Mohammed A. Yassin: Associate Professor at the Department of Clinical Dentistry, Biomaterials section, who is an expert in the field of Tissue Engineering and Regenerative Medicine. He strives to create novel and innovative biomaterials that can interact with stem cells and induce tissue regeneration. He employs state-of-the-art techniques and methods to design, synthesize, and evaluate these biomaterials for various clinical applications.
His passion for Green Biomaterials: he is fascinated by the potential of green biomaterials to address the global ecological challenges we face today. He believes that by using renewable and biodegradable resources, we can create innovative solutions for tissue engineering and regeneration.
His research goals and methods: His research aims to develop novel and sustainable green biomaterials, such as polymers, ceramics, and composites, that can mimic the natural properties and functions of human dental tissues. He uses cutting-edge techniques to design, synthesize, and test these biomaterials, while minimizing the use of toxic and harmful chemicals. He also explores the use of waste-derived compounds to valorize biomass and reduce environmental pollution.
His research outcomes and impacts: His research contributes to the advancement of green biomaterials science and technology, as well as the promotion of a circular “zero waste” economy. He is collaborating with other researchers and industry partners to translate his findings into practical applications.
Course development and Teaching
Mohammed A. Yassin has been responsible for developing and teaching courses at the undergraduate and graduate level on Dental Biomaterials and Regenerative Dentistry .
Yassin is currently the main supervisor and co-supervisor for research-line students, master students and PhD candidates.
- (2023). Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho-ROCK-mediated contractility dependent. Bioengineering & Translational Medicine.
- (2022). Optimization and Validation of a Custom-Designed Perfusion Bioreactor for Bone Tissue Engineering: Flow Assessment and Optimal Culture Environmental Conditions. Frontiers in Bioengineering and Biotechnology. 1-19.
- (2022). Hybrid material based on hyaluronan hydrogels and poly(l-lactide-co-1,3-trimethylene carbonate) scaffolds toward a cell-instructive microenvironment with long-term in vivo degradability. Materials Today Bio. 1-15.
- (2022). Efficacy of treating segmental bone defects through endochondral ossification: 3D printed designs and bone metabolic activities. Materials Today Bio.
- (2022). Contact osteogenesis by biodegradable 3D-printed poly(lactide-co-trimethylene carbonate). Biomaterials Research. 1-19.
- (2021). Understanding of how the properties of medical grade lactide based copolymer scaffolds influence adipose tissue regeneration: Sterilization and a systematic in vitro assessment. Materials Science and Engineering C: Materials for Biological Applications.
- (2021). Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three- dimensional microporous scaffolds. Journal of Biomedical Materials Research. Part A. 1560-1574.
- (2021). Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor. Journal of Tissue Engineering. 1-17.
- (2021). Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs. Frontiers in Bioengineering and Biotechnology. 1-14.
- (2020). Engineering 3D degradable, pliable scaffolds toward adipose tissue regeneration; optimized printability, simulations and surface modification. Journal of Tissue Engineering. 1-17.
- (2020). Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds. Materials & design. 1-11.
- (2020). Comparison of bone regenerative capacity of donor-matched human adipose–derived and bone marrow mesenchymal stem cells. Cell and Tissue Research.
- (2019). Printability and critical insight into polymer properties during direct- extrusion based 3D printing of medical grade polylactide and copolyesters. Biomacromolecules.
- (2019). Nondegradative additive manufacturing of medical grade copolyesters of high molecular weight and with varied elastic response. Journal of Applied Polymer Science.
- (2019). Evaluation of Apical Dimension, Canal Taper and Maintenance of Root Canal Morphology Using XP-endo Shaper. Journal of Contemporary Dental Practice. 136-144.
- (2019). 3D printable Polycaprolactone-gelatin blends characterized for in vitro osteogenic potency. Reactive & functional polymers.
- (2019). 3D and Porous RGDC-Functionalized Polyester-Based Scaffolds as a Niche to Induce Osteogenic Differentiation of Human Bone Marrow Stem Cells. Macromolecular Bioscience.
- (2018). Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model. Stem Cell Research & Therapy. 1-13.
- (2018). Coating 3D Printed Polycaprolactone Scaffolds with Nanocellulose Promotes Growth and Differentiation of Mesenchymal Stem Cells. Biomacromolecules. 4307-4319.
- (2018). Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. . Stem Cell Research & Therapy. 1-15.
- (2017). Role of Hyperplasia of Gingival Lymphatics in Periodontal Inflammation. Journal of Dental Research. 467-476.
- (2017). A copolymer scaffold functionalized with nanodiamond particles enhances osteogenic metabolic activity and bone regeneration. Macromolecular Bioscience. 1-11.
- (2016). Surfactant tuning of hydrophilicity of porous degradable copolymer scaffolds promotes cellular proliferation and enhances bone formation. Journal of Biomedical Materials Research. Part A. 2049-2059.
- (2015). Reinforced degradable biocomposite by homogenously distributed functionalized nanodiamond particles. Macromolecular Materials and Engineering. 436-447.
- (2015). Cell seeding density is a critical determinant for copolymer scaffolds-induced bone regeneration. Journal of Biomedical Materials Research. Part A. 3649-3658.
- (2017). Surface hydrophilicity: a key factor i loping bone tissue engineering constructs .
- (2018). Adipose-Derived Stem Cells for Bone Tissue Engineering.
- (2022). Corrigendum: Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs (Front. Bioeng. Biotechnol., (2021), 9, (783468), 10.3389/fbioe.2021.783468). Frontiers in Bioengineering and Biotechnology.
- (2019). The bone regeneration capacity of 3D-printed templates in calvarial defect models: A systematic review and meta-analysis. Acta Biomaterialia. 1-23.