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Per Øyvind Enger's picture

Per Øyvind Enger

Professor
  • E-mailPer.Enger@uib.no
  • Phone+47 55 58 63 47+47 55 58 63 73
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Gras Navarro, Andrea; Espedal, Heidi; Vareecal Joseph, Justin; Moncho, Laura Trachsel; Bahador, Marzieh; Gjertsen, Bjørn Tore; Kristoffersen, Einar Klæboe; Simonsen, Anne; Miletic, Hrvoje; Enger, Per Øyvind; Rahman, Mohummad Aminur; Enger, Martha Chekenya. 2019. Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival. Cancers. 1-25.
  • Leiss, Lina; Mega, Alessandro; Bontell, Thomas Olsson; Nistér, Monica; Smits, Anja; Corvigno, Sara; Rahman, Mohummad Aminur; Enger, Per Øyvind; Miletic, Hrvoje; Östman, Arne. 2019. Platelet‐derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients. Glia. 1-10.
  • Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya. 2019. Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. British Journal of Cancer. 545-555.
  • Mega, Alessandro; Nilsen, Mette Hartmark; Leiss, Lina Wik; Tobin, Nicholas P.; Miletic, Hrvoje; Sleire, Linda; Strell, Carina; Nelander, Sven; Krona, Cecilie; Hägerstrand, Daniel; Enger, Per Øyvind; Nistér, Monica; Östman, Arne. 2019. Astrocytes enhance glioblastoma growth. Glia. 1-12.
  • Bragstad, Sidsel Marit; Flatebø, Marianne; Natvig, Gerd Karin; Eide, Geir Egil; Skeie, Geir Olve; Behbahani, Maziar; Pedersen, Paal-Henning; Enger, Per Øyvind; Skeie, Bente Sandvei. 2018. Predictors of quality of life and survival following Gamma Knife surgery for lung cancer brain metastases: a prospective study. Journal of Neurosurgery. 71-83.
  • Wallmann, Tatjana; Zhang, Xing-Mei; Wallerius, Majken; Bolin, Sara; Joly, Anne-Laure; Sobocki, Caroline; Leiss, Lina Wik; Jiang, Yiwen; Bergh, Jonas; Holland, Eric C.; Enger, Per Øyvind; Andersson, John; Swartling, Fredrik J.; Miletic, Hrvoje; Uhrbom, Lene; Harris, Robert A.; Rolny, Charlotte. 2018. Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity. iScience.
  • Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille Kayitesi; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind. 2017. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 1-13.
  • Zhu, Huaiyang; Leiss, Lina Wik; Yang, Ning; Rygh, Cecilie Brekke; Mitra, Siddharta S.; Cheshier, Samuel H.; Weissman, Irving L.; Huang, Bin; Miletic, Hrvoje; Bjerkvig, Rolf; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2017. Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy. OncoTarget. 12145-12157.
  • Niklasson, Mia; Maddalo, Ianluca; Sramkova, Zuzana; Mutlu, Ercan; Wee, Shimei; Sekyrova, Petra; Schmidt, Linnéa; Fritz, Nicolas; Dehnisch, Ivar; Kyriatzis, Gregorios; Krafcikova, Michaela; Carson, Brittany B.; Feenstra, Jennifer M.; Marinescu, Voichita D.; Segerman, Anna; Haraldsson, Martin; Gustavsson, Anna-Lena; Hammarström, Lars G.J.; Jenmalm Jensen, Annika; Uhrbom, Lene; Altelaar, A.F. Maarten; Linnarsson, Sten; Uhlén, Per; Trantirek, Lukas; Vincent, C. Theresa; Nelander, Sven; Enger, Per Øyvind; Andäng, Michael. 2017. Membrane-depolarizing channel blockers induce selective glioma cell death by impairing nutrient transport and unfolded protein/amino acid responses. Cancer Research. 1741-1752.
  • Netland, Inger Anne; Førde-Tislevoll, Hilde Elise; Sleire, Linda; Leiss, Lina Wik; Rahman, Mohummad Aminur; Skeie, Bente Sandvei; Miletic, Hrvoje; Enger, Per Øyvind; Goplen, Dorota. 2016. Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats. Journal of Neuro-Oncology.
  • Skeie, Bente Sandvei; Eide, Geir Egil; Flatebø, Marianne; Heggdal, Jan Ingemann; Larsen, Elisabeth; Bragstad, Sidsel Marit; Pedersen, Paal-Henning; Enger, Per Øyvind. 2016. Quality of life is maintained using Gamma Knife radiosurgery: A prospective study of a brain metastases patient cohort. Journal of Neurosurgery. 708-725.
  • Dominguez Valentin, Mev; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Kumar, Surendra; Retière, Christèle; Ulvestad, Elling; Kristensen, Vessela N.; Lund-Johansen, Morten; Lie, Benedicte Alexandra; Enger, Per Øyvind; Njølstad, Gro; Kristoffersen, Einar Klæboe; Lie, Stein Atle; Chekenya, Martha. 2016. Identification of a natural killer cell receptor allele that prolongs survival of cytomegalovirus-positive glioblastoma patients. Cancer Research. 5326-5336.
  • Eskilsson, Eskil; Røsland, Gro Vatne; Talasila, Krishna Mukharji; Knappskog, Stian; Keunen, Olivier; Sottoriva, Andrea; Foerster, Sarah; Solecki, Gergely; Taxt, Torfinn; Jirík, Radovan; Fritah, Sabrina; Harter, Patrick N.; Välk, Kristjan; Hossain, Jubayer; Vareecal Joseph, Justin; Zehtab Jahedi, Roza; Sdik Saed, Halala; Piccirillo, Sara G.; Spiteri, Inma; Euskirchen, Philipp; Leiss, Lina Wik; Graziana, Grazi; Daubon, Thomas; Lund-Johansen, Morten; Enger, Per Øyvind; Winkler, Frank; Ritter, Christoph A.; Niclou, Simone Pierrette; Watts, Colin; Bjerkvig, Rolf; Miletic, Hrvoje. 2016. EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation. Neuro-Oncology. 1644-1655.
  • Netland, Inger Anne; Førde-Tislevoll, Hilde Elise; Sleire, Linda; Leiss, Lina Wik; Rahman, Mohummad Aminur; Skeie, Bente Sandvei; Gjerde, Christiane Helgestad; Enger, Per Øyvind; Goplen, Dorota. 2016. Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models. BMC Cancer. 12 pages.
  • Sleire, Linda; Skeie, Bente Sandvei; Netland, Inger Anne; Førde, Hilde Elise Sundøy; Dodoo, Ernest; Selheim, Frode; Leiss, Lina Wik; Heggdal, Jan Ingemann; Pedersen, Paal-Henning; Wang, Jian; Enger, Per Øyvind. 2015. Drug repurposing: Sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc<sup>-</sup>, leading to glutathione depletion. Oncogene. 5951-5959.
  • Torsvik, Anja; Stieber, Daniel; Enger, Per Øyvind; Golebiewska, Anna; Molven, Anders; Svendsen, Agnete; Westermark, Bengt; Niclou, Simone P; Olsen, Thale Kristin; Enger, Martha Chekenya; Bjerkvig, Rolf. 2014. U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells . Cancer Medicine. 812-824.
  • Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; Jacobsen, Hege; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian. 2014. Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. European Journal of Cancer. 3262-3270.
  • Gras Navarro, Andrea; Kmiecik, Justyna; Leiss, Lina Wik; Zelkowski, Mateusz; Engelsen, Agnete; Bruserud, Øystein; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha. 2014. NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. Journal of Immunology. 6192-6206.
  • Dodoo, Ernest; Huffmann, Beate; Peredo, Inti; Grinaker, Hanne; Sinclair, Georges; Machinis, Theofilos; Enger, Per Øyvind; Skeie, Bente Sandvei; Pedersen, Paal-Henning; Ohlsson, Marcus; Orrego, Abiel; Kraepelien, Thomas; Barsoum, Pierre; Benmakhlouf, Hamza; Herrman, Lars; Svensson, Mikael; Lippitz, Bodo. 2014. Increased Survival Using Delayed Gamma Knife Radiosurgery for Recurrent High-Grade Glioma: A Feasibility Study . World Neurosurgery. e623-e632.
  • Brekke, Cecilie; Wang, Jian; Thuen, Marte; Gras Navarro, Andrea; Huuse-Røneid, Else Marie; Thorsen, Frits Alan; Poli, Aurélie; Zimmer, Jacques; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLOS ONE.
  • Rygh, Cecilie Brekke; Wang, Jian; Thuen, Marte; Navarro, Andrea Gras; Huuse, Else Marie; Thorsen, Frits; Poli, Aurélie; Zimmer, J.; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. PLOS ONE. 12 pages.
  • Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina Wik; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2014. A novel GFP nude rat model to investigate tumor-stroma interactions. Cancer Cell International.
  • Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina Wik; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian. 2014. A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma. Journal of Translational Medicine.
  • Poli, Aurélie; Wang, Jian; Domingues, Olivia; Planaguma, Jesus; Yan, Tao; Brekke, Cecilie; Skaftnesmo, Kai Ove; Thorsen, Frits Alan; McCormack, Emmet ; Hentges, François; Pedersen, Paal-Henning; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha. 2013. Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. OncoTarget. 1527-1546.
  • Skeie, Bente Sandvei; Enger, Per Øyvind; Ganz, Jeremy Christopher; Skeie, Geir Olve; Parr, Elisabeth; Hatteland, Signe; Ystevik, Birgit; Heggdal, Jan Ingemann; Pedersen, Paal-Henning. 2013. Gamma knife surgery of colorectal brain metastases: a high prescription dose of 25 Gy may improve growth control. World Neurosurgery. 525-536.
  • Skeie, Bente Sandvei; Wang, Jian; Dodoo, Ernest; Heggdal, Jan Ingemann; Grønli, Janne; Sleire, Linda; Bragstad, Sidsel Marit; Ganz, Jeremy Christopher; Chekenya, Martha; Mørk, Sverre; Pedersen, Paal-Henning; Enger, Per Øyvind. 2013. Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model. Biomedical research. 9 pages.
  • Jacobsen, Hege; Sleire, Linda; Wang, Jian; Netland, Inger Anne; Mutlu, Ercan; Førde, Hilde Elise Sundøy; Pedersen, Paal-Henning; Gullberg, Donald; Enger, Per Øyvind. 2013. Establishment of a novel dsRed NOD/Scid mouse strain to investigate the host and tumor cell compartments. Cancer Investigation. 221-230.
  • Kmiecik, Justyna; Poli, Aurélie; Brons, Nicolas H.C.; Waha, Andreas; Eide, Geir Egil; Enger, Per Øyvind; Zimmer, Jacques; Chekenya, Martha. 2013. Elevated CD3(+) and CD8(+) tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level. Journal of Neuroimmunology. 71-83.
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Røsland, Gro Vatne; Wang, Jian; Huszthy, Peter Csaba; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Brekkå, Narve; Moen, Ingrid; Nigro, Janice Marie; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mørk, Sverre; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathologica. 683-698.
  • Willingham, Stephen B.; Volkmer, Jens-Peter; Gentles, Andrew J.; Sahoo, Debashis; Dalerba, Piero; Mitra, Siddharta S.; Wang, Jian; Contreras-Trujillo, Humberto; Martin, Robin; Cohen, Justin D.; Lovelace, Patricia; Scheeren, Ferenc A.; Chao, Mark P.; Weiskopf, Kipp; Tang, Chad; Volkmer, Anne Kathrin; Naik, Tejaswitha J.; Storm, Theresa A.; Mosley, Adriane R.; Edris, Badreddin; Schmid, Sersina M.; Sun, Chris K.; Chua, Mei-Sze; Murillo, Oihana; Rajendran, Pradeep; Cha, Adriel C.; Chin, Robert K.; Kim, Dongkyoon; Adorno, Maddalena; Raveh, Tal; Tseng, Diane; Jaiswal, Siddhartha; Enger, Per Øyvind; Steinberg, Gary K.; Li, Gordon; So, Samuel K.; Majeti, Ravindra; Harsh, Griffith R.; van de Rijn, Matt; Teng, Nelson N.H.; Sunwoo, John B.; Alizadeh, Ash A.; Clarke, Michael F; Weissman, Irving L. 2012. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proceedings of the National Academy of Sciences of the United States of America. 6662-6667.
  • Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug. 2012. Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation. BMC Cancer. 10 pages.
  • Skeie, Bente; Enger, Per Øyvind; Brøgger, Jan C; Ganz, Jeremy Christopher; Thorsen, Frits Alan; Heggdal, Jan Ingemann; Pedersen, Paal-Henning. 2012. Gamma knife surgery versus reoperation for recurrent glioblastoma multiforme. World Neurosurgery. 658-669.
  • Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike ; Skaftnesmo, Kai Ove; Planaguma, Jesus; Reed, Rolf K.; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Brekke, Cecilie; Chekenya, Martha. 2011. Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. PLOS ONE. 14 pages.
  • Yan, Tao; Skaftnesmo, Kai Ove; Leiss, Lina Wik; Sleire, Linda; Wang, Jian; Li, XinGang; Enger, Per Øyvind. 2011. Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide. BMC Cancer.
  • Skeie, Bente; Skeie, Geir Olve; Enger, Per Øyvind; Ganz, Jeremy Christopher; Heggdal, Jan Ingemann; Ystevik, Birgit; Hatteland, Signe; Parr, Elisabeth; Pedersen, Paal-Henning. 2011. Gamma Knife Surgery of Colorectal Brain Metastases: A High Prescription Dose of 25 Gy May Improve Growth Control. World Neurosurgery. 684-691.
  • Skeie, Bente; Skeie, Geir Olve; Enger, Per Øyvind; Ganz, Jeremy Christopher; Heggdal, Jan Ingemann; Ystevik, Birgit; Hatteland, Signe; Parr, Elisabeth; Pedersen, Paal-Henning. 2011. Gamma Knife Surgery in Brain Melanomas: Absence of Extracranial Metastases and Tumor Volume Strongest Indicators of Prolonged Survival. World Neurosurgery. 684-691.
  • Svendsen, Agnete; Verhoeff, Joost JC; Immervoll, Heike ; Brøgger, Jan C; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger Anne; Prestegarden, Lars; Planaguma, Jesus; Torsvik, Anja; Kjersem, Anneli Bohne; Sakariassen, Per Øystein; Heggdal, Jan Ingemann; van Furth, Wouter R; Bjerkvig, Rolf; Lund-Johansen, Morten; Enger, Per Øyvind; Felsberg, Joerg; Brons, Nicolas H.C.; Tronstad, Karl Johan; Waha, Andreas; Chekenya, Martha. 2011. Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 495-510.
  • Goplen, Dorota; Bougnaud, Sébastien; Rajcevic, Uros; Bøe, Stig Ove; Skaftnesmo, Kai Ove; Voges, Jurgen; Enger, Per Øyvind; Wang, Jian; Tysnes, Berit Bølge; Lærum, Ole Didrik; Niclou, Simone P; Bjerkvig, Rolf. 2010. alpha B-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells. American Journal of Pathology. 1618-1628.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Sleire, Linda; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Yan, Tao; Askland, Lasse Haugen; Persson, Andreas; Sakariassen, Per Øystein; Enger, Per Øyvind. 2010. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Research. 4274-4279.
  • Enger, Per Øyvind; Skeie, Geir Olve; Thorsen, Frits Alan; Pedersen, Paal-Henning; Skeie, Bente. 2010. Gamma knife surgery of meningiomas involving the cavernous sinus: long-term follow-up of 100 patients. Neurosurgery. 661-669.
  • Johannessen, Tor-Christian Aase; Wang, Jian; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Enger, Per Øyvind; Petersen, Kjell; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjerkvig, Rolf; Tysnes, Berit Bølge. 2009. Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype. Neuropathology and Applied Neurobiology. 380-393.
  • Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekkå, Narve; Li, X; Zhao, P; Mørk, Sverre; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer.
  • Thorsen, Frits Alan; Jirak, Daniel; Wang, Jian; Sykova, Eva; Bjerkvig, Rolf; Enger, Per Øyvind; van der Kogel, Albert; Hajek, Milan. 2008. Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in Biomedicine. 830-838.
  • Chekenya, Martha; Krakstad, Camilla; Svendsen, Agnete; Netland, Inger Anne; Staalesen, Vidar; Tysnes, Berit Bølge; Selheim, Frode; Wang, Jian; Sakariassen, Per Øystein; Sandal, Tone; Lønning, Per Eystein; Flatmark, Torgeir; Enger, Per Øyvind; Bjerkvig, Rolf; Sioud, M; Stallcup, William B. 2008. The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 5182-5194.
  • Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg; Immervoll, Heike; Bøe, Stig Ove; Svendsen, Agnete; Prestegarden, Lars; Røsland, Gro Vatne; Thorsen, Frits Alan; Stuhr, Linda Elin Birkhaug; Molven, Anders; Bjerkvig, Rolf; Enger, Per Øyvind. 2008. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 761-768.
  • Niclou, Simone P; Danzeisen, Claude; Eikesdal, Hans Petter; Wiig, Helge; Brons, Nicolaas HC; Poli, Aurélie MF; Svendsen, Agnete; Torsvik, Anja; Enger, Per Øyvind; Terzis, Jorge A; Bjerkvig, Rolf. 2008. A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. The FASEB Journal. 3120-3128.
  • Thorsen, Frits Alan; Enger, Per Øyvind; Wang, Jian; Bjerkvig, Rolf; Pedersen, PH. 2007. Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. Journal of Neuro-Oncology. 1-10.
  • Goplen, Dorota; Wang, Jian; Enger, Per Øyvind; Tysnes, Berit Bølge; Terzis, A. Jorge A.; Lærum, Ole Didrik; Bjerkvig, Rolf. 2006. Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Research. 9895-9902.
  • Sundlisæter, Eirik; Wang, Jian; Sakariassen, Per Øystein; Marie, Michael Bruno Eric; Mathisen, Juan Robbie; Karlsen, Bård-Ove; Prestegarden, Lars; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Primary glioma spheroids maintain tumourogenicity and essential phenotypic traits after cryopreservation. Neuropathology and Applied Neurobiology. 419-427.
  • Brekke, Cecilie; Lundervold, Arvid; Enger, Per Øyvind; Brekken, Christian; Stålsett, Eli; Pedersen, Tina Bugge; Haraldseth, Olav; Krüger, Per Gøran; Bjerkvig, Rolf; Chekenya, Martha. 2006. NG2 expression regulates vascular morphology and function in human brain tumours. NeuroImage. 965-976.
  • Huszthy, Peter Csaba; Brekken, Christian; Pedersen, Tina Bugge; Thorsen, Frits Alan; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Haraldseth, Olav; Lonning, PE; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Antitumor efficacy improved by local delivery of species-specific endostatin. Journal of Neurosurgery. 118-128.
  • Sakariassen, Per Øystein; Prestegarden, Lars; Wang, Jian; Skaftnesmo, Kai Ove; Mahesparan, Rupavathana; Molthoff, Carla; Sminia, Peter; Sundlisæter, Eirik; Misra, Anjan; Tysnes, Berit Bølge; Chekenya, Martha; Peters, Hans; Lende, Gabriel; Kalland, Karl-Henning; Øyan, Anne Margrete; Petersen, Kjell; Jonassen, Inge; van der Kogel, Albert; Feuerstein, Burt G.; Terzis, A. Jorge A.; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 16466-16471.
  • Brekke, Cecilie; Lundervold, Arvid; Enger, Per Øyvind; Brekken, Christian; Stålsett, Eli; Pedersen, Tina Bugge; Haraldseth, Olav; Kruger, Per Gunnar; Bjerkvig, Rolf; Chekenya, M. 2005. NG2 expression regulates vascular morphology and function in human brain tumours. NeuroImage. 965-976.
  • Chekenya, M; Hjelstuen, Mari H.; Enger, Per Øyvind; Haraldseth, Olav; Bjerkvig, Rolf. 2002. NG2 proteoglycan promotes angiogenesis-dependent tumor growth in the central nervous system by sequestering angiostatin. The FASEB Journal. 586-588.
  • Read, Tracy-Ann; Sorensen, DR; Mahesparan, R; Enger, Per Øyvind; Timpl, R; Olsen, BR; Hjelstuen, Mari H.; Haraldseth, Olav; Bjerkvig, Rolf. 2001. Local endostatin treatment of gliomas administered by microencapsulated producer cells. Nature Biotechnology. 29-34.
Lecture
  • Cirillo, Davide; Sarowar, Shahin; Adamsen, Tom Christian Holm; Enger, Per Øyvind; Bjørsvik, Hans-Rene. 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • Cirillo, Davide; Adamsen, Tom Christian Holm; Enger, Per Øyvind; Hartmark Nilsen, Mette; Bjørsvik, Hans-Rene. 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
Academic lecture
  • Cirillo, Davide; Sarowar, Shahin; Adamsen, Tom Christian Holm; Karlsson, Staffan; Elmore, Chad; Enger, Per Øyvind; Bjørsvik, Hans-René. 2019. Synthesis of targeting molecules : PET and therapeutics.
  • Cirillo, Davide; Adamsen, Tom Christian Holm; Enger, Per Øyvind; Hartmark Nilsen, Mette; Bjørsvik, Hans-Rene. 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • Cirillo, Davide; Adamsen, Tom Christian Holm; Enger, Per Øyvind; Hartmark Nilsen, Mette; Bjørsvik, Hans-Rene. 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution .
  • Brekken, Christian; Enger, Per Øyvind; Bjerkvig, Rolf; Haraldseth, Olav. 2002. Endostatin Gene Transduction of Glioma Cells Modifies Brain Tumor Development: Assessment by Magnetic Resonance Imaging.
Masters thesis
  • Thorkildsen, Evy Marie. 2019. Sulfasalazine analogues to overcome radioresistance in cancer.
  • Lellahi, Seyed Mohammad. 2014. POU3f2 in human gliomas -Expression pattern and functional role.
  • Leiss, Lina Wik. 2011. Impact of hypoxia on the expression of cell line markers and behavior of cultured glioma cell lines.
  • Johannessen, Mireille Kayitesi. 2011. GROWTH OF GLIOBLASTOMA XENOGRAFTS IN THE BRAINS OF NOD/SCID MICE FOLLOWING ADMINISTRATION OF A DEMYELINATING AGENT.
  • Andersen, Synne Marte. 2010. Aquaporin 1 and Aquaporin 4 in Glioblastoma Multiforme.
  • Kroondijk, Liesbeth. 2008. Involvement of E2F5 in brain tumour progression.
Doctoral dissertation
  • Netland, Inger Anne. 2015. Targeting survival signalling pathways in glioblastoma. Preclinical studies of sulfasalazine, dactolisib and buparlisib.
Abstract
  • Sleire, Linda; Skeie, Bente Sandvei; Netland, Inger Anne; Heggdal, Jan Ingemann; Pedersen, Paal-Henning; Enger, Per Øyvind. 2013. Sulfasalazine sensitizes glioblastoma cells to radiation treatment. Neuro-Oncology. 239-239.
  • Leiss, Lina Wik; Gjerde, Christiane; Saed, Halala Sdik; Rahman, Aminur; Lellahi, Mohammad; Enger, Per Øyvind. 2013. Oct 7 IS EXPRESSED IN HUMAN GLIOMAS AND CORRELATES WITH MALIGNANCY GRADE. Neuro-Oncology. 20-21.
  • Talasila, Krishna Mukharji; Soentgerath, Anke; Euskirchen, Philipp; Rosland, Gunnar Alm; Wang, Jian; Huszthy, Peter; Prestegarden, Lars; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Eskilsson, Eskil; Stieber, Daniel; Keunen, Olivier; Nigro, Janice; Vintermyr, Olav Karsten; Lund-Johansen, Morten; Niclou, Simone P; Mork, Stian; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Neuro-Oncology. 6-6.
  • Førde, Hilde Elise Sundøy; Netland, Inger Anne; Sleire, Linda; Skeie, Bente Sandvei; Enger, Per Øyvind; Goplen, Dorota. 2013. COMBINED ANTI-ANGIOGENIC AND ANTI-INVASIVE TREATMENT OF ORTHOTOPICALLY ENGRAFTED HUMAN GBM XENOGRAFTS. Neuro-Oncology. 43-43.
  • Eskilsson, Eskil; Talasila, Krishna Mukharji; Røsland, Gro Vatne; Leiss, Lina Wik; Sdik Saed, Halala; Brekkå, Narve; Sakariassen, Per Øystein; Lund-Johansen, Morten; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2013. ACTIVATION OF THE PROTOTYPICAL SFK c-Src PROMOTES ANGIOGENESIS OF HUMAN GLIOBLASTOMA. Neuro-Oncology. 3-3.
  • Leiss, Lina Wik; Manini, Ivana; Enger, Per Øyvind. 2012. HYPOXIA INDUCES CELL PROLIFERATION, EXPRESSION OF ANGIOGENIC FACTORS, AND PRIMITIVE NEURONAL MARKERS IN NORMAL GLIAL CELLS. Neuro-Oncology. 11-11.
  • Brekke, Cecilie; Thuen, Marte; Poli, Aurélie; Wang, Jian; Lokka, Guro; Huuse, Else Marie; Thorsen, Frits Alan; Enger, Per Øyvind; Chekenya, Martha. 2012. Early MRI findings of targeting the NG2 proteoglycan in GBM. The FASEB Journal. 1 pages.
  • Wang, Jian; Mutlu, Ecran; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Jacobsen, Hege; Talasila, Krishna Mukharji; Sleire, Linda; Pettersen, Kjell; Miletic, Hrvoje; Andersen, Synne Marte; Mitra, Siddharta; Weissman, Irving; Li, XinGang; Kalland, Karl-Henning; Enger, Per Øyvind. 2011. TUMOR-ASSOCIATED GLIAL CELLS PROMOTE GROWTH OF GBM XENOGRAFTS IN EGFP NOD/SCID MICE. Neuro-Oncology. 55-55.
  • Jacobsen, Hege; Dicko, Aly; Wang, Jian; Storli, Kristian Eeg; Leh, Sabine; Thorsen, Frits Alan; Pavlin, Tina; Sondenaa, Karl; Gullberg, Donald; Bjerkvig, Rolf; Enger, Per Øyvind. 2011. Separate analysis of the cancer and stroma cell populations from orthotopically implanted tumor biopsies in eGFP scid mice. Clinical and Experimental Metastasis. 203-203.
  • Chekenya, Martha; Wang, Jian; Poli, A; Thuen, Marte; Brekke, Cecilie; Thorsen, Frits Alan; Zimmer, J; Enger, Per Øyvind. 2010. THERAPEUTIC TARGETING OF THE NG2 PROTEOGLYCAN WITH MAB 9.2.27 AND ADOPTIVELY TRANSFERRED NK CELLS LYSES HUMAN GLIOBLASTOMA MULTIFORME IN VIVO. Neuro-Oncology. 9-9.
  • Sleire, Linda; Wang, Jian; Heggdal, Jan; Pedersen, Paal-Henning; Enger, Per Øyvind. 2010. SULFASALAZINE SENSITIZES GLIOBLASTOMA CELLS TO RADIATION TREATMENT. Neuro-Oncology. 109-109.
  • Chekenya, Martha; Netland, Inger Anne; Verhoeff, Joost JC; Svendsen, Agnete; Brøgger, Jan; Immervoll, Heike ; Planaguma, Jesus; Kjersem, Anneli Bohne; Sakariassen, Per Øystein; Bjerkvig, Rolf; Heggedal, JI; Enger, Per Øyvind; Tronstad, Karl Johan; van Furth, Wouter R. 2010. NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. Neuro-Oncology. 8-8.
  • Wang, Jian; Tsinkalovsky, Oleg; Svendsen, Agnete; Prestegarden, Lars; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. Neuro-Oncology. 221-222.
  • Wang, Jian; Tsinkalovsky, Oleg; Zhao, P; Prestegarden, L; Li, X; Cormark, E; Gjertsen, Bjørn Tore; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. TARGETING THE TUMOR STROMA: A NOVEL THERAPEUTIC STRATEGY BASED ON SEPARATE ANALYSIS OF THE MALIGNANT AND STROMAL CELL COMPARTMENTS IN BRAIN TUMORS. Neuro-Oncology. 965-965.
  • Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekka, N; Li, X; Mork, S; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. PHENOTYPIC MODULATION OF EXPERIMENTAL GLIOMAS: PROGRESSION FROM GLIOMATOSIS CEREBRI-LIKE LESIONS TO GLIOBLASTOMA. Neuro-Oncology. 897-897.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Askland, L; Persson, A; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Hovland, Randi; Enger, Per Øyvind. 2009. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. Neuro-Oncology. 917-917.
  • Huszthy, Peter Csaba; Wang, Jian; Enger, Per Øyvind; Bjerkvig, Rolf; Miletic, Hrvoje. 2008. Human glioblastoma tissue engraftment in immunocompetent rodent hosts. Neuro-Oncology. 815-815.
  • Niclou, Simone P; Danzeisen, Claude; Brons, Nicolaas HC; Eikesdal, Hans Petter; Enger, Per Øyvind; Bjerkvig, Rolf. 2008. Complete separation and phenotyping of the tumor-host cellular compartments in tumor bearing nod/scid mice. Neuro-Oncology. 1148-1148.
  • Niclou, SP; Danzeisen, C; Brons, NHC; Eikesdal, Hans Petter; Enger, Per Øyvind; Bjerkvig, Rolf. 2008. COMPLETE SEPARATION AND PHENOTYPING OF THE TUMOR-HOST CELLULAR COMPARTMENTS IN TUMOR-BEARING NOD/SCID MICE. Neuro-Oncology. 853-854.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Lasse, A; Andreas, P; Oystein, SP; Skaftnesmo, KO; Randi, H; Enger, Per Øyvind. 2008. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. Neuro-Oncology. 778-778.
  • Sakariassen, Per Øystein; Prestegarden, Lars; Wang, Jian; Terzis, A. Jorge A.; Bjerkvig, Rolf; Enger, Per Øyvind. 2004. Forced differentiation suppresses the proliferative rate of cancer cells in brain tumours. Neuro-Oncology.
  • Enger, Per Øyvind; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Wang, Jian; Sundlisæter, Eirik; Prestegarden, Lars; Misra, Anjan; Tysnes, Berit Bølge; Chekenya, Martha; Feuerstein, Burt G.; Terzis, A. Jorge A.; Bjerkvig, Rolf. 2004. Angiogenesis-independent growth by brain tumor cells exhibiting cancer stem cell properties. Neuro-Oncology. 309-309.
Poster
  • Thuen, Marte; Wang, Jien; Enger, Per Øyvind; Poli, Aurelie; Løkka, Guro; Huuse, Else Marie; Thorsen, Frits Alan; Brekke, Cecilie; Chekenya, Martha. 2011. Therapeutic Targeting of NG2 Proteoglycan with MAb & Pre-Armed NK Cells in Human GMB Evaluated with Dynamic Enhanced & Diffusion Weighted MRI in Rats.
  • Johannessen, Tor-Christian Aase; Wang, Jian; Skaftnesmo, Kai Ove; Sakariassen, Per Øystein; Enger, Per Øyvind; Petersen, Kjell; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjerkvig, Rolf; Tysnes, Berit Bølge. 2009. Highly infiltrative brain tumors show reduced chemosensitivity associated with a stem cell-like phenotype.
  • Brekken, Christian; Brekke, Cecilie; Chekenya, M; Enger, Per Øyvind; Pedersen, Tina Bugge; Lundervold, Arvid; Haraldseth, Olav. 2003. Phenotyping by MRI: NG2 Receptor Status Modifies Human Glioblastoma Development.
  • Brekken, Christian; Brekke, Cecilie; Chekenya, M; Enger, Per Øyvind; Lundervold, Arvid; Pedersen, Tina Bugge; Bjerkvig, Rolf; Haraldseth, Olav. 2003. NG2 receptor status modifies human glioblastoma development: Assessment by MRI.
  • Brekken, Christian; Enger, Per Øyvind; Bjerkvig, Rolf; Haraldseth, Olav. 2002. Endostatin gene trandsuction of glioma cells modifies brain tumor development: Assessment by MRI.
Academic literature review
  • Sleire, Linda; Førde-Tislevoll, Hilde Elise; Netland, Inger Anne; Leiss, Lina Wik; Skeie, Bente Sandvei; Enger, Per Øyvind. 2017. Drug repurposing in cancer. 74-91.
  • Prestegarden, Lars; Enger, Per Øyvind. 2010. Cancer stem cells in the central nervous system - a critical review. 8255-8258.
  • Sundlisæter, Eirik; Dicko, Aly; Sakariassen, Per Øystein; Søndenaa, Karl; Enger, Per Øyvind; Bjerkvig, Rolf. 2007. Lymphangiogenesis in colorectal cancer - Prognostic and therapeutic aspects. 1401 -1409.
Medical Student Research Thesis
  • Mutlu, Ercan. 2015. Tumour-associated glial cells promote the Growth of GBM xenografts.

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