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Olav Mella

Professor
  • E-mailOlav.Mella@uib.no
  • Phone+47 55 97 20 10+47 55 97 20 69
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Lande, Asgeir; Fluge, Øystein; Strand, Elin Bolle; Flåm, Siri Tennebø; Sosa, Daisy Duarte; Mella, Olav; Egeland, Torstein; Saugstad, Ola Didrik; Lie, Benedicte Alexandra; Viken, Marte K. 2020. Human Leukocyte Antigen Alleles Associated With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Scientific Reports.
  • Fluge, Øystein; Rekeland, Ingrid Gurvin; Lien, Katarina; Thurmer, Hanne; Borchgrevink, Petter Chr.; Schäfer, Christoph; Sørland, Kari; Assmus, Jörg; Ktoridou-Valen, Irini; Herder, Ingrid; Gotaas, Merethe Otelie Eide; Kvammen, Øivind; Baranowska, Katarzyna Anna; Bohnen, Louis Marie Leonardus Joseph; Martinsen, Sissel; Lonar, Ann Elin; Solvang, Ann-Elise Havnen; Gya, Arne Edvard Sørli; Bruland, Ove; Risa, Kristin; Alme, Kine; Dahl, Olav; Mella, Olav. 2019. B-lymphocyte depletion in patients with myalgic encephalomyelitis/chronic fatigue syndrome: A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine. 585-593.
  • Rekeland, Ingrid Gurvin; Fluge, Øystein; Alme, Kine; Risa, Kristin; Sørland, Kari; Mella, Olav; de Vries, Annick; Schjøtt, Jan. 2018. Rituximab serum concentrations and anti-rituximab antibodies during B-cell depletion therapy for myalgic encephalopathy/chronic fatigue syndrome. Clinical Therapeutics. 9.
  • Gunther, Oliver P; Gardy, Jennifer L; Stafford, Phillip; Fluge, Øystein; Mella, Olav; Tang, Patrick; Miller, Ruth R; Parker, Shoshana M; Johnston, Stephen A; Patrick, David M. 2018. Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Molecular Neurobiology. 1-9.
  • Fluge, Øystein; Mannsåker, Bård; Torp, Anders; Mjaaland, Ingvil; Helgeland, Lars; Klos, Jan; Mella, Olav; Berentsen, Sigbjørn; Meyer, Peter Albert. 2017. Consolidative radiotherapy to residual masses after chemotherapy is associated with improved outcome in diffuse large B-cell lymphoma. A retrospective, population-based study. Clinical Lymphoma, Myeloma & Leukemia. 125-135.
  • Lunde, Sigrid; Kristoffersen, Einar Klæboe; Sapkota, Dipak; Risa, Kristin; Dahl, Olav; Bruland, Ove; Mella, Olav; Fluge, Øystein. 2016. Serum BAFF and APRIL levels, T-lymphocyte subsets, and immunoglobulins after B-cell depletion using the monoclonal anti-CD20 antibody rituximab in myalgic encephalopathy/chronic fatigue syndrome. PLOS ONE.
  • Fluge, Øystein; Mella, Olav; Bruland, Ove; Risa, Kristin; Dyrstad, Sissel Elisabeth; Alme, Kine; Rekeland, Ingrid Gurvin; Sapkota, Dipak; Røsland, Gro Vatne; Fosså, Alexander; Ktoridou-Valen, Irini; Lunde, Sigrid; Sørland, Kari; Lien, Katarina; Herder, Ingrid; Thurmer, Hanne; Gotaas, Merete E; Baranowska, Katarzyna Anna; Bohnen, Louis M.L.J.; Schäfer, Christoph; Mccann, Adrian; Sommerfelt, Kristian; Helgeland, Lars; Ueland, Per Magne; Dahl, Olav; Tronstad, Karl Johan. 2016. Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight.
  • Loebel, Madlen; Grabowski, Patricia; Heidecke, Harald; Bauer, Sandra; Hanitsch, Leif G.; Wittke, Kirsten; Meisel, Christian; Reinke, Petra; Volk, Hans-Dieter; Fluge, Øystein; Mella, Olav; Scheibenbogen, Carmen. 2016. Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome. Brain, behavior, and immunity. 32-39.
  • Fluge, Øystein; Risa, Kristin; Lunde, Sigrid; Alme, Kine; Rekeland, Ingrid Gurvin; Sapkota, Dipak; Kristoffersen, Einar Klæboe; Sørland, Kari; Bruland, Ove; Dahl, Olav; Mella, Olav. 2015. B-lymphocyte depletion in myalgic encephalopathy/chronic fatigue syndrome. An open-label phase II study with rituximab maintenance treatment. PLOS ONE.
  • Arving, Cecilia; Thormodsen, Inger; Brekke, Guri; Mella, Olav; Berntsen, Sveinung; Nordin, Karin. 2013. Early rehabilitation of cancer patients - a randomized controlled intervention study. BMC Cancer. 7 pages.
  • Westermann, Anneke; Mella, Olav; Van der Zee, Jacoba; Jones, Ellen L.; Van der Steen-Banasik, Elzbieta; Koper, Peter; Uitterhoeve, Appolina L.J.; de Wit, Ronald; van der Velden, Jacobus; Burger, Curt; Schem, Baard-Christian; Van der Wilt, Clasina L.; Dahl, Olav; Prosnitz, Leonard R.; van Tinteren, Harm. 2012. Long-term survival data of triple modality treatment of stage IIB-III-IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia - an update. International Journal of Hyperthermia. 549-553.
  • Fluge, Øystein; Bruland, Ove; Risa, Kristin; Storstein, Anette; Kristoffersen, Einar Klæboe; Sapkota, Dipak; Næss, Halvor; Dahl, Olav; Nyland, Harald Inge; Mella, Olav. 2011. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLOS ONE. 13 pages.
  • Borkamo, Erling Dahl; Schem, Baard-Christian; Fluge, Øystein; Bruland, Ove; Dahl, Olav; Mella, Olav. 2009. cDNA microarray analysis of serially sampled cervical cancer specimens from patients treated with thermochemoradiotherapy. International Journal of Radiation Oncology, Biology, Physics. 1562-1569.
  • Overgaard, Jens; Gonzalez-Gonzales, Dionisio; Hulshof, Maarten C.C.H.; Arcangeli, Giorgio; Dahl, Olav; Mella, Olav; Bentzen, Søren M. 2009. Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicenter randomized trial by The European Society for Hyperthermic Oncology. International Journal of Hyperthermia. 323-334.
  • Fluge, Øystein; Mella, Olav. 2009. Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series. BMC Neurology. 7 pages.
  • Haldorsen, Ingfrid Salvesen; Kråkenes, Jostein; Krossnes, Bård Kronen; Mella, Olav; Espeland, Ansgar. 2009. CT and MR imaging features of primary central nervous system lymphoma in Norway, 1989-2003. American Journal of Neuroradiology. 744-751.
  • Borkamo, Erling Dahl; Fluge, Øystein; Mella, Olav; Akslen, Lars A.; Bruland, Ove; Dahl, Olav. 2008. Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour. Radiotherapy and Oncology. 435-442.
  • Haldorsen, Ingfrid Salvesen; Kråkenes, Jostein; Goplen, Anne K.; Dunlop, Oona; Mella, Olav; Espeland, Ansgar. 2008. AIDS-related primary central nervous system lymphoma: a Norwegian national survey 1989-2003. BMC Cancer. 8 pages.
  • Kolstad, Arne; Risberg, Terje; Bremnes, Yngve; Wilsgaard, Tom; Holte, Harald; Klepp, Olbjørn; Mella, Olav; Wist, Erik. 2004. Use of complementary and alternative therapies: a national multicentre study of oncology health professionals in Norway. Supportive Care in Cancer. 312-318.
  • Risberg, Terje; Bremnes, Yngve; Kolstad, Arne; Holte, Harald; Wist, Erik; Mella, Olav; Klepp, Olbjørn. 2004. Tilbud om komplementærbehandling i sykehus. Tidsskrift for Den norske legeforening. 3078-3080.
  • Risberg, Terje; Bremnes, Yngve; Kolstad, Arne; Holte, Harald; Wist, Erik; Mella, Olav; Klepp, Olbjørn. 2004. Tilbud om komplementær behandling i sykehus? Tidsskrift for Den norske legeforening. 3078-3080.
  • Krossnes, Bård Kronen; Mella, Olav; Wester, Knut; Mørk, Sverre. 2004. Pigmented astrocytoma with suprasellar location: case report and literature review. Acta Neuropathologica. 461-466.
  • Risberg, Terje; Kolstad, Arne; Bremnes, Yngve; Holte, Harald; Wist, Erik; Mella, Olav; Klepp, Olbjørn; Wilsgaard, Tom; Cassileth, B.R. 2004. Knowledge of and attitudes toward complementary and alternative therapies: a national multicentre study of oncology professionals in Norway. European Journal of Cancer. 529-535.
  • Haldorsen, Ingfrid Salvesen; Aarseth, Jan H; Hollender, Aase; Larsen, John Ludvig; Espeland, Ansgar; Mella, Olav. 2004. Incidence, Clinical Features, Treatment and Outcome of Primary Central Nervous System Lymphoma in Norway. Acta Oncologica. 520-529.
  • Risberg, Terje; Kolstad, Arne; Wist, Erik; Holthe, Harald; Mella, Olav; Klepp, Olbjørn. 2003. Skal alternative utøvere behandle kreft - hva mener onkologiske helsearbeidere? Tidsskrift for Den norske legeforening. 3059-3061.
  • Risberg, Terje; Kolstad, Arne; Wist, Erik; Holte, Harald; Mella, Olav; Klepp, Olbjørn. 2003. Should alternative therapists treat cancer-what is the opinion of oncology health personnel? Tidsskrift for Den norske legeforening. 3059-3061.
  • NLG, The Nordic Lymphoma Group; Mella, Olav. 2003. CHOP is superior to CNOP in elderly patients with aggressive lymphoma while outcome is unaffected by filgrastim treatment: results of a Nordic Lymphoma Group randomized trial. Blood. 3840-3848.
  • Muren, Ludvig; Mella, Olav; Hafslund, Rune; Dahl, Olav. 2002. Norwegian Oncologists' Expectations of Intensity-modulated Radiotherapy. Acta Oncologica. 562-565.
  • Eikesdal, Hans Petter; Bjerkvig, Rolf; Raleigh, James A.; Mella, Olav; Dahl, Olav. 2001. Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia. Radiotherapy and Oncology. 313-320.
  • Lønning, Per Eystein; Taylor, Paul D.; Anker, Gun; Iddon, Julie; Wie, Liv; Jørgensen, Linn-Marie; Mella, Olav; Howell, Anthony. 2001. High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy. Breast Cancer Research and Treatment. 111-116.
  • Eikesdal, Hans Petter; Bjerkvig, Rolf; Mella, Olav; Dahl, Olav. 2001. Combretastatin A-4 and hyperthermia; a potent combination for the treatment of solid tumors. Radiotherapy and Oncology. 147-154.
  • Eikesdal, Hans Petter; Schem, Baard Christian; Mella, Olav; Dahl, Olav. 2000. The new tubulin-inhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma. International Journal of Radiation Oncology, Biology, Physics. 645-652.
  • Eikesdal, Hans Petter; Schem, Baard-Christian; Mella, Olav; Dahl, Olav. 2000. The new tubulin-inhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma. International Journal of Radiation Oncology, Biology, Physics. 645-652.
  • Dahl, Olav; Dalene, Ronny; Schem, Baard Christian; Mella, Olav. 1999. Status of clinical hyperthermia. Acta Oncologica. 863-873.
  • Guttormsen, Anne Berit; Ueland, Per Magne; Lønning, Per Eystein; Mella, Olav; Refsum, Helga. 1998. Kinetics of total plasma homocysteine during basal conditions. Clinical Chemistry. 1886-1891.
  • Guttormsen, Anne Berit; Ueland, Per Magne; Lønning, Per Eystein; Mella, Olav; Refsum, Helga. 1998. Kinetics of plasma total homocysteine in patients receiving high- dose methotrexate therapy. Clinical Chemistry. 1987-1989.
  • Krossnes, Bård Kronen; Geisler, Stephanie; Mella, Olav. 1998. Intravenous infusion of glucose and the vasodilator sodium nitroprusside in combination with local hyperthermia: Effects on tumour pH and tumour re in the BT4An rat tumour model. International Journal of Hyperthermia. 403-416.
  • Krossnes, Bård Kronen; Geisler, Stephanie; Mella, Olav. 1998. Intravenous infusion of glucose and the vasodilator sodium nitroprusside in combinaiton with local hyperthermia: Effects on tumour pH and tumour response in the BT(4)AN rat tumour model. International Journal of Hyperthermia. 403-416.
  • Pyrhönen, S; Valavaara, R; Modig, H; Pawlicki, M; Pienkowski, T; Gundersen, S; Bauer, J; Westman, G; Lundgren, S; Blanco, G; Mella, Olav; et al., [Mangler fornavn]. 1997. Comparison of toremifene and tamoxifen in postmenopausal patients with advanced breast cancer: a randomized double-blind, the "nordic" phase III st. British Journal of Cancer. 270-277.
  • Krossnes, Bård Kronen; Mella, Olav; Dahl, Olav. 1996. Use of the vasodilator sodium nitroprusside during local hyperthermia: Effects on tumor temperature and tumor response in a rat tumor model. International Journal of Radiation Oncology, Biology, Physics. 403-415.
  • Holte, H.; Kvaløy, Stein; Engan, T; Evensen, Stein A.; Mella, Olav; Tangen, Jon-Magnus; Wesenberg., Finn; Wist, Erik. 1996. Høydosebehandling med autolog stamcellestøtte ved maligne lidelser. Tidsskrift for Den norske legeforening. 2577-81.
  • Holte, Harald; Kvaløy, Stein O; Engan, Terje; Evensen, Stein A.; Mella, Olav; Tangen, Jon-Magnus; Wesenberg, Finn; Wist, Erik A. 1996. Høydosebehandling med autolog stamcellestøtte ved maligne lidelser. Tidsskrift for Den norske legeforening. 2577-2281.
  • Krossnes, Bård Kronen; Mella, Olav; Tyssebotn, Ingvald. 1996. Effect of sodium nitroprusside-induced hypotension on the blood flow in subcutaneous and intramuscular BT4AN tumors and normal tissues in rats. International Journal of Radiation Oncology, Biology, Physics. 393-401.
  • Krossnes, Bård Kronen; Mella, Olav; Tyssebotn, Ingvald. 1996. Effect of sodium nitroprusside-induced hypotension on the blood flow in subcutaneous and intramuscular BT(4)AN tumors and normal tissues in rats. International Journal of Radiation Oncology, Biology, Physics. 393-401.
  • Holte, Harald; Mella, Olav; Wist, Erik A.; Telhaug, Ragnar; Hannisdal, Einar; Abrahamsen, Arne Foss. 1996. ChlVPP is as effective as alternating ChlVPP/ABOD in advanced stage Hodgkin's disease. Acta Oncologica. 73-80.
  • Schem, B-C; Rozsinski, S; Krossnes, BK; Mella, Olav. 1995. Timing of hypertonic glucose and thermochemotherapy in the BT%eAn rat glioma: Relation to intratumoral pH reduction and circulatory changes after glucose supply. International Journal of Radiation Oncology, Biology, Physics. 409-416.
  • Overgaard, J; Gonzalez Gonzalez, D; Hulshof, MCCM; Arcangeli, G; Dahl, Olav; Mella, Olav; Berntzen, SM. 1995. Randomized trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. The Lancet. 540-543.
  • Hornsleth, SN; Mella, Olav. 1995. Hypertermi: Biologi - Fysik - Klinik. Helsetjeneste, Medisinsk Teknikk, Økonomi, Ledelse. 21-27.
Report
  • Kvaløy, Stein O; Engan, T; Evensen, SA; Holte, Harald; Mella, Olav; Tangen, JM; Wesenberg, F. 1995. Høydosebehandling med autolog stamcellestøtte ved maligne lidelser. Instilling fra rådgivende gruppe nedsatt av Helsedirektoratet, senere Statens Helsetilsyn. .
Academic lecture
  • Arving, Cecilia; Thormodsen, Inger; Aaslund, Mona Kristin; Berntsen, Sveinung; Mella, Olav; Nordin, Karin. 2014. “The prevalence of distress, emotional reactivity, fatigue and health related quality of life among newly diagnosed cancer patients starting adjuvant treatment”.
  • Schem, Baard-Christian; Froystein, T.; Hjertaker, B. T.; Larsen, Annette; Mella, Olav. 2003. Trimodality treatment with regional hyperthermia, radiotherapy and chemotherapy in primary inoperable or recurrent rectal carcinoma.
  • Schem, Baard-Christian; Larsen, Annette; Froystein, T.; Hjertaker, B. T.; Mella, Olav. 2003. Trimodality treatment of inoperable/locally recurrent rectal cancer with hyperthermia, radiotherapy and chemotherapy. Pilot studies.
  • Schem, Baard-Christian; Larsen, Annette; Froystein, T.; Hjertaker, B. T.; Mella, Olav. 2003. Regional hyperthermia in addition to chemoradiotherapy in cervical carcinoma: Results of a phase II study.
  • Larsen, Annette; Schem, Baard-Christian; Ekanger, Roald; Mella, Olav. 2003. Regional hyperthermia in addition to chemoradiotherapy in cervical cancer: results of a phase II-study.
  • Westermann, Anneke M.; Jones, Ellen; Schem, Baard-Christian; Van der Zee, Jacoba; Van der Steen-Banasik, Elzbieta; Koper, Peter; Mella, Olav; Uitterhoeve, Lon J.; de Wit, Ronald; VAn der Velden, Ko; Burger, Curt; Van der Wilt, C. L.; Dahl, Olav; Prosnitz, Leonard R. 2003. Regional hyperthermia added to chemoradiotherapy in advanced cervical cancer: Multicenter international feasibility.
Reader opinion piece
  • Tronstad, Karl Johan; Fluge, Øystein; Mella, Olav. 2018. Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon . Tidsskrift for Den norske legeforening. 12-13.
  • Tronstad, Karl Johan; Fluge, Øystein; Lien, Katarina; Sommerfelt, Kristian; Mella, Olav. 2017. Mer om pyruvat dehydrogenase og kronisk utmattelsessyndrom. Tidsskrift for Den norske legeforening.
  • Tronstad, Karl Johan; Fluge, Øystein; Mella, Olav. 2017. Chronic fatigue syndrome and pyruvate dehydrogenase function. Tidsskrift for Den norske legeforening.
  • Dahl, Olav; Mella, Olav. 2002. Hyperthermia alone or combined with cisplatin in addition to radiotherapy for advanced uterine cervical cancer. International Journal of Hyperthermia. 25-30.
Academic commentary
  • Tronstad, Karl Johan; Fluge, Øystein; Mella, Olav. 2018. Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon.
Non-fiction book
  • Mella, Olav; Melien, Øyvind; Bjordal, Kristin; Kaasa, Stein. 1999. Cytostatika Medikamentell kreftbehandling kap. 8 Kvalme og oppkast ved cytostatikabehandling. Institutt for farmakoterapi og Den Norske Kreftforening.
Feature article
  • Schem, B-C; Mella, Olav. 1997. Når ansvarsfraskrivelse blir arbeidsform. [Kronikk]. Aftenposten (morgenutg. : trykt utg.).
  • Mella, Olav. 1997. Fremtidens kreftbehandling. [Kronikk]. Bergens Tidende.
  • Lønning, Per Eystein; Mella, Olav. 1996. Dagbladet på ville veier. Dagbladet. 3.
Doctoral dissertation
  • Mella, Olav. 1990. Optimization of hyperthemia and chemotherapy in an experi- mental brain tumour model.
Academic chapter/article/Conference paper
  • Dahl, Inger Marie S.; Wisløff, Finn; Børset, Magne; Mella, Olav. 2009. Myelomatose. 11 pages.
  • Wisløff, F; Mella, Olav; Dahl, IM. 1999. Myelomatose. 5 pages.
  • Mella, Olav; Melien, Ø; Bjordal, K; Kaasa, S. 1999. Kvalme og oppkast ved cytostaticabehandling. 8 pages.
Abstract
  • Waldeland, Einar; Dahl, Olav; Odland, Odd Harald; Kvaløy, Stein Olav; Lund, Jo-Åsmund; Malinen, Eirik; Marienhagen, Kirsten; Sylvarnes, Rune; Muren, Ludvig Paul; Pedersen, Geir; Pedersen, Brit; Vadset, Pål Ove; Wanderås, Anne Dybdahl; Mella, Olav. 2014. Particle therapy in Norway - report from the national project group. Radiotherapy and Oncology. 314-314.
Poster
  • Westermann, Anneke M.; Schem, Baard-Christian; Van der Zee, Jacoba; Jones, Ellen; Van der Steen-Banasik, Elzbieta; Mella, Olav; de Wit, Ronald; Uitterhoeve, Lon J.; Van der Wilt, C. L.; Prosnitz, Leonard R. 2003. Regional hyperthermia added to chemoradiotherapy in advanced cervical cancer: Multicenter international feasibility.
  • Schem, Baard-Christian; Frøystein, T.; Hjertaker, B. T.; Dahl, Olav; Mella, Olav. 2001. Regional Hyperthermia as part of trimodality treatment of locally advanced/locally recurrent cervical carcinoma, and primarily inoperable/locally recurrent carcinoma.
  • Muren, Ludvig; Mella, Olav; Hafslund, R.; Dahl, Olav. 2001. National survey of IMRT expectations in Norway.

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