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Karianne Fjeld's picture
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Jørgen Barth

Karianne Fjeld

Researcher
Department of Clinical Medicine
  • E-mailKarianne.Fjeld@uib.no
  • Phone+47 55 97 67 93
  • Visitor Address
    Haukeland University Hospital
    The Laboratory Building, 8th floor
    Room 
    8480
  • Postal Address
    Postboks 7804
    5020 Bergen
  • Pancreatitis
  • Pancreatic cancer
  • Mody-diabetes (monogenic diabetes)

Affiliated with the following reasearch groups:

https://www.uib.no/en/diabetes

https://pancreas.w.uib.no

Academic article
  • Show author(s) (2022). Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases. Journal of Clinical Endocrinology and Metabolism (JCEM). e1455-e1466.
  • Show author(s) (2022). The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice. Pancreatology (Print). 1099-1111.
  • Show author(s) (2021). The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity. Journal of Biological Chemistry. 1-13.
  • Show author(s) (2021). Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis. European Journal of Gastroenterology and Hepathology. 839-843.
  • Show author(s) (2020). Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding. Human Mutation. 1967-1978.
  • Show author(s) (2020). Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells . Cells. 1-19.
  • Show author(s) (2020). Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro. The Journal of Inherited Metabolic Disease (JIMD). 1-13.
  • Show author(s) (2020). Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis. Pancreatology (Print). 377-384.
  • Show author(s) (2019). The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis. Pancreatology (Print). 531-534.
  • Show author(s) (2018). The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants. Journal of Biological Chemistry. 19476-19491.
  • Show author(s) (2017). Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Molecular and Cellular Endocrinology. 146-157.
  • Show author(s) (2017). Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer. Pancreatology (Print). 83-88.
  • Show author(s) (2016). Length of variable numbers of tandem repeats in the carboxyl ester lipase (CEL) gene may confer susceptibility to alcoholic liver cirrhosis but not alcoholic chronic pancreatitis. PLOS ONE.
  • Show author(s) (2016). Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 4636-4641.
  • Show author(s) (2015). Glycogenin-2 is dispensable for liver glycogen synthesis and glucagon-stimulated glucose release. Journal of Clinical Endocrinology and Metabolism (JCEM). E767-E775.
  • Show author(s) (2015). A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. Nature Genetics. 518-522.
  • Show author(s) (2014). Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction. Journal of Biological Chemistry. 29097-29111.
  • Show author(s) (2013). The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis. Pancreatology (Print). 29-32.
  • Show author(s) (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 34593-34605.
  • Show author(s) (2005). Dynamic expression of Wnt signaling-related Dickkopf1,-2, and-3 mRNAs in the developing mouse tooth. Developmental Dynamics. 161-166.
  • Show author(s) (2005). Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice. Journal of Molecular Histology. 419-426.
  • Show author(s) (2005). Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfβ1 regulate semaphorin 3a expression in the dental mesenchyme. Development. 323-334.
  • Show author(s) (2004). Glial cell line-derived neurotrophic factor (GDNF) from adult rat tooth serves a distinct population of large-sized trigeminal neurons. European Journal of Neuroscience. 2089-2098.
  • Show author(s) (2003). NK1-, NK2-, NK3-, and CGRP1-receptors identified in rat oral soft tissues, bone- and hard tissue cells. Cell and Tissue Research. 383-391.
  • Show author(s) (2003). Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. Mechanisms of Development. 270-276.
  • Show author(s) (2003). Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. Mechanisms of Development. 270-276.
Academic lecture
  • Show author(s) (2003). Wnt signaling in tooth morphogenesis.
  • Show author(s) (2003). Functions of SLIT1 in tooth morphogenesis.
Editorial
  • Show author(s) (2016). Lipase genetic variants in chronic pancreatitis: when the end is wrong, all's not well. Gastroenterology. 1515-1518.
Thesis at a second degree level
  • Show author(s) (2000). The effect of beta1-integins on the phenotype of human gliomas.
  • Show author(s) (2000). The effect of Beta1-integrins on the invasive phenotype of human gliomas.
Feature article
  • Show author(s) (2015). Du vet nesten ingenting om det, men dette er et av kroppens mest sentrale organer. Aftenposten (morgenutg. : trykt utg.).
Doctoral dissertation
  • Show author(s) (2006). The Wnt pathway. Studies on Wnt signaling and regulation in the developing tooth.
Interview
  • Show author(s) (2004). Dyrking av det Perfekte Smil.
Abstract
  • Show author(s) (2013). Cellular re-uptake of secreted carboxyl-ester lipase protein in CEL-MODY, a syndrome of diabetes and pancreatic exocrine dysfunction. Diabetologia. S152-S152.
  • Show author(s) (2008). Structural changes in the repeated region of the carboxyl-ester lipase (CEL) gene and the development of diabetes. Diabetologia. S123-S123.
Academic literature review
  • Show author(s) (2018). The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Pancreatology (Print). 12-19.

More information in national current research information system (CRIStin)

Fields of competence 
Diabetes
Molecular Biology
Molecular genetics
Mouse models
Pancreatic cancer