- E-mailLars.Herfindal@uib.no
- Phone+47 55 97 46 28+47 974 03 493
- Visitor AddressHaukeland universitetssykehus, Laboratoriebygget
- Postal AddressPostboks 78045020 Bergen
Journal articles
- 2018. Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue. Bioconjugate chemistry. 29: 493-502. doi: 10.1021/acs.bioconjchem.7b00807
- 2018. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of enzyme inhibition and medicinal chemistry (Print). 33: 370-375. doi: 10.1080/14756366.2017.1421638
- 2017. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 7:8725: 1-15. doi: 10.1038/s41598-017-08975-y
- 2017. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 25: 2285-2293. doi: 10.1016/j.bmc.2017.02.058
- 2016. Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale. 8: 862-877. doi: 10.1039/c5nr07289a
- 2016. Cyanobacteria as a source for novel anti-leukemic compounds. Current Pharmaceutical Biotechnology. 17: 78-91. doi: 10.2174/1389201016666150826121124
- 2016. The use of nanocarriers in acute myeloid leukaemia therapy: Challenges and current status. Current Pharmaceutical Biotechnology. 17: 30-41. doi: 10.2174/1389201016666150817095045
- 2016. Toward personalized treatment for acute myeloid leukemia. Current Pharmaceutical Biotechnology. 17: 4-5.
- 2016. Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia. Current Pharmaceutical Biotechnology. 17: 4-5.
- 2016. Toxic aromatic compounds from fruits of Narthecium ossifragum L. Phytochemistry. 132: 76-85. doi: 10.1016/j.phytochem.2016.09.010
- 2015. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of enzyme inhibition and medicinal chemistry (Print). 30: 180-188. doi: 10.3109/14756366.2014.899594
- 2015. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 23: 7313-7323. doi: 10.1016/j.bmc.2015.10.031
- 2015. Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. Marine Drugs. 13: 6505-6520. doi: 10.3390/md13106505
- 2014. New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 57: 108-115. doi: 10.1016/j.bioorg.2014.09.004
- 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLoS ONE. 9. doi: 10.1371/journal.pone.0094926
- 2014. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 12: 2036-2053. doi: 10.3390/md12042036
- 2014. 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 9: 2646-2655. doi: 10.1021/cb500436p
- 2014. Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics. doi: 10.1016/j.ejpb.2014.04.002
- 2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 449: 357-363. doi: 10.1016/j.bbrc.2014.05.032
- 2014. Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 29: 361-369. doi: 10.1080/0269249X.2014.889040
- 2014. Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity, light, temperature and nitrate. Diatom Research. 29: 361-369. doi: 10.1080/0269249X.2014.889040
- 2014. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 98: 603-610. doi: 10.1007/s00253-013-5320-0
- 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease. 4. doi: 10.1038/cddis.2013.39
- 2013. Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer. 13. doi: 10.1186/1471-2407-13-341
- 2013. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 437: 603-608. doi: 10.1016/j.bbrc.2013.07.007
- 2013. Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 280: 322-322.
- 2013. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 11: 332-349. Published 2013-01-30. doi: 10.3390/md11020332
- 2012. Nanokolloidar som verkty for å betra distribusjon av legemiddel. Naturen. 3: 103-110.
- 2012. Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLoS ONE. 7. doi: 10.1371/journal.pone.0041222
- 2012. The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 1818: 3000-3009. doi: 10.1016/j.bbamem.2012.07.015
- 2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 8: 360-367. doi: 10.1021/mp1002224
- 2011. The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 38: 489-501. doi: 10.1007/s10295-010-0791-9
- 2010. A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem (Print). 11: 1594-1599. doi: 10.1002/cbic.201000179
- 2010. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 8: 2659-2672. doi: 10.3390/md8102659
- 2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 52: 5758-5762. doi: 10.1021/jm900502e
- 2009. Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 16: 1109-1121. doi: 10.1016/j.chembiol.2009.09.014
- 2009. Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 7: 605-623. doi: 10.3390/md7040605
- 2008. Bioactive peptides from cyanobacteria. Journal of Peptide Science. 14: 93-93.
- 2008. Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and synechococcus. Marine Drugs. 6: 1-11.
- 2006. Microcystin produces disparate effects on liver cells in a dose dependent manner. Mini-Reviews in medical chemistry. 6: 279-285. doi: 10.2174/138955706776073475
- 2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 13: 1191-1202. doi: 10.1038/sj.cdd.4401798
- 2005. A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 46: 252-260. doi: 10.1016/j.toxicon.2005.04.005
- 2005. Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 74: 294-306. doi: 10.1016/j.aquatox.2005.06.005
- 2004. Havet som apotek. Naturen. 1. 15-24.
- 2002. Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 2: 197-210.
- 2001. Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 110: 139-140.
- 2000. Anrikning av vannløselige komponenter i Artemia. Norsk Fiskeoppdrett. 7: 26-27.
Reports and theses
- 2006. Apoptosis modulating and anti-thrombotic activities from marine micro-organisms.
- 2005. The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis. Medimond. 6 pages.
Book sections
- 2007. Serine/Threonine Protein Phosphatases in Apoptosis. 7, pages 151-166. In:
- 2007. Apoptosis, Cell Signaling, and Human Diseases Molecular Mechanisms, Volume 2. 402 pages. ISBN: 978-1-58829-882-9.
More information in national current research information system (CRIStin)
Fields of competence