Silje Skrede's picture

Silje Skrede

Professor, Head of innovation
  • E-mailSilje.Skrede@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2024). Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe. Basic & Clinical Pharmacology & Toxicology.
  • Show author(s) (2024). Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model. CNS Neuroscience & Therapeutics.
  • Show author(s) (2023). Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro. International Immunopharmacology. 1-5.
  • Show author(s) (2023). Depression trajectories and cytokines in schizophrenia spectrum disorders - A longitudinal observational study. Schizophrenia Research. 77-87.
  • Show author(s) (2022). Ocrelizumab quantitation by liquid chromatography-tandem mass spectrometry. Journal of Mass Spectrometry and Advances in the Clinical Lab. 53-60.
  • Show author(s) (2022). GLP-1 agonists: superior for mind and body in antipsychotic-treated patients? Trends in endocrinology and metabolism. 628-638.
  • Show author(s) (2022). Determination of methotrexate and its metabolites in human plasma by electromembrane extraction in conductive vials followed by LC-MS/MS. Advances in Sample Preparation. 8 pages.
  • Show author(s) (2021). Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness. Psychological Medicine. 1-10.
  • Show author(s) (2021). Illicit substances detected through high-resolution MS analysis in urine samples are associated with greater symptom burden in patients with psychosis. Emerging Trends in Drugs, Addictions, and Health.
  • Show author(s) (2020). Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial. The Lancet Psychiatry. 945-954.
  • Show author(s) (2019). One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects. International Journal of Neuropsychopharmacology. 358-369.
  • Show author(s) (2019). Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology. 1-9.
  • Show author(s) (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research. 253-260.
  • Show author(s) (2017). Subchronic olanzapine exposure leads to increased expression of myelination-related genes in rat fronto-medial cortex. Translational Psychiatry.
  • Show author(s) (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 1-12.
  • Show author(s) (2017). Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. International Journal of Neuropsychopharmacology. 1005-1012.
  • Show author(s) (2016). Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. Nutrients. 1-13.
  • Show author(s) (2016). Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. Translational Psychiatry.
  • Show author(s) (2016). Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment. European Neuropsychopharmacology. 589-598.
  • Show author(s) (2016). Blue-blocking glasses as additive treatment for mania: A randomized placebo-controlled trial. Bipolar Disorders. 221-232.
  • Show author(s) (2016). A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms. 48-63.
  • Show author(s) (2015). The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. Stem Cell Research. 530-541.
  • Show author(s) (2015). Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. European Neuropsychopharmacology. 923-932.
  • Show author(s) (2015). Incident users of antipsychotic agents and future use of cholesterol-lowering drugs: An observational, pharmacoepidemiologic study. Journal of Clinical Psychiatry. e111-e116.
  • Show author(s) (2015). Antipsychotic-induced metabolic effects in the female rat: Direct comparison between long-acting injections of risperidone and olanzapine. Journal of Psychopharmacology. 1280-1289.
  • Show author(s) (2014). Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects. International Journal of Neuropsychopharmacology. 91-104.
  • Show author(s) (2014). Blocking blue light during mania - markedly increased regularity of sleep and rapid improvement of symptoms: A case report. Bipolar Disorders. 894-898.
  • Show author(s) (2014). Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect. British Journal of Haematology. 200-211.
  • Show author(s) (2013). Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. PLOS ONE. 10 pages.
  • Show author(s) (2013). Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research.
  • Show author(s) (2012). Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. International Journal of Neuropsychopharmacology. 163-179.
  • Show author(s) (2012). Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment. PLOS ONE. 11 pages.
  • Show author(s) (2012). Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology. 783-794.
  • Show author(s) (2011). Olanzapine-induced hyperphagia and weight gain associate with crexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLOS ONE. 9 pages.
  • Show author(s) (2011). Lipogenic effects of psychotropic drugs: focus on the SREBP system. Frontiers in Bioscience. 49-60.
  • Show author(s) (2009). Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacology.
  • Show author(s) (2009). Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology. 73-84.
  • Show author(s) (2006). Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs. BMC Neuroscience.
  • Show author(s) (2005). Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
  • Show author(s) (2003). Schizofreni og membranpatologi - har antipsykotika en rolle i "membranteorien"? Tidsskrift for Den norske legeforening. in press.
  • Show author(s) (2015). Nye brukere av antipsykotika og utvikling av diabetes mellitus. SAMBA/14/15. SAMBA/14/15. .
  • Show author(s) (2022). Elektromembran-ekstraksjon i Bergen.
Academic lecture
  • Show author(s) (2023). TDM for mAbs - prospects based on progress of analytical methods.
  • Show author(s) (2022). Rituximab in the treatment of multiple sclerosis: A pharmacokinetic-pharmacodynamic model.
  • Show author(s) (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats.
  • Show author(s) (2016). Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.
  • Show author(s) (2015). Night work - disturbances in sleep and circadian rhythm parameters. An animal model.
  • Show author(s) (2013). Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. 307-309.
Short communication
  • Show author(s) (2019). Short communication: Distribution of psychotropic drugs into lipoproteins. Therapeutic Drug Monitoring. 766-771.
Masters thesis
  • Show author(s) (2023). Zebrafish Larvae as a Model Organism to Study Biotransformation.
  • Show author(s) (2022). Electromembrane extraction of immunosuppressants.
  • Show author(s) (2021). Electromembrane extraction of methotrexate and its metabolites.
  • Show author(s) (2020). Drug transport in blood: Lipoproteins as transporters of psychotropic drugs.
  • Show author(s) (2018). Gene Expression Changes in Rat Brain Following Long-term Antipsychotic Drug Exposure.
Popular scientific article
  • Show author(s) (2018). Virker antipsykotika gjennom stimulering av myelinproduksjon i hjernen? BestPractice Psykiatri/Nevrologi/Geriatri.
  • Show author(s) (2018). Selektive serotonin-reopptaks-hemmere (SSRI) og blødningsrisiko. Utposten.
Letter to the editor
  • Show author(s) (2021). Therapeutic Drug Monitoring vs Standard Therapy during Infliximab Induction in Patients with Chronic Immune-Mediated Inflammatory Diseases. Journal of the American Medical Association (JAMA). 1068-1069.
  • Show author(s) (2019). Stability of antidepressants and antipsychotics in gel separator tubes. Therapeutic Drug Monitoring. 249-250.
Doctoral dissertation
  • Show author(s) (2020). Lipid effects during antipsychotic drug treatment and their relevance for clinical outcomes.
  • Show author(s) (2012). Developing a rodent model for antipsychotic-induced metabolic adverse effects.
  • Show author(s) (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats. Journal of Sleep Research. 57-57.
  • Show author(s) (2023). "Virtual Pharma" - a digital tool for visualizing pharmacokinetics and pharmacodynamics.
  • Show author(s) (2022). LC-MS/MS quantification of ocrelizumab in the treatment of multiple sclerosis .
  • Show author(s) (2021). Establishing an LC-MS/MS method as a tool in a TDM approach when treating multiple sclerosis with monoclonal antibodies.
  • Show author(s) (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light. .
  • Show author(s) (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.
  • Show author(s) (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.
  • Show author(s) (2017). The influence of 3 weeks of antipsychotic treatment on cell adhesion molecules in drug naive patients with schizophrenia spectrum disorder .
Academic literature review
  • Show author(s) (2023). Peripheral and central macrophages in obesity. Frontiers in Endocrinology.
  • Show author(s) (2023). Dog-assisted interventions for adults diagnosed with schizophrenia and related disorders: a systematic review. Frontiers in Psychiatry. 21 pages.
  • Show author(s) (2021). Understanding the Effects of Antipsychotics on Appetite Control. Frontiers in Nutrition.
  • Show author(s) (2014). A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation. Frontiers in Psychiatry.
  • Show author(s) (2020). Norsk Psykiatrisk Forening: Kliniske råd for nedtrapping og seponering av antipsykotiske legemidler.

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