• E-mailRuth.Brenk@uib.no
  • Phone+47 55 58 60 70
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

Our overall research goal is to improve methods used for structure-based drug design and to apply these methods to design inhibitors for enzymes with biological relevance. A key point in our research is the interplay of theoretical and experimental methods.

To read more about what we do, check out our homepage .


For a full list of publications click here.

Journal articles
  • Irsheid, Lina; Wehler, Thomas; Borek, Christoph; Kiefer, Werner; Brenk, Ruth; Ortiz-Soto, Maria Elena; Seibel, Jurgen; Schirmeister, Tanja. 2019. Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design. PLoS ONE. 14: 1-19. doi: 10.1371/journal.pone.0216132
  • Klein, Raphael; Linciano, Pasquale; Celenza, Guiseppe; Bellio, Pierangelo; Papaioannou, Sofia; Blazques, Jesus; Cendron, Laura; Brenk, Ruth; Tondi, Donatella. 2018. In silico identification and experimental validation of hits active against KPC-2 β-lactamase. PLoS ONE. 13. doi: 10.1371/journal.pone.0203241
  • Rekand, Illimar Hugo; Brenk, Ruth. 2017. Ligand design for riboswitches, an emerging target class for novel antibiotics. Future Medicinal Chemistry. 9: 1649-1662. doi: 10.4155/fmc-2017-0063
  • Sarkar, Aurijit; Brenk, Ruth. 2015. To hit or not to hit, that is the question -genome-wide structure-based druggability predictions for pseudomonas aeruginosa proteins. PLoS ONE. 19:e0137279. doi: 10.1371/journal.pone.0137279
Book sections
  • Wehler, Thomas; Brenk, Ruth. 2017. Structure-Based Discovery of Small Molecules Binding to RNA. Chapter. In:
    • Garner, Amanda. 2017. RNA Therapeutics. Springer. 259 pages. ISBN: 978-3-319-68090-3.

More information in national current research information system (CRIStin)

Research groups