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Mohummad Aminur Rahman's picture

Mohummad Aminur Rahman

Chief Engineer
  • E-mailAminur.Rahman@uib.no
  • Phone+47 55 58 64 23+47 913 85 110
  • Visitor Address
    Jonas Lies Vei 91
    5009 Bergen
    Room 
    6A122cA
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Gras Navarro, Andrea; Espedal, Heidi; Vareecal Joseph, Justin; Moncho, Laura Trachsel; Bahador, Marzieh; Gjertsen, Bjørn Tore; Kristoffersen, Einar Klæboe; Simonsen, Anne; Miletic, Hrvoje; Enger, Per Øyvind; Rahman, Mohummad Aminur; Enger, Martha Chekenya. 2019. Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival. Cancers. 11:996: 1-25. doi: 10.3390/cancers11070996
  • Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya. 2019. Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. British Journal of Cancer. 121: 545-555. doi: 10.1038/s41416-019-0551-1
  • Haspels, Heleen Neeltje; Rahman, Mohummad Aminur; Vareecal Joseph, Justin; Gras Navarro, Andrea; Enger, Martha Chekenya. 2018. Glioblastoma Stem-Like Cells Are More Susceptible Than Differentiated Cells to Natural Killer Cell Lysis Mediated Through Killer Immunoglobulin-Like Receptors-Human Leukocyte Antigen Ligand Mismatch and Activation Receptor-Ligand Interactions. Frontiers in Immunology. 9. doi: 10.3389/fimmu.2018.01345
  • Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya. 2017. Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients. Oncoimmunology. 6: 1-15. doi: 10.1080/2162402X.2017.1336272
  • Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille Kayitesi; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind. 2017. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 17:108: 1-13. doi: 10.1186/s12885-017-3109-8
  • Dominguez Valentin, Mev; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Kumar, Surendra; Retière, Christèle; Ulvestad, Elling; Kristensen, Vessela N.; Lund-Johansen, Morten; Lie, Benedicte Alexandra; Enger, Per Øyvind; Njølstad, Gro; Kristoffersen, Einar Klæboe; Lie, Stein Atle; Chekenya, Martha. 2016. Identification of a natural killer cell receptor allele that prolongs survival of cytomegalovirus-positive glioblastoma patients. Cancer Research. 76: 5326-5336. doi: 10.1158/0008-5472.CAN-16-1162
  • Netland, Inger Anne; Førde-Tislevoll, Hilde Elise; Sleire, Linda; Leiss, Lina Wik; Rahman, Mohummad Aminur; Skeie, Bente Sandvei; Gjerde, Christiane Helgestad; Enger, Per Øyvind; Goplen, Dorota. 2016. Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models. BMC Cancer. 16:657. 12 pages. doi: 10.1186/s12885-016-2712-4
  • Netland, Inger Anne; Førde-Tislevoll, Hilde Elise; Sleire, Linda; Leiss, Lina Wik; Rahman, Mohummad Aminur; Skeie, Bente Sandvei; Miletic, Hrvoje; Enger, Per Øyvind; Goplen, Dorota. 2016. Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats. Journal of Neuro-Oncology. doi: 10.1007/s11060-016-2158-1
  • Hoppmann, Verena; Thorstensen, Tage; Kristiansen, Per Eugen; Veiseth, Silje Veie; Rahman, Mohummad Aminur; Finne, Kenneth; Aalen, Reidunn B.; Aasland, Rein. 2011. The CW domain, a new histone recognition module in chromatin proteins. EMBO Journal. 30: 1939-1952. doi: 10.1038/emboj.2011.108
  • Veiseth, Silje Veie; Rahman, Mohummad Aminur; Yap, Kyoko L.; Fischer, Andreas; Jacobsen, Wolfgang Mathias; Reuter, Gunter; Zhou, Ming-Ming; Aalen, Reidunn B.; Thorstensen, Tage. 2011. The SUVR4 Histone Lysine Methyltransferase Binds Ubiquitin and Converts H3K9me1 to H3K9me3 on Transposon Chromatin in Arabidopsis. PLoS Genetics. 7. 14 pages. doi: 10.1371/journal.pgen.1001325

More information in national current research information system (CRIStin)

  1. Rahman MA, Gras Navarro A, Brekke J, Engelsen A, Bindesbøll C, Sarowar S,  Bahador M, Bifulco E, Gjertsen BT, Goplen D, Enger PØ, Selheim F, Simonsen A, Chekenya M. Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs survival. Br J Cancer. 2019 Aug 15. doi: 10.1038/s41416-019-0551-1.  
  2. Andrea Gras Navarro, Heidi Espedal, Justin Vareecal Joseph, Laura Trachsel-Moncho, Marzieh Bahador, Bjørn Tore Gjertsen, Einar Klæboe Kristoffersen, Anne Simonsen, Hrvoje Miletic, Per Øyvind Enger, Mohummad Aminur Rahman,* and Martha Chekenya*. Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival. Cancers (Basel). 2019 Jul 17;11(7). pii: E996. doi: 10.3390/cancers11070996. *Co-corresponding. 
  3. Haspels HN, Rahman MA, Joseph JV, Gras Navarro A and Chekenya M (2018) Glioblastoma Stem-Like Cells Are More Susceptible Than Differentiated Cells to Natural Killer Cell Lysis Mediated Through Killer Immunoglobulin-Like Receptors–Human Leukocyte Antigen Ligand Mismatch and Activation Receptor–Ligand Interactions. Front. Immunol. 9:1345. doi: 10.3389/fimmu.2018.01345
  4. Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya. Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients. Oncoimmunology2017 ;Volum 6.(8:e1336272) s. 1-15
  5. Leiss L, Mutlu E, Øyan A, Yan T, Tsinkalovsky O, Sleire L, Petersen K, Rahman MA, Johannessen M, Mitra SS, Jacobsen HK, Talasila KM, Miletic H, Jonassen I, Li X, Brons NH, Kalland KH, Wang J,Enger PØ. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 2017 Feb 7;17(1):108. doi: 10.1186/s12885-017-3109-8.
  6. Netland IA, Førde HE, Sleire L, Leiss L, Rahman MA, Skeie BS, Gjerde CH, Enger PØ, Goplen D. Dactolisib (NVP-BEZ235) toxicity in murinebrain tumour models. BMC Cancer. 2016 Aug 19;16:657. doi: 10.1186/s12885-016-2712-4. 
  7. Dominguez-Valentin M*, Gras Navarro A*, Rahman AM*,  Kumar S, Retière C, Ulvestad E, Kristensen V, Lund-Johansen M, Lie BA, Enger PØ, Njølstad G, Kristoffersen E, Lie SA, Chekenya M. Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients. Cancer Res. 2016 Sep 15;76(18):5326-36. doi: 10.1158/0008-5472.CAN-16-1162. (* Contributed equally, Authors named alphabetically) 
  8. Netland IA, Førde HE, Sleire L, Leiss L, Rahman MA, Skeie BS, Miletic H, Enger PØ, Goplen D. Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats. J Neurooncol. 2016 Aug;129(1):57-66. doi: 10.1007/s11060-016-2158-1.
  9. Kumpf R, Thorstensen T, Rahman MA, Heyman J, Nenseth HZ, Lammens T, Herrmann U, Swarup R, Veiseth SV, Emberland G, Bennett MJ, De Veylder L, Aalen RB. ASH1 RELATED3 (ASHR3) encodes a SET domain protein controlling Cell division patterns in the Quiescent Centre and Meristematic Zone of Arabidopsis Roots via Histone 3 Lysine 36 Monomethylation. Plant Physiol. 2014 Oct;166(2):632-43. doi: 10.1104/pp.114.244798.
  10. Rahman MA, Kristiansen PE, Veiseth SV, Andersen JT, Yap KL, Zhou MM, Sandlie I, Thorstensen T, Aalen RB. The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Biochemistry. 2014 Apr 8;53(13):2091-100. doi: 10.1021/bi401436h.
  11. Hoppmann V, Thorstensen T, Kristiansen PE, Veiseth SV, Rahman MA, Finne K, Aalen RB, Aasland R. The CW domain, a new histone recognition module in chromatin proteins. EMBO J. 2011 May 18;30(10):1939-52. doi: 10.1038/emboj.2011.108.
  12. Veiseth SV, Rahman MA, Yap KL, Fischer A, Egge-Jacobsen W, Reuter G, Zhou MM, Aalen RB, Thorstensen T. The SUVR4 Histone Lysine Methyltransferase Binds Ubiquitin and Converts H3K9me1 to H3K9me3 on Transposon Chromatin in Arabidopsis. PLoS Genet. 2011 Mar;7(3):e1001325. doi: 10.1371/journal.pgen.1001325
  13. MA Rahman, SC Bachar, M Rahmatullah. Analgesic and antiinflammatory activity of methanolic extract of Acalypha indica Linn. Pak. J. Pharm. Sci 23 (3), 256-258
  14. M Rahmatullah, MN Hasan, MA Rahman, AHMZ Ali, N Nahar, R Jahan, A Khatun, R Ahmed, S Ahsan, D Nasrin. School children's intellectual function when exposed to drinking water containing arsenic at Madartola (an arsenic affected area) in Bangladesh. Advances in Environmental Biology, 172-178
  15. M Rahmatullah, NK Das, MA Rahman, T Sultana, R Jahan. A Preliminary study on co-cultivation of Mozambique tilapia (Oreochromis mossambicus) with bronze featherback (Notopterus notopterus) in shallow homestead ponds. Indian J. Fish 56 (1), 43-45

     

 

Accepted abstract for poster presentations (Manuscripts in preparation) 
1. Mohummad Aminur Rahman et. Al., The transcription factor POU3F2 is expressed in human gliomas and promotes tumorigenesis in vivo. Cancer Research 08/2015; 75(15 Supplement) 

2. Christiane H. Gjerde et. Al., FGFR4 is expressed in the tumor and stromal compartments of human gliomas of all grades and histologies. Cancer Research 08/2015; 75(15 Supplement)

  • PhD in Molecular Biosciences (2012) at Department of Molecular Biosciences, University of Oslo, Norway
  • Master in Bio-and Food Technology (2007) at Department of Bio-and food technology, Lund University, Sweden
  • Bachelor in Biotechnology (1997-2001) at Biotechnology Discipline, Khulna University, Bangladesh

Projects:

  • BORTEM-17 Phase IB/II trial: investigating the safety and survival benefits for patients with recurrent glioblastoma with unmethylated MGMT promoter treated with Bortezomib and Temozolomide in a specific schedule.
     
  • Identifying novel drugs to sensitize glioblastoma (GBM) cells to Temozolomide chemotherapy: Approximately 50% of the glioblastoma (GBM) patients with unmethylated MGMT promoter gain marginal benefit from Temozolomide chemotherapy.  My project is focused on investigating the novel drugs combinations that may potentiate the efficacy of Temozolomide chemotherapy and/or radiotherapy against GBM.
  • Bioinformatic analysis of sequencing data: This project aims to identify immune and cancer related genes that may inform disease associations or impact prognosis, respectively. I use large population databases including sequencing data deposited in The Cancer Genome Atlas project (TCGA), 1000 genomes as well as sequencing data from our local biobanks (patients and healthy population).
  • Characterization of epigenetic changes in immune cell subsets as a result of prior human cytomegalovirus infection in n brain tumor patients.