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Lars A. Akslen's picture

Lars A. Akslen

Professor, Centre Director of CCBIO
  • E-mailLars.Akslen@uib.no
  • Phone+47 55 97 31 82
  • Visitor Address
    Dept. of Pathology, Sentralblokka 2nd floor, Haukeland University Hospital (HUH)
    or CCBIO, Sentralblokka 2nd floor, Haukeland University Hospital (HUH)
  • Postal Address
    Postboks 7804
    5020 Bergen

Akslen is a certified specialist in surgical pathology and is directing the Tumor Biology Research Group (since the establishment in 1995) at Department of Clinical Medicine (University of Bergen). Since 2013, Akslen is the director of Centre for Cancer Biomarkers CCBIO. Akslen´s team, and now CCBIO, are engaged in translational cancer research with a strong focus on  exploration and validation of novel biomarkers for more biologically based classification and grading of malignant tumors, as a better guide for targeted treatment. The group has included projects on various cancers, such as breast cancer, malignant melanoma, prostate cancer, and gynecologic cancers. Studies of human tumor samples are combined with experimental cell and animal models to improve translation. The overall aim is to provide novel biomarkers which can assist in prediction of aggressive tumor behavior and be helpful in tailored treatment.

Academic article
  • Hoem, Dag; Straume, Oddbjørn; Immervoll, Heike ; Akslen, Lars A.; Molven, Anders. 2013. Vascular proliferation is associated with survival in pancreatic ductal adenocarcinoma. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 1037-1046.
  • Ozhand, Ali; Lee, Eunjung; Wu, Anna H.; Ellingjord-Dale, Merete; Akslen, Lars A.; McKean-Cowdin, Roberta; Ursin, Giske. 2013. Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55. PLOS ONE. 8 pages.
  • Arnesen, Thomas; Glomnes, Nina; Strømsøy, Siri S.; Knappskog, Stian; Heie, Anette; Akslen, Lars A.; Grytaas, Marianne Aardal; Varhaug, Jan Erik; Gimm, Oliver; Brauckhoff, Michael. 2013. Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway. Langenbeck's archives of surgery (Print). 869-874.
  • Engstrøm, Monica J; Opdahl, Signe; Hagen, Anne Irene; Romundstad, Pål Richard; Akslen, Lars A.; Haugen, Olav A.; Vatten, Lars Johan; Bofin, Anna M. 2013. Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients. Breast Cancer Research and Treatment. 463-473.
  • Puntervoll, Hanne Eknes; Yang, Xiaohong R.; Vetti, Hildegunn Høberg; Bachmann, Ingeborg M.; Avril, Marie Françoise; Benfodda, Meriem; Catricala, Caterina; Dalle, Stéphane; Duval-Modeste, Anne B.; Ghiorzo, Paola; Grammatico, Paola; Harland, Mark; Hayward, Nicholas K.; Hu, Hui-Han; Jouary, Thomas; Martin-Denavit, Tanguy; Ozola, Aija; Palmer, Jane M.; Pastorino, Lorenza; Pjanova, Dace; Soufir, Nadem; Steine, Solrun; Stratigos, Alexander J.; Thomas, Luc; Tinat, Julie; Tsao, Hensin; Veinalde, Rūta; Tucker, Margaret A.; Bressac-de Paillerets, Brigitte B.D.; Newton-Bishop, Julia A.; Goldstein, Alisa M.; Akslen, Lars A.; Molven, Anders. 2013. Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. Journal of Medical Genetics. 264-U82.
  • Moestue, Siver Andreas; Huuse, Else Marie; Lindholm, Evita Maria; Bofin, Anna M.; Engebråten, Olav; Mælandsmo, Gunhild; Akslen, Lars A.; Gribbestad, Ingrid S. 2013. Low-molecular contrast agent DCE-MRI and DW-MRI in early assessment of bevacizumab treatment in breast cancer xenografts. Journal of Magnetic Resonance Imaging. 1043-1053.
  • Wik, Elisabeth; Ræder, Maria B; Krakstad, Camilla; Trovik, Jone; Birkeland, Even; Høivik, Erling Andre; Mjøs, Siv; Werner, Henrica Maria Johanna; Mannelqvist, Monica; Stefansson, Ingunn Marie; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga Birgitte. 2013. Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clinical Cancer Research. 1094-1105.
  • Ræder, Maria B; Birkeland, Even; Trovik, Jone; Krakstad, Camilla; Shehata, Shyemaa; Schumacher, Steven; Zack, Travis I.; Krohn, Antje; Werner, Henrica Maria Johanna; Moody, Susan E.; Wik, Elisabeth; Stefansson, Ingunn Marie; Holst, Frederik; Øyan, Anne Margrete; Tamayo, Pablo; Mesirov, Jill P.; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Beroukhim, Rameen; Salvesen, Helga Birgitte. 2013. Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. PLOS ONE. 9 pages.
  • Trovik, Jone; Wik, Elisabeth; Werner, Henrica Maria Johanna; Krakstad, Camilla; Helland, Harald; Vandenput, Ingrid; Njølstad, Tormund Salvesen; Stefansson, Ingunn; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Amant, Frédéric; Akslen, Lars A.; Salvesen, Helga Birgitte. 2013. Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial. European Journal of Cancer. 3431-3441.
  • Garcia-Dios, Diego A; Lambrechts, Diether; Coenegrachts, Lieve; Vandenput, Ingrid; Capoen, An; Webb, Penelope M.; Ferguson, Kaltin; Akslen, Lars A.; Claes, Bart; Vergote, Ignace; Moerman, Philippe; Robays, Johan Van; Marcickiewicz, Janusz; Salvesen, Helga Birgitte; Spurdle, Amanda B; Amant, Frédéric. 2013. High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma. Gynecologic Oncology. 327-334.
  • Klingen, Tor Audun; Chen, Ying; Suhrke, Pål; Stefansson, Ingunn Marie; Gundersen, Marian D.; Akslen, Lars A. 2013. Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas. Diagnostic Pathology.
  • Pedersen, Torbjørn Østvik; Blois, Anna; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln. 2013. Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs. Stem Cell Research & Therapy. 10 pages.
  • Haldorsen, Ingfrid S.; Grüner, Renate; Husby, Jenny Hild Aase; Magnussen, Inger Johanne; Werner, Henrica Maria Johanna; Salvesen, Øyvind; Bjørge, Line; Stefansson, Ingunn Marie; Akslen, Lars A.; Trovik, Jone; Taxt, Torfinn; Salvesen, Helga Birgitte. 2013. Dynamic contrast-enhanced MRI in endometrial carcinoma identifies patients at increased risk of recurrence. European Radiology. 2916-2925.
  • Catena, Raúl; Bhattacharya, Nandita; El Rayes, Tina; Wang, Suming; Choi, Hyejin; Gao, Dingcheng; Ryu, Seongho; Joshi, Natasha; Bielenberg, Diane; Lee, Sharrell B.; Haukaas, Svein Andreas; Gravdal, Karsten; Halvorsen, Ole Johan; Akslen, Lars A.; Watnick, Randolph S.; Mittal, Vivek. 2013. Bone marrow-derived Gr1(+) cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1. Cancer Discovery. 578-589.
  • Veinalde, Rūta; Ozola, Aija; Azarjana, Kristine; Molven, Anders; Akslen, Lars A.; Donina, Simona; Proboka, Guna; Cema, Ingrida; Baginskis, Ainars; Pjanova, Dace. 2013. Analysis of Latvian familial melanoma patients shows novel variants in the noncoding regions of CDKN2A and that the CDK4 mutation R24H is a founder mutation. Melanoma research. 221-226.
  • Iles, Mark M.; Law, Matthew H.; Stacey, Simon N.; Han, Jiali; Fang, Shenying; Pfeiffer, Ruth; Harland, Mark; MacGregor, Stuart; Taylor, John C.; Aben, Katja K.; Akslen, Lars A.; Avril, Marie Françoise; Azizi, Esther; Bakker, Bert; Benediktsdottir, Kristun R.; Bergman, Wilma; Scarra, Giovanna Bianchi; Brown, Kevin M.; Calista, Donato; Chaudru, Valerie; Fargnoli, Marie Concetta; Cust, Anne E.; Demenais, Florence; de Waal, Anne C.; Debniak, Tadeusz; Elder, David E.; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Elizabeth M.; Goldstein, Alisa M.; Gruis, Nelleke A.; Hansson, Johan; Helsing, Per; Hočevar, Marko; Höiom, Veronica; Hopper, John L.; Ingvar, Christian; Janssen, Marjolein; Jenkins, Mark A.; Kanetsky, Peter A.; Kiemeney, Lambertus A.; Lang, Julie L.; Lathrop, G. Mark; Leachman, Sancy; Lee, Jeffrey E.; Lubiński, Jan; Mackie, Rona M.; Mann, Graham J.; Martin, Nicholas G.; Mayordomo, Jose Ignacio; Molven, Anders; Mulder, Suzanne; Nagore, Eduardo; Novakovic, Srdjan; Okamoto, Ichiro; Olafsson, Jon H.; Olsson, Håkan; Pehamberger, Hubert; Peris, Ketty; Grasa, Maria Pilar; Planelles, Dolores; Puig, Susana; Puig-Butille, Joan Anton; Randerson-Moor, Juliette; Requena, Celia; Rivoltini, Licia; Rodolfo, Monica; Santinami, Mario; Sigurgeirsson, Bardur; Snowden, Helen; Song, Fengju; Sulem, Patrick; Thorisdottir, Kristin; Tuominen, Rainer; Van Belle, Patricia; van der Stoep, Nienke; van Rossum, Michelle M.; Wei, Qingyi; Wendt, Judith; Zelenika, Diane; Zhang, Mingfeng; Landi, Maria Teresa; Thorleifsson, Gudmar; Bishop, D. Timothy; Amos, Christopher I.; Hayward, Nicholas K.; Stefansson, Kari; Bishop, Julia A. Newton; Barrett, Jennifer H. 2013. A variant in FTO shows association with melanoma risk not due to BMI. Nature Genetics. 428-432.
  • Arnes, Jarle; Stefansson, Ingunn Marie; Straume, Oddbjørn; Baak, Jan P.A.; Lønning, Per Eystein; Foulkes, William D.; Akslen, Lars A. 2012. Vascular proliferation is a prognostic factor in breast cancer. Breast Cancer Research and Treatment. 501-510.
  • Ladstein, Rita Grude; Bachmann, Ingeborg M.; Straume, Oddbjørn; Akslen, Lars A. 2012. Tumor necrosis is a prognostic factor in thick cutaneous melanoma. American Journal of Surgical Pathology. 1477-1482.
  • Straume, Oddbjørn; Shimamura, Takeshi; Lampa, Michael J.G.; Carretero, Julian; Øyan, Anne Margrete; Jia, Di; Borgman, Christa L.; Soucheray, Margaret; Downing, Sean R.; Short, Sarah M.; Kang, Soo-Young; Wang, Suoming; Chen, Liang; Collett, Karin; Bachmann, Ingeborg M.; Wong, Kwok-Kin; Shapiro, Geoffrey I.; Kalland, Karl-Henning; Folkman, Judah; Watnick, Randolph S.; Akslen, Lars A.; Naumov, George N. 2012. Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 8699-8704.
  • Ladstein, Rita Grude; Bachmann, Ingeborg M.; Straume, Oddbjørn; Akslen, Lars A. 2012. Prognostic Importance of the Mitotic Marker Phosphohistone H3 in Cutaneous Nodular Melanoma. Journal of Investigative Dermatology. 1247-1252.
  • Ellingjord-Dale, Merete; Lee, Eunjung; Couto, Elisabeth; Ozhand, Ali; Qureshi, Samera Azeem; Hofvind, Solveig; Van Den Berg, David J; Akslen, Lars A.; Grotmol, Tom; Ursin, Giske. 2012. Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users. Breast Cancer Research.
  • Brauckhoff, Michael; Varhaug, Jan Erik; Hauptmann, Steffen; Akslen, Lars A.; Thanh, P. Nguyen; Viste, Asgaut; Heie, Anette; Dralle, Henning. 2012. Peritoneal carcinosis in apparently benign cortisol producing adrenal adenoma >= 5 cm in diameter: the need of regular postoperative surveillance. Experimental and clinical endocrinology & diabetes. 472-476.
  • Krüger, Kristi; Stefansson, Ingunn Marie; Collett, Karin; Arnes, Jarle; Aas, Turid; Akslen, Lars A. 2012. Microvessel proliferation by co-expression of endothelial nestin and Ki-67 is associated with a basal-like phenotype and aggressive features in breast cancer. Breast. 1-7.
  • Helsing, Per; Nymoen, Dag Andre; Rootwelt, Helge; Vårdal, Mari H; Akslen, Lars A.; Molven, Anders; Andresen, Per Arne. 2012. MC1R, ASIP, TYR, and TYRP1 gene variants in a population-based series of multiple primary melanomas. Genes, Chromosomes and Cancer. 654-661.
  • Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth; Engelsen, Ingeborg Bøe; Werner, Henrica Maria Johanna; Birkeland, Even; Ræder, Maria B; Øyan, Anne Margrete; Stefansson, Ingunn Marie; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga Birgitte. 2012. Loss of GPER identifies new targets for therapy among a subgroup of ER alpha-positive endometrial cancer patients with poor outcome. British Journal of Cancer. 1682-1688.
  • Huuse, Else Marie; Moestue, Siver Andreas; Lindholm, Evita Maria; Bathen, Tone Frost; Nalwoga, Hawa; Krüger, Kristi; Bofin, Anna M.; Mælandsmo, Gunhild; Akslen, Lars A.; Engebråten, Olav; Gribbestad, Ingrid S. 2012. In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts. Journal of Magnetic Resonance Imaging. 1098-1107.
  • Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug. 2012. Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation. BMC Cancer. 10 pages.
  • Lindholm, Evita Maria; Kristian, Alexandr; Nalwoga, Hawa; Kruger, Kristi; Nygård, Ståle; Akslen, Lars A.; Mælandsmo, Gunhild; Engebråten, Olav. 2012. Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts. Molecular Oncology. 418-427.
  • Nygård, Yngve; Haukaas, Svein Andreas; Waage, Jo Erling Riise; Halvorsen, Ole Johan; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian. 2012. Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97 % of significant prostate cancers. Scandinavian Journal of Urology and Nephrology. 211-216.
  • Schuster, Cornelia; Eikesdal, Hans Petter; Puntervoll, Hanne Eknes; Geisler, Jürgen; Geisler, Stephanie; Heinrich, Daniel; Molven, Anders; Lønning, Per Eystein; Akslen, Lars A.; Straume, Oddbjørn. 2012. Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLOS ONE. 8 pages.
  • Nalwoga, Hawa; Arnes, Jarle; Stefansson, Ingunn Marie; Wabinga, Henry; Foulkes, William D.; Akslen, Lars A. 2011. Vascular proliferation is increased in basal-like breast cancer. Breast Cancer Research and Treatment. 1063-1071.
  • Ke, Xisong; Li, Wencheng; Hovland, Randi; Qu, Yi; Liu, Run-hui; McCormack, Emmet Martin; Thorsen, Frits Alan; Olsen, Jan Roger; Molven, Anders; Kogan-Sakin, Ira; Rotter, Varda; Akslen, Lars A.; Øyan, Anne Margrete; Kalland, Karl-Henning. 2011. Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. Experimental Cell Research. 234-247.
  • Myklebust, Line Merethe; Akslen, Lars A.; Varhaug, Jan Erik; Lillehaug, Johan R. 2011. Receptor for Activated Protein C Kinase 1 (RACK1) Is Overexpressed in Papillary Thyroid Carcinoma. Thyroid. 1217-1225.
  • Mauland, Karen Klepsland; Trovik, Jone; Wik, Elisabeth; Ræder, Maria B; Njølstad, Tormund Salvesen; Stefansson, Ingunn Marie; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjørge, Tone; Akslen, Lars A.; Salvesen, Helga Birgitte. 2011. High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer. British Journal of Cancer. 921-926.
  • Akslen, Lars A.; Straume, Oddbjørn; Geisler, Stephanie; Sørlie, Therese; Chi, Jen-Tan Ashley; Aas, Turid; Børresen-Dale, Anne-Lise ; Lønning, Per Eystein. 2011. Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer. British Journal of Cancer. 9-12.
  • Barrett, Jennifer H.; Iles, MM; Harland, M; Taylor, JC; Aitken, JF; Andresen, Per Arne; Akslen, Lars A.; Armstrong, BK; Avril, MF; Azizi, E; Bakker, B; Bergman, W; Bianchi-Scarra, G; Bressac-de Paillerets, B; Calista, D; Cannon-Albright, LA; Corda, E; Cust, AE; Debniak, T; Duffy, D; Dunning, AM; Easton, DF; Friedman, E; Galan, P; Ghiorzo, P; Giles, GG; Hansson, J; Hocevar, M; Hoiom, V; Hopper, JL; Ingvar, C; Janssen, B; Jenkins, MA; Jonsson, G; Kefford, RF; Landi, G; Landi, MT; Lang, J; Lubinski, J; Mackie, R; Malvehy, J; Martin, NG; Molven, Anders; Montgomery, GW; van Nieuwpoort, FA; Novakovic, S; Olsson, H; Pastorino, L; Puig, S; Puig-Butille, JA; Randerson-Moor, J; Snowden, H; Tuominen, R; VanBelle, P; van der Stoep, N; Whiteman, DC; Zelenika, D; Han, JL; Fang, SY; Lee, JE; Wei, QY; Lathrop, GM; Gillanders, EM; Brown, KM; Goldstein, AM; Kanetsky, PA; Mann, GJ; MacGregor, S; Elder, DE; Amos, CI; Hayward, NK; Gruis, NA; Demenais, F; Bishop, JAN; Bishop, D. Timothy. 2011. Genome-wide association study identifies three new melanoma susceptibility loci. Nature Genetics. 1108-U98.
  • Mannelqvist, Monica; Stefansson, Ingunn Marie; Bredholt, Geir; Bø, Trond Hellem; Øyan, Anne Margrete; Jonassen, Inge; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Akslen, Lars A. 2011. Gene Expression Patterns Related to Vascular Invasion and Aggressive Features in Endometrial Cancer. American Journal of Pathology. 861-871.
  • Hegen, Anja; Blois, Anna; Tiron, Crina Elena; Hellesøy, Monica; Micklem, David Robert; Nör, Jacques E; Akslen, Lars A.; Lorens, James. 2011. Efficient in vivo vascularization of tissue-engineering scaffolds. Journal of Tissue Engineering and Regenerative Medicine. E52-E62.
  • Ladstein, Rita Grude; Bachmann, Ingeborg M.; Straume, Oddbjørn; Akslen, Lars A. 2010. Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma. BMC Cancer. 15 pages.
  • Nalwoga, Hawa; Arnes, Jarle; Wabinga, Henry; Akslen, Lars A. 2010. Expression of aldehyde dehydrogenase a (ALDH1) is associated with basal-like markers and features of aggressive tumors in African breast cancer. British Journal of Cancer. 369-375.
  • Gjerdrum, Christine; Tiron, Crina Elena; Høiby, Torill; Stefansson, Ingunn Marie; Haugen, Hallvard; Sandal, Tone; Collett, Karin; Li, Shan; McCormack, Emmet Martin; Gjertsen, Bjørn Tore; Micklem, David Robert; Akslen, Lars A.; Glackin, Carlotta A.; Lorens, James. 2010. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proceedings of the National Academy of Sciences of the United States of America. 1124-1129.
  • Klingen, Tor Audun; Klaasen, Herman; Chen, Ying; Akslen, Lars A. 2009. Secondary breast cancer: a 5-year population-based study with review of the literature. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 762-767.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2009. Proliferation of immature tumor vessels is a novel marker of clinical progression in prostate cancer. Cancer Research. 4708-4715.
  • Bruland, Ove; Fluge, Øystein; Akslen, Lars A.; Eiken, Hans Geir; Lillehaug, Johan R.; Varhaug, Jan Erik; Knappskog, Per Morten. 2009. Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas. BMC Cancer. 425.
  • Fluge, Øystein; Gravdal, K; Carlsen, Erik; Vonen, Barthold; Kjellevold, K; Refsum, S; Lilleng, R; Eide, Tor J.; Halvorsen, TB; Tveit, Kjell Magne; Otte, AP; Akslen, LA; Dahl, O. 2009. Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis. British Journal of Cancer. 1282-1289.
  • Wik, Elisabeth; Trovik, Jone; Iversen, Ole-Erik; Engelsen, Ingeborg Bøe; Stefansson, Ingunn Marie; Vestrheim, LC; Haugland, Hans K.; Akslen, Lars A.; Salvesen, Helga Birgitte. 2009. Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting. American Journal of Obstetrics and Gynecology. 603-607.
  • Lin, Biaoyang; Utleg, Angelita G.; Gravdal, Karsten; White, James T.; Halvorsen, Ole Johan; Lu, Wei; True, Lawrence D.; Vessella, Robert; Lange, Paul H.; Nelson, Peter S.; Hood, Leroy; Kalland, Karl-Henning; Akslen, Lars A. 2008. WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence. Clinical Cancer Research. 1397-1406.
  • Akslen, Lars A.; Puntervoll, Hanne Eknes; Bachmann, Ingeborg M.; Straume, Oddbjørn; Vuhahula, Edda; Kumar, Rajiv; Molven, Anders. 2008. Mutation analysis of the EGFR-NRAS-BRAF pathway in melanomas from black Africans and other subgroups of cutaneous melanoma. Melanoma research. 29-35.
  • Engelsen, Ingeborg Bøe; Mannelqvist, Monica; Stefansson, Ingunn Marie; Carter, Scott L.; Beroukhim, Rameen; Øyan, Anne Margrete; Otte, Ariel P.; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga. 2008. Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma. British Journal of Cancer. 1662-1669.
  • Borkamo, Erling Dahl; Fluge, Øystein; Mella, Olav; Akslen, Lars A.; Bruland, Ove; Dahl, Olav. 2008. Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour. Radiotherapy and Oncology. 435-442.
  • Engelsen, Ingeborg Bøe; Stefansson, Ingunn Marie; Beroukhim, Rameen; Sellers, William R.; Meyerson, Matthew; Akslen, Lars A.; Salvesen, Helga. 2008. HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas. International Journal of Oncology. 307-316.
  • Nalwoga, Hawa; Arnes, Jarle; Wabinga, Henry; Akslen, Lars A. 2008. Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 515-525.
  • Tischkowitz, Marc; Brunet, Jean-Sébastien; Bégin, Louis R.; Huntsman, David G.; Cheang, Maggie C.U. ; Akslen, Lars A.; Nielsen, Torsten O.; Foulkes, William D. 2007. Use of immunohistochemical markers can refine prognosis in triple negative breast cancer. BMC Cancer. 11 pages.
  • Nalwoga, Hawa; Arnes, Jarle; Wabinga, Henry; Akslen, Lars A. 2007. Frequency of the basal-like phenotype in African breast cancer. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 1391-1399.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2007. A Switch from E-Cadherin to N-Cadherin Expression Indicates Epithelial to Mesenchymal Transition and Is of Strong and Independent Importance for the Progress of Prostate Cancer. Clinical Cancer Research. 7003-7011.
  • Engelsen, Ingeborg; Stefansson, Ingunn Marie; Akslen, Lars A.; Salvesen, Helga. 2006. Pathologic expression of p53 or p16 in preoperative curettage specimens identifies high-risk endometrial carcinomas. American Journal of Obstetrics and Gynecology. 979-986.
  • Stefansson, Ingunn Marie; Salvesen, Helga; Akslen, Lars A. 2006. Loss of p63 and cytokeratin 5/6 expression is associated with more aggressive tumors in endometrial carcinoma patients. International Journal of Cancer. 1227-1233.
  • Fluge, Øystein; Bruland, Ove; Akslen, Lars A.; Lillehaug, Johan; Varhaug, Jan Erik. 2006. Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid. 161-175.
  • Collett, Karin; Eide, Geir Egil; Arnes, Jarle; Stefansson, Ingunn Marie; Eide, Johan; Braaten, Audun; Aas, Turid; Otte, Ariel P.; Akslen, Lars A. 2006. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clinical Cancer Research. 1168-1174.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2006. Expression of bFGF/FGFR-1 and vascular proliferation related to clinicopathologic features and tumor progress in localized prostate cancer. Virchows Archiv. 68-74.
  • Engeland, Anders; Tretli, Steinar; Akslen, Lars Andreas; Bjørge, Tone. 2006. Body size and thyroid cancer in two million Norwegian men and women. British Journal of Cancer. 366-370.
  • Straume, Oddbjørn; Akslen, Lars A. 2005. Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma. British Journal of Cancer. 933-938.
  • Bachmann, Ingeborg; Straume, Oddbjørn; Puntervoll, Hanne Eknes; Kalvenes, May Britt; Akslen, Lars A. 2005. Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clinical Cancer Research. 8606-8614.
  • Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Olsen, Sue; Rostad, Kari; Haukaas, Svein Andreas; Bakke, August; Marzolf, Bruz; Dimitrov, Krassen; Stordrange, Laila; Lin, Biaoyang; Jonassen, Inge; Hood, Leroy; Akslen, Lars A.; Kalland, Karl-Henning. 2005. Gene expression profiles in prostate cancer: Association with patient subgroups and tumour differentiation. International Journal of Oncology. 329-336.
  • Sharma, Praveen; Sahni, Narinder S; Tibshirani, Robert; Skaane, Per; Urdal, Petter; Berghagen, Hege; Jensen, Marianne; Moen, Cecilie; Kristiansen, Lena; Sharma, Pradeep; Zaka, Alia; Arnes, Jarle; Sauer, Torill; Akslen, Lars A.; Schlichting, Ellen; Børresen-Dale, Anne-Lise; Lönneborg, Anders. 2005. Early detection of breast cancer based on gene-expression patterns in peripheral blood cells. Breast Cancer Research. 634-644.
  • Foulkes, WD; Brunet, JS; Stefansson, Ingunn Marie; Straume, Oddbjørn; Chappuis, PO; Begin, LR; Hamel, N; Goffin, JR; Wong, N; Trudel, M; Kapusta, L; Porter, P; Akslen, Lars A. 2004. The prognostic implication of the basal-like (cyclin E-high/p27(low)/p53(+)/glomeruloid-microvascular-proliferation(+)) phenotype of BRCA1-related breast cancer. Cancer Research. 830-835.
  • Salvesen, Helga; Stefansson, Ingunn Marie; Kretzschmar, EI; Gruber, P; Macdonald, ND; Ryan, A; Jacobs, IJ; Akslen, Lars A.; Das, S. 2004. Significance of PTEN alterations in endometrial carcinoma: a population-based study of mutations, promoter methylation and PTEN protein expression. International Journal of Oncology. 1615-1623.
  • Stefansson, Ingunn Marie; Salvesen, Helga; Akslen, Lars A. 2004. Prognostic impact of histological grade and vascular invasion compared with tumor cell proliferation in endometrial carcinoma of endometrioid type. Histopathology. 472-479.
  • Stefansson, Ingunn Marie; Salvesen, Helga; Akslen, Lars A. 2004. Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer. Journal of Clinical Oncology. 1242-1252.
  • Macdonald, ND; Salvesen, Helga; Ryan, A; Malatos, S; Stefansson, Ingunn Marie; Iversen, Ole-Erik; Akslen, Lars A.; Das, S; Jacobs, IJ. 2004. Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series. International Journal of Gynecological Cancer. 957-965.
  • Eikesdal, Hans Petter; Straume, Oddbjørn; Akslen, Lars A.; Dahl, Olav. 2004. Karnydanning og tumorkar som mål for kreftterapi. Tidsskrift for Den norske legeforening. 1919-1922.
  • Nielsen, TO; Hsu, FD; Jensen, K; Cheang, M; Karaca, G; Hu, Z; Hernandez-Boussard, T; Livasy, C; Cowan, D; Dressler, L; Akslen, Lars A.; Ragaz, J; Gown, AM; Gilks, CB; Van de Rijn, M; Perou, CM. 2004. Immunohistochemical and Clinical Characterization of the Basal-like Subtype of Invasive Breast Carcinoma. Clinical Cancer Research. 5367-5374.
  • Bachmann, Ingeborg; Straume, Oddbjørn; Akslen, Lars A. 2004. Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas. International Journal of Oncology. 1559-1565.
  • Das, S; MacDonald, N; Ryan, A; Jacobs, IJ; Lynch, ED; Akslen, Lars A.; Salvesen, Helga. 1999. The PTEN gene is methylated in endometrial carcinoma and associated with advanced disease and microsattelite instability. (Abs. no. 207). American Journal of Human Genetics. S. 209.
  • Lønning, Per Eystein; Johnsen, H; Geisler, Stephanie; Aas, T; Smith-Sørensen, B; Akslen, Lars A.; Børresen-Dale, AL. 1999. TP53 as a predictor of response to chemotherpy in breast cancer. RSO Scientific Updates. 73-88.
  • Salvesen, Helga; Akslen, Lars A. 1999. Strong prognostic influence of reduced p16 protein expression in endometrial carcinomas. A large population based study. (Abstract no. 0-079). Virchows Archiv. 185.
  • Salvesen, Helga; Akslen, Lars A. 1999. Significance of tumor associated macrophages. VEGF and TSP-1 expression for tumor angiogenesis and prognosis in endometrial carcinomas. International Journal of Cancer. 539-543.
  • Salvesen, Helga; Akslen, Lars A. 1999. Significance of tumor associated macrophages, VEGF and TSP-1 for angiogenesis and prognosis of endometrial carcinoma. International Journal of Cancer. 538-43.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1999. Prognostic value of tumor angiogenesis, Ki67, p53 and p21 protein expression - a population based endometrial carcinoma study. Journal of Clinical Oncology. 595-99.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1999. Prognostic significance of angiogenesis, Ki-67, p53 and p21 expression - a population-based endometrial carcinoma study. International Journal of Oncology. 395-399.
  • Straume, Oddbjørn; Akslen, Lars A. 1999. Loss of nuclear expression of p16 protein correlates with increased tumor cell proliferation and poor patient outcome in patients with vertical growth phase melanoma. (Abstract no. P-487). Virchows Archiv. 314.
  • Geisler, Stephanie; Lønning, Per Eystein; Aas, T; Johnsen, H; Fluge, Ø; Haugen, Dagny R. Faksvåg; Lillehaug, Johan; Akslen, Lars A.; Børresen-Dale, AL. 1999. Influence of TP53 gene alterations and Her-2 expression on the respons to treatment with doxorubicin in locally advanced breast cancer. (Abs. no. 227). Breast Cancer Research and Treatment.
  • Hove, Leif M; Akslen, Lars A. 1999. Clinicopathological characteristics of melanomas of the hand. Journal of Hand Surgery - British and European Volume. 460-64.
  • Hove, Leif M; Akslen, Lars A. 1999. Clinicopathological characteristics of melanomas of the hand. Journal of Hand Surgery - British and European Volume. 460-64.
  • Straume, Oddbjørn; Salvesen, Helga; Akslen, Lars A. 1999. Angiogenesis is prognostically important in vertical growth phase melanomas. International Journal of Oncology. 595-599.
  • Frich, L; Akslen, Lars A.; Glattre, E. 1998. Økt forekomst av kreft i skjoldkjertelen blant norske kvinner gift med fiskere. Tidsskrift for Den norske legeforening. 4202-4205.
  • Akslen, Lars A.; Sothern, RB. 1998. Seasonal variations in the presentation and growth of thyroid cancer. British Journal of Cancer. 1174-1179.
  • Heuch, Jane M.; Heuch, Ivar; Akslen, Lars A.; Kvåle, Gunnar. 1998. Risk of primary childhood brain tumors related to birth characteristics: a Norwegian prospective study. International Journal of Cancer. 498-503.
  • Heuch, Jane M.; Heuch, Ivar; Akslen, Lars A.; Kvåle, Gunnar. 1998. Risk of primary childhood brain tumors related to birth characteristics: a Norwegian prospective study. International Journal of Cancer. 498-503.
  • Heuch, Jane M.; Heuch, Ivar; Akslen, Lars A.; Kvåle, Gunnar. 1998. Risk of primary childhood brain tumors related to birth characteristics: a Norwegian prospective study. International Journal of Cancer. 498-503.
  • Heuch, Jane M.; Heuch, Ivar; Akslen, Lars A.; Kvåle, Gunnar. 1998. Risk of primary childhood brain tumors related to birth characteristics: a Norwegian prospective study. International Journal of Cancer. 498-503.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1998. Prognostic impact of morphometric nuclear grade of endometrial carcinoma. Cancer. 956-964.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1998. Prognostic impact of morphometric nuclear grade in endometrial carcinoma. Cancer. 956-964.
  • Salvesen, Helga; Akslen, Lars A.; Albrektsen, Grethe; Iversen, Ole-Erik. 1998. Poorer survival of nulliparous women with endometrial carcinoma. Cancer. 1328-1333.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1998. Independent prognostic importance of microvessel density in endometrial carcinoma. British Journal of Cancer. 1140-1144.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1998. Identification of high-risk patients by assessment of nuclear Ki67 expression in a prosepective study of endometrial carcinoma patients. Clinical Cancer Research. 2779-2785.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1998. Identification of high-risk patients by assessment of nuclear Ki-67 expression in a prospective study of endometrial carcinomas. Clinical Cancer Research. 2779-2785.
  • Akslen, Lars A.; Monstad, S. E.; Larsen, B.; Straume, O.; Øgreid, D. 1998. Frequent mutations of the p53 gene in cutaneous melanoma of the nodular type. International Journal of Cancer. 91-95.
  • Akslen, Lars A.; Monstad, SE; Larsen, B; Straume, O; Øgreid, D. 1998. Frequent mutations of the p53 gene in cutaneous melanoma of the nodular type. International Journal of Cancer. 91-95.
  • Faksvåg Haugen, D.R.; Varhaug, J.E.; Akslen, Lars A.; Lillehaug, J.R. 1998. Diagnostisk molekylærbiologi ved solide svulster: Thyreoideacancer. Tidsskrift for Den norske legeforening. 2199-2203.
  • Haugen, Dagny R. Faksvåg; Varhaug, Jan Erik; Akslen, Lars A.; Lillehaug, Johan. 1998. Diagnostisk molekylærbiologi ved solide svulster - thyreoidea. Tidsskrift for Den norske legeforening. 2199-2203.
  • Salvesen, Helga; Akslen, Lars A.; Albrektsen, Grethe; Iversen, Ole-Erik. 1998. Decreased survival for nulliparous women with endometrial carcinoma. Is the relationship due to biology or behaviour? Cancer. 1328-1333.
  • Salvesen, Helga; Akslen, Lars A.; Iversen, Torbjørn; Iversen, Ole-Erik. 1997. Recurrent endometrial carcinoma and the value of routine follow-up. British Journal of Obstetrics and Gynaecology. 1302-1307.
  • Paulsen, Trond H; Aas, Turid; Børresen, A-L; Varhaug, Jan Erik; Lønning, Per Eystein; Akslen, Lars A. 1997. Angiogenesis does not predict clinical response to doxorubicin monotherapy in patients with locally advanced breast cancer. International Journal of Cancer. 138-140.
  • Aas, Turid; Geisler, Stephanie; Paulsen, Trond H; Børresen, Anne-Lise; Varhaug, Jan Erik; Lønning, Per Eystein; Akslen, Lars A. 1996. Primary systemic treatment with weekly doxorubicin monotherapy in women with locally advanced breast cancer; Clinical experience and parameters predicting outcome. Acta Oncologica. 5-8.
  • Straume, O; Akslen, Lars A. 1996. Independent prognostic importance of vascular invasion in nodular melanomas. Cancer. 1211-1219.
  • Ness, GO; Bjerkvig, Rolf; Akslen, Lars A.; Lillehaug, JR; Varhaug, Jan Erik. 1995. Primary organ culture of non-neoplastic and neoplastic thyroid tissue multicellular spheroids. International Journal of Oncology. 1071-1078.
  • Ness, GO; Bjerkvig, Rolf; Akslen, Lars A.; Lillehaug, JR; Varhaug, Jan Erik. 1995. Primary organ culture of non-neoplastic and neoplastic thyroid tissue as multicellular spheroids. International Journal of Oncology. 1071-1078.
  • Ness, GO; Bjerkvig, Rolf; Akslen, Lars A.; Lillehaug, JR; Varhaug, Jan Erik. 1995. Primary organ culture of non-neoplastic and neoplastic thyroid tissue as multicellular spheroids. International Journal of Oncology. 1071-1078.
  • Akslen, Lars A.; Varhaug, Jan Erik. 1995. Oncoproteins and tumor progression in papillary thyroid carcinoma. Presence of epidermal growth factor receptor (EGF-R), c-erbB-2 protein, estrogen receptor related protein (p29), p21-ras protein and proliferation indicators in relation to tumor recurrences and patients survival. Cancer. 1643-1654.
  • Akslen, Lars A.; Varhaug, Jan Erik. 1995. Oncoproteins and tumor progression in papillary thyroid carcinoma. Presence of epidermal growth factor receptor (EGF-R), c-erbB-2 protein, estrogen receptor related protein (29), p21-ras protein and proliferation indicators in relation to tumor recurrences and patient survival. Cancer. 1643-1654.
  • Høstmark, J; Aas, T; Akslen, Lars A.; Varhaug, Jan Erik. 1995. Lack of diagnostic value of DNA content and p53 immunostaining in normal, hyperplastic and neoplastic parathyroid tissue. Oncology Reports. 69-72.
  • Akslen, Lars A. 1995. Histopatologiens betydning for vurdering av kreftforekomst og kreftårsaker. Tidsskrift for Den norske legeforening. 943-946.
  • Kitinya, JN; Mbonde, MP; Guther, HJ; Akslen, Lars A. 1994. Ploidy and proliferative rates in carcinomas of the breast in Tanzania. East African Medical Journal. 195-198.
  • Akslen, Lars A. 1994. Kreft i skjoldbruskkjertelen - økning i yngre årskull. Kreftnytt. 4-6.
  • Akslen, Lars A.; Varhaug, Jan Erik; Aas, T; Andersen, Knut-Jan. 1994. Increase of endo-and exo-peptidases in thyroid tumors. Oncol Rep. 953-956.
  • Akslen, Lars A.; Varhaug, Jan Erik; Aas, T; Andersen, KJ. 1994. Increase of endo- and exo-peptidases in thyroid tumors. Oncol Rep. 953-956.
  • Akslen, Lars A.; Myking, Andreas O; Salvesen, Helga; Varhaug, Jan Erik. 1993. Prognostic importance of various clinicopathological features in papillary thyroid carcinoma. European Journal of Cancer. 44-51.
  • Akslen, Lars A. 1993. Prognostic importance of histologic grading in papillary thyroid carcinoma. Cancer. 2680-2685.
  • Akslen, Lars A.; Myking, Andreas O; Salvesen, Helga; Varhaug, Jan Erik. 1993. Prognostic impact of EGF-receptor in papillary thyroid carcinoma. British Journal of Cancer. 808-812.
  • Akslen, Lars A.; Myking, Andreas O; Salvesen, Helga; Varhaug, Jan Erik. 1993. Prognostic impact of EGF-receptor in papillary thyroid carcinoma. British Journal of Cancer. 808-812.
  • Akslen, Lars A.; Haldorsen, T.; Thoresen, Steinar Østerbø; Glattre, E. 1993. Incidence pattern of thyroid cancer in Norway: influence of birth cohort and time period. International Journal of Cancer. 183-187.
  • Salvesen, Helga; Njølstad, Pål Rasmus; Akslen, Lars A.; Albrektsen, Grethe; Viste, Asgaut; Søreide, Odd; Varhaug, Jan Erik. 1992. Thyroid carcinoma. Results from surgical treatment in 211 consecutive patients. European Journal of Surgery. 521-526.
  • Akslen, Lars A.; Glattre, E. 1992. Second malignancies in thyroid cancer patients: a population-based survey of 3658 cases from Norway. European Journal of Cancer. 491-495.
  • Akslen, Lars A.; Mørkve, Odd. 1992. Expression of p53 protein in cutaneous melanoma. International Journal of Cancer. 13-16.
  • Haugen, Dagny R. Faksvåg; Akslen, Lars A.; Varhaug, Jan Erik; Lillehaug, Johan. 1992. Expression of c-erbB-2 protein in papillary thyroid carcinomas. British Journal of Cancer. 832-837.
  • Salvesen, Helga; Njølstad, Pål Rasmus; Akslen, Lars A.; Albrektsen, Grethe; Søreide, Odd; Varhaug, Jan Erik. 1992. Disease free and cause specific survival in patients with papillary thyroid carcinoma. A multifactorial analysis. European Journal of Surgery. 583-589.
  • Akslen, Lars A.; Myking, Andreas O. 1992. Differentiated thyroid carcinomas: the relevance of various pathological features for tumour classification and prediction of tumour progress. Virchows Archiv. A, Pathological anatomy and histopathology. 17-23.
  • Salvesen, Helga; Njølstad, Pål Rasmus; Akslen, Lars A.; Abreksten, Grethe; Viste, Asgaut; Søreide, Odd; Varhaug, Jan Erik. 1991. Thyroid carcinoma: Results from surgical treatment in 211consecutive patients. European Journal of Surgery. 521-526.
  • Akslen, Lars A.; Haldorsen, T.; Thoresen, Steinar Østerbø; Glattre, E. 1991. Survival and cause of death in thyroid cancer: A population-based study of 2479 cases from Norway. Cancer Research. 1234-1241.
  • Glattre, E.; Høstmark, A.; Thoresen, Steinar Østerbø; Smith, A. J.; Akslen, Lars A. 1990. Provocation of thyroid neoplasms in female Wistar rats fed n-3 or n-6 fatty acids in the feed. Thyroidology. 1-3.
  • Rotevatn, Svein; Akslen, Lars A.; Bjerke, Elisabeth. 1989. Lifestyle and mortality among Norwegian men. Preventive Medicine. 433-443.
  • Rotevatn, S.; Akslen, Lars A.; Bjelke, Erik. 1988. Life-style and caridovascular mortality among Norwegian men (Abstract). Circulation. 479.
Academic lecture
  • Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe. 2016. Molecular subtypes of breast cancer: long-term incidence trends and prognostic differences.
  • Valla, Marit; Engstrøm, Monica J; Ytterhus, Borgny; Hansen, Åse Kristin Skain; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. 2016. FGD5 amplification in breast cancer patients is associated with tumour proliferation and a poorer prognosis.
  • Engstrøm, Monica J; Opdahl, Signe; Hagen, Anne Irene; Romundstad, Pål Richard; Akslen, Lars A.; Haugen, Olav A.; Vatten, Lars Johan; Bofin, Anna M. 2013. Molekylære subtyper og overlevelse ved brystkreft.
  • Engstrøm, Monica J; Opdahl, Signe; Hansen, Åse Kristin Skain; Romundstad, Pål Richard; Vatten, Lars Johan; Akslen, Lars A.; Hagen, Anne Irene; Haugen, Olav Anton; Bofin, Anna M. 2013. Molekylære subtyper og overlevelse ved brystkreft.
  • Biermann, Martin; Johnsen, Boel; Naum, Alexandru Gratian; Haugland, Hans Kristian; Akslen, Lars A.; Varhaug, Jan Erik; Brauckhoff, Michael. 2012. Multimodal imaging for suspected recurrent differentiated thyroid cancer (DTC): FDG-PET-CT, I-131-SPECT-CT, ultrasound (US) and US-guided fine needle biopsy (FNB).
  • Biermann, Martin; Johnsen, Boel; Naum, Alexandru Gratian; Akslen, Lars A.; Varhaug, Jan Erik; Brauckhoff, Michael. 2011. Multimodal imaging for diagnosis and treatment of recurrent differentiated thyroid cancer (DTC)FDG-PET-CT, contrast-enhanced CT (CE-CT), I-131-SPECT-CT, ultrasound (US) and US-guided fine needle biopsy (FNB).
  • Huuse, Else Marie; Moestue, Siver Andreas; Bathen, Tone Frost; Bofin, Anna M.; Mælandsmo, Gunhild; Akslen, Lars A.; Engebråten, Olav; Gribbestad, Ingrid S. 2011. In vivo Dynamic Contrast Enhanced MRI & Histopathological Assessment of Tumor Angiogenesis in Luminal-like and Basal-like Breast Cancer Xenografts.
  • Biermann, Martin; Johnsen, Boel; Naum, Alexandru Gratian; Akslen, Lars A.; Varhaug, Jan Erik; Brauckhoff, Michael. 2011. FDG-PET-CT, I-131-SPECT-CT, ultrasound (US) and US-guided fine needle biopsy (FNB) for recurrent differentiated thyroid cancer (DTC).
  • Moestue, Siver Andreas; Huuse, Else Marie; Lindholm, Evita Maria; Akslen, Lars A.; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S. 2011. Early vascular response to bevacizumab treatment measured by DCE-MRI in breast cancer xenografts.
  • Moestue, Siver Andreas; Huuse, Else Marie; Lindholm, Evita Maria; Engebråten, Olav; Akslen, Lars A.; Mælandsmo, Gunhild; Gribbestad, Ingrid S. 2011. DCE-MRI for early therapy monitoring of anti-angiogenic therapy.
  • Nygård, Yngve; Waage, Jo Erling Riise; Halvorsen, Ole Johan; Gravdal, Karsten; Akslen, Lars A.; Frugård, Jannicke; Haukaas, Svein Andreas; Beisland, Christian. 2010. Real time elastografi ved cancer prostatae.
  • Nygård, Yngve; Halvorsen, Ole Johan; Gravdal, Karsten; Akslen, Lars A.; Frugård, Jannicke; Haukaas, Svein Andreas; Beisland, Christian. 2010. Preliminære resultater av PCA3 måling i urin hos pasienter med cancer prostatae.
  • Biermann, Martin; Johnsen, Boel; Naum, Alexandru Gratian; Akslen, Lars A.; Varhaug, Jan Erik; Brauckhoff, Michael. 2010. Multimodal imaging of differentiated thyroid cancer: FDG-PET-CT, I-131-SPECT-CT and ultrasound.
  • Huuse, Else Marie; Moestue, Siver Andreas; Lindholm, Evita; Bathen, Tone Frost; Nalvoga, Hawa; Bofin, Anna M.; Mælandsmo, Gunhild; Akslen, Lars A.; Engebraaten, Olav; Gribbestad, Ingrid S. 2010. In vivo magnetic resonance imaging and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts.
  • Reisæter, Lars Anders; Nygård, Yngve; Halvorsen, Ole Johan; Gravdal, Karsten; Rawal, Ravi; Akslen, Lars A.; Haukaas, Svein Andreas; Rørvik, Jarle; Beisland, Christian. 2010. Er preoperativ MR-prostata nyttig for å avklare korrekt T-stadium forut for kirurgi?
  • Reisæter, Lars Anders; Wold, Tor; Haukaas, Svein Andreas; Rørvik, Jarle; Halvorsen, Ole Johan; Akslen, Lars A.; Beisland, Christian. 2010. Er MR-prostata nyttig for å avklare videre oppfølgningsbehov hos pasienter med 2 eller flere negative biopsiserier?
  • Ke, Xisong; Qu, Yi; Rostad, Kari; Li, Wencheng; Lin, Biaoyang; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Jonassen, Inge; Petersen, Kjell; Goldfinger, Naomi; Rotter, Varder; Akslen, Lars A.; Øyan, Anne Margrete; Kalland, Karl-Henning. 2009. Genome-wide profiling of histone H3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis.
  • Ke, Xisong; Li, Wencheng; Qu, Yi; Hovland, Randi; Rostad, Kari; Thorsen, Frits Alan; Akslen, Lars A.; Øyan, Anne Margrete; Kalland, Karl-Henning. 2009. EMT Promotes Malignant Transformation of Prostate Epithelial Cells in Culture.
  • Ke, Xisong; Qu, Yi; Rostad, Kari; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Goldfinger, Naomi; Rotter, Varda; Akslen, Lars A.; Øyan, Anne Margrete; Kalland, Karl-Henning. 2008. Polycomb group target genes and bivalent H3K4 & K27me3 modifications in human embryonic cells were enriched among dysregulated genes in prostate cancer.
  • Ke, Xisong; Qu, Yi; Rostad, Kari; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A.; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning. 2008. Epithelial to mesenchymal transition of a primary, immortalized prostate cell line is associated with gene expression switches of entire cell attachment modules.
  • Ke, Xisong; Øyan, Anne Margrete; Rostad, Kari; Mannelqvist, Monica; Halvorsen, Ole Johan; Bø, Trond Hellem; Olsen, Sue; Haukaas, Svein Andreas; Jonassen, Inge; Akslen, Lars A.; Kalland, Karl-Henning. 2007. Functional oncogenomics and epigenomics analysis of prostate cancer.
  • Rostad, Kari; Schlomm, Thorsten; Haukaas, Svein Andreas; Halvorsen, Ole Johan; Øyan, Anne Margrete; Ke, Xisong; Olsen, Sue; Hellwinkel, Olaf JC; Akslen, Lars A.; Kalland, Karl-Henning. 2007. Detection of TMPRSS2:ERG translocations in the urine of prostate cancer patients and identification of ERG target genes.
  • Kalland, Karl-Henning; Rostad, Kari; Mannelqvist, Monica; Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Olsen, Sue; Haukaas, Svein Andreas; Lin, Biaoyang; Hood, Leroy; Jonassen, Inge; Akslen, Lars A. 2006. Global gene expression analysis of transcription factors in prostate cancer and cell lines.
  • Rostad, Kari; Mannelqvist, Monica; Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Olsen, Sue; Haukaas, Svein Andreas; Hood, Leroy; Jonassen, Inge; Akslen, Lars A.; Kalland, Karl-Henning. 2006. ERG upregulation and related transcription factors in prostate cancer.
  • Kalland, Karl-Henning; Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Rostad, Kari; Olsen, Sue; Haukaas, Svein Andreas; Bakke, August; Marzolf, Bruz; Dimitrov, Krassen; Lin, Biaoyang; Hood, Leroy; Akslen, Lars A. 2004. Gene expression profiling in prostate cancer refined by pairwise comparisons of cDNA microarrays from benign and malignant tissue.
  • Halvorsen, Ole Johan; Rostad, Kari; Øyan, Anne Margrete; Bø, Trond Hellem; Stordrange, Laila; Lin, Biaoyang; Hood, Leroy; Olsen, Sue; Haukaas, Svein Andreas; Jonassen, Inge; Kalland, Karl-Henning; Akslen, Lars A. 2004. Gene expression profiles in prostate cancer: identification of upregulated SIM2 gene validated in archival tissue, relation to histological grading and prognosis.
  • Molven, Anders; Immervold, H; Kugarajh, K; Steine, Solrun; Hoem, Dag; Straume, Oddbjørn; Akslen, Lars A. 2003. Mutation analysis of the RAS-RAF pathway in pancreatic adenocarcinomas and malignant melanomas.
  • Kalland, Karl-Henning; Halvorsen, Ole J.; Øyan, Anne Margrete; Bø, Trond Hellem; Olsen, Sue; Rostad, Kari; Haukaas, Sven; Bakke, August; Marzolf, Bruz; Dimitrov, Krassen; Lin, Biaoyang; Jonasen, Inge; Akslen, Lars A.; Hood, Leroy. 2003. Global analysis of gene expression and regulatory patterns in urogenital tumours using DNA microarrays.
  • Kalland, Karl-Henning; Øyan, Anne Margrete; Akslen, Lars A.; Halvorsen, Ole Johan; Bakke, August; Haukaas, Svein Andreas; Bruserud, Øystein; Gjertsen, Bjørn Tore; Ulvestad, Elling; Hellem Bø, Trond; Jonassen, Inge; Hood, Leroy; Lin, Biaoyang; Dimitrov, Krassen; Marzolf, Bruz. 2003. Global analysis of gene expression and regulatory patterns in cancer.
  • Halvorsen, Ole Johan; Øyan, Anne Margrete; Hellem Bø, Trond; Olsen, Sue; Rostad, Kari; Haukaas, Svein Andreas; Bakke, August M; Marzolf, Bruz; Dimitrov, Krassen; Lin, Biaoyang; Hood, Leroy; Jonassen, Inge; Akslen, Lars A.; Kalland, Karl-Henning. 2003. Gene expression profiling in prostate cancer: cluster analysis and association with tumor differentation.
  • Halvorsen, Ole J.; Øyan, A M; Bø, TH; Olsen, S; Rostad, K; Haukaas, Sven; Bakke, August; Marzolf, B; Dimitrov, K; Lin, B; Jonassen, Inge; Hood, L; Akslen, Lars A.; Kalland, Karl-Henning. 2003. Gene expression profiling in prostate cancer: Cluster analysis and association with tumor differentiation.
  • Halvorsen, Ole J.; Øyan, Anne Margrete; Bø, Trond Hellem; Olsen, Sue; Rostad, Kari; Haukaas, Sven; Bakke, August; Marzolf, Bruz; Dimitrov, Krassen; Lin, Biaoyang; Jonasen, Inge; Hood, Leroy; Akslen, Lars A.; Kalland, Karl-Henning. 2003. Gene expression profiling in prostate cancer.
  • Kalland, Karl-Henning; Akslen, Lars A.; Halvorsen, Ole J.; Øyan, A M; Bakke, August; Haukaas, Sven; Bruserud, Øystein; Gjertsen, BT; Ulvestad, Elling; Bø, TH; Jonassen, Inge; Hood, L; Lin, B; Dimitrov, K; Marzolf, B. 2003. DNA microarray studies of human cancer - pitfalls and outlook.
  • Olsen, Sue; Bø, Trond Hellem; Rostad, Kari; Halvorsen, Ole J.; Øyan, Anne Margrete; Haukaas, Sven; Bakke, August; Marzolf, Bruz; Dimitrov, Krassen; Lin, Biaoyang; Hood, Leroy; Jonasen, Inge; Akslen, Lars A.; Kalland, Karl-Henning. 2003. Comparison of DNA microarray and real time quantitative PCR for quantitation of gene expression of selected genes in prostate cancer.
  • Opsahl, EM; Aas, Turid; Paulsen, Trond Harder; Anker, G; Akslen, Lars A.; Eide, J; Varhaug, Jan Erik. 2002. Cancer mammae behandlet med brystbevarende kirurgi ved Haukeland sykehus 1984-1995.
  • Halvorsen, Ole J.; Haukaas, Sven; Høisæter, Per Åge; Akslen, Lars A. 2001. Prognostisk betydning av angiogenese (microvessel density - MVD) og proliferasjonsmarkøren Ki-67 ved lokalisert prostatacencer.
  • Halvorsen, OJ; Haukaas, Svein Andreas; Høisæter, PÅ; Akslen, Lars A. 1999. Prognostic importance of microvessel density (MVD) in clinically localized prostate cancer.
  • Halvorsen, OJ; Haukaas, Svein Andreas; Høisæter, PÅ; Akslen, Lars A. 1998. Prognostic importance of microvessel density (MVD) in clinically localized prostate cancer.
  • Varhaug, Jan Erik; Boman, Helge; Akslen, Lars A. 1998. Profylaktisk thyroidectomi hos barn - initial erfaring.
  • Hove, LM; Akslen, Lars A. 1998. Malignt melanom på hender.
  • Hove, LM; Akslen, Lars A. 1998. Malignant melanoma of the hand. A 25-year clinico-pathological study.
  • Salvesen, Helga; Iversen, Ole-Erik; Akslen, Lars A. 1997. Independent prognostic importance of microvessel density in endometrial carcinoma. [poster].
  • Rotevatn, S.; Akslen, Lars A.; Bjelke, Erik. 1989. Mortality form ischemic heart disease related to life-style differences among Norwegian men (Abstract).
Academic anthology/Conference proceedings
  • Akslen, Lars A.; Watnick, Randolph S. 2017. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Springer.
Abstract
  • Knutsvik, Gøril; Stefansson, Ingunn Marie; Collett, Karin; Akslen, Lars A. 2013. Proliferation markers PHH3, Ki67 and mitotic count all show significant associations with features of aggressive breast carcinomas and reduced survival. Modern Pathology. 50A-50A.
  • Knutsvik, Gøril; Stefansson, Ingunn Marie; Collett, Karin; Akslen, Lars A. 2013. Proliferation markers PHH3, Ki67 and Mimtotic count all show significant associations with features of aggressive breast carcinomas and reduced survival. Laboratory Investigation. 50A-50A.
  • Tangen, Ingvild Løberg; Krakstad, Camilla; Werner, Henrica Maria Johanna; Øyan, Anne Margrete; Kusonmano, Kanthida; Gilfillan, Siv ; Kalland, Karl-Henning; Akslen, Lars A.; Trovik, Jone; Hurtado, A; Salvesen, Helga Birgitte. 2013. FOXA1 LOSS IN ENDOMETRIAL CANCER IS ASSOCIATED WITH POOR PROGNOSIS AND ER ALPHA LOSS. International Journal of Gynecological Cancer. 1 pages.
  • Knutsvik, Gøril; Stefansson, Ingunn Marie; Collett, Karin; Akslen, Lars A. 2012. Prognostic impact of proliferation markers Ki-67, PHH3 and mitotic count in breast carcinomas. Virchows Archiv. S5-S5.
  • Moestue, Siver Andreas; Flatabø, Silje; Huuse, Else Marie; Lindholm, Evita Maria; Engebraaten, Olav; Maelandsmo, Gunnhild M; Akslen, Lars A.; Gribbestad, Ingrid S. 2012. Metabolic Responses to VEGF Inhibition in Patient-derived Breast Cancer Xenografts. European Journal of Cancer. S32-S32.
  • Nalwoga, Hawa; Arnes, Jarle; Wabinga, H; Akslen, Lars A. 2012. Expression of hypoxia-inducible factor-1a and associations with vascular endothelial growth factor expression, high microvessel density and features of aggressive tumors in African breast cancer. Virchows Archiv. S249-S249.
  • Wik, Elisabeth; Rader, Maria; Krakstad, Camilla; Trovik, Jone; Erling, Hoivik; Mjøs, Siv; Stefansson, Ingunn Marie; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga. 2012. Estrogen receptor a loss in endometrial carcinoma is associated with epithelial-to-mesenchymal transition and a potential for PI3Kinase inhibition. Virchows Archiv. S18-S18.
  • Tiron, Crina Elena; Gjerdrum, Christine; Høiby, Torill; Maugen, Hallvard; Stefansson, Ingunn Marie; Sandal, Tone; Collett, Karin; Li, Shan; McCormack, Emmet Martin; Gjertsen, Bjørn Tore; Micklem, David Robert; Akslen, Lars A.; Glackin, Carlotta A.; Lorens, James. 2011. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Clinical and Experimental Metastasis. 234-235.
  • Stefansson, Ingunn Marie; Mannelquist, M; Salvesen, HB; Akslen, Lars A. 2010. Prognostic importance of vascular proliferation and tumor cell invasion in blood and lymphatic vessels in endometrial carcinoma. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 248-248.
  • Biermann, Martin; Johnsen, Boel; Naum, Alexandru Gratian; Akslen, Lars A.; Varhaug, Jan Erik; Brauckhoff, Michael. 2010. Multimodal imaging of differentiated thyroid cancer: FDG-PET-CT, I-131-SPECT-CT and ultrasound [Abstract]. European Journal of Nuclear Medicine and Molecular Imaging. S291-S291.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2009. Proliferation of immature tumor vessels is a novel marker of clinical progress in prostate cancer. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 233-233.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2008. Vascular proliferation by Nestin/Ki-67 is a novel predictor of the clinical progress of prostate cancer. Histopathology. 276-277.
  • Arnes, Jarle; Foulkes, William D.; Akslen, Lars A. 2008. Candidate stem cell marker ALDH1 expression and relationship with BRCA-mutations and basal-like differentiation in breast carcinoma. Histopathology. 25-25.
  • Bachmann, Ingeborg M.; Eknes, HE; Otte, Ariel P.; Akslen, Lars A. 2007. Loss of BMI-1 expression is associated with the clinical progress of malignant melanoma. Virchows Archiv. 452-452.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2007. Epithelial to mesenchymal transition is of strong prognostic importance in prostate cancer. Virchows Archiv. 344-344.
  • Nalwoga, H; Arnes, Jarle; Wabinga, H; Akslen, Lars A. 2007. Basal-like phenotype is frequent in invasive breast carcinoma from Ugandan Africans and is strongly associated with a high expression of EGFR/c-Kit and features of aggressive tumors. Virchows Archiv. 137-137.
  • Kalland, Karl-Henning; Rostad, Kari; Mannelqvist, Monica; Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Olsen, Sue; Haukaas, Svein Andreas; Lin, Biaoyang; Hood, Leroy; Jonassen, Inge; Akslen, Lars A. 2006. Global gene expression analysis of transcription factors in prostate cancer and cell lines. International Journal of Molecular Medicine. S27.
  • Rostad, Kari; Mannelqvist, Monica; Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Ulvestad, Elling; Olsen, Sue; Haukaas, Svein Andreas; Hood, Leroy; Jonassen, Inge; Akslen, Lars A.; Kalland, Karl-Henning. 2006. ERG upregulation in relation to other transcription factors in prostate cancer. NBS-nytt. 72.
  • Halvorsen, Ole Johan; Rostad, Kari; Øyan, Anne Margrete; Bø, Trond Hellem; Stordrange, Laila; Olsen, Sue; Haukaas, Svein Andreas; Hood, Leroy; Jonassen, Inge; Kalland, Karl-Henning; Akslen, Lars A. 2005. Single-minded 2 homolog gene is overexpressed in prostate cancer. Virchows Archiv. 432-432.
  • Kalland, Karl-Henning; Halvorsen, Ole Johan; Rostad, Kari; Mannelqvist, Monica; Øyan, Anne Margrete; Bø, Trond Hellem; Stordrange, Laila; Olsen, Sue; Haukaas, Svein Andreas; Hood, Leroy; Jonassen, Inge; Akslen, Lars A. 2005. Overexpression of ERG and SIM2 transcription factors in prostate cancer. International Journal of Molecular Medicine. S76-S76.
Academic literature review
  • Geisler, Jürgen; Bachmann, Ingeborg M.; Nyakas, Marta Sølvi; Helsing, Per; Fjøsne, Hans E.; Mæhle, Lovise Olaug; Aamdal, Steinar; Eide, Nils; Svendsen, Henrik Løvendahl; Straume, Oddbjørn; Robsahm, Trude Eid; Dolven-Jacobsen, Kari ; Akslen, Lars A. 2013. Malignt melanom – diagnostikk, behandling og oppfølging i Norge. 2154-2159.
  • Engelsen, Ingeborg Bøe; Akslen, Lars A.; Salvesen, Helga Birgitte. 2009. Biologic markers in endometrial cancer treatment. 693-707.
  • Naumov, George N.; Folkman, Judah; Straume, Oddbjørn; Akslen, Lars A. 2008. Tumor-vascular interactions and tumor dormancy. 569-585.

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