Home
Patricia Natalia Silva Moretti's picture

Patricia Natalia Silva Moretti

Postdoctoral Fellow
  • E-mailPatricia.Moretti@uib.no
  • Phone+47 462 44 511
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
  1. miRNA profile and disease severity in patients with sickle cell anemia.Biassi TP, Guerra-Shinohara EM, Moretti PNS, de Freitas Dutra V, Cabañas-Pedro AC, Mecabo G, Colleoni GWB, Figueiredo MS.Ann Hematol. 2021 Oct 22. https://doi: 10.1007/s00277-021-04665-y.

  2. Aging biological markers in a cohort of antipsychotic-naïve first-episode psychosis patients.Talarico F, Xavier G, Ota VK, Spindola LM, Maurya PK, Tempaku PF, Moretti PS, Gadelha A, Noto M, Noto C, Cordeiro Q, Bressan RA, de Jong S, Santoro ML, Breen G, Belangero SI.Psychoneuroendocrinology. 2021 Oct;132:105350. https://doi: 10.1016/j.psyneuen.2021.105350.

  3. Insights into how environment shapes post-mortem RNA transcription in mouse brain.Bonadio RS, Nunes LB, Moretti PNS, Mazzeu JF, Cagnin S, Pic-Taylor A, de Oliveira SF.Sci Rep.2021 Jun 21;11(1):13008. https://doi: 10.1038/s41598-021-92268-y.

  4. Genotype and phenotype correlation in a family with a 2q37 deletion downstream of HDAC4. Moretti PN, Figueiredo ACV, Saliba A, Versiani BR, Oliveira SF, Pic-Taylor A, Mazzeu JF. Am J Med Genet A. 2020 May 20. doi: 10.1002/ajmg.a.61620. https://doi.org/10.1002/ajmg.a.61620

  5. LINE-1 hypomethylation is associated with poor risperidone response in a first episode of psychosis cohort. Marques DF, Ota VK, Santoro ML, Talarico F, Costa GO, Spindola LM, Cogo-Moreira H, Carvalho CM, Xavier G, Cavalcante DA, Gadelha A, Noto C, Cordeiro Q, Bressan RA, Moretti PN, Belangero SI. Epigenomics. 2020 Jun;12(12):1041-1051. doi: 10.2217/epi-2019-0350. https://doi.org/10.2217/epi-2019-0350

  6. Fluoxetine chronic exposure affects growth, behavior and tissue structure of zebrafish. de Farias NO, Oliveira R, Moretti PNS, E Pinto JM, Oliveira AC, Santos VL, Rocha PS, Andrade TS, Grisolia CK. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Nov;237:108836. doi: 10.1016/j.cbpc.2020.108836. https://doi.org/10.1016/j.cbpc.2020.108836

  7. Defining the Critical Region for Intellectual Disability and Brain Malformations in 6q27 microdeletions. Hanna MD, Moretti PN, de Oliveira CP, Rosa MTA, Versiani BR, de Oliveira SF, Pic-Taylor A, Mazzeu JF. Molecular Syndromology. 2019;10:202-208. doi: 10.1159/000501008. https://doi.org/10.1159/000501008

  8. Gene expression over the course of schizophrenia: from clinical high-risk for psychosis to chronic stages. Ota VK, Moretti PN, Santoro ML, Talarico F, Spindola LM, Xavier G, Carvalho CM, Marques DF, Costa GO, Pellegrino R, de Jong S, Cordeiro Q, Hakonarson H, Breen G, Noto C, Bressan RA, Gadelha A, Jesus Mari J, Belangero SI. NPJ Schizophr. 2019 Mar 28;5(1):5. doi: 10.1038/s41537-019-0073-0. https://doi.org/10.1038/s41537-019-0073-0

  9. DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis. Belangero SI, Ota VK, Gadelha A, Berberian AA, Assunção-Leme IB, Noto C, Christofolini DM, Bellucco FT, Santoro ML, Mazzotti DR, Zugman A, Melaragno MI, Smith MAC, Pellegrino R, Hakonarson H, Cordeiro Q, Moretti PN, Bressan RA, Mari JJ, Jackowski AP. Psychiatry Res. 2019 Apr;274:391-394. doi: 10.1016/j.psychres.2019.02.068. https://doi.org/10.1016/j.psychres.2019.02.068

  10. Accessing Gene Expression in Treatment-Resistant Schizophrenia. Moretti PN, Ota VK, Gouvea ES, Pedrini M, Santoro ML, Talarico F, Spindola LM, Carvalho CM, Noto C, Xavier G, Brietzke E, Gadelha A, Bressan R, Mari J, Belangero S. Mol Neurobiol. 2018 Aug;55(8):7000-7008. doi: 10.1007/s12035-018-0876-4. https://doi.org/10.1007/s12035-018-0876-4

  11. Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort. Santoro ML, Ota V, de Jong S, Noto C, Spindola LM, Talarico F, Gouvea E, Lee SH, Moretti P, Curtis C, Patel H, Newhouse S, Carvalho CM, Gadelha A, Cordeiro Q, Bressan RA, Belangero SI, Breen G. Transl Psychiatry. 2018 Aug 31;8(1):174. doi: 10.1038/s41398-018-0230-7. https://doi.org/10.1038/s41398-018-0230-7

  12. Effect of male-specific childhood trauma on telomere length. Xavier G, Spindola LM, Ota VK, Carvalho CM, Maurya PK, Tempaku PF, Moretti PN, Mazotti DR, Sato JR, Brietzke E, Miguel EC, Grassi-Oliveira R, Mari J, Bressan RA, Gadelha A, Pan PM, Belangero SI. J Psychiatr Res. 2018 Dec;107:104-109.doi:10.1016/j.jpsychires.2018.10.012. https://doi.org/10.1016/j.jpsychires.2018.10.012

  13. Leukocyte telomere length variation in different stages of schizophrenia. Maurya PK, Rizzo LB, Xavier G, Tempaku PF, Ota VK, Santoro ML, Spíndola LM, Moretti PS, Mazzotti DR, Gadelha A, Gouvea ES, Noto C, Maes M, Cordeiro Q, Bressan RA, Brietzke E, Belangero SI. J Psychiatr Res. 2018 Jan; 96:218-223. doi: 10.1016/j.jpsychires.2017.10.016. https://doi.org/10.1016/j.jpsychires.2017.10.016

  14. Stress-related telomere length in children: A systematic review. Coimbra BM, Carvalho CM, Moretti PN, Mello MF, Belangero SI. J Psychiatr Res. 2017 Sep;92:47-54. doi: 10.1016/j.jpsychires.2017.03.023. https://doi.org/10.1016/j.jpsychires.2017.03.023

  15. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. Spindola LM, Pan PM, Moretti PN, Ota VK, Santoro ML, Cogo-Moreira H, Gadelha A, Salum G, Manfro GG, Mari JJ, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel EC, Rohde LA, Sato JR, Bressan RA, Belangero SI. J Psychiatr Res. 2017 Sep;92:24-30. doi: 10.1016/j.jpsychires.2017.03.015. https://doi.org/10.1016/j.jpsychires.2017.03.015

  16. Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls. Matsuzaka CT, Christofolini D, Ota VK, Gadelha A, Berberian AA, Noto C, Mazzotti DR, Spindola LM, Moretti PN, Smith MAC, Melaragno MI, Belangero SI, Bressan RA. Braz J Psychiatry. 2017 Oct-Dec;39(4):302-308. doi: 10.1590/1516-4446-2016-1987. Epub 2017 Mar 2. https://doi.org/10.1590/1516-4446-2016-1987

  17. Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis. Gouvea ES, Ota VK, Noto C, Santoro ML, Spindola LM, Moretti PN, Carvalho CM, Xavier G, Rios AC, Sato JR, Hayashi MA, Brietzke E, Gadelha A, Bressan RA, Cordeiro Q, Belangero SI. Transl Psychiatry. 2016 Oct 4;6(10):e908. doi: 10.1038/tp.2016.159. https://doi.org/10.1038/tp.2016.159

  18. Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis. Noto C, Ota VK, Santoro ML, Gouvea ES, Silva PN, Spindola LM, Cordeiro Q, Bressan RA, Gadelha A, Brietzke E, Belangero SI, Maes M. Mol Neurobiol. 2016 Oct;53(8):5701-9. doi: 10.1007/s12035-015-9489-3. https://doi.org/10.1007/s12035-015-9489-3

  19. A current snapshot of common genomic variants contribution in psychiatric disorders. Santoro ML, Moretti PN, Pellegrino R, Gadelha A, Abílio VC, Hayashi MA, Belangero SI, Hakonarson H. Am J Med Genet B Neuropsychiatr Genet. 2016 Dec;171(8):997-1005. doi: 10.1002/ajmg.b.32475. https://doi.org/10.1002/ajmg.b.32475

  20. Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease. Braga IL, Silva PN, Furuya TK, Santos LC, Pires BC, Mazzotti DR, Bertolucci PH, Cendoroglo MS, Smith MC. Am J Alzheimers Dis Other Demen. 2015 Mar;30(2):139-44. doi: 10.1177/1533317514539540.https://doi.org/10.1177/1533317514539540

  21. Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls. Santoro ML, Gadelha A, Ota VK, Cunha GR, Asevedo E, Noto CS, Spindola LM, Pan PM, Talarico F, Mansur RB, Silva PN, Brietzke E, Cordeiro Q, Bressan RA, Belangero SI. World J Biol Psychiatry. 2015 Sep;16(6):441-446. doi: 10.3109/15622975.2015.1048724. https://doi.org/10.3109/15622975.2015.1048724

  22. Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats (SHR). Diana MC, Santoro ML, Xavier G, Santos CM, Spindola LN, Moretti PN, Ota VK, Bressan RA, Abilio VC, Belangero SI. Psychiatry Res. 2015 Oct 30;229(3):690-4. doi:10.1016/j.psychres.2015.08.021. https://doi.org/10.1016/j.psychres.2015.08.021

  23. Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis. Ota VK, Noto C, Santoro ML, Spindola LM, Gouvea ES, Carvalho CM, Santos CM, Xavier G, Higuchi CH, Yonamine C, Moretti PN, Abílio VC, Hayashi MA, Brietzke E, Gadelha A, Cordeiro Q, Bressan RA, Belangero SI. Eur Neuropsychopharmacol. 2015 Dec;25(12):2416-25. doi: 10.1016/j.euroneuro.2015.09.013.https://doi.org/10.1016/j.euroneuro.2015.09.013

  24. SIRT1, IGFBP-3 and CAV1 Promoter DNA Methylation in Aging. Gigek CO, Lisboa LC, Silva PN, Leal MF, Labio RW, Payão SL, Smith MC. Translational Medicine. 2014. July;4: 133. doi:10.4172/2161- 1025.1000133. https://doi.org/10.4172/2161-1025.1000133

  25. Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR). Santoro ML, Ota VK, Stilhano RS, Silva PN, Santos CM, Diana MC, Gadelha A, Bressan RA, Melaragno MI, Han SW, Abílio VC, Belangero SI. Schizophr Res. 2014 Aug;157(1-3):163-8. doi: 10.1016/j.schres.2014.05.015.https://doi.org/10.1016/j.schres.2014.05.015

  26. Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: a follow-up study in antipsychotic-naïve patients with first-episode psychosis. Ota VK, Noto C, Gadelha A, Santoro ML, Ortiz BB, Andrade EH, Tasso BC, Spindola LM, Silva PN, Abílio VC, Smith Mde A, Sato JR, Brietzke E, Cordeiro Q, Bressan RA, Belangero SI. J Psychiatr Res. 2014 Sep;56:130-6. doi:10.1016/j.jpsychires.2014.05.012. https://doi.org/10.1016/j.jpsychires.2014.05.012

  27. Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: relevance to neuropsychiatric disorders. Santoro ML, Santos CM, Ota VK, Gadelha A, Stilhano RS, Diana MC, Silva PN, Spíndola LM, Melaragno MI, Bressan RA, Han SW, Abílio VC, Belangero SI. Psychiatry Res. 2014 Nov 30;219(3):674-9. doi: 10.1016/j.psychres.2014.05.034. https://doi.org/10.1016/j.psychres.2014.05.034

  28. Analysis of HSPA8 and HSPA9 mRNA expression and promoter methylation in the brain and blood of Alzheimer's disease patients. Silva PN, Furuya TK, Braga IL, Rasmussen LT, Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payão SL, Mill J, Smith MC. J Alzheimers Dis. 2014;38(1):165-70. doi: 10.3233/JAD-130428. https://doi.org/10.3233/jad-130428

  29. Changes in gene expression and methylation in the blood of patients with first-episode psychosis. Ota VK, Noto C, Gadelha A, Santoro ML, Spindola LM, Gouvea ES, Stilhano RS, Ortiz BB, Silva PN, Sato JR, Han SW, Cordeiro Q, Bressan RA, Belangero SI. Schizophr Res. 2014 Nov;159(2-3):358-64. doi: 10.1016/j.schres.2014.09.008. https://doi.org/10.1016/j.schres.2014.09.008

  30. Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naïve first-episode psychosis patients before and after antipsychotic treatment. Ota VK, Noto C, Gadelha A, Santoro ML, Silva PN, Melaragno MI, Smith Mde A, Cordeiro Q, Bressan RA, Belangero SI. Psychiatry Res. 2013 Dec 30;210(3):1290-2. doi:10.1016/j.psychres.2013.09.016. https://doi.org/10.1016/j.psychres.2013.09.016

  31. CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients. Silva PN, Furuya TK, Sampaio Braga I, Rasmussen LT, de Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payão SL, Mill J, Smith MC. J Alzheimers Dis. 2013;33(2):349-55. doi: 10.3233/JAD-2012-121192. https://doi.org/10.3233/jad-2012-121192

  32. Analysis of SNAP25 mRNA expression and promoter DNA methylation in brain areas of Alzheimer's Disease patients. Furuya TK, Silva PN, Payão SL, Bertolucci PH, Rasmussen LT, De Labio RW, Braga IL, Chen ES, Turecki G, Mechawar N, Mill J, Smith MA. Neuroscience. 2012 Sep 18;220:41-6. doi:10.1016/j.neuroscience.2012.06.035. https://doi.org/10.1016/j.neuroscience.2012.06.035

  33. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. Furuya TK, da Silva PN, Payão SL, Rasmussen LT, de Labio RW, Bertolucci PH, Braga IL, Chen ES, Turecki G, Mechawar N, Mill J, de Arruda Cardoso Smith M. Neurochem Int. 2012 Dec;61(7):973-5. doi: 10.1016/j.neuint.2012.07.014. https://doi.org/10.1016/j.neuint.2012.07.014

  34. SMARCA5 methylation and expression in gastric cancer. Gigek CO, Lisboa LC, Leal MF, Silva PN, Lima EM, Khayat AS, Assumpção PP, Burbano RR, Smith Mde A. Cancer Invest. 2011 Feb;29(2):162-6. doi: 10.3109/07357907.2010.543365.https://doi.org/10.3109/07357907.2010.543365

  35. Insulin-like growth factor binding protein-3 gene methylation and protein expression in gastric adenocarcinoma. Gigek CO, Leal MF, Lisboa LC, Silva PN, Chen ES, Lima EM, Calcagno DQ, Assumpção PP, Burbano RR, Smith Mde A. Growth Horm IGF Res. 2010 Jun;20(3):234-8. doi: 10.1016/j.ghir.2010.02.005. https://doi.org/10.1016/j.ghir.2010.02.005

  36. hTERT methylation and expression in gastric cancer. Gigek CO, Leal MF, Silva PN, Lisboa LC, Lima EM, Calcagno DQ, Assumpção PP, Burbano RR, Smith Mde A. Biomarkers. 2009 Dec;14(8):630-6. doi: 10.3109/13547500903225912. https://doi.org/10.3109/13547500903225912

  37. Evidence for the main foot protein gene in Perna perna (Mollusca, Mytilidae). Clezar C, Weber LI, Malaquias GS, Silva PO. Genet Mol Res. 2008 Jun 24;7(2):567-72. http://www.funpecrp.com.br/gmr/year2008/vol7-2/pdf/gmr459.pdf

  38. Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. Silva PN, Gigek CO, Leal MF, Bertolucci PH, de Labio RW, Payão SL, Smith Mde A. J Alzheimers Dis. 2008 Mar;13(2):173-6. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad00787

  39. Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil. Leal M, Lima E, Silva P, Assumpção P, Calcagno D, Payão S, Burbano RR, Smith M. World J Gastroenterol. 2007 May 14;13(18):2568-74. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146816/