My Ph.D. project focusses on the functionalization of biodegradable nanoparticles with an enzyme called tyrosine hydroxylase (TH). This enzyme catalyzes the rate-limiting step in the dopamine synthesis. Dopamine is a signaling molecule used by neurons to control digestion, mood and motion. Parkinson's disease or genetic diseases can lead to lack of TH and dopamine. The ultimate goal of the project is to develop an enzyme replacement therapy using nanoparticles loaded with TH. Nanoparticles can in general be used to deliver drugs to specific tissues in the body at the same that they protect the drug from degradation.
Only in Norwegian:
Talk at the annual business seminar by the Research Council of Norway
Talk at the career week of the faculty of mathematics and natural sciences, University of Bergen, Norway
BMED325: Cellular biochemistry and nanobiochemistry, lecture about the use of nanoparticles in medical research
FARM301: - part 4: Biochemical Methods, clone and purify protein
MEDON1: First semester in medicine and odontology study programs, labexercices in biochemistry (carbohydrates, amino acids, lipids, enzymes, DNA, titration...)
- (2021). Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles. Molecular Pharmaceutics.
- (2018). Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue. Bioconjugate chemistry. 493-502.
- (2018). Self-Reporting Photoluminescent Porous Silicon Microparticles for Drug Delivery. ACS Applied Materials & Interfaces. 3200-3209.
- (2016). Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme. Scientific Reports. 14 pages.
- (2016). The efficiency of maltodextrin and porous silicon nanoparticles for the in vitro and in vivo stabilization of tyrosine hydroxylase.
- (2012). Stabilisation of tyrosine hydroxylase in nanoparticles for enzyme replacement therapy.