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Oddmund Søvik

Adjunct Professor
  • E-mailOddmund.Sovik@uib.no
  • Phone+47 55 97 52 47
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Johansson, Bente Berg; Irgens, Henrik Underthun; Molnes, Janne; Sztromwasser, Pawel Szymon; Aukrust, Ingvild; Juliusson, Petur Benedikt; Søvik, Oddmund; Levy, Shawn; Skrivarhaug, Torild; Joner, Geir; Molven, Anders; Johansson, Stefan; Njølstad, Pål Rasmus. 2017. Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry. Diabetologia. 60: 625-635. doi: 10.1007/s00125-016-4167-1
  • Sagen, Jørn V.; Bjørkhaug, Lise; Haukanes, Bjørn Ivar; Grevle, Louise; Molnes, Janne; Nedrebø, Bjørn Gunnar; Søvik, Oddmund; Njølstad, Pål Rasmus; Johansson, Stefan; Molven, Anders. 2017. The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes. Diabetes Research and Clinical Practice. 133: 142-149. doi: 10.1016/j.diabres.2017.08.001
  • Irgens, Henrik Underthun; Fjeld, Karianne; Johansson, Bente Berg; Ringdal, Monika; Immervoll, Heike; Leh, Sabine Maria; Søvik, Oddmund; Johansson, Stefan; Molven, Anders; Njølstad, Pål Rasmus. 2015. Glycogenin-2 is dispensable for liver glycogen synthesis and glucagon-stimulated glucose release. Journal of Clinical Endocrinology and Metabolism. 100: E767-E775. doi: 10.1210/jc.2014-4337
  • Negahdar, Maria; Aukrust, Ingvild; Molnes, Janne; Solheim, Marie Holm; Johansson, Bente Berg; Sagen, Jørn V.; Dahl-Jørgensen, Knut; Kulkarni, Rohit Rajesh; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2014. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 382: 55-65. doi: 10.1016/j.mce.2013.08.020
  • Aukrust, Ingvild; Bjørkhaug, Lise; Negahdar, Maria; Molnes, Janne; Johansson, Bente Berg; Müller, Yvonne; Haas, Wilhelm; Gygi, Steven P.; Søvik, Oddmund; Flatmark, Torgeir; Kulkarni, Rohit N; Njølstad, Pål Rasmus. 2013. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. Journal of Biological Chemistry. 288: 5951-5962. doi: 10.1074/jbc.M112.393769
  • Cameron, Fergus; de Beaufort, Carine; Aanstoot, HJ; Hoey, Hilary; Lange, Karin; Castaño, Luis; Mortensen, HB; Njølstad, Pål Rasmus; Hvidøre Study Group, [Mangler fornavn]; Aman, Jan; Atchison, J. A.; Barret, T; Bjørndalen, Hilde; Cameron, F J; Castro-Correia, C; Chiarelli, F.; Chiari, G; Dahl-Jørgensen, Knut; Daneman, D.; Danne, T.; Dorchy, Harry; Fisher, L; Kaufman, Francine; Garandeau, Patrick; Greene, Stephanie; Holl, R; Hougaard, P; Jarosz-Chobot, P; Kaprio, Eero A; Kitasato, NM; Kocova, M.; Lebenthal, Y; Martul, Pedro; Meier, LK; Neu, Andreas; Palmert, M; Phillips, M; Pociot, F; Robert, JJ; Robertson, KJ; Roche, Erin; Schoenle, E.; Shalitin, S; Skinner, TC; Skovlund, Søren E.; Søvik, Oddmund; Swift, Peter G F; Tsou, Rosa M; Urakami, Tatsuhiko; Vanelli, Maurizio. 2013. Lessons from the Hvidoere International Study Group on childhood diabetes: be dogmatic about outcome and flexible in approach. Pediatric Diabetes. 14: 473-480. doi: 10.1111/pedi.12036
  • Irgens, Henrik Underthun; Molnes, Janne; Johansson, Bente Berg; Ringdal, Monika; Skrivarhaug, Torild; Undlien, Dag Erik; Søvik, Oddmund; Joner, Geir; Molven, Anders; Njølstad, Pål Rasmus. 2013. Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. Diabetologia. 56: 1512-1519. doi: 10.1007/s00125-013-2916-y
  • Søvik, Oddmund; Irgens, Henrik Underthun; Molnes, Janne; Sagen, Jørn V.; Bjørkhaug, Lise; Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus. 2013. Monogenetic diabetes mellitus in Norway :. Norsk Epidemiologi. 23: 55-60.
  • Gonc, E. Nazli; Ozturk, Burcu Bulum; Haldorsen, Ingfrid S.; Molnes, Janne; Immervoll, Heike; Ræder, Helge; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2012. HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease. Pediatric Diabetes. 13: e1-e5. doi: 10.1111/j.1399-5448.2011.00773.x
  • Negahdar, Maria; Aukrust, Ingvild; Johansson, Bente Berg; Molnes, Janne; Molven, Anders; Matschinsky, Franz M.; Søvik, Oddmund; Kulkarni, Rohit N; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2012. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822: 1705-1715. doi: 10.1016/j.bbadis.2012.07.005
  • Søvik, Oddmund; Aagenæs, Øystein; Eide, Stig Åge; Mackay, Deborah J.G.; Temple, I. Karen; Molven, Anders; Njølstad, Pål Rasmus. 2012. Familial occurrence of neonatal diabetes with duplications in chromosome 6q24: treatment with sulfonylurea and 40-yr follow-up. Pediatric Diabetes. 13: 155-162. doi: 10.1111/j.1399-5448.2011.00776.x
  • Molnes, Janne; Teigen, Knut; Aukrust, Ingvild; Bjørkhaug, Lise; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus. 2011. Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. The FEBS Journal. 278: 2372-2386. doi: 10.1111/j.1742-4658.2011.08160.x
  • Haugstvedt, Anne; Wentzel-Larsen, Tore; Graue, Marit; Søvik, Oddmund; Hanestad, Berit Rokne. 2010. Fear of hypoglycaemia in mothers and fathers of children with Type 1 diabetes is associated with poor glycaemic control and parental emotional distress: a population-based study. Diabetic Medicine. 27: 72-78. doi: 10.1111/j.1464-5491.2009.02867.x
  • Laborie, Lene Bjerke; Mackay, Deborah J.G.; Temple, I. Karen; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2010. DNA hypomethylation, transient neonatal diabetes, and prune belly sequence in one of two identical twins. European Journal of Pediatrics. 169: 207-213. doi: 10.1007/s00431-009-1008-y
  • Njølstad, Pål Rasmus; Hertel, Jens Kristoffer; Søvik, Oddmund; Ræder, Helge; Johansson, Stefan; Molven, Anders. 2010. Fremskritt innen diabetesgenetikk. Tidsskrift for Den norske legeforening. 130: 1145-1149.
  • Molven, Anders; Søvik, Oddmund; Lippe, Charlotte von der; Steine, Solrun; Njølstad, Pål Rasmus; Houge, Gunnar; Prescott, Trine E. 2009. Mutasjonsdiagnostikk ved syndromer knyttet til RAS/MAPK-signalveien. Tidsskrift for Den norske legeforening. 129: 2358-2361.
  • Sandal, Tone; Laborie, Lene Bjerke; Brusgaard, Klaus; Eide, Stig Åge; Christesen, Henrik B.T.; Søvik, Oddmund; Njølstad, Pål Rasmus; Molven, Anders. 2009. The spectrum of ABCC8 mutations in Norwegian patients with congenital hyperinsulinism of infancy. Clinical Genetics. 75: 440-448. doi: 10.1111/j.1399-0004.2009.01152.x
  • Eide, Stig Åge; Ræder, H; Ræder, Helge; Johansson, Stefan; Midthjell, Kristian; Søvik, O; Søvik, Oddmund; Njølstad, Pål Rasmus; Molven, Anders. 2008. Prevalence of HNF1A (MODY3) mutations in a Norwegian population (the HUNT2 Study). Diabetic Medicine. 25: 775-781. doi: 10.1111/j.1464-5491.2008.02459.x
  • Haldorsen, Ingfrid Salvesen; Vesterhus, Mette; Ræder, Helge; Jensen, Dag K.; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2008. Lack of pancreatic body and tail in HNF1B mutation carriers. Diabetic Medicine. 25: 782-787. doi: 10.1111/j.1464-5491.2008.02460.x
  • Molnes, Janne; Bjørkhaug, Lise; Søvik, Oddmund; Njølstad, Pål Rasmus; Flatmark, Torgeir. 2008. Catalytic activation of human glucokinase by substrate binding - residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions. The FEBS Journal. 275: 2467-2481. doi: 10.1111/j.1742-4658.2008.06391.x
  • Molven, Anders; Ringdal, Monika; Nordbo, AM; Nordbø, Anita-Merete; Raeeder, H; Ræder, Helge; Stoy, J; Støy, Julie; Lipkind, Gregory M.; Steiner, Donald F.; Philipson, Louis H.; Bergmann, Ines; Aarskog, Dagfinn; Undlien, Dag Erik; Joner, Geir; Joner, Geir; Søvik, Oddmund; Sovik, O; Bell, Graeme I.; Njølstad, Pål Rasmus. 2008. Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes. 57: 1131-1135. doi: 10.2337/db07-1467
  • Sagen, Jørn V.; Bjørkhaug, Lise; Molnes, Janne; Ræder, Helge; Grevle, Louise; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2008. Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Pediatric Diabetes. 9: 442-449. doi: 10.1111/j.1399-5448.2008.00399.x
  • Sandal, Tone; Søvik, Oddmund; Njølstad, Pål Rasmus; Molven, Anders. 2008. Utredning og behandling av medfødt hyperinsulinisme (1): Molekylære og genetiske aspekter. Pediatrisk Endokrinologi. 28: 37-43.
  • Søvik, Oddmund; Boman, Helge. 2008. Co-occurrence of vitamin D-dependent rickets type 1 and phenylketonuria. Acta Paediatrica. 97: 665-667. doi: 10.1111/j.1651-2227.2008.00722.x
  • Søvik, Oddmund; Juliusson, Petur; Hansen, Eirik V.; Njølstad, Pål Rasmus. 2008. Utredning og behandling av medfødt hyperinsulinisme (2): Diagnostiske og terapeutiske aspekter. Pediatrisk Endokrinologi. 22: 56-63.
  • Søvik, Oddmund; Njølstad, Pål Rasmus; Jellum, Egil; Molven, Anders. 2008. Wolcott-Rallison syndrome with 3-hydroxydicarboxylic aciduria and lethal outcome. Journal of Inherited Metabolic Disease. doi: 10.1007/s10545-008-0866-1
  • Aamodt, Geir; Stene, Lars Christian; Njølstad, Pål; Søvik, Oddmund; Joner, Geir. 2007. Spatiotemporal trends and age-period-cohort modeling of the incidence of type 1 diabetes among children aged < 15 years in Norway 1973-1982 and 1989-2003. Diabetes Care. 30: 884-889. doi: 10.2337/dc06-1568
  • Bjørkhaug, Lise; Molnes, Janne; Søvik, Oddmund; Njølstad, Pål Rasmus; Flatmark, Torgeir. 2007. Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation. Journal of Biological Chemistry. 282: 22757-22764. doi: 10.1074/jbc.M700517200
  • Johansson, Stefan; Ræder, Helge; Eide, Stig Åge; Midthjell, Kristian; Hveem, Kristian; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2007. Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. Diabetes. 56: 3112-3117. doi: 10.2337/db07-0513
  • Laborie, Lene Bjerke; Søvik, Oddmund; Njølstad, Pål Rasmus. 2007. Diagnose og behandling av monogene former for nyfødt- og spebarnsdiabetes. Pediatrisk Endokrinologi. 21: 23-28.
  • Ræder, Helge; Haldorsen, Ingfrid Salvesen; Ersland, Lars; Grüner, Renate; Taxt, Torfinn; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2007. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-Ester lipase. Diabetes. 56: 444-449. doi: 10.2337/db06-0859
  • Søvik, Oddmund; Schubbert, Suzanne; Houge, Gunnar; Steine, Solrun; Norgård, Gunnar; Engelsen, Bernt; Njølstad, Pål Rasmus; Shannon, Kevin; Molven, Anders. 2007. De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features. Journal of Medical Genetics. 44. 6 pages. doi: 10.1136/jmg.2007.049361
  • Søvik, Oddmund; Tansek, Mojca Zerjav; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2007. Management of neonatal and infancy-onset diabetes mellitus. Endocrine Development. 11: 94-105.
  • Júlíusson, PB; Graue, Marit; Wentzel-Larsen, Tore; Søvik, Oddmund. 2006. The impact of continuous subcutaneous insulin infusion on health-related quality of life in children and adolescents with type 1 diabetes. Acta Paediatrica. 95: 1481-1487.
  • Pearson, Ewan R.; Flechtner, Isabelle; Njølstad, Pål Rasmus; Malecki, Maciej T.; Flanagan, Sarah E.; Larkin, Brian; Ashcroft, Frances M.; Klimes, Iwar; Codner, Ethel; Iotova, Violeta; Slingerland, Annabelle S.; Shield, Julian; Robert, Jean-Jaques; Holst, Jens J.; Clark, Penny M.; Ellard, Sian; Søvik, Oddmund; Polak, Michel; Hattersley, Andrew T. 2006. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. New England Journal of Medicine. 355: 467-477.
  • Raeder, Helge; Ræder, Helge; Bjorkhaug, Lise; Bjørkhaug, Lise; Johansson, Stefan; Mangseth, Kjersti; Sagen, Jørn V.; Hunting, Anne; Følling, Ivar; Johansen, Odd; Bjørgaas, Marit; Paus, Povel N.; Søvik, Oddmund; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2006. A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. Diabetes. 55: 1899-1903. doi: 10.2337/db05-1677
  • Ræder, Helge; Johansson, Stefan; Holm, Pål I.; Haldorsen, Ingfrid S.; Mas, Eric; Sbarra, Véronique; Nermoen, Ingrid; Eide, Stig Åge; Grevle, Louise; Bjørkhaug, Lise; Sagen, Jørn V.; Aksnes, Lage; Søvik, Oddmund; Lombardo, Dominique; Molven, Anders; Njølstad, Pål Rasmus. 2006. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics. 38: 54-62. doi: 10.1038/ng1708
  • Ræder, Helge; Nermoen, Ingrid; Johansson, Stefan; Søvik, Oddmund; Molven, Anders; Sagen, Jørn V.; Aksnes, Lage; Haldorsen, Ingfrid S.; Bjørkhaug, Lise; Holm, Pål Ivar; Eide, Stig Åge; Grevle, Louise; Mas, Eric; Sbarra, Véronique; Lombardo, Dominique; Njølstad, Pål Rasmus. 2006. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics. 38: 54-62.
  • Sagen, Jørn; Odili, Stella; Bjørkhaug, Lise; Zelent, Dorothy; Buettger, Carol; Kwagh, Jae; Stanley, Charles; Dahl-Jørgensen, Knut; de Beaufort, Carine; Bell, Graeme I.; Han, Yi; Grimsby, Joseph; Taub, Rebecca; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus; Matschinsky, Franz M. 2006. From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes. 55: 1713-1722. doi: 10.2337/db05-1513
  • Berg, Ansgar; Søvik, Oddmund; Hirth, Asle. 2005. Væskebehandling og risiko for hjerneødem hos barn med diabetiskketoacidose. Tidsskrift for Den norske legeforening. Årg. 125, nr 21. 2932-2935.
  • Bjørkhaug, Lise; Johansson, Stefan; Ræder, Helge; Thorsby, PM; Undlien, DE; Søvik, Oddmund; Molven, Anders; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2005. Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 125: 2968-2972.
  • Graue, Marit; Wentzel-Larsen, Tore; Hanestad, Berit Rokne; Søvik, Oddmund. 2005. Health-related quality of life and metabolic control in adolescents with diabetes: the role of parental care, control and involvement. Journal of Pediatric Nursing : Nursing Care of Children and Families. 20: 373-82.
  • Graue, Marit; Wentzel-Larsen, Tore; Hanestad, Berit Rokne; Søvik, Oddmund. 2005. Evaluation of a program of group visits and computer-assisted consultations in the treatment of adolescents with Type 1 diabetes. Diabetic Medicine. 22: 1522-9.
  • Gundersen, Lise Bj.; Johansson, Stefan; Ræder, Helge; Undlien, Dag E.; Molven, Anders; Søvik, Oddmund; Thorsby, Per; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2005. Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 125: 2968-2972.
  • Sagen, Jørn V.; Baumann, Maren E.; Salvesen, Helga; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2005. Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. Diabetic Medicine. 22: 1012-1015.
  • Sagen, Jørn V.; Pearson, Ewan R.; Johansen, Anders; Spyer, Ghislaine; Søvik, Oddmund; Pedersen, Oluf; Njølstad, Pål Rasmus; Hattersley, Andrew T.; Hansen, Torben. 2005. Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1 alpha mutation carriers. Diabetic Medicine. 22: 406-409.
  • Graue, Marit; Wentzel-Larsen, Tore; Bru, Edvin; Hanestad, Berit Rokne; Søvik, Oddmund. 2004. The Coping Styles of Adolescents with Type 1 Diabetes areAssociated with Degree of Metabolic Control. Diabetes Care. 27: 1313-1317.
  • Graue, Marit; Wentzel-Larsen, Tore; Hanestad, Berit Rokne; Båtsvik, Berit; Søvik, Oddmund. 2003. Measuring self-reported, health-related, quality of life in adolescents with type 1 diabetes using both generic and disease-specific instruments. Acta Paediatrica. 92: 1190-1196.
  • Njølstad, Pål Rasmus; Sagen, Jørn V.; Bjørkhaug, Lise; Odili, Stella; Shehadeh, Naim; Bakry, Doua; Sarici, U; Alpay, Faruk; Molnes, Janne; Molven, Anders; Søvik, Oddmund; Matschinsky, Franz M. 2003. Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway. Diabetes. 52: 2854-2860.
  • Tøndel, Camilla; Lægreid, Liv Marie; Hirth, Asle; Houge, Gunnar; Månsson, Jan - Eric; Søvik, Oddmund. 2003. Intravenøs enzymsubstitusjons-behandling ved Fabry sykdom hos barn. Tidsskrift for Den norske legeforening. 123: 3338-3390.
  • Bjørkhaug, Lise; Horikawa, Y; Ye, Hong; Bell, Graeme I.; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2000. MODY associated with two novel hepatocyte nuclear factor 1 alpha loss of function mutations. Biochemical and Biophysical Research Communications - BBRC. 279: 792-798.
  • Bjørkhaug, Lise; Søvik, Oddmund; Bell, Graeme I.; Njølstad, Pål Rasmus; Molven, Anders. 2000. A simple test for the hot spot mutation P291fsinsC in MODY3. Diabetologia. 43: 818-819.
Book sections
  • Søvik, Oddmund; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2008. MODY5 due to mutations in TCF2 (HNF-1ß): The clinical spectrum with special reference to urogenital malformations. Kapittel, pages 1096-1102. In:
    • Epstein, Charles J.; Erickson, Robert P.; Wynshaw-Boris, Anthony. 2008. Inborn Errors of Development. Oxford University Press. 1664 pages. ISBN: 9780195306910.
  • Njølstad, Pål Rasmus; Molven, Anders; Søvik, Oddmund. 2005. Diagnosis and mangement of MODY in a pediatric setting. Chapter 5, pages 84-93. In:
    • Chiarelli, Francesco; Dahl-Jørgensen, Knut; Kiess, Wieland. 2005. Diabetes in Childhood and Adolescence. S. Karger. 400 pages. ISBN: 3-8055-7766-4.

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