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Lars Heggelund

Associate Professor
  • E-mailLars.Heggelund@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Siljan, William Ward; Holter, Jan Cato; Michelsen, Annika; Nymo, Ståle Haugset; Lauritzen, Trine; Oppen, Kjersti; Husebye, Einar; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars. 2019. Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort study. ERS Monograph. 10 pages.
  • Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Skattum, Lillemor; Bosnes, Vidar; Garred, Peter; Frøland, Stig Sophus; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars. 2018. Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia. Open Forum Infectious Diseases. 7 pages.
  • Dalgard, Olav; Weiland, Ola; Noraberg, Geir; Karlsen, Lars Normann; Heggelund, Lars; Färkkilä, Martti; Balslev, Ulla; Belard, Erika; Øvrehus, Anne; Kjær, Mette Skalshøi; Krarup, Henrik; Røge, Birgit Thorup; Hallager, Sofie; Madsen, Lone G.; Laursen, Alex Lund; Lagging, Martin; Weis, Nina. 2017. Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections - A Scandinavian real-life study. PLOS ONE. 1-8.
  • Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars. 2017. Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia. European Journal of Clinical Investigation. 10 pages.
  • Holter, Jan Cato; Ueland, Thor; Norseth, Jon; Brunborg, Cathrine; Frøland, Stig Sophus; Husebye, Einar; Aukrust, Pål; Heggelund, Lars. 2016. Vitamin D Status and Long-Term Mortality in Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort. PLOS ONE.
  • Holter, Jan Cato; Ueland, Thor; Jenum, Pål; Müller, Fredrik; Brunborg, Cathrine; Frøland, Stig Sophus; Aukrust, Pål; Husebye, Einar; Heggelund, Lars. 2016. Risk factors for long-term mortality after hospitalization for community-acquired pneumonia: a 5-year prospective follow-up study. PLOS ONE.
  • Midgard, Håvard; Bjøro, Benedikte; Mæland, Arild; Zbigniew, Konopski; Kileng, Hege; Damås, Jan Kristian; Paulsen, Jørn; Heggelund, Lars; Sandvei, Per; Ringstad, Jetmund; Karlsen, Lars Normann; Stene-Johansen, Kathrine; Pettersson, John; Dorenberg, Dagny Haug; Dalgard, Olav. 2016. Hepatitis C reinfection after sustained virological response. Journal of Hepatology. 1020-1026.
  • Holter, Jan Cato; Müller, Fredrik; Bjørang, Ola; Samdal, Helvi Holm; Marthinsen, Jon Bache; Jenum, Pål; Ueland, Thor; Frøland, Stig Sophus; Aukrust, Pål; Husebye, Einar; Heggelund, Lars. 2015. Etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in Norway. BMC Infectious Diseases. 11 pages.
  • Heggelund, Lars; Gaustad, Peter; Håvelsrud, Othilde Else; Blom, Jochen; Borgen, Lars; Sundset, Arve; Sørum, Henning; Frøland, Stig Sophus. 2015. Corynebacterium pseudotuberculosis Pneumonia in a veterinary stuent infected during lobaratory work. Open Forum Infectious Diseases. 1-6.
  • Pullar, Nadine Durema; Steinum, Harald Otto; Tonby, Kristian; Heggelund, Lars; Leiva, Rafael Alexander Mo; Ofstad, Randi; Bruun, Johan Nikolai; Dyrhol-Riise, Anne Ma. 2014. Low prevalence of positive interferon-gamma tests in HIV-positive long-term immigrants in Norway. The International Journal of Tuberculosis and Lung Disease. 180-187.
  • Dale, Einar; Heggelund, Lars; Samdal, Helvi Holm; Leegaard, Truls Michael; Edvardsen, Thor; Gjertsen, Erik. 2010. Dramatisk sykehistorie forårsaket av uvanlig bakterie. Tidsskrift for Den norske legeforening. 149-151.
  • Damas, JK; Landro, L; Fevang, B; Heggelund, L; Tjønnfjord, Geir Erland; Floisand, Y; Halvorsen, B; Frøland, Stig Sophus; Aukrust, Pål. 2009. Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication. Clinical and Experimental Immunology. 400-407.
  • Damås, Jan Kristian; Landrø, Linn Aina Ysland; Fevang, Børre; Heggelund, Lars; Frøland, Stig Sophus; Aukrust, Pål. 2009. Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy. AIDS (London). 135-138.
  • Landrø, Linn Aina Ysland; Damås, Jan Kristian; Halvorsen, Bente ; Fevang, Børre; Ueland, Thor; Otterdal, Kari; Heggelund, Lars; Frøland, Stig Sophus; Aukrust, Pål. 2009. CXCL16 in HIV infection - a link between inflammation and viral replication. European Journal of Clinical Investigation. 1017-1024.
  • Landro, L; Damas, JK; Flo, Trude Helen; Heggelund, L; Ueland, T; Tjonnfjord, GE; Espevik, Terje; Aukrust, P; Froland, SS. 2008. Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy. Clinical and Experimental Immunology. 57-63.
  • Holven, Kirsten Bjørklund; Damås, Jan Kristian; Yndestad, Arne; Wæhre, Torgun; Ueland, Thor; Halvorsen, Bente ; Heggelund, Lars; Sandberg, Wiggo Johan; Semb, Anne Grete; Frøland, Stig Sophus; Ose, Leiv; Nenseter, Marit Sofie; Aukrust, Pål. 2006. Chemokines in children with heterozygous familiar hypercholesterolemia - Selective upregulation of RANTES. Arteriosclerosis, Thrombosis and Vascular Biology.
  • Heggelund, L; Mollnes, TE; Espevik, Terje; Muller, F; Kristiansen, KI; Aukrust, P; Froland, SS. 2005. Modulatory effect of mannose-binding lectin on cytokine resposes: possible roles in HIV infection. European Journal of Clinical Investigation. 765-770.
  • Heggelund, L; Mollnes, TE; Espevik, Terje; Muller, F; Kristiansen, KI; Aukrust, P; Frøland, Stig S. 2005. Modulatory effect of mannose-binding lectin on cytokine responses: roles in HIV infection. European Journal of Clinical Investigation. 765-770.
  • Heggelund, Lars; Mollnes, Tom Eirik; Espevik, Terje; Muller, Fredrik; Kristiansen, Knut Ivan; Aukrust, Pål; Frøland, Stig Sophus. 2005. Modulatory effect of mannose-binding lectin on cytokine responses: possible roles in HIV infection. European Journal of Clinical Investigation. 765-770.
  • Fiane, Arnt E; Ueland, Thor; Simonsen, Svein; Scott, Helge; Endresen, Knut; Gullestad, Lars; Geiran, Odd; Haraldsen, Guttorm; Heggelund, Lars; Andreassen, Arne K.; Wergeland, Ragnhild; Frøland, Stig Sophus; Aukrust, Pål; Mollnes, Tom Eirik. 2005. Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation. European Heart Journal. 1660-1665.
  • Fevang, Børre; Mollnes, Tom Eirik; Holm, Are Martin; Ueland, Thor; Heggelund, Lars; Damås, Jan Kristian; Aukrust, Pål; Frøland, Stig Sophus. 2005. Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis. Clinical and Experimental Immunology. 576-584.
  • Heggelund, L; Damas, JK; Yndestad, A; Holm, AM; Muller, F; Lien, E; Espevik, Terje; Aukrust, P; Froland, SS. 2004. Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences. Clinical and Experimental Immunology. 116-121.
  • Heggelund, Lars; Flo, T; Berg, K; Lien, T; Mollnes, TE; Ueland, Thor; Aukrust, Pål; Espevik, T; Frøland, Stig Sophus. 2004. Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). 2437-2439.
  • Heggelund, L; Flo, Trude Helen; Berg, K.; Lien, E; Espevik, Terje. 2004. Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). 2437-2439.
  • Heggelund, L; Muller, F; Lien, E; Yndestad, A; Ueland, T; Kristiansen, KI; Espevik, Terje; Aukrust, P; Froland, SS. 2004. Increased expression of Toll-like receptor 2 on monocytes in HIV infection: Possible roles in inflammation and viral replication. Clinical Infectious Diseases. 264-269.
  • Stylianou, Eva; Bjerkeli, Vigdis; Yndestad, Arne; Heggelund, Lars; Wæhre, Torgun; Damås, Jan Kristian; Aukrust, Pål; Frøland, Stig Sophus. 2003. Raised serum levels of interleukin-18 is associated with disease progression and may contribute to virological treatment failure in HIV-1-infected patients. Clinical and Experimental Immunology. 462-466.
  • Fiane, Arnt E; Videm, Vibeke; Lingaas, PS; Heggelund, L; Nielsen, EW; Geiran, OR; Fung, Michael; Mollnes, Tom Eirik. 2003. Mechanism of complement activation and its role in the inflammatory response following thoraco-abdominal aortic aneurys. Circulation. 849-856.
  • Fiane, Arnt E.; Videm, Vibeke; Lingaas, Per Snorre; Heggelund, Lars; Nielsen, E. Waage; Geiran, Odd; Fung, M.; Mollnes, Tom Eirik. 2003. Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair. Circulation. 849-56.
  • Heggelund, Lars; Mollnes, Tom Eirik; Ueland, Thor; Christophersen, Bjørn; Aukrust, Pål; Frøland, Stig Sophus. 2003. Mannose-Binding Lectin in HIV Infection: Relation to Disease Progression and Highly Active Antiretroviral Therapy. JAIDS. 354-361.
Academic lecture
  • Stray-Pedersen, Asbjørg; Garred, P; Heggelund, Lars; Holmskow, U; Vermeesch, J.; Abrahamsen, Tore G. 2003. A boy with severe pulmonal infectious problems due to NKX2.1 haploinsufficiency and mannan-binding lectin deficiency.
Reader opinion piece
  • Samuelsen, Ørjan; Thilesen, Carina; Heggelund, Lars; Vada, Anne N.; Kümmel, Angela; Sundsfjord, arnfinn. 2011. Identification of NDM-1-producing Enterobacteriaceae in Norway. Journal of Antimicrobial Chemotherapy. 670-672.
Short communication
  • Heggelund, L; Samdal, H Holm; Eggum, R; Jacobsen, T; Bruun, Tone; Elstrøm, Petter. 2007. Severe case of invasive community-acquired methicillin-resistant Staphylococcus aureus infection in Norway. Eurosurveillance.
Letter to the editor
  • Siljan, William; Holter, Jan Cato; Nymo, Ståle Haugset; Schjalm, Camilla; Müller, Fredrik; Jenum, Pål; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars. 2016. Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome. Journal of Infection. 383-386.
Doctoral dissertation
  • Heggelund, Lars. 2005. Innate immunity and human immunodeficiency virus infection. Studies on toll-like receptor 2 and manose-binding lectin.
Poster
  • Stray-Pedersen, Asbjørg; Lindman, C.; Stoltenberg, Lauritz; Heiberg, Arvid; Heggelund, Lars; Vermeesch, J.; Jenum, Pål Arne; Aaberge, Ingeborg S.; Abrahamsen, Tore G. 2002. A boy with neurologic abnormalities, subclinical hypothyroidism, respiratory distress and immunodeficiency due to microdelition of chromosome 14q12 and NKX2.1 haploinsufficiency.

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