- Phone+47 55 97 12 62
- Visitor AddressBarne- og ungdomssjukehuset (BUS1)Haukelandsbakken 155021 BergenRoom6110, 6th floor
- Postal AddressPostboks 78045020 Bergen
Simona Chera obtained her PhD from Department of Genetics and Evolution, at the Faculty of Science, University of Geneva, in 2008, with a focus on cellular and molecular mechanisms acting in regeneration. Afterwards, she was a postdoctoral fellow in Prof. Pedro Herrera lab, characterizing the two age-dependent regenerative mechanisms involved in spontaneous murine pancreatic β-cell regeneration (Thorel et al. 2010, Nature and Chera et al. 2014, Nature). In March 2015, she moved to Bergen, as a postdoctoral fellow in Ræder lab, working on a project involving the differentiation of pancreatic β-cells from human induced pluripotent stem cells, derived from fibroblasts donated by patients with Mature Onset Diabetes of the Young (MODY). She is now an Associate Professor at the Department of Clinical Science, University of Bergen and NCMM Young Associate Investigator.
The main focus throughout her career has been the characterization of the cellular processes and molecular cues governing the balance between tissue regeneration and homeostasis. This has resulted in numerous publications.
In 2015 she received two prestigious grants: the Novo Nordisk Foundation Excellence Project for Endocrinology Research, for characterizing and reversing β-cell senescence and proliferation quiescence in monogenic diabetes; and two Young Talent Research Projects funded by the Research Council of Norway, aiming at characterizing the cellular and molecular basis of the gradual failure of insulin-producing β-cells in diabetes by using a novel in vivo strategy involving transplanted induced pluripotent stem cells (iPSCs) derived from monogenic diabetes patients (MODY patients).
- 2019. Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review. Stem Cells. doi: 10.1002/stem.3118
- 2019. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 567: 43-48. doi: 10.1038/s41586-019-0942-8
- 2018. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nature Cell Biology. 20: 1267-1277. doi: 10.1038/s41556-018-0216-y
- 2016. Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion. Current Opinion in Genetics and Development. 40: 1-10. doi: 10.1016/j.gde.2016.05.010
- 2019. The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. Frontiers in Endocrinology.
- 2019. Reprogrammed Cells Display Distinct Proteomic SignaturesAssociated with Colony Morphology Variability. Stem Cells International.
- 2019. Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells. Frontiers in Endocrinology.
- 2019. In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica.
- 2019. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 43-48.
- 2018. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nature Cell Biology. 1267-1277.
- 2018. Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLOS ONE. 1-15.
- 2017. Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. Scientific Reports. 1-14.
- 2017. Converting adult pancreatic islet α cells into β cells by targeting both Dnmt1 and Arx. Cell Metabolism. 622-634.
- 2019. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. bioRxiv - the preprint server for biology.
- 2019. Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review.
- 2016. Stress-induced adaptive islet cell identity changes. 87-96.
- 2016. Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion. 1-10.
Recent publications (last 5 years):
- Vethe H, Ghila L, Hoareau L, Bjørlykke Y, Berle M, Haaland ØA, Hoareau L, Paulo J, Scholz H, Chera S, Ræder H. “Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells” – Front. Endocrinol., 2019, 08 May doi: 10.3389/fendo.2019.00293
- Furuyama K, Chera S, van Gurp L, Damond N, Oropeza D, Ghila L, Vethe H, Paulo JA, Joosten AM, Berney T, Bosco D, Dorrel C, Grompe M, Ræder H, Roep BO, Thorel F and Herrera PL, Diabetes relief in mice by glucose-sensing insulin-secreting human a-cells, Nature 2019 567: 43–48
- Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright C, Thomas MK, Furuyama K, Chera S and Herrera PL, Pancreatic Islet-Autonomous Signals Modulate Identity Changes of Glucagon+ α-Cells, Nature Cell Biology 2018 Nov;20(11):1267-1277. doi: 10.1038/s41556-018-0216-y. PMID: 30361701
- Berle M, Ghila L, Vethe H, Chaudhry A, Garberg H, Beisland C, Haaland ØA, Oveland E, Halvorsen OJ, Davidsson T, Chera S. Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLoS One 2018 Nov 12;13(11):e0206475. doi: 10.1371/journal.pone.0206475. PMID: 30419021
- Vethe H, Bjørlykke Y, Ghila LM, Paulo JA, Scholz H, Gygi SP, Chera S, Ræder H. Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. Scientific Reports. 2017 Jul 6;7(1):4780. doi: 10.1038/s41598-017-04979-w. PMID: 28684784 Cellular and Molecular Mechanisms of Regeneration in Pancreas
- Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK. Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx, 2017 Cell Metabolism 25(3):622-634.
- Cigliola V, Thorel F, Chera S, Herrera PL. Stress-induced adaptive islet cell identity changes 2016 Diabetes Obes Metab. 2016 Sep;18 Suppl 1:87-96. doi: 10.1111/dom.12726.
- Chera S, Herrera PL. Regeneration of Pancreatic Insulin-Producing Cells by In Situ Adaptive Cell Conversion, 2016 Current Opinion in Genetics and Development 40:1-10, 10.1016/j.gde.2016.05.010
- Chera S, Baronnier-Caffé D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL. Diabetes recovery by age-dependent conversion of pancreatic δ- or α-cells into insulin producers 2014 Nature 514(7523):503-507 [Comment in Nat Rev Endocrinol. 2014: Diabetes: reprogrammed pancreatic δ-cells restore insulin production].