Knut Teigen's picture

Knut Teigen

  • E-mailKnut.Teigen@uib.no
  • Phone+47 55 58 63 28
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Holtan, Josephine Prener; Teigen, Knut; Aukrust, Ingvild; Bragadottir, Ragnheidur; Houge, Gunnar. 2019. Dominant ARL3-related retinitis pigmentosa. Ophthalmic Genetics. 40: 124-128. doi: 10.1080/13816810.2019.1586965
  • Humisto, Anu; Jokela, Jouni; Teigen, Knut; Wahlsten, Matti; Permi, Perttu; Sivonen, Kaarina; Herfindal, Lars. 2019. Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. Biochimica et Biophysica Acta - Biomembranes. 1861: 1510-1521. doi: 10.1016/j.bbamem.2019.03.010
  • Kouznetsova, Valentina L.; Hu, Hannah; Teigen, Knut; Zanetti, Maurizio; Tsigelny, Igor F. 2017. Cripto stabilizes GRP78 on the cell membrane. Protein Science. 27: 653-661. doi: 10.1002/pro.3358
  • Leandro, João; Stokka, Anne Jorunn; Teigen, Knut; Andersen, Ole Andreas; Flatmark, Torgeir. 2017. Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation. FEBS Open Bio. 7: 1026-1036. doi: 10.1002/2211-5463.12243
  • Hole, Magnus; Jorge Finnigan, Ana; Underhaug, Jarl; Teigen, Knut; Martinez, Aurora. 2016. Pharmacological chaperones that protect Tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms. Current Drug Targets. 17: 1515-1526. doi: 10.2174/1389450117666160307143512
  • Hole, Magnus; Underhaug, Jarl; Diez, Hector; Ying, Ming; Røhr, Åsmund Kjendseth; Jorge-Finnigan, Ana; Fernàndez-Castillo, Noèlia; Garcia-Cazorla, Àngels; Kristoffer Andersson, K.; Teigen, Knut; Martinez, Aurora. 2016. Erratum: Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms (Biochimica et Biophysica Acta - Proteins and Proteomics (2015) 1854:9 (1078-1089) DOI: 10.1016/j.bbapap.2015.04.030). Biochimica et Biophysica Acta - Proteins and Proteomics. 1864: 317. doi: 10.1016/j.bbapap.2015.11.008
  • Skjevik, Åge Aleksander; Madej, Benjamin D.; Dickson, Callum J.; Lin, Charles; Teigen, Knut; Walker, Ross C.; Gould, Ian R. 2016. Simulation of lipid bilayer self-assembly using all-atom lipid force fields. Physical Chemistry, Chemical Physics - PCCP. 18: 10573-10584. doi: 10.1039/c5cp07379k
  • Hole, Magnus; Underhaug, Jarl; Diez, Hector; Ying, Ming; Røhr, Åsmund Kjendseth; Jorge Finnigan, Ana; Fernàndez-Castillo, Noèlia; García-Cazorla, Angels; Andersson, K. Kristoffer; Teigen, Knut; Martinez, Aurora. 2015. Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms. Biochimica et Biophysica Acta - Proteins and Proteomics. 1854: 1078-1089. doi: 10.1016/j.bbapap.2015.04.030
  • Skjevik, Åge Aleksander; Madej, Benjamin D.; Dickson, Callum J.; Teigen, Knut; Walker, Ross C.; Gould, Ian R. 2015. All-atom lipid bilayer self-assembly with the AMBER and CHARMM lipid force fields. Chemical Communications. 51: 4402-4405. doi: 10.1039/c4cc09584g
  • Winge, Ingeborg; Teigen, Knut; Fossbakk, Agnete; Mahootchi, Elaheh; Kleppe, Rune; Sköldberg, Filip; Kämpe, Olle; Haavik, Jan. 2015. Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. Neurochemistry International. 90: 173-184. doi: 10.1016/j.neuint.2015.08.013
  • Dickson, Callum J.; Madej, Benjamin D.; Skjevik, Åge Aleksander; Betz, Robin M.; Teigen, Knut; Gould, Ian R.; Walker, Ross C. 2014. Lipid14: The amber lipid force field. Journal of Chemical Theory and Computation. 10: 865-879. doi: 10.1021/ct4010307
  • Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Doskeland, Stein Ove. 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLoS ONE. 9. doi: 10.1371/journal.pone.0094926
  • Skjevik, Åge Aleksander; Mileni, Mauro; Baumann, Anne; Halskau, Øyvind; Teigen, Knut; Raymond C., Stevens; Martinez, Aurora. 2014. The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. Journal of Molecular Biology. 426: 150-168. doi: 10.1016/j.jmb.2013.09.012
  • Lindstad, Rune I.; Teigen, Knut; Skjeldal, Lars. 2013. Inhibition of sorbitol dehydrogenase by nucleosides and nucleotides. Biochemical and Biophysical Research Communications - BBRC. 435: 202-208. doi: 10.1016/j.bbrc.2013.04.081
  • Martin, Ianire; Underhaug, Jarl; Celaya, Garbiñe; Moro, Fernando; Teigen, Knut; Martinez, Aurora; Muga, Arturo. 2013. Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. Journal of Medicinal Chemistry. 56: 7177-7189. doi: 10.1021/jm400499k
  • Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Doskeland, Stein Ove; Selheim, Frode; Herfindal, Lars. 2013. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 11: 332-349. Published 2013-01-30. doi: 10.3390/md11020332
  • Madej, Benjamin D.; Skjevik, Age; Teigen, Knut; Walker, Ross C. 2012. AMBER-Lipid 11: A new modular lipid force field for molecular dynamics. Abstract of Papers of the American Chemical Society. 243. 1 pages.
  • Skjevik, Åge Aleksander; Madej, Benjamin D.; Walker, Ross C.; Teigen, Knut. 2012. LIPID11: A modular framework for lipid simulations using amber. Journal of Physical Chemistry B. 116: 11124-11136. doi: 10.1021/jp3059992
  • Walker, Ross C.; Skjevik, Åge Aleksander; Teigen, Knut. 2012. Developing a comprehensive modular phospholipid force field for AMBER. Abstract of Papers of the American Chemical Society. 243. 1 pages.
  • Dao, Khanh Kim; Pey, Angel L.; Gjerde, Anja Underhaug; Teigen, Knut; Byeon, In-Ja L.; Doskeland, Stein Ove; Gronenborn, Angela M.; Martinez, Aurora. 2011. The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLoS ONE. 6. 10 pages. doi: 10.1371/journal.pone.0017602
  • Molnes, Janne; Teigen, Knut; Aukrust, Ingvild; Bjørkhaug, Lise; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus. 2011. Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. The FEBS Journal. 278: 2372-2386. doi: 10.1111/j.1742-4658.2011.08160.x
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2011. Formation of the Iron-Oxo Hydroxylating Species in the Catalytic Cycle of Aromatic Amino Acid Hydroxylases. Chemistry - A European Journal. 17: 3746-3758. doi: 10.1002/chem.201002910
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2011. Substrate Hydroxylation by the Oxido-Iron Intermediate in Aromatic Amino Acid Hydroxylases: A DFT Mechanistic Study. European Journal of Inorganic Chemistry. 17. 2720-2732. doi: 10.1002/ejic.201001218
  • Skjevik, Åge Aleksander; Haug, Bengt Erik; Lygre, Henning; Teigen, Knut. 2011. Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: A molecular dynamics study. Biophysical Chemistry. 154: 18-25. doi: 10.1016/j.bpc.2010.12.002
  • Skjærven, Lars; Grant, Barry; Muga, Arturo; Teigen, Knut; McCammon, Andrew; Reuter, Nathalie; Martinez, Aurora. 2011. Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations. PloS Computational Biology. 7. doi: 10.1371/journal.pcbi.1002004
  • Flydal, Marte Innselset; Mohn, Tonje Cecilie; Pey, Rodroguez Angel Luis; Siltberg-Liberles, Jessica; Teigen, Knut; Martinez, Aurora. 2010. Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications. Amino Acids. 39: 1463-1475. doi: 10.1007/s00726-010-0611-6
  • Olsson, Elaine; Teigen, Knut; Martinez, Aurora; Jensen, Vidar Remi. 2010. The aromatic amino acid hydroxylase mechanism: A perspective from computational chemistry. Advances in Inorganic Chemistry. 62: 437-500. doi: 10.1016/S0898-8838(10)62011-9
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2010. Water dissociation and dioxygen binding in phenylalanine hydroxylase. European Journal of Inorganic Chemistry. 3. 351-356. doi: 10.1002/ejic.200900489
  • Martinez, Aurora; Calvo, Ana C; Teigen, Knut; Pey, Angel. 2009. Rescuing proteins of low kinetic stability by chaperones and natural ligands; phenylketonuria, a case study. Progress in Nucleic Acid Research and Molecular Biology. 83: 89-134. doi: 10.1016/S0079-6603(08)00603-X
  • Siltberg-Liberles, Jessica; Flydal, Marte Innselset; Teigen, Knut; Martinez, Aurora. 2009. Evolution of regulation, structure and function in phenylalanine hydroxylase. Pteridines. 20: 42-50.
  • Skjevik, Åge Aleksander; Teigen, Knut; Martinez, Aurora. 2009. Overview of computational methods employed in early-stage drug discovery. Future Medicinal Chemistry. 1: 49-63. doi: 10.4155/FMC.09.7
  • Hodneland, Erlend; Teigen, Knut. 2007. A simple method to calculate the accessible volume of protein-bound ligands: Application for ligand selectivity. Journal of Molecular Graphics and Modelling. 26: 429-433. doi: 10.1016/j.jmgm.2007.01.011
  • Teigen, Knut; Mckinney, Jeffrey Alan; Haavik, Jan; Martinez, Aurora. 2007. Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Current Medicinal Chemistry. 14: 455-467. doi: 10.2174/092986707779941023
  • Dao, Khanh Kim; Teigen, Knut; Kopperud, Reidun Kristin; Hodneland, Erlend; Schwede, Frank; Mellgren, Anne Elisabeth Christensen; Martinez, Aurora; Doskeland, Stein Ove. 2006. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 281: 21500-21511. doi: doi:10.1074/jbc.M603116200
  • Pey, Angel; Martinez, Aurora; Charubala, Ramamurthy; Maitland, Derek J.; Teigen, Knut; Calvo, Ana; Pfleiderer, Wolfgang; Wood, John M.; Schallreuter, Karin U. 2006. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. The FASEB Journal. 20: 2130-2132. doi: 10.1096/fj.06-5835fje
  • Teigen, Knut; Jensen, Vidar Remi; Martinez, Aurora. 2005. The reaction mechanism of phenylalanine hydroxylase. A question of coordination. Pteridines. 16: 27-34.
  • Miranda, Frederico F.; Thorolfsson, Matthias; Teigen, Knut; Sanchez-Ruiz, Jose Manuel; Martinez, Aurora. 2004. Structural and stability effects of phosphorylation � Localized structural changes in phenylalanine hydroxylase. Protein Science. 13: 1219-1226.
  • Pey, Angel; Thorolfsson, Matthias; Teigen, Knut; Ugarte, Magdalena; Martinez, Aurora. 2004. Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase. Journal of the American Chemical Society. 126: 13670-13678.
  • Teigen, Knut; Dao, Khanh Kim; Mckinney, Jeffrey Alan; Gorren, A.C.F.; Mayer, B.; Frøystein, Nils Åge; Haavik, Jan; Martinez, Aurora. 2004. Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. Journal of Medicinal Chemistry. 47: 5962-5971.
  • Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora. 1999. The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase. Implications for the catalytic mechanism. Journal of Molecular Biology. 294: 807-823.
  • Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora. 1999. The structural Basis of the Recognition of Phenylalanine and Pterine Cofactors by Phenylalanine Hydroxylase. Implications for the Catalytic Mechanism. Journal of Molecular Biology. 294: 807-823.
Reports and theses
  • Teigen, Knut. 2004. Structural and Functional Aspects of Pterin-Binding Enzymes - A Nuclear Magnetic Resonance Spectroscopy and Molecular Modeling Study.
Book sections
  • Skjærven, Lars; Teigen, Knut; Martinez, Aurora. 2014. Structure–Function Relationships in the Aromatic Amino Acid Hydroxylases Enzyme Family: Evolutionary Insights. http://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0025581/abstract. In:
    • Bynum, William F. 2014. eLS. John Wiley & Sons. ISBN: 9780470015902.
  • Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut; Jensen, Vidar Remi. 2010. The aromatic amino acid hydroxylase mechanism: a perspective from computational chemistry. 62, pages 437-500. In:
    • van Eldik, Rudi; Harvey, Jeremy. 2010. Theoretical and Computational Inorganic Chemistry. Elsevier. 500 pages. ISBN: 978-0-12-380874-5.

More information in national current research information system (CRIStin)

Research groups