Kimberley Joanne Hatfield
Guest Researcher, Researcher
- Visitor AddressHaukeland universitetssykehus, Laboratoriebygget5009 Bergen
- Postal AddressPostboks 78045020 Bergen
The main research aim is to characterize metabolic phenotypes of human leukemia cells, and investigate how metabolic pathways may be implicated in the development of cancer cells`drug resistance.
Additional research interests include the contribution of the microenvironment in acute myeloid leukemia (AML); in particular how leukemia cells are influenced by stromal cells and chemokines, and how leukemia cells adapt to changes in oxygen levels and nutrient availability.
- (2022). Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients. Cancers. 21 pages.
- (2022). NPM1-mutated patient-derived AML cells are more vulnerable to rac1 inhibition. Biomedicines. 16 pages.
- (2022). MicroRNA serum profiles and chronic graft-versus-host disease. Blood Advances. 5295-5306.
- (2022). Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibition. International Journal of Molecular Sciences. 21 pages.
- (2022). Endocan in Acute Leukemia: Current Knowledge and Future Perspectives. Biomolecules.
- (2021). Effects of the autophagy‐inhibiting agent chloroquine on acute myeloid leukemia cells; characterization of patient heterogeneity. Journal of Personalized Medicine. 1-23.
- (2020). The PI3K-AKT-MTOR signaling pathway in human acute myeloid leukemia (AML) cells. International Journal of Molecular Sciences. 1-22.
- (2020). Targeting cellular metabolism in acute myeloid leukemia and the role of patient heterogeneity. Cells. 1-26.
- (2019). Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy. Cells.
- (2019). Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells. Signal Transduction and Targeted Therapy.
More information in national current research information system (CRIStin)
Bergen Research Foundation funded project: Characterization of metabolic phenotypes and signaling pathways in acute myeloid leukemia and their role in anti-leukemia treatment.