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Stein Ove Døskeland's picture

Stein Ove Døskeland

Professor, Professor emeritus
  • E-mailStein.Doskeland@uib.no
  • Phone+47 55 58 63 76
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • 2020. Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia. Cancers.
  • 2020. Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiologica.
  • 2019. Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia. bioRxiv - the preprint server for biology.
  • 2019. Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. 1-17.
  • 2019. Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis . eLIFE.
  • 2019. A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 567-578.
  • 2018. Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome. International Journal of Molecular Sciences. 1-11.
  • 2018. Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. International Journal of Molecular Sciences. 1-21.
  • 2018. Epac1−/− mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast‐enhanced magnetic resonance imaging with contrast agents of different molecular weights. Acta Physiologica. 1-14.
  • 2018. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of enzyme inhibition and medicinal chemistry (Print). 370-375.
  • 2018. Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLOS ONE.
  • 2017. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 2285-2293.
  • 2017. Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 441-452.
  • 2017. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
  • 2016. Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutrition & Metabolism. 1-11.
  • 2015. cAMP-dependent Protein Kinase A (PKA) - Mediated c-Myc degradation is dependent on the relative proportion of PKA-I and PKA-II isozymes. Molecular Pharmacology. 469-476.
  • 2015. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 7313-7323.
  • 2015. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of enzyme inhibition and medicinal chemistry (Print). 180-188.
  • 2015. B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. Journal of Clinical Investigation. 3051-3062.
  • 2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
  • 2014. Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. Proteomics. 1971-1976.
  • 2014. New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 108-115.
  • 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
  • 2014. Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics.
  • 2014. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 2036-2053.
  • 2014. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
  • 2014. 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 2646-2655.
  • 2013. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
  • 2013. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
  • 2013. Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer.
  • 2013. DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PLOS ONE. 12 pages.
  • 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
  • 2013. Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid-induced maturation of acute promyelocytic leukemia cells. Molecular Pharmacology. 1057-1065.
  • 2012. The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 3000-3009.
  • 2012. Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLOS ONE.
  • 2012. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PLOS ONE. 11 pages.
  • 2011. The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLOS ONE. 10 pages.
  • 2011. The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 489-501.
  • 2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
  • 2011. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
  • 2011. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death and Differentiation. 11 pages.
  • 2010. UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity. PLOS ONE. 13 pages.
  • 2010. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2659-2672.
  • 2010. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
  • 2010. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry. 14062-14070.
  • 2010. A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem. 1594-1599.
  • 2009. POSTMan (POST-translational modification analysis), a software application for PTM discovery. Proteomics. 1400-1406.
  • 2009. Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
  • 2009. Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. Journal of Proteomics & Bioinformatics. 244-245.
  • 2009. Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
  • 2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
  • 2008. cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. Journal of Biological Chemistry. 7196-7205.
  • 2008. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Molecular and Cellular Biology. 3804-3816.
  • 2008. Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. Journal of Biological Chemistry. 22723-22736.
  • 2008. Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. Blood. 2866-2877.
  • 2007. LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Molecular Cancer.
  • 2007. Cyclic adenosine 3 ',5 '-monophosphate(cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells. Endocrinology. 4612-4622.
  • 2006. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 21500-21511.
  • 2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
  • 2005. Substrate enhances the sensitivity of type I protein kinase a to cAMP. Journal of Biological Chemistry. 13279-13284.
  • 2005. Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 294-306.
  • 2005. A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 252-260.
  • 2004. cAMP protects neutrophils against TNF?-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). Journal of Leukocyte Biology. 641-647.
  • 2004. Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. Blood. 2775-2782.
  • 2004. Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia. 1989-1996.
  • 2003. cAMP effector mechanisms. Novel twists for an "old" signaling system. FEBS Letters. 121-126.
  • 2003. cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. Journal of Biological Chemistry. 35394-35402.
  • 2003. Search for new cyclic AMP-binding proteins. FEBS Letters. 103-107.
  • 2003. Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells. Chemistry and Biology. 609-618.
  • 2003. Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. Journal of Biological Chemistry. 38548-38556.
  • 2003. Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Molecular Biology of the Cell. 3292-3304.
  • 2002. Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 197-210.
  • 2002. Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. Journal of Biological Chemistry. 2804-2811.
  • 2002. Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses. Journal of Hematotherapy & Stem Cell Research. 469-481.
  • 2002. A Novel Extraneuronal Role for Cylin-dependent Protein Kinase 5 (CDK5), Modulation of cAMP-induced apoptosis in rat leukemia cells. Journal of Biological Chemistry. 20783-20793.
  • 2001. Establishment of okadaic acid resistant cell clones using a cDNA expression library. Cell Death and Differentiation. 754-766.
  • 2001. Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environmental Toxicology. 225-233.
  • 2001. Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. International Journal of Occupational Medicine and Environmental Health. 335-344.
  • 2001. Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 139-140.
  • 2000. Membrane permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorganic & Medicinal Chemistry Letters. 571-573.
  • 2000. Ectopic expression of Bcl-2 switches over nuclear signalling for cAMP-inducd apoptosis to granulocytic differentiation. Cell Death and Differentiation. 1081-1089.
  • 2000. Apoptosemekanismen - mulige vinklinger for kreftbehandling. Tidsskrift for Den norske legeforening. 61.
  • 2000. An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon. 347-360.
  • 2000. 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry. 8803-8812.
  • 1999. cAMP induces co-translational modification of proteins in IPC-81 cells. Biochemical Journal. 369-377.
  • 1999. Ultrarapid apoptosis inducted by phosphatase inhibitors. Cell Death Differ. Cell Death and Differentiation. 1099-1108.
  • 1999. An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon. 347-360.
  • 1998. Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon. 1101-1114.
  • 1998. Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation. 660-668.
  • 1998. A number of morphologically distinct types of regulated (apoptotic) cell death can be induced in leukemia cells, depending on the nature and intens the death-inducing agent. (invited review). Scanning microscopy.
  • 1997. Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 43-45.
  • 1997. Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 4373-4383.
  • 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • 1997. Fas/APO-1 (CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP. Biochemical and Biophysical Research Communications - BBRC. 20-25.
  • 1996. Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis. Experientia. 963-967.
  • 1994. Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cells. Proc Nat Acad Sci U S A Biol Sci. 8428-8432.
  • 1994. Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. Journal of Cell Science, Supplement. 3363-3377.
  • 1994. Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 834-840.
  • 1994. Apoptotic Cell Death analyzed at the molecular level by two-dimensional gel electrophoresis. Electrophoresis. 503-510.
  • 1994. (Rp)- and (Sp)-8-pideridino-cAMP@<S@> discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase type I and II. European Journal of Biochemistry (EJB). 1089-1094.
  • 1994. (Rp)- and (Sp)-8-pideridino 3', 5'-(cyclic)thiophosphates discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase typeI and II. European Journal of Biochemistry (EJB). 1089-1094.
  • 1993. The genetic subtypes of cAMP-dependent protein kinase - functionally different or redundant? Biochimica et Biophysica Acta. 249-258.
  • 1993. Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis. FEBS Letters. 16-20.
  • 1993. Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemic (IPC-81) cells. Exp Cell Res. 157-161.
  • 1993. Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 293-301.
  • 1993. Exogenous substrate stimulate autodephosphorylation of cyclic-AMP-dependent protein kinase II. Biochemical Journal. 497-503.
  • 1993. Elevated cAMP gives short-term inhibition and long-term stimulation of hepatocyte DNA replication: Roles of the cAMP-dependent protein kinase subunits. Journal of Cellular Physiology. 160-170.
  • 1993. Apoptotisk celledød. NBS-nytt. 6-12.
  • 1993. Anti-apoptotic effect of heterozygously expressed mutant RI (Ala%3%3%6 ->Asp) subunit of cAMP-kinase I in a rat leukaemia cell line. Journal of Biological Chemistry. 8332-8340.
  • 1992. cAmp-dependent protein kinase type I mediates the inhibitory effects of cAMP on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • 1992. Phenylatanine modulates positively the cAMP-dependant phosphorylation and modulates negatively the vasopressin-and okadeic acid-induced phosphorylation of phenylalanine 4-monoxygenase in intact rat hepatocytes. European Journal of Biochemistry (EJB). 161-170.
  • 1992. Phenylalanine modulates differently the phosphorylation of phenylalanine 4-monooxygenase in intact rat hepatocytes exposed to cAMP and Ca2+-elevating agents. European Journal of Biochemistry (EJB). 161-170.
  • 1992. Differential expression of cAMPkinase subunits is correlated with growth in rat mammary carcinmas and uterus. British Journal of Cancer. 1022-1029.
  • 1992. Derivatives of 1-_b-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimick the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'phosphate (cGMP). Carbohydrate Research. 217-235.
  • 1992. Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • 1991. The protein phosphatase inhibator okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Experimental Cell Research. 237-246.
  • 1991. Supramolecular complexes of cAMP-dependent protein kinase isozymes in bovine adrenal cortex and medulla. Biochemical Society Transactions. 1163-1165.
  • 1991. Restricted effusion of the type 2 isoform of cAMP dependent protein kinase in rat hepatocytes permabilized by digitonin. Biochemical Society Transactions. 1161-1162.
  • 1991. Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. Journal of Cellular Physiology. 73-80.
  • 1991. Mutations that alter the charge of type I regulatory subunit and modify activation properties of cAMP-kinase from S49-mouse lymphoma cells. Journal of Biological Chemistry. 3547-3553.
  • 1991. Hormonial activation of gene transcription in rat-transformed NIH 3T3 cells overexpressing the R2a and R2b subunits of the cAMP dependent protein kinase. Journal of Biological Chemistry. 23074-23082.
  • 1991. High-molecular-mass complexes of the regulatory subunits of cyclic AMP-dependent protein kinase. Biochemical Society Transactions. 1163-1165.
  • 1988. Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth. Proceedings of the National Academy of Sciences of the United States of America. 6319-6233.
Popular scientific lecture
  • 2002. Bioprospektering.
  • 2002. Apoptose - kommersielle aspekter.
Academic lecture
  • 2009. SMALL-RING MACROLACTAMS WITH ACYL SIDE CHAIN: NEW INSIGHTS INTO THE BIOSYNTHESIS AND ITS EVOLUTION.
  • 2004. cAMP protects neutrophils against TNFa-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • 2004. Development of a sensitive PP2A binding assay for microcystin and nodularin.
  • 2003. cAMP-dependent protein kinase signaling. A potential drug target.
  • 2003. cAMP induced protein phosphorylation in acute myelogenous leukemia cells.
  • 2003. cAMP effector mechanisms. Novel twists for an "old" signalling system.
  • 2003. Proteomics. Possibilities and role of PROBE unit.
  • 2003. Protein kinases involved in leukemia cell apoptosis.
  • 2003. PROBE. Progress report and visions for proteomics.
  • 2003. Identification of phosphorylated targets in ultrarapidly induced apoptosis.
  • 2003. Apoptosisd methodology. Clinical aspects.
  • 2003. Apoptosis. mechanistic and clinical aspects.
  • 2002. cAMP signalling related to apoptosis.
  • 2002. cAMP protects neutrophils against TNF_-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • 2002. cAMP and okadaic acid induced apoptosis.
  • 2002. The cAMP-binding site of EPAC-1.
  • 2002. Regulated cell death.
  • 2002. New apoptosis-modulating substances from marine microalgae.
  • 2002. Cyclin-dependent protein kinases and cell death.
  • 2002. Cell death induced by natural compounds. The significance of distinct phenotypes.
  • 2002. Bioactive compounds from cyanobacteria.
  • 2002. Apoptose. Klinisk relevans og metodikk.
  • 2001. Use of retroviral expression in the elucidation of PKA in cell signaling and apoptosis pathways.
  • 2001. Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • 2001. Cell death in HeLa cells.
  • 2001. 3-Thia fatty acid induces mitochondrial alterations and triggers apoptosis in cancer cells.
  • 1998. Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
  • 1998. Membranpermeable und bioaktivierbare Analoga von cGMP als Aktivatoren von Apoptosis in IPC-81 Leukämiezellen,.
  • 1998. Marine cyanobacteria as a source for bioactive (apoptosis-modifying) compounds with potential as cell biology reagents and drugs.
  • 1998. Distinct apoptotic death forms. Distinct pathways and functions?
  • 1993. Signal-induced Apoptosis in Myeloid Leukemia. Apoptosis or Programmed Cell Death. From Basic Research to Clinical Application.
  • 1993. "Cyclic AMP dependent protein kinase and phosphatase inhibitors induces different phenotypic forms of cell death.".
  • 1989. Characterization and hormonal regulation of cAMP-dependent protein kinase in rat Sertoli cells.
Feature article
  • 1999. cAMP inhibits translation by inducing Ca2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells. FEBS Letters. 97-101.
  • 1998. Injected cytochrome c induces apoptosis. Nature. 449-450.
Doctoral dissertation
  • 2017. Exchange Proteins directly Activated by cAMP (Epac): Physiological roles and Regulation of expression .
  • 2015. Cell death induction by free and encapsulated cancer drug candidates.
  • 2007. New lessons from an "old" drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia.
  • 1980. Binding proteins for cyclic AmP in mammalian tissues : some aspects of their interaction with cyclic AMP and their use in competitive binding assays for cyclic AMP.
Interview
  • 2002. Giftalger tar livet av kreftceller.
  • 2002. Celledødsbødler fra havet.
  • 2002. "Nobelprisen i Medisin 2002".
Academic chapter/article/Conference paper
  • 2009. Cyclic nucleotide analogs.
  • 2007. Serine/Threonine Protein Phosphatases in Apoptosis. 16 pages.
  • 2004. Cyclic Nucleotide Analogs as Tools to investigate Cyclic Nucleotide Signalling. 6 pages.
  • 1996. Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate.
  • 1991. Criteria used to judge that a cellular response is mediated by cAMP. 12 pages.
Abstract
  • 2013. Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 322-322.
  • 2012. Microvascular permeability in the absence of Epac1 activity. The FASEB Journal. 1 pages.
  • 2008. Cyclic nucleotide analogs as probes for signaling pathways. Naunyn-Schmiedeberg's Archives of Pharmacology. 31-31.
  • 2006. Camp-dependent protein kinase. European Journal of Pharmaceutical Sciences. S4-S5.
  • 2006. A staurosporine story: Indolocarbazole orthoamides and fluorinated analogs of LY333531. European Journal of Pharmaceutical Sciences. S3-S3.
  • 2006. 14-3-3 proteins as substrates for cAMP-dependent protein kinase. European Journal of Pharmaceutical Sciences. S27-S27.
Poster
  • 2010. Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3.
  • 2009. The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
  • 2007. Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets.
  • 2003. Myeloid leukemia cell differentiation by bcl-2 and camp involves induction of ccaat/enhancer binding protein ? (c/ebp?), nuclear accumulation of c/ebp?, and direct interaction between bcl-2 and c/ebp?
  • 2003. Differential Expression of Splicing factor SR proteins and Their phosphorylation in Cell Stress leading to Apoptosis.
  • 2002. Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins- Development of a sensitive in vitro assay.
  • 2002. Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins - development of a sensitive in vitro bioassay.
  • 2002. Phosphorylated targets in ultrarapidly induced apoptosis.
  • 2002. Effects of a new bioactive substance from a marine microalga on mammalian cells.
  • 2002. Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase. Development of a new compound selective for EPAC 1 activation.
  • 2002. Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase.
  • 2001. TWO NOVEL APOPTOSIS-MODULATION SUBSTANCES ISOLATED FROM MARINE MICRO-ALGAE.
  • 2001. New apoptosis-modulating substances from marine microalgae.
  • 2001. Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • 2001. Differential Affinities of C-subunit Isozymes of the cAMP-Dependent Protein Kinase for Pseudosubstrates and Substrates.
  • 2001. Development of a sensitive in vitro bioassay for diarrhetic shellfish poisoning (DSP) toxins.
  • 2001. Comparison of the cAMP binding sites of EPAC-1 and cAMP kinase.
  • 1997. Detedtion of toxins from marine cyanobacteria based on their affinity for protein phosphatase 2A and their ability to induce apoptosis in salmon hepatocytes.
  • 1993. Morphometrical and morphological characterization of cell death induced by cAMP dependent protein kinase in rat myeloid leukemia cell line.
Academic literature review
  • 2015. Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. 6505-6520.
  • 2011. The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. 1393-1405.
  • 2011. The 14-3-3 proteins in regulation of cellular metabolism. 713-719.

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