Simon Erling Nitter Dankel
Researcher
- E-mailSimon.Dankel@uib.no
- Phone+47 943 08 637
- Visitor AddressLaboratory Building, 9th floorHaukeland university hospital5020 BergenRoom9230
- Postal AddressPostboks 78045020 Bergen
Metabolism, nutrition, adipose tissue, type 2 diabetes, gene regulation, genetics/genomics
Academic article
- 2021. Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes. 680-695.
- 2021. Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes.
- 2021. Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 10 pages.
- 2021. A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metabolism. 615-628.
- 2020. Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity. Nature Communications. 1-9.
- 2020. COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. Scientific Reports. 1-11.
- 2020. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 684-701.
- 2020. 3-hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and brown adipocyte metabolism. Diabetes. 1903-1916.
- 2019. The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
- 2019. The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
- 2019. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
- 2019. Plasma amino acids and incident type 2 diabetes in patients with coronary artery disease. Diabetes Care. 1225-1233.
- 2019. Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes. Molecular Metabolism. 21-36.
- 2019. Genredigering - eit felles ansvar. Tidsskrift for Den norske legeforening. 2 pages.
- 2019. Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.
- 2018. IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity.
- 2017. Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 85-99.
- 2015. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLOS ONE. 19 pages.
- 2015. FTO obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine. 895-907.
- 2015. COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology. 134-146.
- 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
- 2014. Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 343-358.
- 2014. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
- 2014. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine.
- 2013. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 10 pages.
- 2013. Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 2495-2503.
- 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.
- 2011. Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLOS ONE. 10 pages.
- 2010. cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1013-1019.
- 2010. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 12 pages.
Lecture
- 2019. Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity .
Academic lecture
- 2020. Low 3-hydroxyisobutyrate (3-HIB) and high methylmalonic acid (MMA) levels in plasma reflect increased hepatic fatty acid oxidation.
- 2019. Inhibition of the serine transporter SLC7A10 limits antioxidant capacity and promotes lipid storage in adipocytes.
- 2019. Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
- 2019. A novel amino acid transporter modulating insulin resistance via adipocytes .
- 2018. Amino acid metabolism in adipocytes.
- 2017. Impaired amino acid transport in adipocytes promotes visceral fat storage .
- 2017. Amino acid transport in adipocytes modulates visceral fat accumulation and diabetes risk.
- 2014. Preadipocyte and Adipocyte Heterogeneity within a Single White Fat Depot in Humans.
- 2012. Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism.
- 2012. Integrative genomics links homeobox transcription factors to intra-abdominal obesity.
- 2009. Bariatric surgery dramatically alters global gene expression in adipose tissue.
Masters thesis
- 2019. The relationship between quality and quantity of dietary carbohydrates, SCFAs and gastrointestinal health in obesity – A randomized control dietary intervention (CARBFUNC).
- 2019. Effects of carbohydrate quality and quantity on fecal short-chain fatty acids and symptoms of gastrointestinal health in people with obesity: a randomized controlled trial (CARBFUNC).
- 2007. Role of cAMP/PKA in Regulation of GRIP1- and PGC1a-Mediated Coactivation of Nuclear Receptor HNF4a.
- 2006. Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha.
Letter to the editor
- 2021. Reply to JJ Christensen et al. American Journal of Clinical Nutrition.
Doctoral dissertation
- 2011. Transcriptomics of adipose tissue – Integrative search for obesity candidate genes.
Academic chapter/article/Conference paper
- 2020. Analysis of Megavariate Data in Functional Omics. 52 pages.
- 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 pages.
Abstract
- 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 1 pages.
- 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. S429-S429.
Poster
- 2019. Inhibition of serine transporter SLC7A10 promotes lipid accumulation through altered BCAA catabolism in adipocytes.
- 2019. Generation and validation of immortalized human paired subcutaneous and omental adipocyte models to study obesity.
- 2019. Adipocyte amino acid metabolism in obesity-related metabolic diseases .
- 2018. Irx5 regulates body weight via amyloid precursor protein (App) and mitochondrial respiration in adipocytes.
- 2018. Irx5 regulates body weight via amyloid precursor protein and mitochondrial respiration in adipocytes.
- 2018. Inhibition of the serine transporter SLC7A10 promotes lipid storage by limiting antioxidant capacity in adipocytes.
- 2018. Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
- 2018. Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
- 2018. Gene marker panel for omental and subcutaneous adipocytes in humans .
- 2018. ASC-1 transports serine and curbs visceral obesity.
- 2014. SLC7A10, a novel adipocyte-enriched gene with a potential role in adipocyte differentiation.
- 2014. Role of homeobox transcription factors IRX3 and IRX5 in mitochondrial development and activity in adipose tissue.
- 2014. A moderate energy-restricted very-high-fat diet reduces fat mass and improves metabolic health in abdominally obese middle-aged men.
- 2013. Role of homeobox transcription factor IRX5 in obesity and metabolic health.
- 2013. Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice.
- 2012. Candidate genes for fat regain after weight cycling in mice.
- 2012. CDKN1A associates with fat regain after weight cycling in mice.
- 2011. The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss.
- 2011. Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue.
- 2011. Differential Expression of Inflammatory and Metabolic Genes in Adipose Tissue of Patients with Primary Huperparathyroidism.
- 2011. Characterization of Global Gene Expression in Breast Cancer Cells after cAMP/PKA-mediated downregulation of Steroid Receptor Coactivator 2.
- 2010. Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity.
- 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss.
- 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery.
- 2008. cAMP/PKA Exerts Differential Effects on GRIP1- and PGC-1α-Mediated HNF-4α Transcriptional Activity in HepG2 and COS-1 Cells.
- 2008. cAMP Regulates Nuclear Receptor Coactivator GRIP1–Mediated Coactivation of HNF-4alpha in HepG2 Cells.
- 2007. Regulation of HNF-4alpha transcriptional activity by the coactivators GRIP1 and PGC-1alpha.
Academic literature review
- 2021. The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk. American Journal of Clinical Nutrition.
- 2011. Tissue-specific effects of bariatric surgery including mitochondrial function. International Journal of Obesity. 435245.
Article in business/trade/industry journal
- 2021. The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk. American Journal of Clinical Nutrition.
- 2017. Nutrition, health and chronic diseases. Indremedisineren. 16-18.
More information in national current research information system (CRIStin)
Regulatory genomics
Drug/nutrition - gene interactions
Adipocyte genes and energy metabolism
Adipose tissue function and type 2 diabetes
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