Mona Synnøve Bjune's picture

Mona Synnøve Bjune

Guest Researcher
  • E-mailmona.s.nilsen@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen

The main focus of my Ph.d project is to study molecular mechanisms and gene variants related to obesity, diabetes and non-alcoholic fatty liver disease. This involves performing cell culture work with fat cells and liver cells from mice and humans, followed by molecular biology techniques, including purification and quantification of proteins, DNA and RNA from various cell samples, as well as follow-up analyzes such as cDNA synthesis, real-time qPCR, SDS-PAGE and Western blotting. In addition, I use a number of other methods such as transfection, Seahorse XF assay, fatty acid uptake measurements, ROS analyzes, proliferation analyzes, oil red o lipid staining and collection of cell culture medium for amino acid/metabolite quantification (GC-MS/MS).

I am part of the Hormone Laboratory Research Group (https://www.uib.no/en/rg/hormonelaboratory)

Involved in teaching of bachelor students in human nutrition

Co-supervising master students

Academic article
  • Show author(s) (2023). Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease. EBioMedicine. 18 pages.
  • Show author(s) (2021). Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes. 680-695.
  • Show author(s) (2021). Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 10 pages.
  • Show author(s) (2020). 3-hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and brown adipocyte metabolism. Diabetes. 1903-1916.
Academic lecture
  • Show author(s) (2022). Nedbrytningen av BCAAs i humane leverceller er assosiert med fettleversykdom.
  • Show author(s) (2021). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver.
  • Show author(s) (2020). Low 3-hydroxyisobutyrate (3-HIB) and high methylmalonic acid (MMA) levels in plasma reflect increased hepatic fatty acid oxidation.
  • Show author(s) (2019). Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
  • Show author(s) (2019). A novel amino acid transporter modulating insulin resistance via adipocytes ​.
  • Show author(s) (2018). Amino acid metabolism in adipocytes.
  • Show author(s) (2022). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver.
  • Show author(s) (2019). Inhibition of serine transporter SLC7A10 promotes lipid accumulation through altered BCAA catabolism in adipocytes​.
  • Show author(s) (2019). Adipocyte amino acid metabolism in obesity-related metabolic diseases .

More information in national current research information system (CRIStin)

PhD project: "Branched-chain amino acid metabolism in obesity and insulin resistance"


Board member in Research School in Clinical Medicine