- E-mailLars.Herfindal@uib.no
- Phone+47 55 97 46 28
- Visitor AddressHaukeland universitetssykehus, Laboratoriebygget5009 Bergen
- Postal AddressPostboks 78045020 Bergen
Academic article
- (2022). Synthesis of new pyrazolo[4,3-a]phenanthridine Pim-1 inhibitors and evaluation of their cytotoxic activity towards the MOLM-13 acute myeloid leukemia cell line. Bioorganic & Medicinal Chemistry Letters. 5 pages.
- (2022). Graphene-based phenformin carriers for cancer cell treatment: a comparative study between oxidized and pegylated pristine graphene in human cells and zebrafish. Nanoscale Advances. 1668-1680.
- (2022). Determination of methotrexate and its metabolites in human plasma by electromembrane extraction in conductive vials followed by LC-MS/MS. Advances in Sample Preparation. 8 pages.
- (2022). A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium. Scientific Reports.
- (2022). A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae. Biology Open.
- (2022). A liposomal formulation of simvastatin and doxorubicin for improved cardioprotective and anti-cancer effect. International Journal of Pharmaceutics.
- (2021). Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation. International Journal of Pharmaceutics. 14 pages.
- (2021). New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells. RSC Medicinal Chemistry. 767-778.
- (2021). Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide. ACS Omega. 24619-24629.
- (2021). Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity. Physiologia Plantarum : An International Journal for Plant Biology. 612-623.
- (2020). Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study. Immunity,Inflammation and Disease. 342-359.
- (2020). New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry. 1-8.
- (2020). Cyclodextrin Complexation Studies as the First Step for Repurposing of Chlorpromazine . International Journal of Pharmaceutics.
- (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. iScience. 1-40.
- (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. 1-17.
- (2019). Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria . Toxins. 1-17.
- (2019). Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L. Phytochemistry. 67-77.
- (2019). Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. Biochimica et Biophysica Acta - Biomembranes. 1510-1521.
- (2019). Anticancer activity in Planctomycetes. Frontiers in Marine Science. 10 pages.
- (2019). A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae). Heliyon. 1-13.
- (2019). A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 567-578.
- (2018). Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue. Bioconjugate chemistry. 493-502.
- (2018). Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of Enzyme Inhibition and Medicinal Chemistry. 370-375.
- (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 2285-2293.
- (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
- (2016). Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale. 862-877.
- (2016). Toxic aromatic compounds from fruits of Narthecium ossifragum L. Phytochemistry. 76-85.
- (2016). Cyanobacteria as a source for novel anti-leukemic compounds. Current Pharmaceutical Biotechnology. 78-91.
- (2015). Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 7313-7323.
- (2015). Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of Enzyme Inhibition and Medicinal Chemistry. 180-188.
- (2014). Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
- (2014). New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 108-115.
- (2014). Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
- (2014). Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics.
- (2014). Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 2036-2053.
- (2014). Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
- (2014). Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 361-369.
- (2014). Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 361-369.
- (2014). 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 2646-2655.
- (2013). Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
- (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
- (2013). Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer.
- (2013). Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
- (2012). The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 3000-3009.
- (2012). Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLOS ONE.
- (2011). The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 489-501.
- (2011). Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
- (2010). Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2659-2672.
- (2010). A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem. 1594-1599.
- (2009). Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
- (2009). Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
- (2009). Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
- (2008). Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and synechococcus. Marine Drugs. 1-11.
- (2006). CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
- (2005). Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 294-306.
- (2005). A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 252-260.
- (2002). Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 197-210.
- (2001). Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 139-140.
Report
- (2005). The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis. .
Academic lecture
- (2017). Rome –en unik kilde til nye antileukemi naturprodukter.
- (2017). Isolation and screening of novel planctomycetes from Svarthamar ice Cave, Northern Norway.
- (2011). Bioactive compounds from culturable marine microorganisms.
- (2003). Drug potentials from marine cyanobacteria and microalgae from Norwegian waters.
- (2002). New apoptosis-modulating substances from marine microalgae.
- (2002). Bioactive compounds from cyanobacteria.
- (1999). Effect of feeding Artemia enriched with free phenylalanine and tyrosine to larval Japanese flounder.
Editorial
- (2016). Toward personalized treatment for acute myeloid leukemia. Current Pharmaceutical Biotechnology. 4-5.
- (2016). Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia. Current Pharmaceutical Biotechnology. 4-5.
Short communication
- (2021). NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform. Physiologia Plantarum : An International Journal for Plant Biology. 507-513.
- (2019). Short communication: Distribution of psychotropic drugs into lipoproteins. Therapeutic Drug Monitoring. 766-771.
Masters thesis
- (2022). Electromembrane extraction of immunosuppressants.
- (2021). Electromembrane extraction of methotrexate and its metabolites.
- (2020). Zebrafish Larvae as a Model to Study Doxorubicin-Induced Cardiotoxicity.
- (2020). Drug transport in blood: Lipoproteins as transporters of psychotropic drugs.
- (2019). Zebrafish Larvae as a Model to Study Doxorubicin-Induced Cardiotoxicity.
- (2019). Antileukemia activity of plant natural products and hemisynthetic analogs.
- (2016). The production and characterization of drug-loaded liposomal and PLGA nanocarriers for targeted treatment of acute myeloid leukemia.
- (2016). The efficiency of maltodextrin and porous silicon nanoparticles for the in vitro and in vivo stabilization of tyrosine hydroxylase.
- (2015). The role of Epac1 in endothelial barrier function Fluorescence intensity measurements of nano capsules in Wnt1-induced breast cancer.
- (2012). In vivo biodistribution of fluorescent nanocolloids intended for drug delivery. Evaluation of PEGylation state and fluorophore incorporation approach.
- (2012). In vitro validation of multifunctional liposomes for leukaemia and prostate cancer therapy ¿ the folate receptor and the prostate-specific membrane antigen as targets for drug delivery.
- (2008). Platelet inhibitory compounds from marine microorganisms.
- (2008). Bioactive compounds from marine microorganisms: search for anti-leukemic drugs and finding mechanisms of action.
Popular scientific article
- (2012). Nanokolloidar som verkty for å betra distribusjon av legemiddel. Naturen. 103-110.
- (2004). Havet som apotek. Naturen. 15-24.
- (2000). Anrikning av vannløselige komponenter i Artemia. Norsk Fiskeoppdrett. 26-27.
Doctoral dissertation
- (2006). Apoptosis modulating and anti-thrombotic activities from marine micro-organisms.
Interview
- (2019). Mikrobejakten. Langt inne i en isgrotte i Nordland har forskerne lett ettr ny antibiotika. Det haster å hente ut ukjente bakteriestammer, for verdens minste organismer står if are for å smelte bort.
Academic chapter/article/Conference paper
- (2007). Serine/Threonine Protein Phosphatases in Apoptosis. 16 pages.
Abstract
- (2013). Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 322-322.
- (2008). Bioactive peptides from cyanobacteria. Journal of Peptide Science. 93-93.
Poster
- (2022). Targeting high-value products from the epiphytes of Laminaria hyperborea.
- (2022). Precision medicine in childhood cancer - a representative case of neuroblastoma.
- (2019). Preparation of non-oxidized graphene nanosheets for drug delivery.
- (2016). Total synthesis and initial antileukemic evaluation of the phenazine 5,10-dioxide natural products iodinin and myxin.
- (2015). Indeno[1,2-b]indole derivatives as protein kinase CK2 inhibitors: comparison of in silico models for Tox prediction.
- (2012). Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect.
- (2011). Characterization of cytotoxic activities in extracts from two marine invertebrates.
- (2010). Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3.
- (2009). The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
- (2005). Searching cyanobacteria and microalgae from Norwegian waters for drug candidates.
- (2002). Effects of a new bioactive substance from a marine microalga on mammalian cells.
- (2001). TWO NOVEL APOPTOSIS-MODULATION SUBSTANCES ISOLATED FROM MARINE MICRO-ALGAE.
- (2001). New apoptosis-modulating substances from marine microalgae.
Academic literature review
- (2021). Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria . Physiologia Plantarum : An International Journal for Plant Biology. 639-650.
- (2019). Immunoliposomes in acute myeloid leukaemia therapy. An overview of possible targets and obstacles. Current Medicinal Chemistry. 5278-5292.
- (2016). The use of nanocarriers in acute myeloid leukaemia therapy: Challenges and current status. Current Pharmaceutical Biotechnology. 30-41.
- (2015). Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. Marine Drugs. 6505-6520.
- (2006). Microcystin produces disparate effects on liver cells in a dose dependent manner. Mini-Reviews in Medicinal Chemistry. 279-285.
Article in business/trade/industry journal
- (2021). The under-explored chemistry of seaweeds. NBS-nytt. 14-18.
More information in national current research information system (CRIStin)
Fields of competence