Malene Skuseth Slinning
- E-mailmalene.slinning@uib.no
- Visitor AddressThormøhlens gate 53 A/B5006 Bergen
- Postal AddressPostboks 78035020 Bergen
Vaults are large ribonucleoprotein complexes (13 MDa) found in most eukaryotic organisms. The mammalian vault complex consists of three proteins; the major vault protein (MVP), telomerase-associated protein 1 (TEP1), and vault poly(ADP-ribose) polymerase, as well as small untranslated vault RNAs. The functional role of the vault complex is still poorly understood. However, it has been hypothesized to be involved in various cellular processes such as cell signaling, transport, multidrug resistance, and immune response. The PhD project aims to functionally characterize the vault complex using the salmon louse (Lepeophtheirus salmonis) as a model.
- (2022). Phosphoinositide 3-kinase signalling in the nucleolus. Advances in Biological Regulation. 10 pages.
- (2021). Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins. Molecular & Cellular Proteomics. 18 pages.
- (2021). Phosphoinositide 3-kinase signalling in the nucleolus. Advances in Biological Regulation. 10 pages.
More information in national current research information system (CRIStin)
LiceVault-Â Implementing a model organism for studying vault function and application as smart adjuvant for fish vaccination.