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Mihaela-Roxana Cimpan's picture

Mihaela-Roxana Cimpan

Professor
Department of Clinical Dentistry
  • E-mailMihaela.Cimpan@uib.no
  • Phone+47 55 58 62 63
  • Visitor Address
    Biomaterials - Department for Clinical Dentistry, Årstadveien 19, Bergen 5009, Norway
    Aarstadveien 19-21
    5009 Bergen
    Room 
    D04.010
  • Postal Address
    Postboks 7804
    5020 Bergen
  • Biomaterials, Biocompatibiltiy
  • Nanomaterials
  • Biological effects of biomaterials and nanomaterials
  • Nanotoxicology
  • Nanomedicine
  • Developmanet of new techniques for evaluating the biological effects of nanomaterials

dental students, dental hygienist students, specialist candidates, PhD candidates, BSc and MSc students in Nanotechnology and Nanoscience

Academic article
  • Show author(s) (2023). Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction. International Journal of Molecular Sciences. 13 pages.
  • Show author(s) (2022). Polycrystalline diamond coating on orthopedic implants: Realization and role of surface topology and chemistry in adsorption of proteins and cell proliferation. ACS Applied Materials & Interfaces. 44933-44946.
  • Show author(s) (2022). Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpression. Frontiers in Pharmacology. 1-16.
  • Show author(s) (2022). Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models. Biomedicine & Pharmacotherapy. 14 pages.
  • Show author(s) (2021). Predicting intention of Norwegian dental health-care workers to use nanomaterials: An application of the augmented theory of planned behavior. European Journal of Oral Sciences. 1-10.
  • Show author(s) (2021). A strategy towards the generation of testable adverse outcome pathways for nanomaterials. Altex. 580-594.
  • Show author(s) (2020). Thermodynamic parameters at bio-nano interface and nanomaterial toxicity: A case study on BSA interaction with ZnO, SiO2 and TiO2. Chemical Research in Toxicology. 2054-2071.
  • Show author(s) (2020). Risk governance of emerging technologies demonstrated in terms of its applicability to nanomaterials. Small. 12 pages.
  • Show author(s) (2020). Label-free impedance flow cytometry for nanotoxicity screening. Scientific Reports.
  • Show author(s) (2019). Use of nanomaterials in dentistry: covariates of risk and benefit perceptions among dentists and hygienists in Norway. Acta Odontologica Scandinavica. 152-160.
  • Show author(s) (2019). Knowledge about nanotechnology and intention to use nanomaterials: a comparative study among dental students in Norway and Romania. European journal of dental education. 79-87.
  • Show author(s) (2018). TiO2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner. Journal of Biomedical Materials Research. Part A. 2582-2593.
  • Show author(s) (2018). Label-free monitoring of uptake and toxicity of endoprosthetic wear particles in human cell cultures. International Journal of Molecular Sciences. 1-14.
  • Show author(s) (2018). In vitro cytotoxicity assessment of nanodiamond particles and their osteogenic potential. Journal of Biomedical Materials Research. Part A. 1697-1707.
  • Show author(s) (2017). Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. Journal of Oral Pathology & Medicine. 214-222.
  • Show author(s) (2017). CHITOSAN MODIFIED POLY(LACTIC-CO-GLYCOLIC) ACID NANOPARTICLES INTERACTION WITH NORMAL, PRECANCEROUS KERATINOCYTES AND DENTAL PULP CELLS. Stomatology Edu Journal. 16-26.
  • Show author(s) (2016). Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. Journal of Oral Pathology & Medicine. 214-222.
  • Show author(s) (2016). Contact-dependent transfer of TiO2 nanoparticles between mammalian cells. Nanotoxicology. 204-215.
  • Show author(s) (2015). The effect of blood protein adsorption on cellular uptake of anatase TiO2 nanoparticles. International Journal of Nanomedicine. 687-695.
  • Show author(s) (2013). In vitro reconstruction of human junctional and sulcular epithelium. Journal of Oral Pathology & Medicine. 396-404.
  • Show author(s) (2013). An impedance-based high-throughput method for evaluating the cytotoxicity of nanoparticles. Journal of Physics: Conference Series (JPCS). 10 pages.
  • Show author(s) (2012). Role of physicochemical characteristics in the Uptake of TiO2 nanoparticles by fibroblasts. Toxicology in Vitro. 469-479.
  • Show author(s) (2012). Limited in-depth invasion of Fusobacterium nucleatum into in vitro reconstructed human gingiva. Archives of Oral Biology. 344-351.
  • Show author(s) (2009). Fusobacterium nucleatum Enters Normal Human Oral Fibroblasts In Vitro. Journal of Periodontology. 1174-1183.
  • Show author(s) (2009). Agglomeration and Sedimentation of TiO2 Nanoparticles in Cell Culture Medium. Colloids and Surfaces B: Biointerfaces. 83-87.
  • Show author(s) (2008). Induction of cell death by TiO2 nanoparticles: studies on a human monoblastoid cell line. Toxicology in Vitro. 1689-1696.
  • Show author(s) (2005). The coinitiator DMABEE induces death by apoptosis and necrosis in human monoblastoid cells. Clinical Oral Investigations. 168-172.
  • Show author(s) (2002). Comparative corrosion studies in the case of Nicromal alloy. Timisoara Medical Journal. 39-40.
  • Show author(s) (2001). Detection of cadmium in six denture base acrylic resins. Romanian Biotechnological Letters. 387-392.
  • Show author(s) (2000). The effect of heat- and auto-polymerized denture base polymers on clonogenicity, apoptosis, and necrosis in fibroblasts: denture base polymers induce apoptosis and necrosis. Acta Odontologica Scandinavica. 217-228.
  • Show author(s) (2000). Patterns of cell death induced by eluates from denture base acrylic resins in U-937 human monoblastoid cells. European Journal of Oral Sciences. 59-69.
  • Show author(s) (1999). Comparison of physical and mechanical properties of some commonly used eastern and western European denture base acrylic resins. Revista Nationala de Stomatologie. 4-9.
  • Show author(s) (1999). Assessment of uncertainty in mechanical testing of dental biomaterials. Quality Assurance: Good Practice Regulation & Law. 213-228.
Lecture
  • Show author(s) (2021). NanoSafety Research Group: Projects and Collaborations.
  • Show author(s) (2020). Reflecting on Ethical, Legal and Societal Aspects of Nanosafety .
  • Show author(s) (2019). Presentation of the Nano-group research .
Popular scientific lecture
  • Show author(s) (2017). How to be a part of a big european project.
  • Show author(s) (2016). presentasjon av forskningen til Nanogruppen.
  • Show author(s) (2014). presentasjon: Biologiske effekter av nanomaterialer.
  • Show author(s) (2012). Fyllingsmaterialer i konserverende tannbehandling etter utfasing av amalgam.
  • Show author(s) (2009). Nanoteknologi - den nye kuren?
Academic lecture
  • Show author(s) (2022). Towards risk governance of nanomaterials: adaptation and validation of test methods for characterization and hazard assessment.
  • Show author(s) (2022). Nanomaterials and Nanotoxicology.
  • Show author(s) (2022). MODERN DENTAL PROSTHETIC MATERIALS AT THE CONFLUENCE OF SCIENCE, TECHNOLOGY AND ART.
  • Show author(s) (2022). Label-free Impedance-based Methods for Nanotoxicity Assessment.
  • Show author(s) (2021). Sustainability in dental medicine - tools for assessment and outcomes - Session chair.
  • Show author(s) (2020). Screening Nano-Ethical Issues .
  • Show author(s) (2020). Generation of testable adverse outcome pathways (AOPs) for nanomaterial human hazard assessment.
  • Show author(s) (2020). Development of an Adverse Outcome Pathway for Chronic and Multi-Generational Impacts of Nanomaterials in the Environmental Indicator Species Daphnia Magna .
  • Show author(s) (2020). Building networks to increase the chance of external financing .
  • Show author(s) (2019). NanoMed prosjekter.
  • Show author(s) (2019). Impact of TiNbN wear particles on osteoblastic differentiation capacity and induction of inflammatory reactions.
  • Show author(s) (2018). Bridging Human- and Eco-nanosafety in Norway & Establishing a Norwegian platform for NanoSafety - Introduction .
  • Show author(s) (2017). Validation of an Impedance-Based Flow Cytometry Technique for High-Throughput Nanotoxicity Screening.
  • Show author(s) (2017). Presentasjon av Nano-prosjekter.
  • Show author(s) (2017). Organised the Workshop and held presentation on Human nanosafety Methods development .
  • Show author(s) (2017). Nanotoxicity of GEMNS particles.
  • Show author(s) (2017). Label-free methods used in nanotoxicity testing.
  • Show author(s) (2017). Impedance-based methods for high throughput nanotoxicity screening.
  • Show author(s) (2017). Cellular uptake and toxicity of charged silica nanoparticles.
  • Show author(s) (2016). Nano-TiO2 Penetrates Human Oral Mucosa.
  • Show author(s) (2016). Microfluidics in nanotoxicity testing.
  • Show author(s) (2016). CELLULAR UPTAKE AND TOXICITY OF POSITIVELY AND NEGATIVELY CHARGED SILICA NANOPARTICLES.
  • Show author(s) (2015). participation at the kick-off meeting fro NANO2021 NorNANoREG project.
  • Show author(s) (2015). Overview Results in the NANO2021 NorNANoREG project.
  • Show author(s) (2015). EU og NFR prosjekter - Nanotoksikologi ved seksjon for Biomaterialer.
  • Show author(s) (2014). Treatment of cells with nanoparticles boosts intercellular communication.
  • Show author(s) (2014). Nanoparticle penetration in 3D oral mucosa models.
  • Show author(s) (2013). Assessment of TiO2 nanoparticle cytotoxicity by real-time impedance-based monitoring.
  • Show author(s) (2012). Imaging of nanoparticles in cells.
  • Show author(s) (2012). Cellular Uptake of TiO2 Nanoparticles: Role of Physico-Chemical Properties.
  • Show author(s) (2012). An Impedance-based High-throughput Method for Evaluating the Cytotoxicity of Nanoparticles.
  • Show author(s) (2011). Role of Physicochemical Characteristics in the Uptake of TiO2 Nanoparticles by Fibroplasts.
  • Show author(s) (2011). Nanomaterials, Nanoparticles, Nanotoxicology.
  • Show author(s) (2010). Nanotechnology: The New Cure?
  • Show author(s) (2010). Deltakelse på ROUND TABLE CONFERENCE "Nano science and technology in relation to health, environment, safety and regulations" Venue: The Norwegian Academy of Science and Letters (DNVA) Drammensveien 78, Oslo.
  • Show author(s) (2010). Biological effects of nanoparticles released from implants.
  • Show author(s) (2009). In Vitro Biological Effects of TiO2 Nanoparticles.
  • Show author(s) (2008). Nanotoxicology in relation to Biomaterials.
  • Show author(s) (2008). Fusobacterium nucleatum Enters Oral Fibroblasts.
  • Show author(s) (2007). Utvikling og bruk av LST (lymfocytt stimuleringstest) i forskningssammenheng.
  • Show author(s) (2001). Role of antioxidants in the prevention of cell death by apoptosis induced by dental biomaterials.
  • Show author(s) (1999). ’Biocompatibility of dental materials with special reference to apoptosis’.
  • Show author(s) (1997). In vitro biological effects and physical properties of poly(methyl methacrylate)-based denture base resins.
  • Show author(s) (1996). ’Comparison of physical and mechanical properties of Eastern European and Western European acrylic resins for denture base’.
  • Show author(s) (1995). ’Physical and mechanical properties of PMMA-based denture base resins’.
Thesis at a second degree level
  • Show author(s) (2021). Holdninger til tannpleieprodukter med fluor.
  • Show author(s) (2011). Impedance-based cellular assays: Applicability in Nanotoxicology.
  • Show author(s) (2009). Hjemmebleking av tenner: Bivirkninger og forebygging av disse.
Masters thesis
  • Show author(s) (2022). Non-invasive impedance-based methods to assess the effects of nanomaterials on human and fish cells.
  • Show author(s) (2022). Development of Endothelial Barrier Models for Nanotoxicity Testing.
  • Show author(s) (2022). Cyclic Voltammetry to Monitor Total Antioxidant Capacity of In-Vitro Biological Models Exposed to Nanomaterials.
  • Show author(s) (2020). Microfluidic-based biomimetic models for toxicological and therapeutic testing of nanoparticles.
  • Show author(s) (2018). Impedance-based microfluidic device for assessing the cytotoxicity of nanoparticles.
  • Show author(s) (2016). Penetration of negatively and positively charged SiO2 nanoparticles into normal, dysplastic, and cancer human oral mucosa.
  • Show author(s) (2016). Cellular uptake and toxicity of positively and negatively charged silica nanoparticles in A549 human lung carcinoma cells.
  • Show author(s) (2015). Nanotechnology in dentistry. Assessment of current knowledge of dental students on the use of nanomaterials in dentistry and investigation of nanoparticle internalization in a human oral mucosa model.
  • Show author(s) (2015). FREMSKRITT INNENFOR NANOTEKNOLOGI VED DIAGNOSTIKK OG BEHANDLING AV KREFT.
  • Show author(s) (2014). A Microfluidic Chip-Based Impedance Flow Cytometry Method for Evaluating the Cytotoxicity of Nanoparticles.
  • Show author(s) (2013). Nanoteknologi og dentale fyllingsmaterialer.
  • Show author(s) (2012). Interactions between TiO2 nanoparticles and fibroblasts investigated by impedance-based monitoring.
  • Show author(s) (2011). Effekt av ekstern bleking på mineralisert tannvev.
Popular scientific article
  • Show author(s) (2012). Hvor trygt er Nano? Nanotoksikologi – et tverrfaglig forskningsfelt. Naturen. 121-125.
Doctoral dissertation
  • Show author(s) (2017). Titanium Dioxide and Diamond Nanoparticles: In-vitro assessment of the effects on the oral mucosal barrier and bone biology.
  • Show author(s) (2012). Interactions between Fusobacterium nucleatum and Primary Oral cells, In Vitro Studies in Monolayer and Organotypic Culture Models.
  • Show author(s) (2000). In vitro biological effects and physical properties of poly(methyl methacrylate)-based denture base resins.
Interview
  • Show author(s) (2019). Finner nye metoder for å kartlegge biologiske effekter av nanopartikler.
  • Show author(s) (2010). Nanotechnology - effects on human health and environment.
Abstract
  • Show author(s) (2003). 4-N,N-dimethyl amino benzoic acid ethylester induces apoptosis and necrosis in U-937 cells. Journal of Dental Research. 343-343.
  • Show author(s) (2001). Vitamin E prevents apoptosis and necrosis in U-937 cells exposed to eluates from autopolymerized denture base acrylic resins. Journal of Dental Research. 1291-1291.
  • Show author(s) (1999). Altered clonogenicity and induction of apoptotic cell death in L929 cells exposed to denture base acrylic resins. Journal of Dental Research. 315-315.
  • Show author(s) (1998). A comparative study of cytopathogenic effects of four denture base acrylic resins. Journal of Dental Research. 816-816.
  • Show author(s) (1996). Comparison of physical and mechanical properties of eastern and western European denture base acrylic resins. Journal of Dental Research. 294-294.
Poster
  • Show author(s) (2022). Monitoring nanoparticle-induced oxidative stress using cyclic voltammetry and fluorescence-based assays.
  • Show author(s) (2022). Impedance-based real-time assessment of nanotoxicity in human and fish cells.
  • Show author(s) (2022). Development of vascular models to study the transport and effect of nanomaterials. .
  • Show author(s) (2022). Assessment of nanoparticle-induced oxidative stress using cyclic voltammetry and the convolution technique.
  • Show author(s) (2021). Non-invasive Impedance-based Methods for Nanotoxicity Assessment.
  • Show author(s) (2021). Impedance-based methods forvnanotoxicity testing.
  • Show author(s) (2021). Identifying the relevance of existing adverse outcome pathways for nanomaterials.
  • Show author(s) (2021). Factors Influencing the use of Nanomaterials in Dentistry.
  • Show author(s) (2021). Cyclic Voltammetry-based methods for nanotoxicity testing.
  • Show author(s) (2021). Assessment of nano- TiO2 and ZnO toxicity on rainbow trout gut cells using label-free impedance-based real-time monitoring .
  • Show author(s) (2020). Reflecting on Ethics of Nanosafety .
  • Show author(s) (2019). Nanocarrier-directed drug delivery for breast cancer treatment.
  • Show author(s) (2019). Label-free impedance-based nanotoxicity testing: Static vs. dynamic exposure to nanomaterials.
  • Show author(s) (2019). Dental Health Care Workers’ Intention to Use Nanomaterials.
  • Show author(s) (2019). Biomimetic impedance-based assessment of the biological effects of anticancer nanoparticles .
  • Show author(s) (2018). Relating thermodynamics to the dominant contributions determining the toxicity of nanomaterials.
  • Show author(s) (2018). Perception of risks and benefits related to nanomaterials.
  • Show author(s) (2018). Label-free impedimetric analysis of the cytotoxic effects of nanomaterials under dynamic in-vivo like conditions.
  • Show author(s) (2018). Impedance Flow Cytometry for in vitro Screening of Graphene-encapsulated Magnetic Nanoparticles.
  • Show author(s) (2017). Impedance-based methods for label-free rapid nanotoxicity screening.
  • Show author(s) (2016). Toxicological assessment of nano-diamond particles used in tissue engineering scaffolds for bone tissue regeneration.
  • Show author(s) (2016). TiO2 nanoparticles disrupt attachment, cytoskeletal networks and migration of human osteoblast-like cells in a size dependent manner.
  • Show author(s) (2016). Nano-TiO2 penetrates human oral mucosa.
  • Show author(s) (2016). High throughput nanoTOX screening using impedance: A data analysis example.
  • Show author(s) (2016). Cytotoxicity of engineered nanomaterials assessed by impedance-based monitoring.
  • Show author(s) (2014). Uptake of TiO2 nanoparticles in a human oral mucosa model.
  • Show author(s) (2014). Role of particle size in the uptake of nano-TiO2.
  • Show author(s) (2014). Deeper penetration of TiO2 nanoparticles in neoplastic vs. Normal human oral mucosa models.
  • Show author(s) (2014). Comparison of uptake of TiO2 nanoparticles in normal and cancer human oral mucosa models.
  • Show author(s) (2014). Assessment of knowledge about nanotechnology in dentistry among dental students.
  • Show author(s) (2014). A Microfluidic Chip-Based Impedance Flow Cytometry Method for Evaluating the Cytotoxicity of Nanoparticles.
  • Show author(s) (2011). A Co-Culture System to Study the Intercellular Transfer of TiO2 NPs and Endosomal Organelles.
  • Show author(s) (2010). Cellular uptake of TiO2 nanoparticles investigated by Ultrahigh Resolution Imaging system.
  • Show author(s) (2009). Interaction between TiO2 nanoparticles and fibroblasts.
  • Show author(s) (2009). Course Design for Preparatory courses in Cariology / Biomaterials for 2nd year Dental Students.
  • Show author(s) (2009). Alternativ Vurderingsform for emnet Integrert Klinisk Innføringskurs.
  • Show author(s) (2008). In vitro reconstruction of human sulcular epithelium.
  • Show author(s) (2008). Fusobacterium nucleatum Enters the in Vitro Engineered Human Oral Mucosa.
  • Show author(s) (2007). Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts.
  • Show author(s) (2007). Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts.
  • Show author(s) (2007). Cellular Responses to TiO2 Nanoparticles: In Vitro Study on a Human Monoblastoid Cell Line.
  • Show author(s) (2007). Aggregation and sedimentation of TiO2 nanoparticles.
  • Show author(s) (2007). Aggregation and Sedimentation of TiO2 Nanoparticles.
  • Show author(s) (2006). Isolation of mesenchymal precursor cells from dental pulp.
  • Show author(s) (2006). Glutathione protects against cell death induced by autopolymerized resins.
  • Show author(s) (2003). PMMA-based Denture Base Acrylic Resins Induce Cell Death by Apoptosis and Necrosis in U-937 Monoblastoid Cells and L929 Mouse Fibroblasts.
  • Show author(s) (1999). ’Altered clonogenicity and induction of apoptotic cell death in L929 cells exposed to denture base acrylic resins’.
  • Show author(s) (1996). Comparison of physical and mechanical properties of eastern and western European denture base acrylic resins.
Academic literature review
  • Show author(s) (2020). Epigenetics in breast cancer therapy—New strategies and future nanomedicine perspectives. Cancers. 32 pages.
  • Show author(s) (2019). Microfluidics for studying metastatic patterns of lung cancer. Journal of Nanobiotechnology. 1-30.
  • Show author(s) (2017). High throughput toxicity screening and intracellular detection of nanomaterials. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 1-30.
Website (informational material)
  • Show author(s) (2017). Hva kan grafén brukes til? Norske forskere bruker grafén til alt fra desinfisering til kreftbehandling. Er det bare fantasien som setter grenser for hva materialet kan brukes til?

More information in national current research information system (CRIStin)

"A common European approach to the regulatory testing of nanomaterials" NANoREG - the project is funded by the FP7 European Framework Program on Nanoscience, Nanotechnologies, materials and new production technologies (2013-2017) - Principal investigator

“National initiative towards developing a common approach to the regulatory testing of manufactured nanomaterials” (NorNANoREG) – project funded by the Norwegian Research Council, the NANO2021 program (2014-2017) - Principal investigator and task leader

“Self-navigated integrin receptors seeking "thermally-smart" multifunctional few-layer graphene-encapsulated magnetic nanoparticles for molecular MRIguided anticancer treatments in "real time" personalized nanomedicine (GEMNS)” (2015 - 2018) - financed by EuroNanoMed II, through EC’s 7th Framework Programme - Principal investigator and leader of the Norwegian partners

"Development of impedance-based non-invasive techniques for evaluating the biological effects of nanoparticles" (2013-2016) - funded by UH-nett Vest - project leader

“Innovative Nanopharmaceuticals: Targeting breast cancer stem cells by a novel combination of epigenetic and anticancer drugs with gene therapy (INNOCENT)” (2017-2020) - financed by EuroNanoMed II - Principal investigator v/UiB

"Science-based Risk Governance of Nano-Technology" (RiskGone) (2019-2023) - finnanced by HORIZON2020 (H2020-NMBP-13-2018 RIA, grant agreement nr. 814425) - WP co-leader

"Towards a reliable assessment of nanomaterial health effects using advanced biological models and assays" (NanoBioReal) (2019-2022) - finnanced by the Norwegian Research Coucil, NANO2021 program - coordinator

COST action "Nano2Clinic" - partner

PhD in Biomaterials (2001), research, teaching, supervision, clinical experience as dental instructor and from private praxis