Simon E Nitter Dankel

Associate Professor

Department of Clinical Science

Hormone Laboratory Research Group

E-mailSimon.Dankel@uib.no
Visitor Address
Laboratory Building, 9th floor

Haukeland university hospital

5020 Bergen

Room
9230
Postal Address
Postboks 7804

5020 Bergen

Metabolism, nutrition, adipose tissue, type 2 diabetes, gene regulation, genetics/genomics

Journal articles

Bjune, Jan-Inge; Dyer, Laurence; Røsland, Gro Vatne; Tronstad, Karl Johan; Njølstad, Pål Rasmus; Sagen, Jørn V.; Dankel, Simon N; Mellgren, Gunnar. 2019. The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné; Fandalyuk, Zinayida; Skurk, Thomas; Hauner, Hans; Sagen, Jørn V.; Rydén, Mikael; Arner, Peter; Mellgren, Gunnar. 2019. The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 101:153999: 1-12. doi: 10.1016/j.metabol.2019.153999
Gudbrandsen, Oddrun Anita; Dankel, Simon N; Skumsnes, Lillian; Flølo, Tone Nygaard; Folkestad, Oddry H; Nielsen, Hans Jørgen; Våge, Villy; Mohn, Arne-Christian; Nedrebø, Bjørn Gunnar; Sagen, Jørn V.; Fernø, Johan; Mellgren, Gunnar. 2019. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 9:14817: 1-7. doi: 10.1038/s41598-019-51347-x
McCann, Adrian; Melvær, Giil Lasse; Ulvik, Arve; Seifert, Reinhard; Rebnord, Eirik Wilberg; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Meyer, Klaus; Strand, Elin; Dankel, Simon N; Ueland, Per Magne; Nygård, Ottar. 2019. Plasma amino acids and incident type 2 diabetes in patients with coronary artery disease. Diabetes Care. 42: 1225-1233. doi: 10.2337/dc18-2217
Ramirez, Alfred K; Dankel, Simon N; Cai, Weikang; Sakaguchi, Masaji; Kasif, Simon; Kahn, C. Ronald. 2019. Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes. Molecular Metabolism. 22: 21-36. doi: 10.1016/j.molmet.2019.01.006
Svärd, Jessica; Røst, Therese Halvorsen; Sommervoll, Camilla Elise Nergård; Haugen, Christine; Gudbrandsen, Oddrun Anita; Christensen, Anne Elisabeth; Rødahl, Eyvind; Fernø, Johan; Dankel, Simon N; Sagen, Jørn V.; Mellgren, Gunnar. 2019. Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports. 9. doi: 10.1038/s41598-018-37501-x

Bjune, Jan-Inge; Haugen, Christine; Gudbrandsen, Oddrun Anita; Nordbø, Ole Petter; Nielsen, Hans Jørgen; Våge, Villy; Njølstad, Pål Rasmus; Sagen, Jørn V.; Dankel, Simon N; Mellgren, Gunnar. 2018. IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity. doi: 10.1038/s41366-018-0275-y

Lied, Gülen Arslan; Dankel, Simon N; Gudbrandsen, Oddrun Anita. 2017. Nutrition, health and chronic diseases. Indremedisineren. 2. 16-18.
Veum, Vivian Lohmann; Laupsa-Borge, Johnny; Eng, Øyvin Andre Solberg; Rostrup, Espen; Larsen, Terje H; Nordrehaug, Jan Erik; Nygård, Ottar; Sagen, Jørn V.; Gudbrandsen, Oddrun Anita; Dankel, Simon N; Mellgren, Gunnar. 2017. Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 105: 85-99. doi: 10.3945/ajcn.115.123463

Claussnitzer, Melina; Dankel, Simon N; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S.; Beaudry, Jacqueline L.; Puviindran, Vijitha; Abdennur, Nezar A.; Liu, Jannel; Svensson, Per-Arne; Hsu, Yi-Hsiang; Drucker, Daniel J.; Mellgren, Gunnar; Hui, Chi-Chung; Hauner, Hans; Kellis, Manolis. 2015. FTO obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine. 373: 895-907. doi: 10.1056/NEJMoa1502214
Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N; Fenne, Ingvild Sveinsgjerd; Skartveit, Linn; Drangevåg, Andreas; Bozickovic, Olivera; Flågeng, Marianne Hauglid; Søiland, Håvard; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2015. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLOS ONE. 10. 19 pages. doi: 10.1371/journal.pone.0122339
McCulloch, Laura J.; Rawling, Tom J.; Sjöholm, Kajsa; Franck, Niclas; Dankel, Simon N; Price, Emily J.; Knight, Bridget; Liversedge, Neil H.; Mellgren, Gunnar; Nyström, Fredrik; Carlsson, Lena M.; Kos, Katarina. 2015. COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology. 156: 134-146. doi: 10.1210/en.2014-1042

Claussnitzer, Melina; Dankel, Simon E Nitter; Klocke, Bernward; Grallert, Harald; Glunk, Viktoria; Berulava, Tea; Lee, Heekypung; Oskolkov, Nikolay; Fadista, João; Ehlers, Kerstin; Wahl, Simone; Hoffmann, Christoph; Qian, Kun; Rönn, Tina; Riess, Helene; Müller-Nurasyid, Martina; Bretschneider, Nancy; Schroeder, Timm; Skurk, Thomas; Horsthemke, Bernhard; Spieler, Derek; Klingenspor, Martin; Seifert, Martin; Kern, Michael J.; Mejhert, Niklas; Dahlman, Ingrid; Hansson, Ola; Hauck, Stefanie M.; Blüher, Matthias; Arner, Peter; Groop, Leif; Illig, Thomas; Suhre, Karsten; Hsu, Yi-Hsiang; Mellgren, Gunnar; Hauner, Hans; Laumen, Helmut. 2014. Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 156: 343-358. doi: 10.1016/j.cell.2013.10.058
Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Borkowski, Kamil; Fjære, Even; Midtbø, Lisa Kolden; Haugen, Christine; Solsvik, Margit; Lavigne, Ann Marie; Liaset, Bjørn; Sagen, Jørn V.; Kristiansen, Karsten; Mellgren, Gunnar; Madsen, Lise. 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. 306: E210-E224. doi: 10.1152/ajpendo.00188.2013
Dankel, Simon E Nitter; Svärd, Jessica; Matthä, Simone; Claussnitzer, Melina; Klöting, Nora; Glunk, Viktoria; Fandalyuk, Zinayida; Grytten, Elise; Solsvik, Margit; Nielsen, Hans Jørgen; Busch, Christian; Hauner, Hans; Blüher, Matthias; Skurk, Thomas; Sagen, Jørn V.; Mellgren, Gunnar. 2014. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 22: 1807-1813. doi: 10.1002/oby.20758
Ussar, Siegfried; Lee, Kevin; Dankel, Simon N; Boucher, Jeremie; Haering, Max-Felix; Kleinridders, Andre; Thomou, Thomas; Xue, Ruidan; Macotela, Yazmin; Cypess, Aaron; Tseng, Yu-Hua; Mellgren, Gunnar; Kahn, C. Ronald. 2014. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine. 6. Published 2014-06-30. doi: 10.1126/scitranslmed.3008490

Fenne, Ingvild Sveinsgjerd; Helland, Thomas; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Mellgren, Gunnar; Sagen, Jørn V. 2013. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 8. 10 pages. doi: 10.1371/journal.pone.0070096
Methlie, Paal; Dankel, Simon E Nitter; Myhra, Tone Sæterdal; Christensen, Bjørn Jostein; Gjerde, Jennifer; Fadnes, Dag Jone Stokke; Våge, Villy; Løvås, Kristian; Mellgren, Gunnar. 2013. Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 21: 2495-2503. doi: 10.1002/oby.20449

Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer; Nielsen, Hans Jørgen; Solsvik, Margit Hildershavn; Haugen, Christine; Christensen, Bjørn Jostein; Hoang, Tuyen; Fadnes, Dag Jone Stokke; Busch, Christian; Våge, Villy; Sagen, Jørn V.; Mellgren, Gunnar. 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 36: 1195-1202. doi: 10.1038/ijo.2011.240

Christensen, Monika; Dankel, Simon E Nitter; Nordbø, Yngve; Varhaug, Jan Erik; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLOS ONE. 6. 10 pages. doi: 10.1371/journal.pone.0020481
Dankel, Simon E Nitter; Staalesen, Vidar; Bjørndal, Bodil; Berge, Rolf Kristian; Mellgren, Gunnar; Burri, Lena. 2011. Tissue-specific effects of bariatric surgery including mitochondrial function. International Journal of Obesity. 2011: 435245. doi: 10.1155/2011/435245

Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. 57: S429-S429.
Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 5. 12 pages. doi: 10.1371/journal.pone.0011033
Dankel, Simon E Nitter; Hoang, Tuyen; Flågeng, Marianne Hauglid; Sagen, Jørn V.; Mellgren, Gunnar. 2010. cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1803: 1013-1019. doi: 10.1016/j.bbamcr.2010.05.008
Hoang, Tuyen; Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Veum, Vivian Lohmann; Våge, Villy; Steen, Vidar Martin; Sagen, Jørn V.; Mellgren, Gunnar. 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 31. 1 pages.

Reports and theses

Dankel, Simon E Nitter. 2011. Transcriptomics of adipose tissue – Integrative search for obesity candidate genes. University of Bergen.

Dankel, Simon E Nitter. 2007. Role of cAMP/PKA in Regulation of GRIP1- and PGC1a-Mediated Coactivation of Nuclear Receptor HNF4a. 61 pages.

Dankel, Simon. 2006. Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha. Institutt for indremedisin. Universitetet i Bergen, Universitetet i Bergen. 61 pages.

Book sections

Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Hoang, Tuyen; Gjerde, Jennifer; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 2, pages 35-66. In:
- Bates, Margaret K; Kerr, Regina M. 2011. Nuclear Receptors. Nova Science Publishers, Inc.. 174 pages. ISBN: 978-1-61209-980-4.