Simon E Nitter Dankel

Researcher

Department of Clinical Science

Hormone Laboratory Research Group

E-mailSimon.Dankel@uib.no
Visitor Address
Laboratory Building, 9th floor

Haukeland university hospital

5020 Bergen

Room
9230
Postal Address
Postboks 7804

5020 Bergen

Metabolism, nutrition, adipose tissue, type 2 diabetes, gene regulation, genetics/genomics

Academic article

Bjune, Jan-Inge; Dyer, Laurence; Røsland, Gro Vatne; Tronstad, Karl Johan; Njølstad, Pål Rasmus; Sagen, Jørn V.; Dankel, Simon N; Mellgren, Gunnar. 2019. The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné; Fandalyuk, Zinayida; Skurk, Thomas; Hauner, Hans; Sagen, Jørn V.; Rydén, Mikael; Arner, Peter; Mellgren, Gunnar. 2019. The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
Gudbrandsen, Oddrun Anita; Dankel, Simon N; Skumsnes, Lillian; Flølo, Tone Nygaard; Folkestad, Oddry H; Nielsen, Hans Jørgen; Våge, Villy; Mohn, Arne-Christian; Nedrebø, Bjørn Gunnar; Sagen, Jørn V.; Fernø, Johan; Mellgren, Gunnar. 2019. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
McCann, Adrian; Melvær, Giil Lasse; Ulvik, Arve; Seifert, Reinhard; Rebnord, Eirik Wilberg; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Meyer, Klaus; Strand, Elin; Dankel, Simon N; Ueland, Per Magne; Nygård, Ottar. 2019. Plasma amino acids and incident type 2 diabetes in patients with coronary artery disease. Diabetes Care. 1225-1233.
Ramirez, Alfred K; Dankel, Simon N; Cai, Weikang; Sakaguchi, Masaji; Kasif, Simon; Kahn, C. Ronald. 2019. Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes. Molecular Metabolism. 21-36.
Dankel, Dorothy Jane; Dankel, Simon N. 2019. Genredigering - eit felles ansvar. Tidsskrift for Den norske legeforening. 2 pages.
Svärd, Jessica; Røst, Therese Halvorsen; Sommervoll, Camilla Elise Nergård; Haugen, Christine; Gudbrandsen, Oddrun Anita; Mellgren Christensen, Anne Elisabeth; Rødahl, Eyvind; Fernø, Johan; Dankel, Simon N; Sagen, Jørn V.; Mellgren, Gunnar. 2019. Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.

Bjune, Jan-Inge; Haugen, Christine; Gudbrandsen, Oddrun Anita; Nordbø, Ole Petter; Nielsen, Hans Jørgen; Våge, Villy; Njølstad, Pål Rasmus; Sagen, Jørn V.; Dankel, Simon N; Mellgren, Gunnar. 2018. IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity.

Veum, Vivian Lohmann; Laupsa-Borge, Johnny; Eng, Øyvin Andre Solberg; Rostrup, Espen; Larsen, Terje H; Nordrehaug, Jan Erik; Nygård, Ottar; Sagen, Jørn V.; Gudbrandsen, Oddrun Anita; Dankel, Simon N; Mellgren, Gunnar. 2017. Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 85-99.

Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N; Fenne, Ingvild Sveinsgjerd; Skartveit, Linn; Drangevåg, Andreas; Bozickovic, Olivera; Flågeng, Marianne Hauglid; Søiland, Håvard; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2015. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLOS ONE. 19 pages.
Claussnitzer, Melina; Dankel, Simon N; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S.; Beaudry, Jacqueline L.; Puviindran, Vijitha; Abdennur, Nezar A.; Liu, Jannel; Svensson, Per-Arne; Hsu, Yi-Hsiang; Drucker, Daniel J.; Mellgren, Gunnar; Hui, Chi-Chung; Hauner, Hans; Kellis, Manolis. 2015. FTO obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine. 895-907.
McCulloch, Laura J.; Rawling, Tom J.; Sjöholm, Kajsa; Franck, Niclas; Dankel, Simon N; Price, Emily J.; Knight, Bridget; Liversedge, Neil H.; Mellgren, Gunnar; Nyström, Fredrik; Carlsson, Lena M.; Kos, Katarina. 2015. COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology. 134-146.

Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Borkowski, Kamil; Fjære, Even; Midtbø, Lisa Kolden; Haugen, Christine; Solsvik, Margit; Lavigne, Ann Marie; Liaset, Bjørn; Sagen, Jørn V.; Kristiansen, Karsten; Mellgren, Gunnar; Madsen, Lise. 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
Claussnitzer, Melina; Dankel, Simon E Nitter; Klocke, Bernward; Grallert, Harald; Glunk, Viktoria; Berulava, Tea; Lee, Heekypung; Oskolkov, Nikolay; Fadista, João; Ehlers, Kerstin; Wahl, Simone; Hoffmann, Christoph; Qian, Kun; Rönn, Tina; Riess, Helene; Müller-Nurasyid, Martina; Bretschneider, Nancy; Schroeder, Timm; Skurk, Thomas; Horsthemke, Bernhard; Spieler, Derek; Klingenspor, Martin; Seifert, Martin; Kern, Michael J.; Mejhert, Niklas; Dahlman, Ingrid; Hansson, Ola; Hauck, Stefanie M.; Blüher, Matthias; Arner, Peter; Groop, Leif; Illig, Thomas; Suhre, Karsten; Hsu, Yi-Hsiang; Mellgren, Gunnar; Hauner, Hans; Laumen, Helmut. 2014. Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 343-358.
Dankel, Simon E Nitter; Svärd, Jessica; Matthä, Simone; Claussnitzer, Melina; Klöting, Nora; Glunk, Viktoria; Fandalyuk, Zinayida; Grytten, Elise; Solsvik, Margit; Nielsen, Hans Jørgen; Busch, Christian; Hauner, Hans; Blüher, Matthias; Skurk, Thomas; Sagen, Jørn V.; Mellgren, Gunnar. 2014. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
Ussar, Siegfried; Lee, Kevin; Dankel, Simon N; Boucher, Jeremie; Haering, Max-Felix; Kleinridders, Andre; Thomou, Thomas; Xue, Ruidan; Macotela, Yazmin; Cypess, Aaron; Tseng, Yu-Hua; Mellgren, Gunnar; Kahn, C. Ronald. 2014. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine.

Fenne, Ingvild Sveinsgjerd; Helland, Thomas; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Mellgren, Gunnar; Sagen, Jørn V. 2013. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 10 pages.
Methlie, Paal; Dankel, Simon E Nitter; Myhra, Tone Sæterdal; Christensen, Bjørn Jostein; Gjerde, Jennifer; Fadnes, Dag Jone Stokke; Våge, Villy; Løvås, Kristian; Mellgren, Gunnar. 2013. Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 2495-2503.

Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer; Nielsen, Hans Jørgen; Solsvik, Margit Hildershavn; Haugen, Christine; Christensen, Bjørn Jostein; Hoang, Tuyen; Fadnes, Dag Jone Stokke; Busch, Christian; Våge, Villy; Sagen, Jørn V.; Mellgren, Gunnar. 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.

Christensen, Monika; Dankel, Simon E Nitter; Nordbø, Yngve; Varhaug, Jan Erik; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLOS ONE. 10 pages.

Dankel, Simon E Nitter; Hoang, Tuyen; Flågeng, Marianne Hauglid; Sagen, Jørn V.; Mellgren, Gunnar. 2010. cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1013-1019.
Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 12 pages.

Lecture

Dankel, Simon N; Tallapragada, Divya Sri Priyanka; Armstrong, Nasa-Sinnott; Sagen, Jørn V.; Claussnitzer, Melina; Mellgren, Gunnar. 2019. Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity .

Academic lecture

Åsen Jersin, Regine; Dankel, Simon N. 2019. Inhibition of the serine transporter SLC7A10 limits antioxidant capacity and promotes lipid storage in adipocytes.
Nilsen, Mona Synnøve; Åsen Jersin, Regine; McCann, Adrian; Ulvik, Arve; Madsen, Andre; Svensson, Per-Arne; Sagen, Jørn V.; Ueland, Per Magne; Tell, Grethe S.; Mellgren, Gunnar; Dankel, Simon N. 2019. Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
Åsen Jersin, Regine; Tallapragada, Divya Sri Priyanka; Nilsen, Mona Synnøve; Dankel, Simon N. 2019. A novel amino acid transporter modulating insulin resistance via adipocytes .

Nilsen, Mona Synnøve; Åsen Jersin, Regine; Madsen, Andre; McCann, Adrian; Svensson, Per-Arne; Ueland, Per Magne; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N. 2018. Amino acid metabolism in adipocytes.

Åsen Jersin, Regine; Dankel, Simon N; Madsen, Andre; Willems, Aron. 2017. Impaired amino acid transport in adipocytes promotes visceral fat storage .
Willems, Aron; Åsen Jersin, Regine; Dankel, Simon N; Madsen, Andre. 2017. Amino acid transport in adipocytes modulates visceral fat accumulation and diabetes risk.

Dankel, Simon N; Ramirez, Alfred; Xue, Ruidan; Lee, Kevin; Thomou, Thomas; Kasif, Simon; Tseng, Yu-Hua; Kahn, C Ronald. 2014. Preadipocyte and Adipocyte Heterogeneity within a Single White Fat Depot in Humans.

Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Fjære, Even; Haugen, Christine; Sagen, Jørn V.; Mellgren, Gunnar; Madsen, Lise. 2012. Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism.
Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Christoforou, Andrea; Haugen, Christine; Røst, Therese Halvorsen; Gudbrandsen, Oddrun Anita; Veum, Vivian Lohmann; Solsvik, Margit; Våge, Villy; Nielsen, Hans Jørgen; Busch, Christian; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2012. Integrative genomics links homeobox transcription factors to intra-abdominal obesity.

Mellgren, Gunnar; Dankel, Simon E Nitter. 2009. Bariatric surgery dramatically alters global gene expression in adipose tissue.

Masters thesis

Berg, Malin Rofstad. 2019. The relationship between quality and quantity of dietary carbohydrates, SCFAs and gastrointestinal health in obesity – A randomized control dietary intervention (CARBFUNC).
Storaas, Inghild. 2019. Effects of carbohydrate quality and quantity on fecal short-chain fatty acids and symptoms of gastrointestinal health in people with obesity: a randomized controlled trial (CARBFUNC).

Dankel, Simon E Nitter. 2007. Role of cAMP/PKA in Regulation of GRIP1- and PGC1a-Mediated Coactivation of Nuclear Receptor HNF4a.

Dankel, Simon. 2006. Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha.

Doctoral dissertation

Dankel, Simon E Nitter. 2011. Transcriptomics of adipose tissue – Integrative search for obesity candidate genes.

Academic chapter/article/Conference paper

Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Hoang, Tuyen; Gjerde, Jennifer; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 pages.

Abstract

Hoang, Tuyen; Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Veum, Vivian Lohmann; Våge, Villy; Steen, Vidar Martin; Sagen, Jørn V.; Mellgren, Gunnar. 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 1 pages.
Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. S429-S429.

Poster

Åsen Jersin, Regine; Nilsen, Mona Synnøve; Tallapragada, Divya Sri Priyanka; Dankel, Simon N. 2019. Inhibition of serine transporter SLC7A10 promotes lipid accumulation through altered BCAA catabolism in adipocytes.
Tallapragada, Divya Sri Priyanka; Laber, Samantha; Mellgren, Gunnar; Claussnitzer, Melina; Dankel, Simon N. 2019. Generation and validation of immortalized human paired subcutaneous and omental adipocyte models to study obesity.
Nilsen, Mona Synnøve; Åsen Jersin, Regine; Madsen, Andre; McCann, Adrian; Svensson, Per-Arne; Ueland, Per Magne; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N. 2019. Adipocyte amino acid metabolism in obesity-related metabolic diseases .

Bjune, Jan-Inge; Haugen, Christine; Gudbrandsen, Oddrun Anita; Nordbø, Ole Petter; Njølstad, Pål Rasmus; Sagen, Jørn V.; Dankel, Simon N; Mellgren, Gunnar. 2018. Irx5 regulates body weight via amyloid precursor protein (App) and mitochondrial respiration in adipocytes.
Bjune, Jan-Inge; Haugen, Christine; Gudbrandsen, Oddrun Anita; Nordbø, Ole Petter; Njølstad, Pål Rasmus; Sagen, Jørn V.; Dankel, Simon N; Mellgren, Gunnar. 2018. Irx5 regulates body weight via amyloid precursor protein and mitochondrial respiration in adipocytes.
Åsen Jersin, Regine; Dankel, Simon N. 2018. Inhibition of the serine transporter SLC7A10 promotes lipid storage by limiting antioxidant capacity in adipocytes.
Åsen Jersin, Regine; Madsen, Andre; Dankel, Simon N. 2018. Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
Jersin, Regine; Madsen, Andre; Willems, Aron; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N. 2018. Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
Tallapragada, Divya Sri Priyanka; Mellgren, Gunnar; Dankel, Simon N. 2018. Gene marker panel for omental and subcutaneous adipocytes in humans .
Åsen Jersin, Regine; Dankel, Simon N. 2018. ASC-1 transports serine and curbs visceral obesity.

Fernø, Johan; Willems, Aron; Dankel, Simon N; Mellgren, Gunnar. 2014. SLC7A10, a novel adipocyte-enriched gene with a potential role in adipocyte differentiation.
Haugen, Christine; Dankel, Simon N; Kim, K. Han; Solsvik, Margit; Sagen, Jørn V.; Gudbrandsen, Oddrun Anita; Hui, C.-C.; Mellgren, Gunnar. 2014. Role of homeobox transcription factors IRX3 and IRX5 in mitochondrial development and activity in adipose tissue.
Veum, Vivian Lohmann; Laupsa-Borge, Johnny; Eng, Øyvin Solberg; Rostrup, Espen; Larsen, Terje H; Nordrehaug, Jan Erik; Nygård, Ottar; Sagen, Jørn V.; Dankel, Simon E Nitter; Mellgren, Gunnar. 2014. A moderate energy-restricted very-high-fat diet reduces fat mass and improves metabolic health in abdominally obese middle-aged men.

Haugen, Christine; Dankel, Simon E Nitter; Kim, K. Han; Solsvik, Margit; Sagen, Jørn V.; Gudbrandsen, Oddrun Anita; Hui, C.-C.; Mellgren, Gunnar. 2013. Role of homeobox transcription factor IRX5 in obesity and metabolic health.
Haugen, Christine; Dankel, Simon E Nitter; Kim, K. Han; Solsvik, Margit; Sagen, Jørn V.; Gudbrandsen, Oddrun Anita; Hui, C.-C.; Mellgren, Gunnar. 2013. Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice.

Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Fjære, Even; Haugen, Christine; Sagen, Jørn V.; Mellgren, Gunnar; Madsen, Lise. 2012. Candidate genes for fat regain after weight cycling in mice.
Degerud, Eirik Magnus Meek; Dankel, Simon E Nitter; Fjære, Even; Haugen, Christine; Sagen, Jørn V.; Mellgren, Gunnar; Madsen, Lise. 2012. CDKN1A associates with fat regain after weight cycling in mice.

Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer; Nielsen, Hans Jørgen; Solsvik, Margit Hildershavn; Haugen, Christine; Christensen, Bjørn Jostein; Hoang, Tuyen; Busch, Christian; Fadnes, Dag Jone Stokke; Våge, Villy; Sagen, Jørn V.; Mellgren, Gunnar. 2011. The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss.
Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Gudbrandsen, Oddrun Anita; Veum, Vivian Lohmann; Våge, Villy; Steen, Vidar Martin; Sagen, Jørn V.; Mellgren, Gunnar. 2011. Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue.
Christensen, Monika; Dankel, Simon E Nitter; Nordbø, Yngve; Varhaug, Jan Erik; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Differential Expression of Inflammatory and Metabolic Genes in Adipose Tissue of Patients with Primary Huperparathyroidism.
Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid; Helland, Thomas; Dankel, Simon E Nitter; Mellgren, Gunnar. 2011. Characterization of Global Gene Expression in Breast Cancer Cells after cAMP/PKA-mediated downregulation of Steroid Receptor Coactivator 2.

Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Gudbrandsen, Oddrun Anita; Veum, Vivian Lohmann; Våge, Villy; Steen, Vidar Martin; Sagen, Jørn V.; Mellgren, Gunnar. 2010. Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity.
Hoang, Tuyen; Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Veum, Vivian Lohmann; Våge, Villy; Steen, Vidar M; Sagen, Jørn V.; Mellgren, Gunnar. 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss.
Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery.

Dankel, Simon E Nitter; Hoang, Tuyen; Sagen, Jørn V.; Mellgren, Gunnar. 2008. cAMP/PKA Exerts Differential Effects on GRIP1- and PGC-1α-Mediated HNF-4α Transcriptional Activity in HepG2 and COS-1 Cells.
Dankel, Simon E Nitter; Hoang, Tuyen; Sagen, Jørn V.; Mellgren, Gunnar. 2008. cAMP Regulates Nuclear Receptor Coactivator GRIP1–Mediated Coactivation of HNF-4alpha in HepG2 Cells.

Mellgren, Gunnar; Hoang, Tuyen; Sagen, Jørn V.; Dankel, Simon E Nitter. 2007. Regulation of HNF-4alpha transcriptional activity by the coactivators GRIP1 and PGC-1alpha.

Academic literature review

Dankel, Simon E Nitter; Staalesen, Vidar; Bjørndal, Bodil; Berge, Rolf Kristian; Mellgren, Gunnar; Burri, Lena. 2011. Tissue-specific effects of bariatric surgery including mitochondrial function. 435245.

Article in business/trade/industry journal