- E-mailaminur.rahman@uib.no
- Visitor AddressJonas Lies Vei 915009 BergenRoom6A122cA
- Postal AddressPostboks 78045020 Bergen
Academic article
- (2023). Survival in a consecutive series of 467 glioblastoma patients: Association with prognostic factors and treatment at recurrence at two independent institutions. PLOS ONE.
- (2022). Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. Frontiers in Cell and Developmental Biology. 1-23.
- (2021). Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. Neuro-Oncology. 1885-1897.
- (2020). Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study. Immunity,Inflammation and Disease. 342-359.
- (2019). Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival. Cancers. 1-25.
- (2019). Platelet‐derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients. Glia. 1-10.
- (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. British Journal of Cancer. 545-555.
- (2018). Glioblastoma Stem-Like Cells Are More Susceptible Than Differentiated Cells to Natural Killer Cell Lysis Mediated Through Killer Immunoglobulin-Like Receptors-Human Leukocyte Antigen Ligand Mismatch and Activation Receptor-Ligand Interactions. Frontiers in Immunology.
- (2017). Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 1-13.
- (2017). Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients. Oncoimmunology. 1-15.
- (2016). Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats. Journal of Neuro-Oncology.
- (2016). Identification of a natural killer cell receptor allele that prolongs survival of cytomegalovirus-positive glioblastoma patients. Cancer Research. 5326-5336.
- (2016). Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models. BMC Cancer. 12 pages.
- (2014). The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Biochemistry. 2091-2100.
- (2014). The ASH1-RELATED3 SET-domain protein controls cell division competence of the meristem and the quiescent center of the arabidopsis primary root. Plant Physiology. 632-643.
- (2014). ASH1 RELATED3 (ASHR3) encodes a SET domain protein controlling Cell division patterns in the Quiescent Centre and Meristematic Zone of Arabidopsis Roots via Histone 3 Lysine 36 Monomethylation. Plant Physiology.
- (2011). The SUVR4 Histone Lysine Methyltransferase Binds Ubiquitin and Converts H3K9me1 to H3K9me3 on Transposon Chromatin in Arabidopsis. PLoS Genetics. 14 pages.
- (2011). The CW domain, a new histone recognition module in chromatin proteins. EMBO Journal. 1939-1952.
Masters thesis
- (2022). Two distinct biomarkers and their role in glioblastoma biological behavior.
- (2016). Treatment with Bortezomib Sensitizes Glioblastoma Cells to Temozolomide.
- (2014). POU3f2 in human gliomas -Expression pattern and functional role.
Academic chapter/article/Conference paper
- (2022). Tumor–Host Interactions in Malignant Gliomas. 10 pages.
Poster
- (2015). The transcription factor POU3F2 is expressed in human gliomas and promotes tumorigenesis in vivo.
- (2015). FGFR4 is expressed in the tumor and stromal compartments of human gliomas of all grades and histologies.
- (2014). The transcription factor POU3f2 uniformly express in human gliomas and promotes tumorigenesis and overall growth rate in vivo.
More information in national current research information system (CRIStin)
- Leiss L, Mega A, Olsson Bontell T, Nistér M, Smits A, Corvigno S, Rahman MA, Enger PØ, Miletic H, Östman A. Platelet-derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients. Glia. 2020 May;68(5):979-988. doi: 10.1002/glia.23756. Epub 2019 Nov 26
- Rahman MA, Gras Navarro A, Brekke J, Engelsen A, Bindesbøll C, Sarowar S, Bahador M, Bifulco E, Gjertsen BT, Goplen D, Enger PØ, Selheim F, Simonsen A, Chekenya M. Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs survival. Br J Cancer. 2019 Aug 15. doi: 10.1038/s41416-019-0551-1.
- Andrea Gras Navarro, Heidi Espedal, Justin Vareecal Joseph, Laura Trachsel-Moncho, Marzieh Bahador, Bjørn Tore Gjertsen, Einar Klæboe Kristoffersen, Anne Simonsen, Hrvoje Miletic, Per Øyvind Enger, Mohummad Aminur Rahman,* and Martha Chekenya*. Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival. Cancers (Basel). 2019 Jul 17;11(7). pii: E996. doi: 10.3390/cancers11070996. *Co-corresponding.
- Haspels HN, Rahman MA, Joseph JV, Gras Navarro A and Chekenya M (2018) Glioblastoma Stem-Like Cells Are More Susceptible Than Differentiated Cells to Natural Killer Cell Lysis Mediated Through Killer Immunoglobulin-Like Receptors–Human Leukocyte Antigen Ligand Mismatch and Activation Receptor–Ligand Interactions. Front. Immunol. 9:1345. doi: 10.3389/fimmu.2018.01345
- Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya. Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients. Oncoimmunology2017 ;Volum 6.(8:e1336272) s. 1-15
- Leiss L, Mutlu E, Øyan A, Yan T, Tsinkalovsky O, Sleire L, Petersen K, Rahman MA, Johannessen M, Mitra SS, Jacobsen HK, Talasila KM, Miletic H, Jonassen I, Li X, Brons NH, Kalland KH, Wang J,Enger PØ. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 2017 Feb 7;17(1):108. doi: 10.1186/s12885-017-3109-8.
- Netland IA, Førde HE, Sleire L, Leiss L, Rahman MA, Skeie BS, Gjerde CH, Enger PØ, Goplen D. Dactolisib (NVP-BEZ235) toxicity in murinebrain tumour models. BMC Cancer. 2016 Aug 19;16:657. doi: 10.1186/s12885-016-2712-4.
- Dominguez-Valentin M*, Gras Navarro A*, Rahman AM*, Kumar S, Retière C, Ulvestad E, Kristensen V, Lund-Johansen M, Lie BA, Enger PØ, Njølstad G, Kristoffersen E, Lie SA, Chekenya M. Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients. Cancer Res. 2016 Sep 15;76(18):5326-36. doi: 10.1158/0008-5472.CAN-16-1162. (* Contributed equally, Authors named alphabetically)
- Netland IA, Førde HE, Sleire L, Leiss L, Rahman MA, Skeie BS, Miletic H, Enger PØ, Goplen D. Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats. J Neurooncol. 2016 Aug;129(1):57-66. doi: 10.1007/s11060-016-2158-1.
- Kumpf R, Thorstensen T, Rahman MA, Heyman J, Nenseth HZ, Lammens T, Herrmann U, Swarup R, Veiseth SV, Emberland G, Bennett MJ, De Veylder L, Aalen RB. ASH1 RELATED3 (ASHR3) encodes a SET domain protein controlling Cell division patterns in the Quiescent Centre and Meristematic Zone of Arabidopsis Roots via Histone 3 Lysine 36 Monomethylation. Plant Physiol. 2014 Oct;166(2):632-43. doi: 10.1104/pp.114.244798.
- Rahman MA, Kristiansen PE, Veiseth SV, Andersen JT, Yap KL, Zhou MM, Sandlie I, Thorstensen T, Aalen RB. The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Biochemistry. 2014 Apr 8;53(13):2091-100. doi: 10.1021/bi401436h.
- Hoppmann V, Thorstensen T, Kristiansen PE, Veiseth SV, Rahman MA, Finne K, Aalen RB, Aasland R. The CW domain, a new histone recognition module in chromatin proteins. EMBO J. 2011 May 18;30(10):1939-52. doi: 10.1038/emboj.2011.108.
- Veiseth SV, Rahman MA, Yap KL, Fischer A, Egge-Jacobsen W, Reuter G, Zhou MM, Aalen RB, Thorstensen T. The SUVR4 Histone Lysine Methyltransferase Binds Ubiquitin and Converts H3K9me1 to H3K9me3 on Transposon Chromatin in Arabidopsis. PLoS Genet. 2011 Mar;7(3):e1001325. doi: 10.1371/journal.pgen.1001325
- MA Rahman, SC Bachar, M Rahmatullah. Analgesic and antiinflammatory activity of methanolic extract of Acalypha indica Linn. Pak. J. Pharm. Sci 23 (3), 256-258
- M Rahmatullah, MN Hasan, MA Rahman, AHMZ Ali, N Nahar, R Jahan, A Khatun, R Ahmed, S Ahsan, D Nasrin. School children's intellectual function when exposed to drinking water containing arsenic at Madartola (an arsenic affected area) in Bangladesh. Advances in Environmental Biology, 172-178
- M Rahmatullah, NK Das, MA Rahman, T Sultana, R Jahan. A Preliminary study on co-cultivation of Mozambique tilapia (Oreochromis mossambicus) with bronze featherback (Notopterus notopterus) in shallow homestead ponds. Indian J. Fish 56 (1), 43-45
Accepted abstract for poster presentations (Manuscripts in preparation)
1. Mohummad Aminur Rahman et. Al., The transcription factor POU3F2 is expressed in human gliomas and promotes tumorigenesis in vivo. Cancer Research 08/2015; 75(15 Supplement)
2. Christiane H. Gjerde et. Al., FGFR4 is expressed in the tumor and stromal compartments of human gliomas of all grades and histologies. Cancer Research 08/2015; 75(15 Supplement)
Projects:
- BORTEM-17 Phase IB/II trial: investigating the safety and survival benefits for patients with recurrent glioblastoma with unmethylated MGMT promoter treated with Bortezomib and Temozolomide in a specific schedule.
- Identifying novel drugs to sensitize glioblastoma (GBM) cells to Temozolomide chemotherapy: Approximately 50% of the glioblastoma (GBM) patients with unmethylated MGMT promoter gain marginal benefit from Temozolomide chemotherapy. My project is focused on investigating the novel drugs combinations that may potentiate the efficacy of Temozolomide chemotherapy and/or radiotherapy against GBM.
- Bioinformatic analysis of sequencing data: This project aims to identify immune and cancer related genes that may inform disease associations or impact prognosis, respectively. I use large population databases including sequencing data deposited in The Cancer Genome Atlas project (TCGA), 1000 genomes as well as sequencing data from our local biobanks (patients and healthy population).
- Characterization of epigenetic changes in immune cell subsets as a result of prior human cytomegalovirus infection in n brain tumor patients.
- PhD in Molecular Biosciences (2012) at Department of Molecular Biosciences, University of Oslo, Norway
- Master in Bio-and Food Technology (2007) at Department of Bio-and food technology, Lund University, Sweden
- Bachelor in Biotechnology (1997-2001) at Biotechnology Discipline, Khulna University, Bangladesh
Fields of competence