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Silje Skrede

Professor, NORMENT
  • E-mailSilje.Skrede@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen

Antipsychotic agents, while proving beneficial for many patients suffering from schizophrenia bipolar disorder, have recognized metbolic adverse effects such as increased appetite, weight gain, diabetes and dyslipidemia. The overall aim of my research has been to idenify molecular mehcanisms mediating these metabolic effects, with particular emphasis on effects on gene expression. Results from cultured cells and animal models show how some antipsychotic agents can activate regulatory mechanisms in appetite control centers in the hypothalamus, as well as genes encoding rate-limiting enzymes of lipid synthesis in peripheral tissues such as the liver and adipose tissues. Revealing the impact of antipsychotic agents at this detailed level may aid future development of drugs with less harmful side effects. 

Interestingly, many of the same biological pathways are interesting in the context of sleep and biological rhythms. Exeriments performed by the Bergen Stress and Sleep Group have demonstrated how disruption of biological rhytms through forced shift work in the rat stimulated the expression of lipid synthesis-related genes in the liver. Furthermore, altered expression of so-called clock genes may be important both in the central nervous system and in peripheral tissues. 

In addition, since 2011 I have been acting as co-ordinator and analytic adviser for the biobank belonging to the BestIntro (Bergen-Stavanger-Innsbruck-Trondheim) study. Approximately 6000 biological samples have been collected from patients included in this randomized controlled trial, which aims to compare clinical and adverse effects of three different antipsychotic agents. 

Academic article
  • Ersland, Kari Merete; Myrmel, Lene Secher; Fjære, Even; Berge, Rolf Kristian; Madsen, Lise; Steen, Vidar Martin; Skrede, Silje. 2019. One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects. International Journal of Neuropsychopharmacology. 358-369.
  • Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel; Bahrami, Shahram; Andreassen, Ole Andreas; Steen, Vidar Martin; Djurovic, Srdjan; Hughes, Timothy. 2019. Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology. 1-9.
  • Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid; Steen, Vidar Martin. 2018. Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research. 253-260.
  • Ersland, Kari Merete; Skrede, Silje; Stansberg, Christine; Steen, Vidar Martin. 2017. Subchronic olanzapine exposure leads to increased expression of myelination-related genes in rat fronto-medial cortex. Translational psychiatry.
  • Marti, Andrea Rørvik; Patil, Sudarshan; Mrdalj, Jelena; Meerlo, Peter; Skrede, Silje; Pallesen, Ståle; Pedersen, Torhild; Bramham, Clive R.; Grønli, Janne. 2017. No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 1-12.
  • Marti, Andrea Rørvik; Meerlo, Peter; Grønli, Janne; Hasselt, Sjoerd van; Mrdalj, Jelena; Pallesen, Ståle; Pedersen, Torhild; Henriksen, Tone Elise Gjøtterud; Skrede, Silje. 2016. Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. Nutrients. 1-13.
  • Steine, Iris Mulders; Zayats, Tetyana; Stansberg, Christine; Pallesen, Ståle; Mrdalj, Jelena; Håvik, Bjarte; Soule, Jonathan; Haavik, Jan; Milde, Anne Marita; Skrede, Silje; Murison, Robert; Krystal, John H; Grønli, Janne. 2016. Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. Translational psychiatry.
  • Steen, Vidar Martin; Skrede, Silje; Polushina, Tatiana; López, Miguel; Andreassen, Ole Andreas; Fernø, Johan; Le Hellard, Stephanie. 2016. Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment. European Neuropsychopharmacology. 589-598.
  • Henriksen, Tone Elise Gjøtterud; Skrede, Silje; Fasmer, Ole Bernt; Schøyen, Helle Kristine; Leskauskaite, Ieva; Bjørke-Bertheussen, Janette; Assmus, Jörg; Hamre, Børge; Grønli, Janne; Lund, Anders. 2016. Blue-blocking glasses as additive treatment for mania: A randomized placebo-controlled trial. Bipolar Disorders. 221-232.
  • Grønli, Janne; Meerlo, Peter; Pedersen, Torhild; Pallesen, Ståle; Skrede, Silje; Marti, Andrea Rørvik; Wisor, Jonathan; Murison, Robert; Henriksen, Tone Elise Gjøtterud; Rempe, Michael J.; Mrdalj, Jelena. 2016. A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms. 48-63.
  • Reikvam, Håkon; Brenner, Annette; Hagen, Karen Marie; Liseth, Knut; Skrede, Silje; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2015. The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. Stem Cell Research. 530-541.
  • Fernø, Johan; Ersland, Kari Merete; Duus, Inger Hødnebø; González-García, Ismael; FOSSAN, KJELL OVE; Berge, Rolf Kristian; Steen, Vidar Martin; Skrede, Silje. 2015. Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. European Neuropsychopharmacology. 923-932.
  • Skrede, Silje; Tvete, Ingunn Fride; Tanum, Lars; Steen, Vidar Martin; Bramness, Jørgen Gustav. 2015. Incident users of antipsychotic agents and future use of cholesterol-lowering drugs: An observational, pharmacoepidemiologic study. Journal of Clinical Psychiatry. e111-e116.
  • Ersland, Kari Merete; Skrede, Silje; Røst, Therese Halvorsen; Berge, Rolf Kristian; Steen, Vidar Martin. 2015. Antipsychotic-induced metabolic effects in the female rat: Direct comparison between long-acting injections of risperidone and olanzapine. Journal of Psychopharmacology. 1280-1289.
  • Skrede, Silje; Martins, Luis; Berge, Rolf Kristian; Steen, Vidar Martin; López, Miguel; Fernø, Johan. 2014. Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects. International Journal of Neuropsychopharmacology. 91-104.
  • Henriksen, Tone Elise Gjøtterud; Skrede, Silje; Fasmer, Ole Bernt; Hamre, Børge; Grønli, Janne; Lund, Anders. 2014. Blocking blue light during mania - markedly increased regularity of sleep and rapid improvement of symptoms: A case report. Bipolar Disorders. 894-898.
  • Reikvam, Håkon; Tamburini, Jerome; Skrede, Silje; Holdhus, Rita; Poulain, Laury; Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2014. Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect. British Journal of Haematology. 200-211.
  • Steen, Vidar Martin; Nepal, Chirag; Ersland, Kari Merete; Holdhus, Rita; Nævdal, Marianne Strømme; Ratvik, Siri Merete; Skrede, Silje; Håvik, Bjarte. 2013. Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. PLOS ONE. 10 pages.
  • Skrede, Silje; Steen, Vidar Martin; Fernø, Johan. 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research.
  • Skrede, Silje; Fernø, Johan; Vázquez, Maria Jesús; Fjær, Sveinung; Pavlin, Tina; Lunder, Niclas; Vidal-Puig, Antonio; Diéguez, Carlos; Berge, Rolf Kristian; López, Miguel; Steen, Vidar Martin. 2012. Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. International Journal of Neuropsychopharmacology. 163-179.
  • Skrede, Silje; Fernø, Johan; Bjørndal, Bodil; Brede, Wenche Rødseth; Bohov, Pavol; Berge, Rolf Kristian; Steen, Vidar Martin. 2012. Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment. PLOS ONE. 11 pages.
  • Jassim, Goran; Skrede, Silje; Vázquez, Maria Jesús; Vik-Mo, Audun Osland; Lunder, Niclas; Diéguez, Carlos; Vidal-Puig, Antonio; Berge, Rolf Kristian; López, Miguel; Steen, Vidar Martin; Fernø, Johan; Wergedahl, Hege. 2012. Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology. 783-794.
  • Fernø, Johan; Varela, Luis; Skrede, Silje; Vázquez, Maria Jesús; Nogueiras, Ruben; Diéguez, Carlos; Vidal-Puig, Antonio; Steen, Vidar Martin; López, Miguel. 2011. Olanzapine-induced hyperphagia and weight gain associate with crexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLOS ONE. 9 pages.
  • Fernø, Johan; Skrede, Silje; Vik-Mo, Audun Osland; Jassim, Goran; Le Hellard, Stephanie; Steen, Vidar Martin. 2011. Lipogenic effects of psychotropic drugs: focus on the SREBP system. Frontiers in Bioscience. 49-60.
  • Vik-Mo, Audun Osland; Fernø, Johan; Skrede, Silje; Steen, Vidar Martin. 2009. Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacology.
  • Fernø, Johan; Vik-Mo, Audun Osland; Jassim, Goran; Håvik, Bjarte; Berge, Kjetil; Skrede, Silje; Gudbrandsen, Oddrun Anita; Waage, Jo Erling Riise; Lunder, Niclas; Mørk, Sverre; Berge, Rolf Kristian; Jørgensen, Hugo A; Steen, Vidar Martin. 2009. Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology. 73-84.
  • Fernø, Johan; Skrede, Silje; Vik-Mo, Audun Osland; Håvik, Bjarte; Steen, Vidar Martin. 2006. Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs. BMC Neuroscience.
  • Fernø, Johan; Ræder, Maria Therese Barøy; Vik-Mo, Audun Osland; Skrede, Silje; Glambek, Marte; Tronstad, Karl Johan; Breilid, Harald; Løvlie, Roger; Berge, Rolf Kristian; Stansberg, Christine; Steen, Vidar Martin. 2005. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
  • Skrede, Silje; Holmsen, Holm A. 2003. Schizofreni og membranpatologi - har antipsykotika en rolle i "membranteorien"? Tidsskrift for Den norske legeforening. in press.
Report
  • Tvete, Ingunn Fride; Bramness, Jørgen Gustav; Skrede, Silje; Steen, Vidar Martin; Tanum, Lars. 2015. Nye brukere av antipsykotika og utvikling av diabetes mellitus. SAMBA/14/15. SAMBA/14/15. .
Academic lecture
  • Marti, Andrea Rørvik; Mrdalj, Jelena; Skrede, Silje; Pedersen, Torhild Thue; Meerlo, Peter; van Hasselt, Sjoerd Johan; Henriksen, Tone Elise Gjøtterud; Pallesen, Ståle; Murison, Robert; Grønli, Janne. 2016. Simulated night work alters clock gene expression in central and peripheral tissue in rats.
  • Steine, Iris Mulders; Zayats, Tetyana; Stansberg, Christine; Mrdalj, Jelena; Håvik, Bjarte; Haavik, Jan; Milde, Anne Marita; Skrede, Silje; Murison, Robert; Pallesen, Ståle; Grønli, Janne. 2016. Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.
  • Mrdalj, Jelena; Pedersen, Torhild Thue; Marti, Andrea Rørvik; Wisor, Jonathan; Meerlo, Peter; Pallesen, Ståle; Skrede, Silje; Murison, Robert; Henriksen, Tone Elise Gjøtterud; Grønli, Janne. 2015. Night work - disturbances in sleep and circadian rhythm parameters. An animal model.
Editorial
  • Skrede, Silje; Fernø, Johan; Steen, Vidar Martin. 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. 307-309.
Short communication
  • Serkland, Trond T.; Schjøtt, Jan; Berg, Jon Andsnes; Herfindal, Lars; Riedel, Bettina; Skrede, Silje. 2019. Short communication: Distribution of psychotropic drugs into lipoproteins. Therapeutic Drug Monitoring. 766-771.
Masters thesis
  • Bakken, Vibeke Løvås. 2018. Gene Expression Changes in Rat Brain Following Long-term Antipsychotic Drug Exposure.
Popular scientific article
  • Ersland, Kari Merete; Skrede, Silje. 2018. Virker antipsykotika gjennom stimulering av myelinproduksjon i hjernen? BestPractice Psykiatri/Nevrologi/Geriatri.
  • Skrede, Silje. 2018. Selektive serotonin-reopptaks-hemmere (SSRI) og blødningsrisiko. Utposten.
Letter to the editor
  • Berg, Jon Andsnes; Schjøtt, Jan; Carstensen, Kjersti; FOSSAN, KJELL OVE; Skrede, Silje; Bjånes, Tormod Karlsen; Serkland, Trond Trætteberg; Riedel, Bettina. 2019. Stability of antidepressants and antipsychotics in gel separator tubes. Therapeutic Drug Monitoring. 249-250.
Doctoral dissertation
  • Skrede, Silje. 2012. Developing a rodent model for antipsychotic-induced metabolic adverse effects.
Abstract
  • Marti, Andrea Rørvik; Mrdalj, Jelena; Skrede, Silje; Pedersen, Torhild Thue; Meerlo, Peter; van Hasselt, Sjoerd Johan; Henriksen, Tone Elise Gjøtterud; Pallesen, Ståle; Murison, Robert; Grønli, Janne. 2016. Simulated night work alters clock gene expression in central and peripheral tissue in rats. Journal of Sleep Research. 57-57.
Poster
  • Marti, Andrea Rørvik; Skrede, Silje; Mrdalj, Jelena; Pedersen, Torhild; Bjerrum, Louise Haugen; waslander, jorrit; Ersland, Kari Merete; Henriksen, Tone Elise Gjøtterud; Bramham, Clive R.; Grønli, Janne. 2018. Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light. .
  • Grønli, Janne; Marti, Andrea Rørvik; waslander, jorrit; Skrede, Silje; Mrdalj, Jelena; Pedersen, Torhild; Bjerrum, Louise Haugen; Henriksen, Tone Elise Gjøtterud; Bramham, Clive R. 2018. Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.
  • Marti, Andrea Rørvik; waslander, jorrit; Skrede, Silje; Mrdalj, Jelena; Pedersen, Torhild; Bjerrum, Louise Haugen; Henriksen, Tone Elise Gjøtterud; Bramham, Clive R.; Grønli, Janne. 2018. Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.
  • Kroken, Rune Andreas; Løberg, Else-Marie; Gjestad, Rolf; Steen, Vidar Martin; Skrede, Silje; Bruserud, Øystein; Fathian, Farivar; Reitan, Solveig Merete Klæbo; Rettenbacher, maria; Fleischhacker, Wolfgang. 2017. The influence of 3 weeks of antipsychotic treatment on cell adhesion molecules in drug naive patients with schizophrenia spectrum disorder .
Academic literature review
  • Kroken, Rune; Løberg, Else-Marie; Drønen, Tore; Grüner, Renate; Hugdahl, Kenneth; Kompus, Kristiina; Skrede, Silje; Johnsen, Erik. 2014. A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation.

More information in national current research information system (CRIStin)