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Karl Albert Brokstad's picture

Karl Albert Brokstad

Senior Engineer
  • E-mailKarl.Brokstad@uib.no
  • Phone+47 55 97 46 22+47 988 43 314
  • Visitor Address
    Broegelmann Research Laboratory, Dept. of Clinical Sciences, University of Bergen
    The Laboratory Building 5th floor, Haukeland University Hospital
    N-5021 Bergen
    Room 
    5375
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • 2020. Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction. Journal of Infectious Diseases. 21-32.
  • 2020. Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children. Journal of Infectious Diseases.
  • 2020. Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children. Journal of Infectious Diseases. 1528-1537.
  • 2020. A randomized, double-blind, placebo-controlled clinical study to investigate the efficacy of herring roe oil for treatment of psoriasis. Acta Dermato-Venereologica. 1-6.
  • 2019. Functional immune response to influenza H1N1 in children and adults after live attenuated influenza virus vaccination. Scandinavian Journal of Immunology. 1-12.
  • 2019. Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. European Journal of Nutrition. 1-17.
  • 2019. Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjogren?s syndrome. Autoimmunity. 242-250.
  • 2018. T follicular-like helper cells in the peripheral blood of patients with primary Sjögren's syndrome. Scandinavian Journal of Immunology. 1-15.
  • 2018. Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nature Chemical Biology. 94-101.
  • 2018. Current concepts on Sjögren's syndrome – classification criteria and biomarkers. European Journal of Oral Sciences. 37-48.
  • 2018. Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue. International Journal of General Medicine. 285-291.
  • 2017. Influenza virus hemagglutinin stalk-specific antibodies in human serum are a surrogate marker for in vivo protection in a serum transfer mouse challenge model. mBio. 1-13.
  • 2017. Influenza A haemagglutinin specific IgG responses in children and adults after seasonal trivalent live attenuated influenza vaccination. Vaccine. 5666-5673.
  • 2017. High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. British Journal of Nutrition. 1368-1378.
  • 2017. H1N1 vaccination in Sjogren's syndrome triggers polyclonal B cell activation and promotes autoantibody production. Annals of the Rheumatic Diseases. 1755-1763.
  • 2017. Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Neurogastroenterology and Motility. 1-9.
  • 2017. Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis. Annals of the Rheumatic Diseases. 2031-2037.
  • 2017. Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. Arthritis Research & Therapy. 1-10.
  • 2017. Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination. Journal of Infectious Diseases. 1527-1535.
  • 2017. 25-hydroxy-vitamin D concentration is not affected by severe or non-severe pneumonia, or inflammation, in young children. Nutrients. 1-11.
  • 2016. Serum calprotectin is a biomarker of carotid atherosclerosis in patients with primary Sjögren's syndrome. Clinical and Experimental Rheumatology. 1006-1012.
  • 2016. Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study. Influenza and Other Respiratory Viruses. 525-531.
  • 2016. Non-proliferating plasma cells detected in the salivary glands and bone marrow of autoimmune NOD.B10.H2b mice, a model for primary Sjögrens syndrome. Autoimmunity. 41-49.
  • 2016. Live attenuated influenza vaccine in children induces b-cell responses in tonsils. Journal of Infectious Diseases. 722-731.
  • 2016. High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. British Journal of Nutrition. 648-657.
  • 2016. Comparative analysis of influenza A(H3N2) virus hemagglutinin specific IgG subclass and IgA responses in children and adults after influenza vaccination. Vaccine. 191-198.
  • 2016. Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer. Proceedings of the National Academy of Sciences of the United States of America. 9339-9344.
  • 2015. Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice. mBio. 13 pages.
  • 2015. The expression of B & T cell activation markers in children’s tonsils following live attenuated influenza vaccine. Human Vaccines & Immunotherapeutics. 1663-1672.
  • 2015. Serum markers in rheumatoid arthritis: A longitudinal study of patients undergoing infliximab treatment. International Journal of Rheumatology. 1-9.
  • 2015. Prediction of Sjögren's syndrome years before diagnosis and identification of patients with early onset and severe disease course by autoantibody profiling. Arthritis & Rheumatology. 2427-2436.
  • 2015. Persistence and avidity maturation of antibodies to A(H1N1)pdm09 in healthcare workers following repeated annual vaccinations. Vaccine. 4146-4154.
  • 2015. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis research and treatment.
  • 2015. Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children. Journal of Infectious Diseases. 1541-1549.
  • 2015. Influenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines. Vaccines. 373-389.
  • 2015. Engraftment of human glioblastoma cells in immunocompetent rats through acquired immunosuppression. PLOS ONE.
  • 2015. Cytokine concentrations in plasma from children with severe and non-severe community acquired pneumonia. PLOS ONE. 16 pages.
  • 2014. The Influence of Tonsillectomy on Total Serum Antibody Levels. Scandinavian Journal of Immunology. 377-379.
  • 2014. Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination. Vaccine. 4550-4557.
  • 2014. Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome. Arthritis and Rheumatism. 2545-2557.
  • 2014. Ductal epithelial expression of Ro52 correlates with inflammation in salivary glands of patients with primary Sjögren's syndrome. Clinical and Experimental Immunology. 244-252.
  • 2014. Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients. Respiratory Research.
  • 2013. Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome. Clinical and Experimental Immunology. 228-237.
  • 2013. Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling. Cancer Research. 7090-7100.
  • 2012. The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants. Human Vaccines & Immunotherapeutics. 653-661.
  • 2012. Minor changes in serum levels of cytokines after removal of amalgam restorations. Toxicology Letters. 120-125.
  • 2012. Low number of memory B cells in the salivary glands of patients with primary Sjögren's syndrome. Autoimmunity. 547-555.
  • 2012. Autoantigen-specific memory B cells in primary Sjögren's syndrome. Scandinavian Journal of Immunology. 61-68.
  • 2011. Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival. Arthritis Research & Therapy. 18 pages.
  • 2011. Phenotypic diversity of peripheral blood plasma cells in primary Sjögren’s Syndrome. Scandinavian Journal of Immunology. 18-28.
  • 2011. Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1363-1368.
  • 2011. Implications of long-term medication of oral steroids and antimalarial drugs in primary Sjögren's syndrome. International Immunopharmacology. 2125-2129.
  • 2011. Distinct phenotypes of plasma cells in spleen and bone marrow of autoimmune NOD.B10.H2b mice. Autoimmunity. 415-426.
  • 2009. Cytokine and autoantibody profiling related to histopathological features in primary Sjögren's syndrome. Rheumatology. 1102-1106.
  • 2009. Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation. BMC Immunology.
  • 2009. Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy. BMC Infectious Diseases. 9 pages.
  • 2009. A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice. Influenza and Other Respiratory Viruses. 21-28.
  • 2009. A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models. Influenza and Other Respiratory Viruses. 107-117.
  • 2007. Sjögren's syndrome - A plethora of clinical and immunological phenotypes with a complex genetic background. Annals of the New York Academy of Sciences. 433-447.
  • 2007. A comparison of the humoral and cellular immune responses at different immunological sites after split influenza virus vaccination of mice. Scandinavian Journal of Immunology. 14-21.
  • 2006. The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice. Vaccine. 6585-6587.
  • 2006. The humoral and cellular responses induced locally and systematically after parenteral influenza vaccination in man. Vaccine. 6577-6580.
  • 2006. Interleukin 5, IL6, IL12, IFN-gamma, RANTES and Fractalkine in human nasal polyps, turbinate mucosa and serum. European Archives of Oto-Rhino-Laryngology. 282-289.
  • 2006. Impaired salivary gland function in NOD mice - Association with changes in cytokine profile but not with histopathologic changes in the salivary gland. Arthritis and Rheumatism. 2300-2305.
  • 2006. Impact of influenza vaccine formulation with a detailed analysis of the cytokine response. Scandinavian Journal of Immunology. 467-475.
  • 2006. Human cell lines used in a micro neutralization test for measuring influenza-neutralizing antibodies. Scandinavian Journal of Immunology. 257-264.
  • 2005. The serological pattern of autoantibodies to the Ro52, Ro60, and La48 autoantigens in primary Sjögren's syndrome patients and healthy controls. Scandinavian Journal of Rheumatology. 49-55.
  • 2005. Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors. European Journal of Neurology. 392-398.
  • 2004. Lymphocyte distribution in the tonsils prior to and after influenza vaccination. Vaccine. 57-63.
  • 1991. Purification and characterization of a 65-kilodalton diisopropylfluorophosphate-binding protein in the outer membrane of Fusobacterium nucleatum Fev1. Scandinavian Journal of Dental Research. 20-29.
  • 1990. Diisopropylfluorophosphate-binding proteins in the outer membrane of Fusobacterium nucleatum: strain variations. FEMS Microbiology Letters. 235-238.
Academic lecture
  • 2016. Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial.
  • 2016. Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial.
  • 2015. Cellular immune responses after live attenuated influenza vaccination in children, a clinical trial.
  • 2005. The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man.
  • 2000. Distribution of MHC class II in alleles in Norwegian primary Sjøgren's syndrome patients:Implications for development of autoantibodies to the Ro52 autoantigen.
Editorial
  • 2016. The 2016 Nobel Prize in Physiology or Medicine. Scandinavian Journal of Immunology.
  • 2006. Pandernic influenza vaccine development: time is of the essence. Expert Review of Vaccines. 603-606.
  • 2006. Pandemic influenza vaccine development: time is of the essence. Expert Review of Vaccines.
Reader opinion piece
  • 2013. Autoantibodies Present Before Symptom Onset in Primary Sjogren Syndrome. Journal of the American Medical Association (JAMA). 1854-1855.
  • 2009. The Immunogenicity of a Cell-derived H7N1 Split Influenza Virion Vaccine in Mice. Scandinavian Journal of Immunology. 576-578.
  • 2005. Influenza specific serum IgE is present in non-allergic subjects. Scandinavian Journal of Immunology. 560-561.
Academic anthology/Conference proceedings
  • 2003. Methods in Molecular Medicine focusing on Methods in Viral Immunity. Springer.
Letter to the editor
  • 2013. Autoantibodies Present Before Symptom Onset in Primary Sjögren Syndorme. Journal of the American Medical Association (JAMA). 1854-1855.
Doctoral dissertation
  • 1995. Qualitative, quantitative and kinetic aspects of the humoral immune response induced systemically and locally after influenza vaccination.
Academic chapter/article/Conference paper
  • 2007. Immunologi og andre fagfelt. 7 pages.
  • 2004. The kinetics of the systemic and local immune response to parenteral influenza vaccination. 4 pages.
  • 2003. Detection of antibodies to influenza virus in human mucosal tissues and fluids.
Abstract
  • 2016. Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial. United European Gastroenterology journal. A101-A101.
  • 2013. Autoantigen-specific memory cell pattern in patients with Primary Sjögren's syndrome. Scandinavian Journal of Immunology. 296-296.
  • 2012. Ro52-and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjogren's syndrome. Immunology. 339-339.
  • 2012. Hyperreactive B cells upon endosomal TLR triggering underlying primary Sjögren's Syndrome. Scandinavian Journal of Immunology. 199-200.
  • 2011. Vaccination of patients with primary Sjögren's syndrome reveals hyperreactive B cell compartment with a skewed maturation pattern. Annals of the Rheumatic Diseases. A67-A67.
  • 2011. Vaccination of Patients with Primary Sjogren's Syndrome Reveals Hyperreactive B Cell Compartment. Scandinavian Journal of Immunology. 369-369.
  • 2010. The Value of Using Diseased Controls in Studies of Autoimmune Rheumatic Diseases. Scandinavian Journal of Immunology. 491-492.
  • 2010. Successful engraftment of glioblastoma biopsy spheroids in immunocompetent rats. European Journal of Cancer. 76-76.
  • 2010. Prednisolon Reduce Cytokine but Increase Autoantibody Levels in Patients with Primary Sjogren's Syndrome. Scandinavian Journal of Immunology. 491-491.
  • 2008. Salivary gland interstitial fluid cytokines in NOD mice. Arthritis and Rheumatism. S796-S796.
  • 2008. Heterogeneity of plasma cell subsets found in the bone marrow of autoimmune NOD.B10.H2b mice. Scandinavian Journal of Immunology. 206-206.
  • 2006. Impaired salivary gland function in nod mice - Association with changes in cytokine profile but not with salivary gland histopathology. Arthritis and Rheumatism. S707-S707.
Poster
  • 2016. Low FODMAP diet alters symptoms, microbiota, short-chain fatty acids and cytokine profiles in patients with IBS: A randomized controlled trial.
  • 2009. Cytokine and autoantibody profiling in primary Sjögren's syndrome.
  • 2007. Immunisation of mice with whole inactivated avian influenza H7N1 virus vaccine.
  • 2005. The cytokine and the antibody responses after vaccination with influenza split or whole virus vaccines in mice.
  • 2005. Cytokine profile and lymphocyte pattern influenced by parenteral influenza vaccination.
Academic literature review
  • 2016. Atherosclerosis in Sjögren's syndrome: Evidence, possible mechanisms and knowledge gaps. 133-142.
  • 2007. Role of B cells in Sjögren's syndrome - from benign lymphoproliferation to overt malignancy. 2159-2170.
  • 2004. Influenza virus: Immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines. 1-15.

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