Home
Mette Vesterhus's picture

Mette Vesterhus

Associate Professor
  • E-mailMette.Vesterhus@uib.no
  • Phone+47 55 97 52 69
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland; Rosendahl, Karen; Juliusson, Petur Benedikt; Olafsdottir, Edda Jonina; Gilja, Odd Helge; Vesterhus, Mette. 2019. Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 706-712.
  • Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia; Moum, Bjørn; Vesterhus, Mette; Karlsen, Tom Hemming; Seljeflot, Ingebjørg; Hov, Johannes Espolin Roksund. 2019. Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print). 371-381.
  • Saffioti, Francesca; Roccarina, Davide; Vesterhus, Mette; Hov, Johannes Espolin Roksund; Rosenberg, William; Pinzani, Massimo; Pereira, Stephen P.; Boberg, Kirsten Muri; Thorburn, Douglas. 2019. Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. European Journal of Clinical Investigation.
  • Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude; Karlsen, Tom Hemming; Beuers, Ulrich; Vesterhus, Mette; Hov, Johannes Espolin Roksund. 2019. Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports.
  • Nielsen, MJ; Thorburn, Douglas; Leeming, DJ; Hov, Johannes Espolin Roksund; Nygård, Ståle; Moum, Bjørn; Saffioti, Francesca; Gilja, Odd Helge; Boberg, Kirsten Muri; Mazza, Giuseppe; Røsjø, Helge; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, MA; Vesterhus, Mette. 2018. Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. 179-189.
  • Eaton, JE; Vesterhus, Mette; McCauley, Bryan M.; Atkinson, EJ; Schlicht, EM; Juran, BD; Gossard, AA; LaRusso, NF; Gores, GJ; Karlsen, Tom Hemming; Lazaridis, KN. 2018. Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. Hepatology. 1-11.
  • Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge; Vesterhus, Mette; Havre, Roald Flesland. 2018. Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements. PLOS ONE. 1-16.
  • Zenouzi, Roman; Liwinski, T; Yamamura, J; Weiler-Normann, Christina; Sebode, Marcial; Keller, S; Lohse, AW; Schramm, C; Aabakken, Lars; Arrive, L; Bowlus, Christopher L.; Bungay, H; Van Buuren, HR; Cardinale, Vincenzo; Carey, EJ; Chazouilleres, O; Cheung, A; Culver, EL; Dufour, JF; Dumonceau, JM; Eaton, JE; Eddowes, EJ; Farkkila, M; Floreani, A; Franceschet, I; Hohenester, SD; Kemmerich, Gunter; Krawczyk, M; Zimmer, Vincent; Lenzen, H; Levy, Cynthia; Marschall, HU; Marzioni, M.; Muratori, Luigi; Pereira, SP; Poley, JW; Rimola, Jordi; Ringe, KI; Rushbrook, Simon M; Simpson, BW; Schrumpf, Erik; Spina, JC; Terziroli Beretta‐Piccoli, B; Trauner, Michael; Tringali, A; Venkatesh, SK; Vesterhus, Mette; Villamil, A; Weismuller, TJ; Ytting, Hanne. 2018. Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret. Alimentary Pharmacology and Therapeutics. 169-178.
  • Goode, EC; Clark, AB; Melis, GM; Srivastava, B; Spiess, K; Gelson, WTH; Trivedi, PJ; Lynch, KD; Castren, Eero; Vesterhus, Mette; Karlsen, Tom Hemming; Ji, SG; Anderson, CA; Thorburn, Douglas; Hudson, M; Heneghan, M; Aldersley, MA; Bathgate, A; Sandford, RN; Alexander, GJ; Chapman, RW; Walmsley, M; Hirschfield, Gideon M.; Rushbrook, SM. 2018. Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. Hepatology. 2120-2135.
  • Trivedi, PJ; Tickle, J; Vesterhus, Mette; Eddowes, P; Bruns, T; Vainio, J; Parker, R; Smith, D; Liaskou, Evaggelia; Thorbjørnsen, Liv Wenche; Hirschfield, GM; Auvinen, K; Hubscher, S; Salmi, M; Adams, DH; Weston, CJ. 2017. Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. Gut. 1135-1145.
  • Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge; Vesterhus, Mette; Havre, Roald Flesland. 2017. Repeatability of shear wave elastography in liver fibrosis phantoms—Evaluation of five different systems. PLOS ONE. 1-16.
  • Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik; Melum, Espen; Thorbjørnsen, Liv Wenche; Paulsen, Vemund; Lundin, Knut Erik Aslaksen; Dale, Inge; Gilja, Odd Helge; Zweers, Serge J.; Vatn, Morten H; Schaap, Frank G.; Jansen, Peter L.M.; Ueland, Thor; Røsjø, Helge; Moum, Bjørn; Ponsioen, Cyriel Y.; Boberg, Kirsten Muri; Färkkilä, Martti; Karlsen, Tom Hemming; Lund-Johansen, Fridtjof. 2017. Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology. 1214-1222.
  • de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus; Thorburn, Douglas; Chazouillères, Olivier; Pares, Albert; Nygård, Ståle; Gilja, Odd Helge; Wunsch, Ewa; Invernizzi, Pietro; Carbone, Marco; Bernuzzi, Francesca; Boberg, Kirsten Muri; Røsjø, Helge; Rosenberg, William; Beuers, Ulrich H.; Ponsioen, Cyriel Y.; Karlsen, Tom Hemming; Vesterhus, Mette. 2017. Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print). 1554-1561.
  • Bende, Felix; Mulabecirovic, Anesa; Popescu, Alina; Sporea, Ioan; Sirli, Roxana; Gilja, Odd Helge; Vesterhus, Mette; Havre, Roald Flesland. 2017. Assessing liver stiffness by 2-D shear wave elastography in a healthy cohort. Ultrasound in Medicine and Biology. 332-341.
  • Hov, Johannes Espolin Roksund; Boberg, Kirsten Muri; Taraldsrud, Eli; Vesterhus, Mette; Boyadzhieva, Maria; Solberg, Inger Camilla; Schrumpf, Erik; Vatn, Morten H; Lie, Benedicte Alexandra; Molberg, Øyvind; Karlsen, Tom Hemming. 2017. Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. Liver international (Print). 458-465.
  • Jendrek, Sebastian Torben; Gotthardt, Daniel; Nitzsche, Thomas; Widmann, Laila; Korf, Tobias; Michaels, Maike Anna; Weiss, Karl Heinz; Liaskou, Evaggelia; Vesterhus, Mette; Karlsen, Tom Hemming; Mindorf, Swantje; Schemmer, Peter; Bär, Florian; Teegen, Bianca; Schröder, Torsten; Ehlers, Marc; Hammers, Christoph Matthias; Komorowski, Lars; Lehnert, Hendrik; Fellermann, Klaus; Derer, Stefanie; Hov, Johannes Espolin Roksund; Sina, Christian. 2017. Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Hepatology. 137-144.
  • Mjelle, Anders Batman; Mulabecirovic, Anesa; Hausken, Trygve; Havre, Roald Flesland; Gilja, Odd Helge; Vesterhus, Mette. 2016. Ultrasound and point shear wave elastography in livers of patients with primary sclerosing cholangitis. Ultrasound in Medicine and Biology. 2146-2155.
  • Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Nygård, Ståle; Vesterhus, Mette; Høivik, Marte; Trøseid, Marius; Marschall, Hanns-Ulrich; Schrumpf, Erik; Moum, Bjørn; Røsjø, Helge; Aukrust, Pål; Karlsen, Tom Hemming; Hov, Johannes Espolin Roksund. 2016. The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut. 611-619.
  • Vesterhus, Mette; Melum, Espen. 2016. Prognostic biomarkers and surrogate end points in PSC. Liver international (Print). 1748-1751.
  • Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge; Havre, Roald Flesland. 2016. In vitro comparison of five different elastography systems for clinical applications, using strain and shear wave technology. Ultrasound in Medicine and Biology. 2572-2588.
  • Mulabecirovic, Anesa; Mjelle, Anders Batman; Vesterhus, Mette; Gilja, Odd Helge; Havre, Roald Flesland. 2016. In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. Ultrasound in Medicine and Biology. 2572-2588.
  • Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tom Hemming; Berge, Rolf Kristian; Hov, Johannes Espolin Roksund. 2016. Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology journal. 532-541.
  • Zweers, Serge J.; Shiryaev, Alexey; Komuta, Mina; Vesterhus, Mette; Hov, Johannes Espolin Roksund; Perugorria, Maria J.; de Waart, D. Rudi; Chang, Jung-Chin; Tol, Shanna; te Velde, Anje A.; de Jonge, Wouter J.; Banales, Jesus M.; Roskams, Tania; Beuers, Ulrich; Karlsen, Tom Hemming; Jansen, Peter L.; Schaap, Frank G. 2016. Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. Liver international (Print). 1370-1377.
  • Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika; Osnes, Liv T. N.; Holm, Kristian; Høivik, Marte; Rashidi, Azita; Dahl, Christen Peder; Vesterhus, Mette; Halvorsen, Bente; Mollnes, Tom Eirik; Berge, Rolf Kristian; Moum, Bjørn; Lundin, Knut Erik Aslaksen; Fevang, Børre; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund. 2016. Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology.
  • Vesterhus, Mette; Hov, Johannes Espolin Roksund; Holm, Anders; Schrumpf, Erik; Nygård, Ståle; Godang, Kristin; Andersen, Ina Marie; Næss, Sigrid; Thorburn, Douglas; Saffioti, Francesca; Vatn, Morten; Gilja, Odd Helge; Lund-Johansen, Fridtjof; Syversveen, Trygve; Braband, Knut; Parés, Albert; Ponsioen, Cyriel Y.; Pinzani, Massimo; Färkkilä, Martti; Moum, Bjørn; Ueland, Thor; Røsjø, Helge; Rosenberg, William; Boberg, Kirsten Muri; Karlsen, Tom Hemming. 2015. Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. Hepatology. 188-197.
  • Karlsen, Tom Hemming; Vesterhus, Mette; Boberg, Kirsten Muri. 2014. Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. 282-301.
  • Ræder, Helge; McAllister, Fiona E.; Tjora, Erling; Bhatt, Sheweta; Haldorsen, Ingfrid S.; Hu, Jiang; Willems, Stefan M.; Vesterhus, Mette; El Ouaamari, Abdelfattah; Liu, Manway; Ræder, Maria B; Immervoll, Heike ; Hoem, Dag; Dimcevski, Georg Gjorgji; Njølstad, Pål Rasmus; Molven, Anders; Gygi, Steven P.; Kulkarni, Rohit N. 2014. Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Diabetes. 259-269.
  • Ræder, Helge; Vesterhus, Mette; El Ouaamari, Abdelfattah; Paulo, Joao A.; McAllister, Fiona E.; Liew, Chong Wee; Hu, Jiang; Kawamori, Dan; Molven, Anders; Gygi, Steven P.; Njølstad, Pål Rasmus; Kahn, C. Ronald; Kulkarni, Rohit N. 2013. Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). PLOS ONE. 11 pages.
  • Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette; Molven, Anders; Njølstad, Pål Rasmus. 2011. The role of pancreatic imaging in monogenic diabetes. Nature Reviews Endocrinology.
  • Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise; Vesterhus, Mette; Ragvin, Anja; Tjora, Erling; Fjeld, Karianne; Hoem, Dag; Johansson, Stefan; Ræder, Helge; Lindquist, Susanne; Hernell, Olle; Cnop, Miriam; Saraste, Jaakko; Flatmark, Torgeir; Molven, Anders; Njølstad, Pål Rasmus. 2011. Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 34593-34605.
  • Vesterhus, Mette; Ræder, Helge; Kurpad, Amarnath J; Kawamori, Dan; Molven, Anders; Kulkarni, Rohit N; Kahn, C Ronald; Njølstad, Pål Rasmus. 2010. Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. Pancreatology (Print). 467-476.
  • Vesterhus, Mette; Haldorsen, Ingfrid Salvesen; Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus. 2008. Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. Journal of Clinical Endocrinology and Metabolism. 3505-3509.
  • Vesterhus, Mette; Ræder, Helge; Johansson, Stefan; Molven, Anders; Njølstad, Pål Rasmus. 2008. Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. Diabetes Care. 306-310.
  • Vesterhus, Mette; Ræder, Helge; Aurlien, Harald; Gjesdal, Clara Gram; Bredrup, Cecilie; Holm, Pål Ivar; Molven, Anders; Bindoff, Laurence; Berstad, Arnold; Njølstad, Pål Rasmus. 2008. Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. Diabetes Care. 1738-1740.
  • Haldorsen, Ingfrid Salvesen; Vesterhus, Mette; Ræder, Helge; Jensen, Dag K.; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2008. Lack of pancreatic body and tail in HNF1B mutation carriers. Diabetic Medicine. 782-787.
Lecture
  • Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge; Mjelle, Anders Batman. 2017. Ultralyd Elastografi.
  • Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge; Vesterhus, Mette; Havre, Roald Flesland. 2017. Måling av vevsstivhet på fantomer med fire ulike «shear wave» elastografisystemer.
Academic lecture
  • Mulabecirovic, Anesa; Mjelle, Anders Batman; Havre, Roald Flesland; Vesterhus, Mette; Gilja, Odd Helge. 2016. Quantification of tissue elasticity in vitro using three clinical shear wave elastography platforms on liver fibrosis phantoms.
  • Mjelle, Anders Batman; Mulabecirovic, Anesa; Hausken, Trygve; Havre, Roald Flesland; Gilja, Odd Helge; Vesterhus, Mette. 2016. Elastography of the Liver in Primary Sclerosing Cholangitis.
  • Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Vesterhus, Mette; Høivik, Marte; Trøseid, Marius; Marschall, Hanns-Ulrich; Schrumpf, Erik; Moum, Bjørn; Aukrust, Pål; Karlsen, Tom Hemming; Hov, Johannes Espolin Roksund. 2015. O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
  • Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge; Havre, Roald Flesland. 2015. In vitro quantification and reproducibility of elasticity measurements using five different elastography systems.
Doctoral dissertation
  • Vesterhus, Mette. 2009. Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man.
Academic chapter/article/Conference paper
  • Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming; Havre, Roald Flesland; Gilja, Odd Helge; Vesterhus, Mette. 2015. Point shear wave elastography of the liver in primary sclerosing cholangitis. 2 pages.
Abstract
  • Havre, Roald Flesland; Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge. 2015. Elasticity Mearsurements Using Four Different Ultrasound Scanners. Ultrasound in Medicine and Biology. 148-149.
  • Vesterhus, Mette; Johansson, Stefan; Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus. 2007. Pancreatic exocrine deficiency is common in MODY 3. Diabetologia. S123-S123.
Poster
  • Mortensen, Joachim Høg; Lunder, Aida Kapic; Manon-Jensen, Tina; Karsdal, MA; Nielsen, Mette; Leeming, DJ; Hov, Johannes Espolin Roksund; Negård, Anne; Jahnsen, Jørgen; Moum, Bjørn; Vesterhus, Mette; Høivik, Marte Lie; Kristensen, Vendel Ailin. 2020. P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study.
  • Mulabecirovic, Anesa; Bende, Felix; Sporea, I; Sirli, Roxana; Popescu, Alina; Gilja, Odd Helge; Vesterhus, Mette; Havre, Roald Flesland. 2017. ASSESSING LIVER STIFFNESS USING 2D-SHEAR WAVE ELASTOGRAPHY IN A HEALTHY COHORT.
  • Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming; Havre, Roald Flesland; Gilja, Odd Helge; Vesterhus, Mette. 2015. Point shear wave elastography of the liver in primary sclerosing cholangitis.
  • Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tor Hemming; Berge, Rolf Kristian; Hov, Johannes Espolin Roksund. 2015. P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.
  • Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tom Hemming; Berge, Rolf Kristian; Hov, Johannes Espolin Roksund. 2015. MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS.
  • Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge; Havre, Roald Flesland. 2015. In vitro quantification and reproducibility of elasticity measurements using four different ultrasound scanners.
Academic literature review
  • Vesterhus, Mette; Karlsen, Tom Hemming. 2020. Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. 1-27.
  • Karlsen, Tom Hemming; Folseraas, Trine; Thorburn, Douglas; Vesterhus, Mette. 2017. Primary sclerosing cholangitis - a comprehensive review. 1298-1323.
  • Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette; Molven, Anders; Njølstad, Pål Rasmus. 2012. The role of pancreatic imaging in monogenic diabetes mellitus. 148-159.

More information in national current research information system (CRIStin)