Spiros Kotopoulis

Associate Professor

Department of Clinical Medicine

E-mailspiros.kotopoulis@uib.no
Visitor Address
Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst

5009 Bergen
Postal Address
Postboks 7804

5020 Bergen

Publications

Academic article

Show author(s) (2023). Real-Time Intravital Imaging of Acoustic Cluster Therapy–Induced Vascular Effects in the Murine Brain. Ultrasound in Medicine and Biology.

Show author(s) (2022). Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation. Ultrasound in Medicine and Biology. 1840-1857.
Show author(s) (2022). SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma? Pharmaceutics.
Show author(s) (2022). Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability . Journal of Visualized Experiments. 20 pages.
Show author(s) (2022). Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery. Ultrasonics sonochemistry.
Show author(s) (2022). Experimental setup for the ultrasonic fractionation of flowing whole blood in a capillary. Current Directions in Biomedical Engineering (CDBME). 89-92.

Show author(s) (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. Pharmaceutics.
Show author(s) (2021). Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model. Cancer Biology & Therapy. 204-215.
Show author(s) (2021). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles. Journal of Controlled Release. 285-295.

Show author(s) (2020). Ultrasound‐ and microbubble‐assisted gemcitabine delivery to pancreatic cancer cells. Pharmaceutics. 1-15.
Show author(s) (2020). Theranostic attributes of acoustic cluster therapy and its use for enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. Frontiers in Pharmacology. 1-11.
Show author(s) (2020). Sonoporation for augmenting chemotherapy of pancreatic ductal adenocarcinoma. Methods in molecular biology. 191-205.
Show author(s) (2020). Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. Pharmaceutics. 1-17.
Show author(s) (2020). Intracellular cytidine deaminase regulates gemcitabine metabolism in pancreatic cancer cell lines. Drug Metabolism And Disposition. 153-158.

Show author(s) (2019). Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells. Pharmaceutics. 1-17.
Show author(s) (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. Proceedings - IEEE Ultrasonics Symposium. 224-226.

Show author(s) (2017). Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. Journal of Controlled Release. 70-80.
Show author(s) (2017). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. Ultrasound in Obstetrics and Gynecology. 236-241.

Show author(s) (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. Journal of the Acoustical Society of America. 2092-2092.
Show author(s) (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: A phase I clinical trial. Journal of the Acoustical Society of America.
Show author(s) (2016). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. Ultrasound in Obstetrics and Gynecology. 236-241.
Show author(s) (2016). Harmonic antibubbles. Archives of Acoustics. 364-364.
Show author(s) (2016). Glass-windowed ultrasound transducers. Ultrasonics. 108-119.
Show author(s) (2016). A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. Journal of Controlled Release. 172-181.

Show author(s) (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. Lecture Notes in Engineering and Computer Science. 750-754.
Show author(s) (2015). Open source, high throughput, ultrasound treatment chamber. Biomedizinische Technik. 77-87.
Show author(s) (2015). Nonlinear echoes from encapsulated antibubbles. Physics Procedia. 1079-1082.
Show author(s) (2015). Acoustically active antibubbles. Acta Physica Polonica. A. 99-102.

Show author(s) (2014). Transparent glass-windowed ultrasound transducers. IEEE International Ultrasonics Symposium Proceedings. 2079-2082.
Show author(s) (2014). Sonoporation: from the lab to human clinical trials. IEEE International Ultrasonics Symposium Proceedings. 846-849.
Show author(s) (2014). Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft. Molecular Imaging and Biology. 53-62.
Show author(s) (2014). Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes. IEEE International Ultrasonics Symposium Proceedings. 1186-1190.
Show author(s) (2014). Acoustic filtering of particles in a flow regime. IEEE International Ultrasonics Symposium Proceedings. 1436-1439.

Show author(s) (2013). Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study. Medical Physics (Lancaster).
Show author(s) (2013). Lab-on-a-chip device for fabrication of therapeutic microbubbles on demand. Biomedizinische Technik. 2 pages.
Show author(s) (2013). High-quality 3D visualization of in-situ ultrasonography. Eurographics. 1-4.

Show author(s) (2012). Real-time sonoporation through HeLa cells. AIP Conference Proceedings. 272-275.
Show author(s) (2012). High-frequency transducer for MR-guided FUS. Biomedizinische Technik.

Show author(s) (2011). Ultrasound and microbubbles assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype. Journal of Controlled Release. 223-230.
Show author(s) (2011). Sonoporation at a low mechanical index. Bubble Science, Engineering and Technology. 3-11.
Show author(s) (2011). Sonoporation at a low MI. Ultrasound in Medicine and Biology. S61-S61.
Show author(s) (2011). Lithium niobate transducers for MRI-guided ultrasonic microsurgery. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. 1570-1576.
Show author(s) (2011). Laser-nucleated acoustic cavitation in focused ultrasound. Review of Scientific Instruments. 9 pages.

Show author(s) (2010). Microfoam formation in a capillary. Ultrasonics. 260-268.
Show author(s) (2010). Lithium niobate ultrasound transducers for high-resolution focused ultrasound surgery. IEEE International Ultrasonics Symposium Proceedings. 72-75.

Show author(s) (2009). Sonic cracking of blue-green algae. Applied Acoustics. 1306-1312.

Show author(s) (2008). Safety radius for algae eradication at 200 kHz - 2.5 MHz. IEEE International Ultrasonics Symposium Proceedings. 1706-1709.

Lecture

Show author(s) (2019). Sonoporation and gemcitabine delivery in pancreatic cancer cell lines.

Academic lecture

Show author(s) (2022). Real-time intravital imaging of the vascular effects induced by Acoustic Cluster Therapy (ACT®) in a murine brain.

Show author(s) (2021). Acoustic Cluster Therapy (ACT®) enhances extravasation and parenchymal accumulation of core-crosslinked polymeric micelles in the brain.

Show author(s) (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.

Editorial

Show author(s) (2012). Sonoporation: why microbubbles create pores. Ultraschall in der Medizin. 97-98.

Reference material

Show author(s) (2012). Micro-acoustics in marine and medical research.

Academic chapter/article/Conference paper

Show author(s) (2021). Sonoporation in pancreatic cancer (PDAC). 3 pages.

Show author(s) (2015). Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. 2 pages.
Show author(s) (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. 5 pages.
Show author(s) (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume. 1 pages.
Show author(s) (2015). Novel multipurpose, low cost, modular, ultrasound transducers. 2 pages.
Show author(s) (2015). Introduction to antibubbles. 6 pages.
Show author(s) (2015). Antibubbles. 1 pages.
Show author(s) (2015). Active leakage detection by searching for antibubbles. 2 pages.

Show author(s) (2014). Acoustically active antibubbles for ultrasound imaging and targeted drug delivery. 1 pages.

Show author(s) (2013). Using ultrasound to separate oil, gas, and water. 6 pages.
Show author(s) (2013). Ultrasound-assisted treatment of an inoperable pancreatic cancer. 4 pages.
Show author(s) (2013). Ultrasound combined with microbubbles modulates signal transduction pathways in blood cells. 2 pages.
Show author(s) (2013). Ultrasound and microbubble enhanced therapy of orthotopic human pancreatic cancer in mice. 3 pages.
Show author(s) (2013). Sonoporation: the hurdles that need to be surpassed. 2 pages.

Show author(s) (2012). Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism. 12 pages.
Show author(s) (2012). Sonoporation: using ultrasound for targeted drug delivery. 3 pages.
Show author(s) (2012). Real-time sonoporation through HeLa cells. 4 pages.
Show author(s) (2012). Nonlinear microbubble behaviour for enhanced drug uptake. 6 pages.
Show author(s) (2012). Microbubbles and cell interactions. 2 pages.
Show author(s) (2012). Hybrid laser-ultrasound cavitation for cloud evolution studies. 10 pages.
Show author(s) (2012). Flow cytometic characterization and sorting of ultrasound contrast agents. 13 pages.
Show author(s) (2012). Biological and medical applications of low-intensity ultrasound. 39 pages.
Show author(s) (2012). Basic Principles: Basic physical principles of medical ultrasound. 18 pages.

Show author(s) (2011). Ultrasound-guided delivery and sonoporation. 3 pages.
Show author(s) (2011). Ultrasound transducers made with lithium niobate for HF HIFU. 2 pages.
Show author(s) (2011). On cells and sound. 6 pages.
Show author(s) (2011). Investigations of microbubble-cell interactions during the sonoporation process. 7 pages.
Show author(s) (2011). Cell-microbubble interaction and intracellular fate of plasmid DNA and microbubbles during the sonoporation process. 2 pages.
Show author(s) (2011). Cancer cell sonoporation at low acoustic amplitudes. 8 pages.
Show author(s) (2011). Biomedical ultrasonics, cavitation, and sonoporation. 2 pages.

Show author(s) (2010). Forming morphing microfoam. 4 pages.

Other

Show author(s) (2014). Ultrasound transducers with an optical window. 36-36.

Abstract

Show author(s) (2016). Ultrasound and microbubble enhanced treatment of inoperable pancreatic adeonocarcinoma. Journal of Clinical Oncology.

Show author(s) (2015). Ultrasound sonoporation in pancreatic adenocarcinoma. Ultrasound in Medicine and Biology. S94-S94.

Show author(s) (2013). High-speed photography of encapsulated microbubbles. Abstract of Papers of the American Chemical Society. 1 pages.

Show author(s) (2011). Therapeutic ultrasound and sonoporation. Biomedizinische Technik. 1 pages.

Poster

Show author(s) (2022). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles.

Show author(s) (2019). role of intracellular cytidine deaminase activity for gemcitabine metabolism in pancreatic cancer cell lines.
Show author(s) (2019). in vitro optimisation of sonoporation conditions in pancreatic cancer.
Show author(s) (2019). Sonoporation and gemcitabine delivery in pancreatic cell lines.
Show author(s) (2019). Sonoporation and gemcitabine delivery in pancreatic cancer cell lines.
Show author(s) (2019). Molecular mechanisms of sonoporation in pancreatic ductal adenocarcinoma (PDAC).
Show author(s) (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines.
Show author(s) (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines.
Show author(s) (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice.