Mathias Ziegler's picture

Mathias Ziegler

Head of Department
  • E-mailMathias.Ziegler@uib.no
  • Phone+47 55 58 45 91+47 992 05 986
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

The NAD metabolome - A key determinant of cancer cell biology

Emerging roles of NAD+ and its metabolites in cell signaling

  • Bockwoldt, Mathias; Houry, Dorothee; Niere, Marc; Gossmann, Toni I.; Reinartz, Ines; Schug, Alexander; Ziegler, Mathias; Heiland, Ines. 2019. Identification of evolutionary and kinetic drivers of NAD-dependent signaling. Proceedings of the National Academy of Sciences of the United States of America. 116: 15957-15966. Published 2019-07-24. doi: 10.1073/pnas.1902346116
  • Lee, Yong Gyu; Reader, Brenda F; Herman, Derrick; Streicher, Adam; Englert, Joshua A; Ziegler, Mathias; Chung, Sangwoon; Karpurapu, Manjula; Park, Gye Young; Christman, John W; Ballinger, Megan N. 2019. Sirtuin 2 enhances allergic asthmatic inflammation. JCI Insight. 4. doi: 10.1172/jci.insight.124710
  • Strømland, Øyvind; Niere, Marc; Nikiforov, Andrey; Van Linden, Magali R; Heiland, Ines; Ziegler, Mathias. 2019. Keeping the balance in NAD metabolism. Biochemical Society Transactions. 47: 119-130. doi: 10.1042/BST20180417
  • Buonvicino, Daniela; Mazzola, Francesca; Zamporlini, Federica; Resta, Francesco; Ranieri, Giuseppe; Camaioni, Emidio; Muzzi, Mirko; Zecchi, Riccardo; Pieraccini, Giuseppe; Dölle, Christian; Calamante, Massimo; Bartolucci, Gianluca; Ziegler, Mathias; Stecca, Barbara; Raffaelli, Nadia; Chiarugi, Alberto. 2018. Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites. Cell Chemical Biology. 25: 471-482.e7. doi: 10.1016/j.chembiol.2018.01.012
  • Shabalin, Konstantin; Nerinovski, Kirill; Yakimov, Alexander; Kulikova, Veronika; Svetlova, Maria; Solovjeva, Ljudmila; Khodorkovskiy, Mikhail; Gambaryan, Stepan; Cunningham, Richard; Migaud, Marie E.; Ziegler, Mathias; Nikiforov, Andrey. 2018. NAD Metabolome Analysis in Human Cells Using 1H NMR Spectroscopy. International Journal of Molecular Sciences. 19: 3906. doi: 10.3390/ijms19123906
  • Varland, Sylvia; Aksnes, Henriette; Kryuchkov, Fedor; Impens, Francis; Haver, Delphi Van; Jonckheere, Veronique; Ziegler, Mathias; Gevaert, Kris; Damme, Petra Van; Arnesen, Thomas. 2018. N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular & Cellular Proteomics. 17: 2309-2323. Published 2018-12-01. doi: 10.1074/mcp.RA118.000982
  • Dölle, Christian; Ziegler, Mathias. 2017. ADP-ribosylation of DNA moving into focus. The FEBS Journal. 284: 3999-4001. doi: 10.1111/febs.14326
  • Van Linden, Magali R; Niere, Marc; Nikiforov, Andrey; Ziegler, Mathias; Dölle, Christian. 2017. Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor for Subcellular NAD Pools. Methods in molecular biology. 1608: 45-56. doi: /10.1007/978-1-4939-6993-7_4
  • Skoge, Renate Hvidsten; Ziegler, Mathias. 2016. SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6. Journal of Cell Science. 129: 2972-2982. doi: 10.1242/jcs.187518
  • Aksnes, Henriette; Van Damme, Petra; Goris, Marianne; Starheim, Kristian K.; Marie, Michael Bruno Eric; Støve, Svein Isungset; Hoel, Camilla; Kalvik, Thomas Vikestad; Hole, Kristine; Glomnes, Nina; Furnes, Clemens; Ljostveit, Sonja; Ziegler, Mathias; Niere, Marc; Gevaert, Kris; Arnesen, Thomas. 2015. An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic n termini of transmembrane proteins and maintains golgi integrity. Cell reports. 10: 1362-1374. doi: 10.1016/j.celrep.2015.01.053
  • Kulikova, Veronika; Shabalin, Konstantin; Nerinovski, Kirill; Dölle, Christian; Niere, Marc; Yakimov, Alexander; Redpath, Philip; Khodorkovskiy, Mikhail; Migaud, Marie E.; Ziegler, Mathias; Nikiforov, Andrey. 2015. Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells. Journal of Biological Chemistry. 290: 27124-27137. Published 2015-11-06. doi: 10.1074/jbc.M115.664458
  • Love, Nick R.; Pollak, Nadine; Dölle, Christian; Niere, Marc; Chen, Yaoyao; Oliveri, Paola; Amaya, Enrique; Patel, Sandip; Ziegler, Mathias. 2015. NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 112: 1386-1391. doi: 10.1073/pnas.1417290112
  • Nikiforov, Andrey; Kulikova, Veronika; Ziegler, Mathias. 2015. The human NAD metabolome: Functions, metabolism and compartmentalization. Critical reviews in biochemistry and molecular biology. 50: 284-297. doi: 10.3109/10409238.2015.1028612
  • Van Linden, Magali R; Dölle, Christian; Pettersen, Ina Katrine Nitschke; Kulikova, Veronika; Niere, Marc; Agrimi, Gennaro; Dyrstad, Sissel Elisabeth; Palmieri, Ferdinando; Nikiforov, Andrey; Tronstad, Karl Johan; Ziegler, Mathias. 2015. Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 290: 27644-27659. Published 2015-11-13. doi: 10.1074/jbc.M115.654129
  • Blacker, Thomas S.; Mann, Zoe F.; Gale, Jonathan E.; Ziegler, Mathias; Bain, Angus J.; Szabadkai, Gyorgy; Duchen, Michael R. 2014. Separating NADH and NADPH fluorescence in live cells and tissues using FLIM. Nature Communications. 5:3936. doi: 10.1038/ncomms4936
  • Gossmann, Toni; Ziegler, Mathias. 2014. Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism. DNA Repair. 23: 39-48. doi: 10.1016/j.dnarep.2014.07.005
  • Love, Nick R.; Ziegler, Mathias; Chen, Yaoyao; Amaya, Enrique. 2014. Carbohydrate metabolism during vertebrate appendage regeneration: What is its role? How is it regulated? A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis. Bioessays. 36: 27-33. doi: 10.1002/bies.201300110
  • Rack, Johannes Gregor M; Lutter, Timo; Bjerga, Gro Elin Kjæreng; Guder, Corina; Ehrhardt, Christine; Varv, Signe; Ziegler, Mathias; Aasland, Rein. 2014. The PHD finger of p300 influences its ability to acetylate histone and non-histone targets. Journal of Molecular Biology. 426: 3960-3972. doi: 10.1016/j.jmb.2014.08.011
  • Rack, Johannes Gregor M; Van Linden, Magali R; Lutter, Timo; Aasland, Rein; Ziegler, Mathias. 2014. Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. Journal of Molecular Biology. 426: 1677-1691. doi: 10.1016/j.jmb.2013.10.027
  • Skoge, Renate Hvidsten; Dölle, Christian; Ziegler, Mathias. 2014. Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. DNA Repair. 23: 33-38. doi: 10.1016/j.dnarep.2014.04.011
  • Dölle, Christian; Rack, Johannes Gregor M; Ziegler, Mathias. 2013. NAD and ADP-ribose metabolism in mitochondria. The FEBS Journal. 280: 3530-3541. doi: 10.1111/febs.12304
  • Dölle, Christian; Skoge, Renate Hvidsten; Van Linden, Magali R; Ziegler, Mathias. 2013. NAD biosynthesis in humans - enzymes, metabolites and therapeutic aspects. Current Topics in Medicinal Chemistry. 13: 2907-2917.
  • Koch-Nolte, Friedrich; Ziegler, Mathias. 2013. Physiology of ADP-ribosylation. The FEBS Journal. 280: 3483-3483. doi: 10.1111/febs.12389
  • Livinskaya, V; Afanasyeva, A; Dölle, Christian; Niere, Marc; Khodorkovskiy, M; Ziegler, Mathias; Nikiforov, Andrey. 2013. Potential role of cytosolic 5'- nucleotidases in human NAD metabolism. The FEBS Journal. 280: 181-181.
  • Schüler, Herwig; Ziegler, Mathias. 2013. Pharmacology of ADP-ribosylation. The FEBS Journal. 280: 3542-3542. doi: 10.1111/febs.12388
  • Stavrum, Anne-Kristin; Heiland, Ines; Schuster, Stefan; Puntervoll, Pål; Ziegler, Mathias. 2013. Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. Journal of Biological Chemistry. 288: 34555-34566. doi: 10.1074/jbc.M113.474908
  • Blacker, Tom S.; Mann, Zoe F.; Gale, Jonathan E.; Ziegler, Mathias; Bain, Angus J.; Duchen, Michael R. 2012. Separation of NADPH and NADH Fluorescence Emission in Live Cells using Flim. Biophysical Journal. 102: 196A-196A.
  • Chiarugi, Alberto; Dølle, Christian; Felici, Roberta; Ziegler, Mathias. 2012. The NAD metabolome - a key determinant of cancer cell biology. Nature Reviews. Cancer. 12: 741-752. doi: 10.1038/nrc3340
  • Gossmann, Toni; Ziegler, Mathias; Puntervoll, Pål; de Figueiredo, Luis F.; Schuster, Stefan; Heiland, Ines. 2012. NAD(+) biosynthesis and salvage - a phylogenetic perspective. The FEBS Journal. 279: 3355-3363. doi: 10.1111/j.1742-4658.2012.08559.x
  • Mashimo, Masato; Niere, Marc; Agledal, Line; Dölle, Christian; Kasamatsu, Atsushi; Kato, Jiro; Moss, Joel; Ziegler, Mathias. 2012. ARH3 catalyzes degradation of mitochondrial matrix-accumulated Poly (ADP-ribose). The FASEB Journal. 26. 1 pages.
  • Niere, Marc; Mashimo, Masato; Agledal, Line; Dølle, Christian; Kasamatsu, Atsushi; Kato, Jiro; Moss, Joel; Ziegler, Mathias. 2012. ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose)glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). Journal of Biological Chemistry. 287: 16088-16102. doi: 10.1074/jbc.M112.349183
  • Koch-Nolte, Friedrich; Fischer, Stefan Martin; Haag, Friedrich; Ziegler, Mathias. 2011. Compartmentation of NAD(+)-dependent signalling. FEBS Letters. 585: 1651-1656. doi: 10.1016/j.febslet.2011.03.045
  • Nikiforov, Andrey; Dølle, Christian; Niere, Marc; Ziegler, Mathias. 2011. Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells FROM ENTRY OF EXTRACELLULAR PRECURSORS TO MITOCHONDRIAL NAD GENERATION. Journal of Biological Chemistry. 286: 21767-21778. doi: 10.1074/jbc.M110.213298
  • Szaszak, M; Winkler, K; Stevens, P; Ziegler, Mathias; Huttmann, G; Solbach, W; Rupp, J. 2011. Molecular mechanisms behind Chlamydia-induced reactive oxygen species production and inflammasome activation. International Journal of Medical Microbiology. 301: 86-87.
  • Ziegler, Mathias. 2011. NAD(+) - a key molecule in cellular signalling. The FEBS Journal. 278: 15-15.
  • de Figueiredo, Luis F.; Gossmann, Toni; Ziegler, Mathias; Schuster, Stefan. 2011. Pathway analysis of NAD(+) metabolism. Biochemical Journal. 439: 341-348. doi: 10.1042/BJ20110320
  • Agledal, Line; Niere, Marc; Ziegler, Mathias. 2010. The phosphate makes a difference: cellular functions of NADP. Redox report. 15: 2-10. doi: 10.1179/174329210X12650506623122
  • Dølle, Christian; Niere, Marc; Lohndal, Emilia; Ziegler, Mathias. 2010. Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cellular and Molecular Life Sciences (CMLS). 67: 433-443. doi: 10.1007/s00018-009-0190-4
  • Evjenth, Rune Henrik; Hole, Kristine; Karlsen, Odd Andre; Ziegler, Mathias; Arnesen, Thomas; Lillehaug, Johan R. 2010. Human Naa50p (Nat5/San) displays both protein N-alpha- and N-epsilon-Acetyltransferase activity. The FEBS Journal. 277: 182-182.
  • Evjenth, Rune Henrik; Hole, Kristine; Ziegler, Mathias; Lillehaug, Johan R. 2010. Application of reverse-phase HPLC to quantify oligopeptide acetylation eliminates interference from unspecific acetyl CoA hydrolysis. The FEBS Journal. 277: 265-266.
  • Hole, Kristine; Karlsen, Odd Andre; Ziegler, Mathias; Arnesen, Thomas; Lillehaug, Johan R.; Ryningen, Anita; Vandekerckhove, Joel; Gevaert, Kris; Anderson, D. 2010. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. The FEBS Journal. 277: 185-185.
  • Lau, Corinna; Dølle, Christian; Gossmann, Toni I.; Agledal, Line; Niere, Marc; Ziegler, Mathias. 2010. Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. Journal of Biological Chemistry. 285: 18868-18876. doi: 10.1074/jbc.M110.107631
  • Dølle, Christian; Ziegler, Mathias. 2009. Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Analytical Biochemistry. 385: 377-379. doi: 10.1016/j.ab.2008.10.033
  • Evjenth, Rune Henrik; Hole, Kristine; Karlsen, Odd Andre; Ziegler, Mathias; Arnesen, Thomas; Lillehaug, Johan R. 2009. Human Naa50p (Nat5/San) Displays Both Protein N-alpha- and N-epsilon-Acetyltransferase Activity. Journal of Biological Chemistry. 284: 31122-31129. doi: 10.1074/jbc.M109.001347
  • Kellmann, Ralf; Schaffner, Carlos António Markus; Grønset, Toril Anne; Satake, Masayuki; Ziegler, Mathias; Fladmark, Kari Espolin. 2009. Proteomic response of human neuroblastoma cells to azaspiracid-1. Journal of Proteomics. 72: 695-707. doi: 10.1016/j.jprot.2009.02.008
  • Koch-Nolte, Friedrich; Haag, F; Guse, AH; Lund, F; Ziegler, Mathias. 2009. Emerging Roles of NAD(+) and Its Metabolites in Cell Signaling. Science Signaling. 2. 5 pages. doi: 10.1126/scisignal.257mr1
  • Lau, Corinna; Niere, Marc; Ziegler, Mathias. 2009. The NMN/NaMN adenylyltransferase (NMNAT) protein family. Frontiers in Bioscience. 14: 410-431. doi: 10.2741/3252
  • Martino, Fabrizio; Kueng, Stephanie; Robinson, Philip; Tsai-Pflugfelder, Monika; van Leeuwen, Fred; Ziegler, Mathias; Cubizolles, Fabien; Cockell, Moira M.; Rhodes, Daniela; Gasser, Susan M. 2009. Reconstitution of yeast silent chromatin: Multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro. Molecular Cell. 33: 323-334. doi: 10.1016/j.molcel.2009.01.009
  • Niere, Marc; Kernstock, Stefan; Koch-Nolte, Friedrich; Ziegler, Mathias. 2008. Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Molecular and Cellular Biology. 28: 814-824. doi: 10.1128/MCB.01766-07
  • Pollak, Nadine; Niere, Marc; Ziegler, Mathias. 2008. NAD kinase levels control the NADPH concentration in human cells. Free radical research. 42: S37-S37.
  • Berger, Felicitas; Lau, Corinna; Ziegler, Mathias. 2007. Regulation of Poly(ADP-ribose)polymerase 1 Activity by the Phosphorylation State of the Nuclear NAD Biosynthetic Enzyme NMN Adenylyl Transferase 1. Proceedings of the National Academy of Sciences of the United States of America. 104: 3765-3770. doi: 10.1073/pnas.0609211104
  • Lewis, Alexamder M.; Masgrau, Roser; Vasudevan, Sridhar R.; Yarnasaki, Michiko; O'Neill, John S.; Garnham, Clive; James, Kristin; Macdonald, Andrew; Ziegler, Mathias; Galione, Antony; Churchill, Grant C. 2007. Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate. Analytical Biochemistry. 371: 26-36. doi: 10.1016/j.ab.2007.08.030
  • Pollak, Nadine; Dølle, Christian; Ziegler, Mathias. 2007. The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochemical Journal. 402: 205-218. doi: 10.1042/BJ20061638
  • Pollak, Nadine; Niere, Marc; Ziegler, Mathias. 2007. NAD kinase levels control the NADPH concentration in human cells. Journal of Biological Chemistry. 282: 33562-33571. Published 2007-11-16. doi: 10.1074/jbc.M704442200
  • Churamani, D; Dickinson, GD; Ziegler, Mathias; Patel, Sandip. 2006. Time sensing by NAADP receptors. Biochemical Journal. 397: 313-320. doi: 10.1042/BJ20060179
  • Ziegler, Mathias. 2006. Biochemistry and pharmacology of enzymes involved in NAD metabolism. Acta Pharmacologica Sinica. 27: 37-37.
  • Ziegler, Mathias. 2006. NAD: metabolism and regulatory functions. 12, pages . In:
    • Bürkle, Alexander. 2006. Poly(ADP-ribosyl)ation. Springer Science+Business Media B.V.. 246 pages. ISBN: 0-387-33371-1.
  • Berger, F.; Lau, Corinna; Dahlmann, M.; Ziegler, Mathias. 2005. Subcellular Compartmentation and Differential Catalytic Properties of the Three Human Nicotinamide Mononucleotide Adenylyltransferase Isoforms. Journal of Biological Chemistry. 280: 36334-36341.
  • Oei, Shiao li; Keil, Claudia; Ziegler, Mathias. 2005. Poly(ADP-ribosylation) and genomic stability. Biochemistry and Cell Biology. 83: 263-269.
  • Ziegler, Mathias. 2005. A vital link between energy and signal transduction - Regulatory functions of NAD(P). The FEBS Journal. 272: 4561-4564.
  • Ziegler, Mathias. 2005. The adenine nucleotide translocase - a carrier protein potentially required for mitochondrial generation of NAD. Biochemistry (Moscow). 70: 173-177.
  • Berger, Felicitas; Ramirez-Hernandez, Maria-Helena; Ziegler, Mathias. 2004. The new life of a centenarian: signalling functions of NAD(P). TIBS -Trends in Biochemical Sciences. Regular ed.. 29: 111-118. doi: 10.1016/j.tibs.2004.01.007
  • Hunt, Lee; Lerner, Felicitas; Ziegler, Mathias. 2004. NAD � new roles in signalling and gene regulation in plants. New Phytologist. 163: 31-44.
  • Nikiforov, A; Svetlova, MP; Solov'eva, LV; Ziegler, Mathias; Oei, Shiao li; Nikolaishvili-Feinberg, N; Codeiro-Stone, M; Tomilin, NV. 2004. Dynamics of some postreplication DNA repair proteins in carcinogen-damaged mammalian cells. Tsitologia. 46: 43-52.
  • Ziegler, Mathias; Niere, Marc. 2004. NAD+ surfaces again. Biochemical Journal. 382. 2 pages. doi: 10.1042/BJ20041217

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