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Lars Prestegarden

Associate Professor
Journal articles
  • Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco; Aasen, Synnøve Nymark; Røsland, Gro Vatne; Varughese, Jobin K.; Bahador, Marzieh; Bernatz, Simon; Braun, Yannick; Harter, Patrick N.; Skaftnesmo, Kai Ove; Ingham, Elizabeth S.; Mahakian, Lisa M.; Tam, Sarah; Tepper, Clifford G.; Petersen, Kjell; Ferrara, Katherine W.; Tronstad, Karl Johan; Lund-Johansen, Morten; Beschorner, Rudi; Bjerkvig, Rolf; Thorsen, Frits. 2019. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta neuropathologica communications. 7:55: 1-19. doi: 10.1186/s40478-019-0712-8
  • Johannessen, Tor-Christian Aase; Hasan-Olive, Md Mahdi; Zhu, Huaiyang; Denisova, Oxana V.; Grudic, Amra; Latif, Md Abdul; Sdik Saed, Halala; Varughese, Jobin K.; Røsland, Gro Vatne; Yang, Ning; Sundstrøm, Terje; Nordal, Anne Birgitte Thomas; Tronstad, Karl Johan; Wang, Jian; Lund-Johansen, Morten; Simonsen, Anne; Janji, Bassam; Westermarck, Jutta; Bjerkvig, Rolf; Prestegarden, Lars. 2018. Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. International Journal of Cancer. 144: 1735-1745. Published 2018-10-05. doi: 10.1002/ijc.31912
  • Wang, Jiwei; Qi, Qichao; Zhou, Wenjing; Feng, Zichao; Huang, Bin; Chen, Anjing; Zhang, Di; Li, Wenjie; Zhang, Qing; Jiang, Zheng; Bjerkvig, Rolf; Prestegarden, Lars; Thorsen, Frits; Wang, Xinyu; Li, Xingang; Wang, Jian. 2018. Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. Autophagy. 14: 2007-2022. doi: 10.1080/15548627.2018.1501133
  • Zhang, Xin; Xu, Ran; Zhang, Chao; Xu, Yangyang; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qiu, Chen; Thorsen, Frits; Prestegarden, Lars; Bjerkvig, Rolf; Wang, Jian; Li, Xingang. 2017. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. Journal of Experimental & Clinical Cancer Research. 36:118: 1-13. doi: 10.1186/s13046-017-0588-z
  • Wang, Jiwei; Qi, Qichao; Feng, Zichao; Zhang, Xin; Huang, Bin; Chen, Anjing; Prestegarden, Lars; Li, Xingang; Wang, Jian. 2016. Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. OncoTarget. 7: 66944-66958. doi: 10.18632/oncotarget.11396
  • Szczepanski, Claudia; Tenstad, Olav; Baumann, Anne; Martinez, Aurora; Myklebust, Reidar; Bjerkvig, Rolf; Prestegarden, Lars. 2014. Identification of a novel lytic peptide for the treatment of solid tumours. Genes & cancer. 5: 186-200.
  • Johannessen, Tor-Christian Aase; Prestegarden, Lars; Grudic, Amra; Hegi, Monika E.; Tysnes, Berit Bølge; Bjerkvig, Rolf. 2013. The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells. Neuro-Oncology. 15: 269-278. doi: 10.1093/neuonc/nos301
  • Sundstrøm, Terje; Varughese, Jobin K.; Harter, Patrick; Prestegarden, Lars; Petersen, Kjell; Azuaje, Fransisco; Tepper, Clifford; Ingham, Elizabeth; Even, Lisa; Johnson, Sarah; Skaftnesmo, Kai Ove; Lund-Johansen, Morten; Bjerkvig, Rolf; Ferrara, Katherine W.; Thorsen, Frits Alan. 2013. BRAIN-SPECIFIC GENE SIGNATURE OF MELANOMA METASTASIS. Neuro-Oncology. 15: 27-27.
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Rosland, Gunnar Alm; Wang, Jian; Huszthy, Peter; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Nigro, Janice; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mork, Stian; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Neuro-Oncology. 15: 6-6. doi: 10.1007/s00401-013-1101-1
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Røsland, Gro Vatne; Wang, Jian; Huszthy, Peter Csaba; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Brekkå, Narve; Moen, Ingrid; Nigro, Janice Marie; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mørk, Sverre; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathologica. 125: 683-698. doi: 10.1007/s00401-013-1101-1
  • Svendsen, Agnete; Verhoeff, Joost JC; Immervoll, Heike; Brøgger, Jan C; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger Anne; Prestegarden, Lars; Planaguma, Jesus; Torsvik, Anja; Kjersem, Anneli Bohne; Sakariassen, Per Øystein; Heggdal, Jan Ingemann; van Furth, Wouter R; Bjerkvig, Rolf; Lund-Johansen, Morten; Enger, Per Øyvind; Felsberg, Joerg; Brons, Nicolas H.C.; Tronstad, Karl Johan; Waha, Andreas; Chekenya, Martha. 2011. Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 122: 495-510. doi: 10.1007/s00401-011-0867-2
  • Szczepanski, C; Bjerkvig, Rolf; Tenstad, Olav; Thorsen, Frits Alan; Wendelbo, Ingvild Haukaas; Martinez, Aurora; Baumann, Anne; Prestegarden, Lars. 2011. Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide. European Journal of Cancer. 47: S148-S148.
  • Prestegarden, Lars; Enger, Per Øyvind. 2010. Cancer stem cells in the central nervous system - a critical review. Cancer Research. 70: 8255-8258. doi: 10.1158/0008-5472.CAN-10-1592
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Sleire, Linda; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Yan, Tao; Askland, Lasse Haugen; Persson, Andreas; Sakariassen, Per Øystein; Enger, Per Øyvind. 2010. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Research. 70: 4274-4279. doi: 10.1158/0008-5472.CAN-09-3904
  • Szczepanski, C; Bjerkvig, Rolf; Prestegarden, Lars. 2010. A new lytic peptide for the treatment of cancer. European Journal of Cancer. 8: 58-59.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Askland, L; Persson, A; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Hovland, Randi; Enger, Per Øyvind. 2009. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. Neuro-Oncology. 11: 917-917.
  • Wang, Jian; Tsinkalovsky, Oleg; Svendsen, Agnete; Prestegarden, Lars; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. Neuro-Oncology. 11: 221-222.
  • Prestegarden, Lars; Misra, Anjan; Ware, ML; Yeh, RF; Bjerkvig, Rolf; Feuerstein, BG. 2008. Amplifying small amounts of tumor DNA allows detection of DNA copy number abberations with array-CGH. BioTechniques. 44: S3-S6.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Lasse, A; Andreas, P; Oystein, SP; Skaftnesmo, KO; Randi, H; Enger, Per Øyvind. 2008. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. Neuro-Oncology. 10: 778-778.
  • Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg; Immervoll, Heike; Bøe, Stig Ove; Svendsen, Agnete; Prestegarden, Lars; Røsland, Gro Vatne; Thorsen, Frits Alan; Stuhr, Linda Elin Birkhaug; Molven, Anders; Bjerkvig, Rolf; Enger, Per Øyvind. 2008. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 122: 761-768. doi: 10.1002/ijc.23130
  • Skaftnesmo, Kai Ove; Prestegarden, Lars; Micklem, David Robert; Lorens, James. 2007. MicroRNAs in tumorigenesis. Current Pharmaceutical Biotechnology. 8: 320-325. doi: 10.2174/138920107783018390
  • Sakariassen, Per Øystein; Prestegarden, Lars; Wang, Jian; Skaftnesmo, Kai Ove; Mahesparan, Rupavathana; Molthoff, Carla; Sminia, Peter; Sundlisæter, Eirik; Misra, Anjan; Tysnes, Berit Bølge; Chekenya, Martha; Peters, Hans; Lende, Gabriel; Kalland, Karl-Henning; Øyan, Anne Margrete; Petersen, Kjell; Jonassen, Inge; van der Kogel, Albert; Feuerstein, Burt G.; Terzis, A. Jorge A.; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 16466-16471. doi: 10.1073/pnas.0607668103
  • Sundlisæter, Eirik; Wang, Jian; Sakariassen, Per Øystein; Marie, Michael Bruno Eric; Mathisen, Juan Robbie; Karlsen, Bård-Ove; Prestegarden, Lars; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Primary glioma spheroids maintain tumourogenicity and essential phenotypic traits after cryopreservation. Neuropathology and Applied Neurobiology. 32: 419-427. doi: 10.1111/j.1365-2990.2006.00744.x
  • Nigro, Janice; Misra, Anjan; Smirnov, I; Prestegarden, Lars; Wanyu, L; Yeh, R; Aldape, K; VandenBerg, S; Feuerstein, B. 2005. Correlating gene expression to DNA copy number identifies genes involved in the pathogenesis of human glioblastoma. Neuro-Oncology. 7: 362-362.
Reports and theses
  • Prestegarden, Lars. 2010. Intratumoral Heterogeneity and Tumor Initiating Cells in Glioblastoma Multiforme. 200 pages.

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