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Mihaela Roxana Cimpan's picture

Mihaela Roxana Cimpan

Professor
  • E-mailMihaela.Cimpan@uib.no
  • Phone+47 55 58 62 63+47 480 22 207
  • Visitor Address
    Biomaterials - Department for Clinical Dentistry, Årstadveien 19, Bergen 5009, Norway
    Aarstadveien 19-21
    5009 Bergen
    Room 
    D04.010
  • Postal Address
    Postboks 7804
    5020 Bergen
  • Biomaterials, Biocompatibiltiy
  • Nanomaterials
  • Biological effects of biomaterials and nanomaterials
  • Nanotoxicology
  • Nanomedicine
  • Developmanet of new techniques for evaluating the biological effects of nanomaterials

dental students, dental hygienist students, specialist candidates, PhD candidates, BSc and MSc students in Nanotechnology and Nanoscience

Academic article
  • 2020. Label-free impedance flow cytometry for nanotoxicity screening. Scientific Reports.
  • 2020. Label-free impedance flow cytometry for nanotoxicity screening. Scientific Reports.
  • 2019. Use of nanomaterials in dentistry: covariates of risk and benefit perceptions among dentists and hygienists in Norway. Acta Odontologica Scandinavica. 1-10.
  • 2019. Knowledge about nanotechnology and intention to use nanomaterials: a comparative study among dental students in Norway and Romania. European journal of dental education. 79-87.
  • 2018. TiO2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner. Journal of Biomedical Materials Research. Part A. 2582-2593.
  • 2018. Label-free monitoring of uptake and toxicity of endoprosthetic wear particles in human cell cultures. International Journal of Molecular Sciences. 1-14.
  • 2018. In vitro cytotoxicity assessment of nanodiamond particles and their osteogenic potential. Journal of Biomedical Materials Research. Part A. 1697-1707.
  • 2017. Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. Journal of Oral Pathology & Medicine. 214-222.
  • 2017. CHITOSAN MODIFIED POLY(LACTIC-CO-GLYCOLIC) ACID NANOPARTICLES INTERACTION WITH NORMAL, PRECANCEROUS KERATINOCYTES AND DENTAL PULP CELLS. Stomatology Edu Journal. 16-26.
  • 2016. Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. Journal of Oral Pathology & Medicine. 214-222.
  • 2016. Contact-dependent transfer of TiO2 nanoparticles between mammalian cells. Nanotoxicology. 204-215.
  • 2015. The effect of blood protein adsorption on cellular uptake of anatase TiO2 nanoparticles. International Journal of Nanomedicine. 687-695.
  • 2013. In vitro reconstruction of human junctional and sulcular epithelium. Journal of Oral Pathology & Medicine. 396-404.
  • 2013. An impedance-based high-throughput method for evaluating the cytotoxicity of nanoparticles. Journal of Physics: Conference Series. 10 pages.
  • 2012. Role of physicochemical characteristics in the Uptake of TiO2 nanoparticles by fibroblasts. Toxicology in Vitro. 469-479.
  • 2012. Limited in-depth invasion of Fusobacterium nucleatum into in vitro reconstructed human gingiva. Archives of Oral Biology. 344-351.
  • 2009. Fusobacterium nucleatum Enters Normal Human Oral Fibroblasts In Vitro. Journal of Periodontology. 1174-1183.
  • 2009. Agglomeration and Sedimentation of TiO2 Nanoparticles in Cell Culture Medium. Colloids and Surfaces B: Biointerfaces. 83-87.
  • 2008. Induction of cell death by TiO2 nanoparticles: studies on a human monoblastoid cell line. Toxicology in Vitro. 1689-1696.
  • 2005. The coinitiator DMABEE induces death by apoptosis and necrosis in human monoblastoid cells. Clinical Oral Investigations. 168-172.
  • 2002. Comparative corrosion studies in the case of Nicromal alloy. Timisoara Medical Journal. 39-40.
  • 2001. Detection of cadmium in six denture base acrylic resins. Romanian Biotechnological Letters. 387-392.
  • 2000. The effect of heat- and auto-polymerized denture base polymers on clonogenicity, apoptosis, and necrosis in fibroblasts: denture base polymers induce apoptosis and necrosis. Acta Odontologica Scandinavica. 217-228.
  • 2000. Patterns of cell death induced by eluates from denture base acrylic resins in U-937 human monoblastoid cells. European Journal of Oral Sciences. 59-69.
  • 1999. Comparison of physical and mechanical properties of some commonly used eastern and western European denture base acrylic resins. Revista Nationala de Stomatologie. 4-9.
  • 1999. Assessment of uncertainty in mechanical testing of dental biomaterials. Quality Assurance: Good Practice Regulation & Law. 213-228.
Popular scientific lecture
  • 2019. Presentation of the Nano-group research .
  • 2017. How to be a part of a big european project.
  • 2016. presentasjon av forskningen til Nanogruppen.
  • 2014. presentasjon: Biologiske effekter av nanomaterialer.
  • 2012. Fyllingsmaterialer i konserverende tannbehandling etter utfasing av amalgam.
  • 2009. Nanoteknologi - den nye kuren?
Academic lecture
  • 2019. NanoMed prosjekter.
  • 2019. Impact of TiNbN wear particles on osteoblastic differentiation capacity and induction of inflammatory reactions.
  • 2018. Bridging Human- and Eco-nanosafety in Norway & Establishing a Norwegian platform for NanoSafety - Introduction .
  • 2017. Validation of an Impedance-Based Flow Cytometry Technique for High-Throughput Nanotoxicity Screening.
  • 2017. Presentasjon av Nano-prosjekter.
  • 2017. Organised the Workshop and held presentation on Human nanosafety Methods development .
  • 2017. Nanotoxicity of GEMNS particles.
  • 2017. Label-free methods used in nanotoxicity testing.
  • 2017. Impedance-based methods for high throughput nanotoxicity screening.
  • 2017. Cellular uptake and toxicity of charged silica nanoparticles.
  • 2016. Nano-TiO2 Penetrates Human Oral Mucosa.
  • 2016. Microfluidics in nanotoxicity testing.
  • 2016. CELLULAR UPTAKE AND TOXICITY OF POSITIVELY AND NEGATIVELY CHARGED SILICA NANOPARTICLES.
  • 2015. participation at the kick-off meeting fro NANO2021 NorNANoREG project.
  • 2015. Overview Results in the NANO2021 NorNANoREG project.
  • 2015. EU og NFR prosjekter - Nanotoksikologi ved seksjon for Biomaterialer.
  • 2014. Treatment of cells with nanoparticles boosts intercellular communication.
  • 2014. Nanoparticle penetration in 3D oral mucosa models.
  • 2013. Assessment of TiO2 nanoparticle cytotoxicity by real-time impedance-based monitoring.
  • 2012. Imaging of nanoparticles in cells.
  • 2012. Cellular Uptake of TiO2 Nanoparticles: Role of Physico-Chemical Properties.
  • 2012. An Impedance-based High-throughput Method for Evaluating the Cytotoxicity of Nanoparticles.
  • 2011. Role of Physicochemical Characteristics in the Uptake of TiO2 Nanoparticles by Fibroplasts.
  • 2011. Nanomaterials, Nanoparticles, Nanotoxicology.
  • 2010. Nanotechnology: The New Cure?
  • 2010. Deltakelse på ROUND TABLE CONFERENCE "Nano science and technology in relation to health, environment, safety and regulations" Venue: The Norwegian Academy of Science and Letters (DNVA) Drammensveien 78, Oslo.
  • 2010. Biological effects of nanoparticles released from implants.
  • 2009. In Vitro Biological Effects of TiO2 Nanoparticles.
  • 2008. Nanotoxicology in relation to Biomaterials.
  • 2008. Fusobacterium nucleatum Enters Oral Fibroblasts.
  • 2007. Utvikling og bruk av LST (lymfocytt stimuleringstest) i forskningssammenheng.
  • 2001. Role of antioxidants in the prevention of cell death by apoptosis induced by dental biomaterials.
  • 1999. ’Biocompatibility of dental materials with special reference to apoptosis’.
  • 1997. In vitro biological effects and physical properties of poly(methyl methacrylate)-based denture base resins.
  • 1996. ’Comparison of physical and mechanical properties of Eastern European and Western European acrylic resins for denture base’.
  • 1995. ’Physical and mechanical properties of PMMA-based denture base resins’.
Thesis at a second degree level
  • 2011. Impedance-based cellular assays: Applicability in Nanotoxicology.
  • 2009. Hjemmebleking av tenner: Bivirkninger og forebygging av disse.
Masters thesis
  • 2018. Impedance-based microfluidic device for assessing the cytotoxicity of nanoparticles.
  • 2016. Penetration of negatively and positively charged SiO2 nanoparticles into normal, dysplastic, and cancer human oral mucosa.
  • 2016. Cellular uptake and toxicity of positively and negatively charged silica nanoparticles in A549 human lung carcinoma cells.
  • 2015. Nanotechnology in dentistry. Assessment of current knowledge of dental students on the use of nanomaterials in dentistry and investigation of nanoparticle internalization in a human oral mucosa model.
  • 2015. FREMSKRITT INNENFOR NANOTEKNOLOGI VED DIAGNOSTIKK OG BEHANDLING AV KREFT.
  • 2014. A Microfluidic Chip-Based Impedance Flow Cytometry Method for Evaluating the Cytotoxicity of Nanoparticles.
  • 2013. Nanoteknologi og dentale fyllingsmaterialer.
  • 2012. Interactions between TiO2 nanoparticles and fibroblasts investigated by impedance-based monitoring.
  • 2011. Effekt av ekstern bleking på mineralisert tannvev.
Popular scientific article
  • 2012. Hvor trygt er Nano? Nanotoksikologi – et tverrfaglig forskningsfelt. Naturen. 121-125.
Doctoral dissertation
  • 2017. Titanium Dioxide and Diamond Nanoparticles: In-vitro assessment of the effects on the oral mucosal barrier and bone biology.
  • 2012. Interactions between Fusobacterium nucleatum and Primary Oral cells, In Vitro Studies in Monolayer and Organotypic Culture Models.
  • 2000. In vitro biological effects and physical properties of poly(methyl methacrylate)-based denture base resins.
Interview
  • 2019. Finner nye metoder for å kartlegge biologiske effekter av nanopartikler.
  • 2010. Nanotechnology - effects on human health and environment.
Abstract
  • 2003. 4-N,N-dimethyl amino benzoic acid ethylester induces apoptosis and necrosis in U-937 cells. Journal of Dental Research. 343-343.
  • 2001. Vitamin E prevents apoptosis and necrosis in U-937 cells exposed to eluates from autopolymerized denture base acrylic resins. Journal of Dental Research. 1291-1291.
  • 1999. Altered clonogenicity and induction of apoptotic cell death in L929 cells exposed to denture base acrylic resins. Journal of Dental Research. 315-315.
  • 1998. A comparative study of cytopathogenic effects of four denture base acrylic resins. Journal of Dental Research. 816-816.
  • 1996. Comparison of physical and mechanical properties of eastern and western European denture base acrylic resins. Journal of Dental Research. 294-294.
Poster
  • 2019. Nanocarrier-directed drug delivery for breast cancer treatment.
  • 2019. Label-free impedance-based nanotoxicity testing: Static vs. dynamic exposure to nanomaterials.
  • 2019. Dental Health Care Workers’ Intention to Use Nanomaterials.
  • 2019. Biomimetic impedance-based assessment of the biological effects of anticancer nanoparticles .
  • 2018. Relating thermodynamics to the dominant contributions determining the toxicity of nanomaterials.
  • 2018. Perception of risks and benefits related to nanomaterials.
  • 2018. Label-free impedimetric analysis of the cytotoxic effects of nanomaterials under dynamic in-vivo like conditions.
  • 2018. Impedance Flow Cytometry for in vitro Screening of Graphene-encapsulated Magnetic Nanoparticles.
  • 2017. Impedance-based methods for label-free rapid nanotoxicity screening.
  • 2016. Toxicological assessment of nano-diamond particles used in tissue engineering scaffolds for bone tissue regeneration.
  • 2016. TiO2 nanoparticles disrupt attachment, cytoskeletal networks and migration of human osteoblast-like cells in a size dependent manner.
  • 2016. Nano-TiO2 penetrates human oral mucosa.
  • 2016. High throughput nanoTOX screening using impedance: A data analysis example.
  • 2016. Cytotoxicity of engineered nanomaterials assessed by impedance-based monitoring.
  • 2014. Uptake of TiO2 nanoparticles in a human oral mucosa model.
  • 2014. Role of particle size in the uptake of nano-TiO2.
  • 2014. Deeper penetration of TiO2 nanoparticles in neoplastic vs. Normal human oral mucosa models.
  • 2014. Comparison of uptake of TiO2 nanoparticles in normal and cancer human oral mucosa models.
  • 2014. Assessment of knowledge about nanotechnology in dentistry among dental students.
  • 2014. A Microfluidic Chip-Based Impedance Flow Cytometry Method for Evaluating the Cytotoxicity of Nanoparticles.
  • 2011. A Co-Culture System to Study the Intercellular Transfer of TiO2 NPs and Endosomal Organelles.
  • 2010. Cellular uptake of TiO2 nanoparticles investigated by Ultrahigh Resolution Imaging system.
  • 2009. Interaction between TiO2 nanoparticles and fibroblasts.
  • 2009. Course Design for Preparatory courses in Cariology / Biomaterials for 2nd year Dental Students.
  • 2009. Alternativ Vurderingsform for emnet Integrert Klinisk Innføringskurs.
  • 2008. In vitro reconstruction of human sulcular epithelium.
  • 2008. Fusobacterium nucleatum Enters the in Vitro Engineered Human Oral Mucosa.
  • 2007. Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts.
  • 2007. Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts.
  • 2007. Cellular Responses to TiO2 Nanoparticles: In Vitro Study on a Human Monoblastoid Cell Line.
  • 2007. Aggregation and sedimentation of TiO2 nanoparticles.
  • 2007. Aggregation and Sedimentation of TiO2 Nanoparticles.
  • 2006. Isolation of mesenchymal precursor cells from dental pulp.
  • 2006. Glutathione protects against cell death induced by autopolymerized resins.
  • 2003. PMMA-based Denture Base Acrylic Resins Induce Cell Death by Apoptosis and Necrosis in U-937 Monoblastoid Cells and L929 Mouse Fibroblasts.
  • 1999. ’Altered clonogenicity and induction of apoptotic cell death in L929 cells exposed to denture base acrylic resins’.
  • 1996. Comparison of physical and mechanical properties of eastern and western European denture base acrylic resins.
Academic literature review
  • 2019. Microfluidics for studying metastatic patterns of lung cancer. 1-30.
  • 2017. High throughput toxicity screening and intracellular detection of nanomaterials. 1-30.
Website (informational material)
  • 2017. Hva kan grafén brukes til? Norske forskere bruker grafén til alt fra desinfisering til kreftbehandling. Er det bare fantasien som setter grenser for hva materialet kan brukes til?

More information in national current research information system (CRIStin)

PhD in Biomaterials (2001), research, teaching, supervision, clinical experience as dental instructor and from private praxis

"A common European approach to the regulatory testing of nanomaterials" NANoREG - the project is funded by the FP7 European Framework Program on Nanoscience, Nanotechnologies, materials and new production technologies (2013-2017) - Principal investigator

“National initiative towards developing a common approach to the regulatory testing of manufactured nanomaterials” (NorNANoREG) – project funded by the Norwegian Research Council, the NANO2021 program (2014-2017) - Principal investigator and task leader

“Self-navigated integrin receptors seeking "thermally-smart" multifunctional few-layer graphene-encapsulated magnetic nanoparticles for molecular MRIguided anticancer treatments in "real time" personalized nanomedicine (GEMNS)” (2015 - 2018) - financed by EuroNanoMed II, through EC’s 7th Framework Programme - Principal investigator and leader of the Norwegian partners

"Development of impedance-based non-invasive techniques for evaluating the biological effects of nanoparticles" (2013-2016) - funded by UH-nett Vest - project leader

“Innovative Nanopharmaceuticals: Targeting breast cancer stem cells by a novel combination of epigenetic and anticancer drugs with gene therapy (INNOCENT)” (2017-2020) - financed by EuroNanoMed II - Principal investigator v/UiB

"Science-based Risk Governance of Nano-Technology" (RiskGone) (2019-2023) - finnanced by HORIZON2020 (H2020-NMBP-13-2018 RIA, grant agreement nr. 814425) - WP co-leader

"Towards a reliable assessment of nanomaterial health effects using advanced biological models and assays" (NanoBioReal) (2019-2022) - finnanced by the Norwegian Research Coucil, NANO2021 program - coordinator

COST action "Nano2Clinic" - partner