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Silke Appel's picture

Silke Appel

Professor
  • E-mailSilke.Appel@uib.no
  • Phone+47 55 97 46 33+47 410 80 067
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    Room 
    5395
  • Postal Address
    Postboks 7804
    5020 Bergen

Dendritic cell biology with special emphasis on aspects that enable their use in immunotherapeutic strategies, both for cancer and autoimmune diseases

 

Member of the organizing committee for the annual "Day of Immunology" (29.4.)

Responsible for

Academic article
  • Show author(s) 2020. Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. European Journal of Immunology. 694-702.
  • Show author(s) 2020. Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. Frontiers in Endocrinology. 1-13.
  • Show author(s) 2020. Dual pro- and anti-inflammatory features of monocyte-derived dendritic cells. Frontiers in Immunology. 1-15.
  • Show author(s) 2019. The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells. Frontiers in Immunology.
  • Show author(s) 2019. Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary sjogren's syndrome. Frontiers in Immunology. 1-18.
  • Show author(s) 2018. Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment? Scandinavian Journal of Immunology. 1-7.
  • Show author(s) 2018. Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. British Journal of Dermatology. 371-380.
  • Show author(s) 2018. Minimum information about T regulatory cells: A step toward reproducibility and standardization. Frontiers in Immunology. 1-15.
  • Show author(s) 2018. Aberrant cell signalling in PBMCs upon IFN-? stimulation in primary Sjogren's syndrome patients associates with type I interferon signature. European Journal of Immunology. 1217-1227.
  • Show author(s) 2018. 3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy. Cancer Immunology and Immunotherapy. 1-10.
  • Show author(s) 2017. Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. Scandinavian Journal of Immunology. 491-502.
  • Show author(s) 2017. Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. Scandinavian Journal of Immunology. 220-226.
  • Show author(s) 2016. Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. PeerJ.
  • Show author(s) 2016. An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. JIM - Journal of Immunological Methods. 58-63.
  • Show author(s) 2015. TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. Scandinavian Journal of Immunology. 523-531.
  • Show author(s) 2015. Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 56-65.
  • Show author(s) 2015. Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls. Journal of the European Academy of Dermatology and Venereology. 2128-2135.
  • Show author(s) 2015. Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome. PLOS ONE. 13 pages.
  • Show author(s) 2014. CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. Acta Dermato-Venereologica. 173-178.
  • Show author(s) 2014. Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. Arthritis Research & Therapy.
  • Show author(s) 2014. Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 20-26.
  • Show author(s) 2013. Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scandinavian Journal of Immunology. 246-254.
  • Show author(s) 2013. No association of primary Sjögren's syndrome with Fcγ receptor gene variants. Genes and Immunity. 234-237.
  • Show author(s) 2013. In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. Arthritis Research & Therapy. 12 pages.
  • Show author(s) 2013. Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. Biointerphases. 12 pages.
  • Show author(s) 2013. Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. Scandinavian Journal of Immunology. 291-297.
  • Show author(s) 2012. The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. PLOS ONE. 7 pages.
  • Show author(s) 2012. Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. PLOS ONE. 9 pages.
  • Show author(s) 2012. Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. Journal of Leukocyte Biology. 729-737.
  • Show author(s) 2011. Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1327-1329.
  • Show author(s) 2011. Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunology. 10 pages.
  • Show author(s) 2011. Dendritic cell populations in patients with self-reported food hypersensitivity. International Journal of General Medicine. 389-396.
  • Show author(s) 2011. Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). Scandinavian Journal of Immunology. 135-143.
  • Show author(s) 2011. Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. Genes and Immunity. 100-109.
  • Show author(s) 2010. Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1235-1238.
  • Show author(s) 2009. Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. Scandinavian Journal of Immunology. 541-546.
  • Show author(s) 2008. New Concepts in the Pathogenesis of Sjogren's Syndrome. Rheumatic Disease Clinics of North America. 833-+.
  • Show author(s) 2007. Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. Endocrine, Metabolic & Immune Disorders - Drug Targets. 93-97.
  • Show author(s) 2006. Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. Blood. 3265-3270.
Reader opinion piece
  • Show author(s) 2013. Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. Genes and Immunity. 532-532.
  • Show author(s) 2012. Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. Acta Dermato-Venereologica. 623-624.
  • Show author(s) 2012. Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). Scandinavian Journal of Rheumatology. 314-315.
  • Show author(s) 2010. The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. Scandinavian Journal of Immunology. 554-554.
Doctoral dissertation
  • Show author(s) 2019. Systemic inflammation in psoriasis: Circulating immune cells and cytokines.
  • Show author(s) 2017. Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome.
  • Show author(s) 2015. Toll-like receptors in primary Sjögren’s syndrome. Special emphasis on B cells.
  • Show author(s) 2011. Epidemiological, clinical, and immunogenetic aspects of primary Sjögren's syndrome.
Abstract
  • Show author(s) 2013. Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 299-300.
  • Show author(s) 2012. No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. Scandinavian Journal of Immunology. 198-198.
  • Show author(s) 2012. Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. Immunology. 331-331.
  • Show author(s) 2012. Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. Immunology. 679-679.
  • Show author(s) 2011. The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. Scandinavian Journal of Immunology. 366-366.
  • Show author(s) 2011. Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. Scandinavian Journal of Immunology. 387-388.
  • Show author(s) 2011. Generation of Tolerogenic Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 378-379.
  • Show author(s) 2011. Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients? Scandinavian Journal of Immunology. 394-394.
  • Show author(s) 2010. Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. Scandinavian Journal of Immunology. 479-479.
  • Show author(s) 2010. Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. Scandinavian Journal of Immunology. 504-504.
  • Show author(s) 2010. Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. Scandinavian Journal of Rheumatology. 32-32.
  • Show author(s) 2010. Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. Scandinavian Journal of Rheumatology. 36-36.
  • Show author(s) 2010. Dendritic cell populations in patients with self-reported food hypersensitivity. Gut. A394.
  • Show author(s) 2010. Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology. 506-507.
  • Show author(s) 2008. Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. Scandinavian Journal of Immunology. 217-217.
  • Show author(s) 2008. Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. Blood. 891-891.
  • Show author(s) 2008. Age-related distribution of cDC and pDC in salivary glands of NOD mice. Scandinavian Journal of Immunology. 206-207.
Poster
  • Show author(s) 2009. Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome.
  • Show author(s) 2009. Fc receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc receptor IIIB copy number variation: No association with primary Sjögren’s syndrome.
  • Show author(s) 2009. Dendritic cells from patients with primary Sjögren's syndrome have slightly enhanced endocytic capacity.
  • Show author(s) 2009. Association of C8orf13-BLK and TNFSF4 Gene Variants with Primary Sjögren's Syndrome.
Academic literature review
  • Show author(s) 2020. The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. Scandinavian Journal of Immunology.
  • Show author(s) 2020. Current knowledge on autoantigens and autoantibodies in psoriasis. Scandinavian Journal of Immunology.
  • Show author(s) 2013. Current status and future perspectives of dendritic cell-based cancer immunotherapy. Scandinavian Journal of Immunology. 167-171.
  • Show author(s) 2012. The 2011 Nobel Prize in physiology or medicine. Scandinavian Journal of Immunology. 1-4.
  • Show author(s) 2011. The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. Immunology Letters. 1-9.
  • Show author(s) 2006. Role of dendritic cells in Sjögren´s syndrome. Scandinavian Journal of Immunology. 219-226.

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