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Kimberley Joanne Hatfield's picture

Kimberley Joanne Hatfield

Researcher , Researcher
  • E-mailKimberley.Hatfield@uib.no
  • Phone+47 55 97 30 37
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen

The main research aim is to characterize metabolic phenotypes of human leukemia cells, and investigate how metabolic pathways may be implicated in the development of cancer cells`drug resistance.
Additional research interests include the contribution of the microenvironment in acute myeloid leukemia (AML); in particular how leukemia cells are influenced by stromal cells and chemokines, and how leukemia cells adapt to changes in oxygen levels and nutrient availability.

  • Melve, Guro Kristin; Ersvær, Elisabeth; Rye, Kristin Paulsen; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Reikvam, Håkon; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2018. The healthy donor profile of immunoregulatory soluble mediators is altered by stem cell mobilization and apheresis. Cytotherapy. 20: 740-754. doi: 10.1016/j.jcyt.2018.02.366
  • Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise; Hernandez-Valladares, Maria; Brenner, Annette; Bartaula-Brevik, Sushma; Berven, Frode; Selheim, Frode; Skavland, Jørn; Gjertsen, Bjørn Tore; Reikvam, Håkon; Bruserud, Øystein. 2018. Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. Expert opinion on therapeutic targets. 22: 639-653. doi: 10.1080/14728222.2018.1487401
  • Nepstad, Ina; Hatfield, Kimberley Joanne; Tvedt, Tor Henrik Anderson; Reikvam, Håkon; Bruserud, Øystein. 2018. Clonal heterogeneity reflected by pi3k-akt-mtor signaling in human acute myeloid leukemia cells and its association with adverse prognosis. Cancers. 10:332: 1-15. doi: 10.3390/cancers10090332
  • Nepstad, Ina; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2018. Resistance to the antiproliferative in vitro effect of PI3K-Akt-mTOR inhibition in primary human acute myeloid leukemia cells is associated with altered cell metabolism. International Journal of Molecular Sciences. 19:382: 1-18. doi: 10.3390/ijms19020382
  • Reikvam, Håkon; Grønningsæter, Ida Sofie; Mosevoll, Knut Anders; Lindås, Roald; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2018. Patients with treatment-requiring chronic graft versus host disease after allogeneic stem cell transplantation have altered metabolic profiles due to the disease and immunosuppressive therapy: Potential implication for biomarkers. Frontiers in Immunology. 8:1979: 1-15. doi: 10.3389/fimmu.2017.01979
  • Hatfield, Kimberley Joanne; Melve, Guro Kristin; Bruserud, Øystein. 2017. Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors. Metabolomics. 13:2: 1-10. doi: 10.1007/s11306-016-1139-x
  • Hauge, Michelle Victoria; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2016. Targeting of cell metabolism in human acute myeloid leukemia - more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling? European Journal of Haematology. 96: 211-221. doi: 10.1111/ejh.12690
  • Kallekleiv, Marit Selvik; Larun, Lillebeth; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2016. Co-transplantation of multipotent mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis. Cytotherapy. 18: 172-185. doi: 10.1016/j.jcyt.2015.11.010
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2016. The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation. Metabolomics. 12. doi: 10.1007/s11306-015-0880-x
  • Reikvam, Håkon; Grønningsæter, Ida Sofie; Ahmed, Aymen B; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2015. Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome. Disease Markers. 2015:943430. 13 pages. doi: 10.1155/2015/943430

More information in national current research information system (CRIStin)

Bergen Research Foundation funded project: Characterization of metabolic phenotypes and signaling pathways in acute myeloid leukemia and their role in anti-leukemia treatment.