- E-mailkatrin.kleinmanns@uib.no
- Phone96703136
- Visitor AddressJonas Lies veg 87Laboratory building 9th floor5021 Bergen
- Postal AddressPostboks 78045020 Bergen
Katrin´s research focuses on the development of immunocompetent patient-derived xenograft (PDX) models of ovarian carcinomas to improve therapeutic interventions through novel immune therapies and targeted fluorescence image-guided surgery. These advanced mouse models are additionally reconstituted with a functional human immune system, which replicate the heterogeneities observed in patient tumours whilst also reproducing key features of the human immune system. Immunotherapies, neither immune-checkpoint inhibitor nor chimeric antigen receptor (CAR) T cells, have been shown successful in ovarian carcinomas, yet. Key drivers for her project are the genomic and phenotypic characterization of her established PDX models including the verification of the genomic fidelity to the paired primary tumors as well as the phenotypic deciphering of the complex tumor microenvironment (TME). The aim of Katrin´s project is to provide a good and reliable preclinical animal model that combines the interactions of the TME, including human immune system and genomic evolution of tumor cells.
Kleinmanns, K. et al. (2022). Modeling the Tumor Microenvironment in Patient-Derived Xenografts: Challenges and Opportunities. In: Akslen, L.A., Watnick, R.S. (eds) Biomarkers of the Tumor Microenvironment. Springer, Cham. https://doi.org/10.1007/978-3-030-98950-7_19
Perrone, M.G.; Vitale, P.; Miciaccia, M.; Ferorelli, S.; Centonze, A.; Solidoro, R.; Munzone, C.; Bonaccorso, C.; Fortuna, C.G.; Kleinmanns, K.; Bjørge, L.; Scilimati, A. Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes. Pharmaceuticals 2022, 15, 668. https://doi.org/10.3390/ph15060668
Kleinmanns, K.; Gullaksen, S.-E.; Bredholt, G.; Davidson, B.; Torkildsen, C.F.; Grindheim, S.; Bjørge, L.; McCormack, E. Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies. Cancers 2022, 14, 3092. doi.org/10.3390/cancers14133092
García de Jalón, E., Kleinmanns, K., Fosse, V. et al. Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model. Mol Imaging Biol 25, 144–155 (2021). https://doi.org/10.1007/s11307-021-01685-y
Popa, M., Fosse, V., Kleinmanns, K., Bjørge, L., McCormack, E. (2021). Xenograft Models of Ovarian Cancer for Therapy Evaluation. In: Kreeger, P.K. (eds) Ovarian Cancer. Methods in Molecular Biology, vol 2424. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1956-8_18
Anandan, S.; Thomsen, L.C.V.; Gullaksen, S.-E.; Abdelaal, T.; Kleinmanns, K.; Skavland, J.; Bredholt, G.; Gjertsen, B.T.; McCormack, E.; Bjørge, L. Phenotypic characterization by mass cytometry of the microenvironment in ovarian cancer and impact of tumor dissociation methods. Cancers 2021, 13, 755.
Kleinmanns, K., et al., The Emerging Role of CD24 in Cancer Theranostics—A Novel Target for Fluorescence Image-Guided Surgery in Ovarian Cancer and Beyond. Journal of Personalized Medicine, 2020. 10(4): p. 255.
Kleinmanns, K., et al., CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model. EBioMedicine, 2020. 56: p. 102783.
Kleinmanns, K., et al., CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. EBioMedicine, 2020. 56: p. 102782.
- (2023). Combining Mass Cytometry Data by CyTOFmerge Reveals Additional Cell Phenotypes in the Heterogeneous Ovarian Cancer Tumor Microenvironment: A Pilot Study. Cancers.
- (2022). Modeling the Tumor Microenvironment in Patient-Derived Xenografts: Challenges and Opportunities. 16 pages.
- (2022). Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies. Cancers. 20 pages.
- (2022). Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes. Pharmaceuticals.
- (2022). Establishment of peritoneal dECM scaffolds for culture of ovarian cancer organoids.
- (2022). Establishment of peritoneal dECM scaffolds for 3D culture of ovarian cancer organoids.
- (2022). Establishment of ovarian cancer organoids on peritoneal dECM scaffolds.
- (2021). Xenograft Models of Ovarian Cancer for Therapy Evaluation. . In:
- (2021). Ovarian Cancer Methods and Protocols. Springer Nature.
- (2021). Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods. Cancers. 1-18.
- (2021). Establishment of ovarian cancer organoids on peritoneal dECM scaffolds.
- (2021). Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model. Molecular Imaging and Biology. 144-155.
- (2020). The emerging role of cd24 in cancer theranostics—a novel target for fluorescence image-guided surgery in ovarian cancer and beyond. Journal of Personalized Medicine. 1-18.
- (2020). CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model . EBioMedicine. 1-12.
- (2020). CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. EBioMedicine. 1-13.
- (2019). rethinking high-grade serous ovarian carcinoma: development of new preclinical animal models for evaluation of image-guided surgery and immunotherapy.
- (2019). EP889 improved cytoreduction of ovarian cancer using CD24 targeted fluorescence image guided surgery in a preclinical murine model.
- (2017). Engraftement optimization, charaterization and tumor spread tracking by preclinical imaging in ovarian cancer patiant.
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