Simon Erling Nitter Dankel

Researcher, Professor of medicine/nutritional biochemistry

E-mailSimon.Dankel@uib.no
Visitor Address
Laboratory Building, 9th floor

Haukeland university hospital

5020 Bergen

Room
9230
Postal Address
Postboks 7804

5020 Bergen

Metabolism, physiology, cell biology, organ crosstalk, nutrition, adipose tissue, obesity, type 2 diabetes, gene regulation, genetics, genomics

Academic article

Show author(s) (2022). Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy. International Journal of Obesity. 739-749.
Show author(s) (2022). Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment. International Journal of Cardiology: Cardiovascular Risk and Prevention (IJCCRP). 1-6.
Show author(s) (2022). MRI adipose tissue segmentation and quantification in R (RAdipoSeg). Diabetology and Metabolic Syndrome. 1-8.
Show author(s) (2022). Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC). Clinical Nutrition. 2345-2355.

Show author(s) (2021). The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk. American Journal of Clinical Nutrition. 277-289.
Show author(s) (2021). Serglycin Is Involved in Adipose Tissue Inflammation in Obesity. Journal of Immunology. 121-132.
Show author(s) (2021). Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes. 680-695.
Show author(s) (2021). Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 10 pages.
Show author(s) (2021). Meal patterns associated with energy intake in people with obesity. British Journal of Nutrition.
Show author(s) (2021). Hepatic Energy Metabolism Underlying Differential Lipidomic Responses to High-Carbohydrate and High-Fat Diets in Male Wistar Rats. Journal of Nutrition. 2610-2621.
Show author(s) (2021). Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Arteriosclerosis, Thrombosis and Vascular Biology. 2563-2574.
Show author(s) (2021). Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study. Clinical Nutrition. 2556-2575.
Show author(s) (2021). A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metabolism. 615-628.

Show author(s) (2020). Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity. Nature Communications. 1-9.
Show author(s) (2020). COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. Scientific Reports. 1-11.
Show author(s) (2020). A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 684-701.
Show author(s) (2020). 3-hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and brown adipocyte metabolism. Diabetes. 1903-1916.

Show author(s) (2019). The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
Show author(s) (2019). The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
Show author(s) (2019). Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
Show author(s) (2019). Plasma amino acids and incident type 2 diabetes in patients with coronary artery disease. Diabetes Care. 1225-1233.
Show author(s) (2019). Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes. Molecular Metabolism. 21-36.
Show author(s) (2019). Genredigering - eit felles ansvar. Tidsskrift for Den norske legeforening. 2 pages.
Show author(s) (2019). Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.

Show author(s) (2018). IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity.

Show author(s) (2017). Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 85-99.

Show author(s) (2015). The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLOS ONE. 19 pages.
Show author(s) (2015). FTO obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine. 895-907.
Show author(s) (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology. 134-146.

Show author(s) (2014). Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
Show author(s) (2014). Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 343-358.
Show author(s) (2014). COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
Show author(s) (2014). ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine.

Show author(s) (2013). Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 10 pages.
Show author(s) (2013). Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 2495-2503.

Show author(s) (2012). The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.

Show author(s) (2011). Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLOS ONE. 10 pages.

Show author(s) (2010). cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1013-1019.
Show author(s) (2010). Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 12 pages.

Lecture

Show author(s) (2019). Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity .

Academic lecture

Show author(s) (2022). Nedbrytningen av BCAAs i humane leverceller er assosiert med fettleversykdom.

Show author(s) (2021). Epigenetic control of adipogenesis by Irx3.
Show author(s) (2021). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver.

Show author(s) (2020). Low 3-hydroxyisobutyrate (3-HIB) and high methylmalonic acid (MMA) levels in plasma reflect increased hepatic fatty acid oxidation.

Show author(s) (2019). Inhibition of the serine transporter SLC7A10 limits antioxidant capacity and promotes lipid storage in adipocytes.
Show author(s) (2019). Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
Show author(s) (2019). A novel amino acid transporter modulating insulin resistance via adipocytes .

Show author(s) (2018). Amino acid metabolism in adipocytes.

Show author(s) (2017). Impaired amino acid transport in adipocytes promotes visceral fat storage .
Show author(s) (2017). Amino acid transport in adipocytes modulates visceral fat accumulation and diabetes risk.

Show author(s) (2014). Preadipocyte and Adipocyte Heterogeneity within a Single White Fat Depot in Humans.

Show author(s) (2012). Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism.
Show author(s) (2012). Integrative genomics links homeobox transcription factors to intra-abdominal obesity.

Show author(s) (2009). Bariatric surgery dramatically alters global gene expression in adipose tissue.

Masters thesis

Show author(s) (2019). The relationship between quality and quantity of dietary carbohydrates, SCFAs and gastrointestinal health in obesity – A randomized control dietary intervention (CARBFUNC).
Show author(s) (2019). Effects of carbohydrate quality and quantity on fecal short-chain fatty acids and symptoms of gastrointestinal health in people with obesity: a randomized controlled trial (CARBFUNC).

Show author(s) (2007). Role of cAMP/PKA in Regulation of GRIP1- and PGC1a-Mediated Coactivation of Nuclear Receptor HNF4a.

Show author(s) (2006). Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha.

Letter to the editor

Show author(s) (2021). Reply to JJ Christensen et al. American Journal of Clinical Nutrition.
Show author(s) (2021). Reply to A Laila. American Journal of Clinical Nutrition. 823-824.

Doctoral dissertation

Show author(s) (2011). Transcriptomics of adipose tissue – Integrative search for obesity candidate genes.

Academic chapter/article/Conference paper

Show author(s) (2020). Analysis of Megavariate Data in Functional Omics. 52 pages.

Show author(s) (2011). Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 pages.

Abstract

Show author(s) (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 1 pages.
Show author(s) (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. S429-S429.

Poster

Show author(s) (2022). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver.

Show author(s) (2019). Inhibition of serine transporter SLC7A10 promotes lipid accumulation through altered BCAA catabolism in adipocytes.
Show author(s) (2019). Generation and validation of immortalized human paired subcutaneous and omental adipocyte models to study obesity.
Show author(s) (2019). Adipocyte amino acid metabolism in obesity-related metabolic diseases .

Show author(s) (2018). Irx5 regulates body weight via amyloid precursor protein (App) and mitochondrial respiration in adipocytes.
Show author(s) (2018). Irx5 regulates body weight via amyloid precursor protein and mitochondrial respiration in adipocytes.
Show author(s) (2018). Inhibition of the serine transporter SLC7A10 promotes lipid storage by limiting antioxidant capacity in adipocytes.
Show author(s) (2018). Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
Show author(s) (2018). Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity.
Show author(s) (2018). Gene marker panel for omental and subcutaneous adipocytes in humans .
Show author(s) (2018). ASC-1 transports serine and curbs visceral obesity.

Show author(s) (2014). SLC7A10, a novel adipocyte-enriched gene with a potential role in adipocyte differentiation.
Show author(s) (2014). Role of homeobox transcription factors IRX3 and IRX5 in mitochondrial development and activity in adipose tissue.
Show author(s) (2014). A moderate energy-restricted very-high-fat diet reduces fat mass and improves metabolic health in abdominally obese middle-aged men.

Show author(s) (2013). Role of homeobox transcription factor IRX5 in obesity and metabolic health.
Show author(s) (2013). Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice.

Show author(s) (2012). Candidate genes for fat regain after weight cycling in mice.
Show author(s) (2012). CDKN1A associates with fat regain after weight cycling in mice.

Show author(s) (2011). The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss.
Show author(s) (2011). Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue.
Show author(s) (2011). Differential Expression of Inflammatory and Metabolic Genes in Adipose Tissue of Patients with Primary Huperparathyroidism.
Show author(s) (2011). Characterization of Global Gene Expression in Breast Cancer Cells after cAMP/PKA-mediated downregulation of Steroid Receptor Coactivator 2.

Show author(s) (2010). Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity.
Show author(s) (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss.
Show author(s) (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery.

Show author(s) (2008). cAMP/PKA Exerts Differential Effects on GRIP1- and PGC-1α-Mediated HNF-4α Transcriptional Activity in HepG2 and COS-1 Cells.
Show author(s) (2008). cAMP Regulates Nuclear Receptor Coactivator GRIP1–Mediated Coactivation of HNF-4alpha in HepG2 Cells.

Show author(s) (2007). Regulation of HNF-4alpha transcriptional activity by the coactivators GRIP1 and PGC-1alpha.

Academic literature review

Show author(s) (2022). The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance. Frontiers in Cell and Developmental Biology. 10 pages.
Show author(s) (2022). Metabolic and Epigenetic Regulation by Estrogen in Adipocytes. Frontiers in Endocrinology. 11 pages.