Karl Johan Tronstad's picture

Karl Johan Tronstad

  • E-mailtronstad@uib.no
  • Phone+47 55 58 64 33+47 932 21 592
  • Visitor Address
    Jonas Lies vei 91
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen

For an updated publication list see Pubmed.

(The links below may not be completely updated)

Academic article
  • Show author(s) (2023). GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nature Cancer. 648-664.
  • Show author(s) (2022). Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development. Cancers. 1-21.
  • Show author(s) (2022). Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines. Cancer & Metabolism. 16 pages.
  • Show author(s) (2022). Activity monitoring and patient-reported outcome measures in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients. PLOS ONE. 21 pages.
  • Show author(s) (2021). The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell reports.
  • Show author(s) (2021). Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells. Scientific Reports. 1-10.
  • Show author(s) (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. Cancers. 24 pages.
  • Show author(s) (2021). Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. Journal of Cellular and Molecular Medicine. 7407-7417.
  • Show author(s) (2021). A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. JCI Insight. 1-19.
  • Show author(s) (2020). Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue. PLOS ONE. 1-16.
  • Show author(s) (2020). Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. Frontiers in medicine. 1-15.
  • Show author(s) (2019). Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion (Amsterdam. Print). 97-110.
  • Show author(s) (2019). The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
  • Show author(s) (2019). Neural stem cells of Parkinson's disease patients exhibit aberrant mitochondrial morphology and functionality. Stem Cell Reports. 878-889.
  • Show author(s) (2019). Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta neuropathologica communications. 1-19.
  • Show author(s) (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer & Metabolism.
  • Show author(s) (2018). Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. International Journal of Cancer. 1735-1745.
  • Show author(s) (2018). Introducing nano-scale quantitative polymerase chain reaction. Biochemical and Biophysical Research Communications - BBRC. 923-926.
  • Show author(s) (2017). The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro-Oncology. 383-393.
  • Show author(s) (2017). Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation. Scientific Reports.
  • Show author(s) (2017). Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. Journal of Lipid Research. 1362-1373.
  • Show author(s) (2016). Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight.
  • Show author(s) (2016). Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function. Scientific Reports.
  • Show author(s) (2015). Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 27644-27659.
  • Show author(s) (2015). A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
  • Show author(s) (2014). Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. PLOS ONE.
  • Show author(s) (2013). Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA). Biochemical and Biophysical Research Communications - BBRC. 573-578.
  • Show author(s) (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 495-510.
  • Show author(s) (2010). Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. Leukemia Research. 77-84.
  • Show author(s) (2010). Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. Journal of Cellular Biochemistry. 574-584.
  • Show author(s) (2009). Hyperoxic treatment induces mesenchymal to epithelial transition in a rat adenocarcinoma model. PLOS ONE.
  • Show author(s) (2009). Hyperoxia increases the uptake of 5-FU in mammary tumors independently of cganges in interstitial pressure and tumor stroma. BMC Cancer.
  • Show author(s) (2009). Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Molecular Cancer.
  • Show author(s) (2008). Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats. Drug Metabolism Letters. 138-145.
  • Show author(s) (2006). Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia? Cancer Immunology and Immunotherapy. 221-228.
  • Show author(s) (2006). A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia. Clinical Cancer Research. 3525-3531.
  • Show author(s) (2005). The metabolic syndrome and the hepatic fatty acid drainage hypothesis. Biochimie. 15-20.
  • Show author(s) (2005). In vitro culture of human osteosarcoma cell lines: a comparison of functional characteristics for cell lines cultured in medium without and with fetal calf serum. Journal of Cancer Research and Clinical Oncology. 377-384.
  • Show author(s) (2005). Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
  • Show author(s) (2001). Growth reduction in glioma cells after treatment with tetradecylthioacetic acid: changes in fatty acid metabolism and oxidative status. Biochemical Pharmacology. 639-649.
  • Show author(s) (1999). In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacyllycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation. Biochemical Journal. 191-197.
  • Show author(s) (2018). ME/CFS - Energisvikt i kroppens celler .
  • Show author(s) (2018). Cellular Energetics in ME/CFS (public).
Popular scientific lecture
  • Show author(s) (2018). Me-forskning i Bergen.
Academic lecture
  • Show author(s) (2018). Cellular Energetics in ME/CFS.
  • Show author(s) (2017). Defective energy metabolism in ME/CFS (Prosjektpresentasjon, NFR BehovME, 2017-2020).
  • Show author(s) (2013). Mitochondrial function, biogenesis and morphology in cellular stress.
  • Show author(s) (2012). Mitochondrial morphology and biogenesis in cellular stress.
  • Show author(s) (1998). Metabolic effects of 3-thia fatty acid in cancer cells.
Reader opinion piece
  • Show author(s) (2018). Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon . Tidsskrift for Den norske legeforening. 12-13.
  • Show author(s) (2017). Mer om pyruvat dehydrogenase og kronisk utmattelsessyndrom. Tidsskrift for Den norske legeforening.
  • Show author(s) (2017). Chronic fatigue syndrome and pyruvate dehydrogenase function. Tidsskrift for Den norske legeforening.
Book review
  • Show author(s) (2004). Book review: Lipid Biochemistry - An Introduction, 5th edn., edited by Michael I. Gurr, John L Harwood and Keith N. Frayn. Blackwell Science Ltd., Oxford (UK) 2002. European Journal of Lipid Science and Technology. 452-452.
Academic commentary
  • Show author(s) (2018). Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon.
Thesis at a second degree level
  • Show author(s) (1997). Proliferation of malignant rat glioma cells in reduced by the sulphur substituted fatty acid analogue tetradecylthioacetic acid; a stud on oxidative status (Cand. scient).
Masters thesis
  • Show author(s) (2020). Hunting metabolic changes in ME/CFS by investigating cellular responses to applied stress and patient serum factors.
  • Show author(s) (2020). Exploring passive transfer of Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) metabolic disturbances on cultured mouse- and human muscle cells.
  • Show author(s) (2019). The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress.
  • Show author(s) (2019). Alterations in cellular metabolism during development of cancer therapy resistance.
  • Show author(s) (2015). The Role of Persistent Organic Pollutants in Induction of Endoplasmic Reticulum Stress in Hepatocytes in vitro and in vivo.
  • Show author(s) (2014). The effect of tetradedecylthioacetic acid on insulin production and mitochondrial function in INS-1E β-cells.
  • Show author(s) (2014). Effekt av hypoksia på Annexin A2 i mitokondrier fra HepG2- og PC12-celler.
  • Show author(s) (2013). Metabolic reprogramming in Slug and Twist overexpressing MCF10A cells.
  • Show author(s) (2012). Mitochondrial function and metabolic stress tolerance in fibroblasts from patients with mutations in POLG.
  • Show author(s) (2012). A study of mitochondrial function, ROS and signaling in Twist overexpressing cells.
  • Show author(s) (2009). Possible interactions between EGFR vIII mediated regulation of proliferation and metabolism in glioma cells.
  • Show author(s) (2009). Mulige interaksjoner mellom tyrosin kinase reseptoren Axl, metabolisme og proliferasjon i brystkreftceller (MDA-MB-231).
  • Show author(s) (2008). Growth Factors and Cardioprotection; - with special reference to insulin and IGF-II survival signalling at ischemic reperfusion.
  • Show author(s) (2007). Mitocondrial metabolism and tumor growth control.
Doctoral dissertation
  • Show author(s) (2019). A study on features and markers of cellular metabolic rewiring.
  • Show author(s) (2017). A study of cellular metabolic flexibility under energy stress.
  • Show author(s) (2012). A mitochondrial reporter system for studies on NRF-1/AMPK activity and regulation in viable cells. Biochimica et Biophysica Acta - Bioenergetics. S70-S70.
  • Show author(s) (2008). Mitochondrial function in cancer cell line models. Biochimica et Biophysica Acta - Bioenergetics. S41-S41.
  • Show author(s) (2007). Synergistic anti-leukemic effect of protein kinase a activator and PPAR7agonist is independent of Bcl-2 status. Blood. 117B-117B.
  • Show author(s) (2018). Metabolic profiling of Colorectal cancer in 3D.
  • Show author(s) (2009). Hyperoxic Treatment induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model.
  • Show author(s) (2004). PPAR-delta activation in relation to reduction of adipose tissue.
  • Show author(s) (2022). Author Correction: Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells (Scientific Reports, (2021), 11, 1, (10487), 10.1038/s41598-021-89861-6). Scientific Reports.
  • Show author(s) (2016). Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
Academic literature review
  • Show author(s) (2021). Pathomechanisms and possible interventions in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Journal of Clinical Investigation.
  • Show author(s) (2014). Regulation and quantification of cellular mitochondrial morphology and content. Current pharmaceutical design. 5634-5652.
  • Show author(s) (2010). Connexin-based signaling in acute myelogenous leukemia (AML). Biochimica et Biophysica Acta - Biomembranes. 1-8.
  • Show author(s) (2007). Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. Expert opinion on therapeutic targets. 1055-1069.
  • Show author(s) (2006). Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML. Expert opinion on therapeutic targets. 51-68.

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