ALA-335 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I. FEBS Letters. 362: 291-294.
Reports and theses
  • Rungruangsak-Torrissen, Krisna; Fismen, Lise; Garberg, Hilde Kristin; Satake, Masayuki; Fladmark, Kari Espolin. 2006. Shellfish toxin azaspiracid-1 induced changes in cytoskeletal proteins in neuronal cells. Institute of Marine Research, Matre Research Station,, Institute of Marine Research and University of Bergen. 28 pages.
  • Rungruangsak-Torrissen, Krisna; Garberg, Hilde Kristin; Thorsen, Anders; Kjesbu, Olav Sigurd; Fladmark, Kari Espolin. 2006. Oocyte development in Atlantic cod (Gadus morhua L.): Trypsin-like specific activity, capacity for protein synthesis and proteomics. Institute of Marine Research, Matre Research Station,, Institute of Marine Research and University of Bergen. 29 pages.
  • Fladmark, Kari Espolin. 1998. Hepatocyte proliferation and apoptosis-regulation by cell communication and phosphorylation. Dr.scient.. -.
Book sections
  • Fladmark, Kari Espolin. 2014. Proteomic tools to elucidate the molecular action of micro-algal toxins. Chapter 7, pages 196-216. In:
    • Rossini, Gian Paolo. 2014. Toxins and Biologically Active Compounds from Microalgae, Volume 2. CRC Press. 700 pages. ISBN: 9781482231465.

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