Lars Herfindal

Professor

Department of Clinical Science

Home Page

E-mailLars.Herfindal@uib.no
Phone+47 55 97 46 28+47 974 03 493
Visitor Address
Haukeland universitetssykehus, Laboratoriebygget
Postal Address
Postboks 7804

5020 Bergen

Publications

Academic article

2020. New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesisand biological evaluation. Bioorganic & Medicinal Chemistry. 1-8.
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2020. Cyclodextrin Complexation Studies as the First Step for Repurposing of Chlorpromazine . International Journal of Pharmaceutics.
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2019. Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. 1-17.
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2019. Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria . Toxins. 1-17.
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2019. Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L. Phytochemistry. 67-77.
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2019. Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. Biochimica et Biophysica Acta - Biomembranes. 1510-1521.
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2019. Anticancer activity in Planctomycetes. Frontiers in Marine Science. 10 pages.
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2019. A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae). Heliyon. 1-13.
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2019. A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 567-578.
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2018. Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue. Bioconjugate chemistry. 493-502.
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2018. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of enzyme inhibition and medicinal chemistry (Print). 370-375.
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2017. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 2285-2293.
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2017. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
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2016. Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale. 862-877.
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2016. Toxic aromatic compounds from fruits of Narthecium ossifragum L. Phytochemistry. 76-85.
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2016. Cyanobacteria as a source for novel anti-leukemic compounds. Current Pharmaceutical Biotechnology. 78-91.
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2015. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 7313-7323.
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2015. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of enzyme inhibition and medicinal chemistry (Print). 180-188.
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2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
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2014. New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 108-115.
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2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
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2014. Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics.
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2014. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 2036-2053.
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2014. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
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2014. Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 361-369.
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2014. Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 361-369.
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2014. 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 2646-2655.
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2013. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
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2013. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
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2013. Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer.
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2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
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2012. The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 3000-3009.
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2012. Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLOS ONE.
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2011. The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 489-501.
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2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
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2010. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2659-2672.
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2010. A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem. 1594-1599.
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2009. Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
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2009. Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
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2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
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2008. Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and synechococcus. Marine Drugs. 1-11.
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2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
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2005. Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 294-306.
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2005. A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 252-260.
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2002. Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 197-210.
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2001. Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 139-140.
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Report

2005. The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis. .
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Academic lecture

2017. Rome –en unik kilde til nye antileukemi naturprodukter.
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2017. Isolation and screening of novel planctomycetes from Svarthamar ice Cave, Northern Norway.
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2011. Bioactive compounds from culturable marine microorganisms.
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2003. Drug potentials from marine cyanobacteria and microalgae from Norwegian waters.
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2002. New apoptosis-modulating substances from marine microalgae.
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2002. Bioactive compounds from cyanobacteria.
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1999. Effect of feeding Artemia enriched with free phenylalanine and tyrosine to larval Japanese flounder.
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Editorial

2016. Toward personalized treatment for acute myeloid leukemia. Current Pharmaceutical Biotechnology. 4-5.
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2016. Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia. Current Pharmaceutical Biotechnology. 4-5.
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Short communication

2019. Short communication: Distribution of psychotropic drugs into lipoproteins. Therapeutic Drug Monitoring. 766-771.
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Masters thesis

2016. The production and characterization of drug-loaded liposomal and PLGA nanocarriers for targeted treatment of acute myeloid leukemia.
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2016. The efficiency of maltodextrin and porous silicon nanoparticles for the in vitro and in vivo stabilization of tyrosine hydroxylase.
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2015. The role of Epac1 in endothelial barrier function Fluorescence intensity measurements of nano capsules in Wnt1-induced breast cancer.
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2012. In vivo biodistribution of fluorescent nanocolloids intended for drug delivery. Evaluation of PEGylation state and fluorophore incorporation approach.
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2012. In vitro validation of multifunctional liposomes for leukaemia and prostate cancer therapy ¿ the folate receptor and the prostate-specific membrane antigen as targets for drug delivery.
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2008. Platelet inhibitory compounds from marine microorganisms.
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2008. Bioactive compounds from marine microorganisms: search for anti-leukemic drugs and finding mechanisms of action.
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