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University of Bergen
Maria Teresa Bezem's picture

Maria Teresa Bezem

PhD Candidate
The Department of Biomedicine
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  • E-mailMaria.Bezem@uib.no
  • Visitor Address
    Jonas Lies vei 91
    Room 
    5A121B
  • Postal Address
    Postboks 7804
    5020 Bergen

My Ph.D. project focusses on the functionalization of biodegradable nanoparticles with an enzyme called tyrosine hydroxylase (TH). This enzyme catalyzes the rate-limiting step in the dopamine synthesis. Dopamine is a signaling molecule used by neurons to control digestion, mood and motion.  Parkinson's disease or genetic diseases can lead to lack of TH and dopamine. The ultimate goal of the project is to develop an enzyme replacement therapy using nanoparticles loaded with TH. Nanoparticles can in general be used to deliver drugs to specific tissues in the body at the same that they protect the drug from degradation.

Only in Norwegian:

Talk at the annual business seminar by the Research Council of Norway

http://www.forskningsradet.no/no/Artikkel/Forskningsradets_neringslivsda...

Talk at the career week of the faculty of mathematics and natural sciences, University of Bergen, Norway

http://www.uib.no/matnat/53691/kva-skal-du-bli

BMED325: Cellular biochemistry and nanobiochemistry, lecture about the use of nanoparticles in medical research

FARM301: - part 4: Biochemical Methods, clone and purify protein

MEDON1: First semester in medicine and odontology study programs, labexercices in biochemistry (carbohydrates, amino acids, lipids, enzymes, DNA, titration...) 

Journal articles
  • Bezem, Maria Teresa; Johannessen, Fredrik Gullaksen; K C, Kunwar Jung; Gundersen, Edvin Tang; Jorge Finnigan, Ana; Ying, Ming; Betbeder, Didier; Herfindal, Lars; Martinez, Aurora. 2018. Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue. Bioconjugate chemistry. 29: 493-502. doi: 10.1021/acs.bioconjchem.7b00807
  • Wang, Joanna; Kumeria, Tushar; Bezem, Maria Teresa; Wang, Jian; Sailor, Michael J. 2018. Self-Reporting Photoluminescent Porous Silicon Microparticles for Drug Delivery. ACS Applied Materials & Interfaces. 10: 3200-3209. doi: 10.1021/acsami.7b09071
  • Bezem, Maria Teresa; Baumann, Anne; Skjærven, Lars; Meyer, Romain; Kursula, Petri; Martinez, Aurora; Flydal, Marte Innselset. 2016. Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme. Scientific Reports. 6:60390. 14 pages. Published 2016-07-27. doi: 10.1038/srep30390
Reports and theses
  • Bezem, Maria Teresa. 2012. Stabilisation of tyrosine hydroxylase in nanoparticles for enzyme replacement therapy. Istitutt for biomedisin, Universitetet i Bergen. 82 pages.

More information in national current research information system (CRIStin)

Research groups