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Rune Kleppe

Senior Adviser
  • E-mailRune.Kleppe@uib.no
  • Phone+47 55 58 40 68
  • Visitor Address
    HIB - Thormøhlensgt. 55
  • Postal Address
    Postboks 7803
    5020 Bergen
Academic article
  • 2019. Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 1-11.
  • 2019. Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40. Journal of Neurochemistry. 1-19.
  • 2018. Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. International Journal of Molecular Sciences. 1-21.
  • 2017. Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. Journal of Biological Chemistry. 14092-14107.
  • 2017. Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 441-452.
  • 2017. In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins. Bioscience Reports. 1-12.
  • 2016. Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins. Amino Acids. 1221-1229.
  • 2016. Exome chip analyses in adult attention deficit hyperactivity disorder. Translational psychiatry. 7 pages.
  • 2015. Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. Neurochemistry International. 173-184.
  • 2015. Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 423-432.
  • 2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
  • 2014. Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ. Molecular & Cellular Proteomics. 2017-2030.
  • 2014. Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins. FEBS Letters. 92-98.
  • 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
  • 2014. Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia. Human Mutation. 880-890.
  • 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
  • 2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
  • 2011. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
  • 2011. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death and Differentiation. 11 pages.
  • 2010. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
  • 2009. Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase and negatively charged membranes. Journal of Biological Chemistry. 32758-32769.
  • 2008. Oxygen dependence of tyrosine hydroxylase. Amino Acids. 455-464.
  • 2008. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochemical Journal. 195-204.
  • 2004. Different stabilities and denaturation pathways for structurally related aromatic amino acid hydroxylases. FEBS Letters. 155-159.
  • 1999. Urea-induced denaturation of human phenylalanine hydroxylase. Journal of Biological Chemistry. 33251-33258.
  • 1999. Urea-induced denaturation of human phenylalanine hydroxylase. Journal of Biological Chemistry. 33251-33258.
Report
  • 2018. Centre for Digital Life Norway - Annual report 2017. .
Lecture
  • 2018. The Digital Life initiative - Funding opportunities.
  • 2018. Ongoing activities in Competence and Infrastructure Networks.
  • 2018. Making your science FAIR with Digital Life Norway.
  • 2018. Implementing Data Management in Digital Life Norway.
  • 2018. Funding opportunities in the Digital Life initiative .
  • 2018. Engaging in Digital Life Norway.
  • 2018. Centre for Digital Life Norway.
  • 2017. Data Management in Digital Life Norway - Integration of NeLS and SEEK.
  • 2017. Data Management in Digital Life Norway.
  • 2017. Centre for Digital Life Norway - National centre for biotechnology research, training and innovation.
  • 2016. The Centre for digital life Norway - presentation of a national centre for biotechnology training, research and innovation.
Academic lecture
  • 2018. dCOD 1.0: DECODING THE SYSTEMS TOXICOLOGY OF ATLANTIC COD (GADUS MORHUA).
  • 2018. Systems modeling of dopamine homeostasis.
  • 1998. Thermodynamic stability of human phenylalanine hydroxylase.
Thesis at a second degree level
  • 1998. A study on the thermodynamic stability of human phenylalanine hydroxylase.
  • 1998. A study on the thermodynamic stability of human phenylalanine hydroxylase.
Masters thesis
  • 2015. Identification of small molecular modulators of 14-3-3 functions. A virtual screening approach with experimental validation.
  • 2015. Discovery of small-molecular disruptors of protein-protein inteactions A virtual screening approach applied to 14-3-3¿ and tyrosine hydroxylase.
  • 2013. The role of 14-3-3 heterodimers in the regulation of human tyrosine hydroxylase.
Doctoral dissertation
  • 2018. On the protein complex between 14-3-3 proteins and tyrosine hydroxylase –Isoform differences and modulation of phosphorylation states.
Abstract
  • 2006. Camp-dependent protein kinase. European Journal of Pharmaceutical Sciences. S4-S5.
  • 2006. 14-3-3 proteins as substrates for cAMP-dependent protein kinase. European Journal of Pharmaceutical Sciences. S27-S27.
Poster
  • 2020. End-to-End Data Management Toolkit for Norwegian Life Scientists.
  • 2019. Mathematical modeling of allosteric regulation in fatty acid synthesis.
  • 2017. Mathematical modeling of regulatory interactions in the fatty acid synthesis pathway.
  • 2017. Mathematical modeling of regulatory interactions in the fatty acid synthesis pathway.
  • 2017. Mathematical modeling of regulatory interactions in the fatty acid synthesis pathway.
  • 2016. Centre for Digital Life Norway A national centre for biotechnology research and innovation.
  • 2010. Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3.
  • 2007. Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets.
Academic literature review
  • 2017. Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease. 167-180.
  • 2015. Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. 6505-6520.
  • 2011. The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. 1393-1405.
  • 2011. The 14-3-3 proteins in regulation of cellular metabolism. 713-719.
  • 2006. Proteomic and computational methods in systems modeling of cellular signaling. 135-145.
  • 2006. Does isoform diversity explain functional differences in the 14-3-3 protein family? 217-223.
Website (informational material)
  • 2016. Nettsider for Senter for Digitalt Liv Norge.

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