- E-mailKari.Fladmark@uib.no
- Phone+47 55 58 45 14
- Visitor AddressThormøhlensgt. 53 A/B
- Postal AddressPostboks 78035020 Bergen
Academic article
- 2019. Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson’s Disease-Related Protein DJ-1. Molecular Neurobiology. 1-17.
- 2018. Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo. Redox Biology. 237-247.
- 2016. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Scientific Reports.
- 2015. The N-terminal acetyltransferase Naa10 is essential for zebrafish development. Bioscience Reports. 10 pages.
- 2015. Algal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometry. Marine Drugs. 7390-7402.
- 2013. Identification of dynamic changes in proteins associated with the cellular cytoskeleton after exposure to okadaic acid. Marine Drugs. 1763-1782.
- 2013. Comparative analysis of IgM sub-variants in salmonid fish and identification of a residue in mu 3 which is essential for MAb4C10 reactivity. Fish and Shellfish Immunology. 667-672.
- 2012. Nodularin exposure induces SOD1 phosphorylation and disrupts SOD1 co-localization with actin filaments. Toxins. 1482-1499.
- 2012. Impact of dietary protein hydrolysates on skeleton quality and proteome in Diplodus sargus larvae. Journal of Applied Ichthyology. 477-487.
- 2012. Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. Cell Biology and Toxicology. 201-212.
- 2012. Dietary lysine imbalance affects muscle proteome in zebrafish (Danio rerio): a comparative 2D-DIGE study. Marine Biotechnology. 643-654.
- 2010. Increased interaction between DJ-1 and the Mi-2/nucleosome remodelling and deacetylase complex during cellular stress. Proteomics. 1494-1504.
- 2009. Proteomic response of human neuroblastoma cells to azaspiracid-1. Journal of Proteomics. 695-707.
- 2009. Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Leukemia Research. 276-287.
- 2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
- 2008. Identification of protein interaction partners by immunoprecipitation: Possible pitfalls and false positives. Experimental and Clinical Hepatology. 16-22.
- 2008. Identification of a novel phosphorylation site of acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes. Experimental Cell Research. 2141-2149.
- 2007. Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics. 1702-1718.
- 2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
- 2004. Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia. 1989-1996.
- 2003. Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling protein 2 (UCP-2) expression. Journal of Biological Chemistry. 30525-30533.
- 2003. Changed Energy State and Increased Mitochondrial B-Oxidation Rate in Liver of Rats Associated with Lowered Proton Electrochemical Potential and Stimulated Uncoupling Protein 2 (UCP-2) Expression. Journal of Biological Chemistry. 30525-30533.
- 2002. Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. Journal of Biological Chemistry. 2804-2811.
- 2001. Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environmental Toxicology. 225-233.
- 2001. Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. International Journal of Occupational Medicine and Environmental Health. 335-344.
- 2000. An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon. 347-360.
- 1999. Ultrarapid apoptosis inducted by phosphatase inhibitors. Cell Death Differ. Cell Death and Differentiation. 1099-1108.
- 1999. Caspase I related protease inhibition retards the execution of okadaic acid and camptothecin induced apoptosis and PAI-2 selective cleavage, but not commitment to cell death in HL-60 cells. British Journal of Cancer. 1685-1691.
- 1999. An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon. 347-360.
- 1998. Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon. 1101-1114.
- 1998. Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation. 660-668.
- 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
- 1997. Fas/APO-1 (CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP. Biochemical and Biophysical Research Communications - BBRC. 20-25.
- 1995. Ala%3%3%5 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I. FEBS Letters. 291-294.
- 1995. ALA-335 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I. FEBS Letters. 291-294.
Report
- 2006. Shellfish toxin azaspiracid-1 induced changes in cytoskeletal proteins in neuronal cells. .
- 2006. Oocyte development in Atlantic cod (Gadus morhua L.): Trypsin-like specific activity, capacity for protein synthesis and proteomics. .
Lecture
- 2016. Functional Analysis of the DJ-1 Protein Using a CRISPR/Cas9 Knockout of the Park7 Gene in Zebrafish.
Academic lecture
- 2018. Role of the Parkinsons Disease-related protein DJ-1 in redox control and neuronal protection.
- 2017. Using zebrafish to understand BMAA-induced neurotoxicity and its relevance to neurodegeneration.
- 2011. The muscle proteome of growing fish is affected by dietary lysine.
- 2009. Saxitoxin biosynthesis in organisms from two kingdoms - horizontal gene transfer or parallel evolution?
- 2008. Identification of DJ1 interaction partners using a quantitative proteomics tool.
- 2006. Late breaker: Revealing the secreted proteome of Mycobacterium tuberculosis H37Rv.
- 2003. cAMP induced protein phosphorylation in acute myelogenous leukemia cells.
- 2002. Protein phosphatases as targets in natural compounds-induced apoptosis.
- 2002. Bioactive compounds from cyanobacteria.
- 1998. Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
- 1998. Marine cyanobacteria as a source for bioactive (apoptosis-modifying) compounds with potential as cell biology reagents and drugs.
- 1998. Distinct apoptotic death forms. Distinct pathways and functions?
Masters thesis
- 2019. Impact of cysteine 106 oxidation on function and localisation of the Parkinson’s disease-related protein DJ-1.
- 2017. The protective function of L-serine in a zebrafish model of B-methylamino-L-alanine induced toxicity.
- 2015. Neuronal DJ-1 functions in a zebrafish model for Parkinson’s Disease.
- 2015. Effects of β-methylamino-L-alanine (BMAA)on brain-derived cell lines and zebrafish.
- 2013. Mechanistic studies of Atlantic cod responses to alkyl-substituted naphthalene and phenanthrene.
- 2012. Role of the Parkinson´s disease-related protein DJ-1 in oxidative stress-induced cell death.
- 2011. DJ-1 expression and function in AML cell lines.
- 2009. Apoptosis-related post translational modifications of endoplasmic reticulum protein-57 (ERp57).
- 2007. A study on the Parkinson’s disease related DJ-1 protein. Possible function and involvement in algal toxin-induced apoptosis.
- 2005. Role of Cu/Zn superoxide dismutase (SOD1) in phosphatase inhibitor-induced apoptosis.
Popular scientific article
- 2003. PROBE-nasjonal plattform i proteomikk. NBS-nytt. 23-24.
- 2001. Biologisk baserte blåskjelltester (BBB). Fiskehelse. 26-33.
Doctoral dissertation
- 2019. Functional importance of the Parkinson’s disease-related protein DJ-1.
- 2015. Cellular responses to algal toxins.
- 2011. The cellular distress proteome. A quantitative study of oxidativily stressed cells.
- 1998. Hepatocyte proliferation and apoptosis-regulation by cell communication and phosphorylation. -.
Interview
- 2019. Denne fisken vil trolig få Parkinson.
- 2016. Studerer sebrafisk for å finne Parkinsonsvar.
- 2016. Sebrafrisk Glem laboratorierotta. Nå er sebrafisken forskernes nye favoritt i kampen mot både fysiske og psykiske sykdommer.
Programme participation
- 2015. Death - a series about life.
Academic chapter/article/Conference paper
- 2014. Proteomic tools to elucidate the molecular action of micro-algal toxins. 21 pages.
Abstract
- 2018. The protein cargo of endothelial cell-derived extracellular vesicles released in response to IL-3 identifies the Wnt signaling pathway as a relevant mediator of inflammation. Journal of Extracellular Vesicles.
- 2006. Proteomic tissue imaging for rapid brain biomarker discovery. European Journal of Neurology. 42-42.
Poster
- 2018. naa10 knockdown and NatA inhibition point to role for the NatA complex in zebrafish dorsoventral axis formation .
- 2018. Functional Analysis of the DJ-1 Protein Using a CRISPR/Cas9 Knockout of the Park7 Gene in Zebrafish.
- 2016. A protective function of increased glial DJ-1 expression in a zebrafish model of Parkinson’s disease.
- 2015. The N-terminal acetyltransferase Naa10 is essential for zebrafish development.
- 2015. High-definition quanlitative and quantitative proteomics of a Parkinson´s disease zebrafish model.
- 2014. Functional Mechanisms Behind the Oxidative Stress Protective Action of DJ-1.
- 2013. Proteome profiling of zebrafish embryos with glial specific over-expression of the Parkinson’s disease-related protein DJ-1.
- 2011. Growth and skeletal muscle proteome of juvenile zebrafish is affected by a dietary lysine.
- 2008. The hyperthermophilic sulfate-reducing archaeon Archaeoglobus fulgidus; a proteomics study on the shift between chemoorganoheterotrophic and chemilithoautotrophic growth.
- 2008. Protein expression changes in human neuroblastoma cells treated with azaspiracid-1.
- 2008. DJ-1 interacts with the chromatin remodelling complex NuRD to regulate apoptotic cell death.
- 2006. Oocyte development in Atlantic cod (Gadus morhua L.): Trypsin-like specific activity, capacity for protein synthesis and proteomics.
- 2006. Comparing the protein identifications obtained using two-dimensional gel electrophoresis or liquid chromatography mass spectrometry on the secreted proteome of Mycobacterium tuberculosis.
- 2003. Differential Expression of Splicing factor SR proteins and Their phosphorylation in Cell Stress leading to Apoptosis.
- 2002. Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins- Development of a sensitive in vitro assay.
- 2002. Phosphorylated targets in ultrarapidly induced apoptosis.
- 1997. Detedtion of toxins from marine cyanobacteria based on their affinity for protein phosphatase 2A and their ability to induce apoptosis in salmon hepatocytes.
Academic literature review
- 2017. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). 94-162.
- 2015. Redox control of protein degradation. 409-420.
- 2006. Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies. 185-198.
- 2006. Algal toxins as guidance to identify phosphoproteins with key roles in apoptotic cell death. 209-215.
More information in national current research information system (CRIStin)
Fields of competence