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Stein Ove Døskeland's picture

Stein Ove Døskeland

Professor Emeritus, Professor emeritus
  • E-mailStein.Doskeland@uib.no
  • Phone+47 55 58 63 76
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) 2021. New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells. RSC Medicinal Chemistry. 767-778.
  • Show author(s) 2020. The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles. Cancers. 1-13.
  • Show author(s) 2020. Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia. Cancers.
  • Show author(s) 2020. Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiologica.
  • Show author(s) 2020. Epac1 is crucial for maintenance of endothelial barrier function through a mechanism partly independent og Rac1. Cells.
  • Show author(s) 2019. Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia. bioRxiv - the preprint server for biology.
  • Show author(s) 2019. Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. 1-17.
  • Show author(s) 2019. Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis . eLIFE.
  • Show author(s) 2019. A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 567-578.
  • Show author(s) 2018. Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome. International Journal of Molecular Sciences. 1-11.
  • Show author(s) 2018. Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. International Journal of Molecular Sciences. 1-21.
  • Show author(s) 2018. Epac1−/− mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast‐enhanced magnetic resonance imaging with contrast agents of different molecular weights. Acta Physiologica. 1-14.
  • Show author(s) 2018. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of Enzyme Inhibition and Medicinal Chemistry. 370-375.
  • Show author(s) 2018. Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLOS ONE.
  • Show author(s) 2017. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 2285-2293.
  • Show author(s) 2017. Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 441-452.
  • Show author(s) 2017. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
  • Show author(s) 2016. Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutrition & Metabolism. 1-11.
  • Show author(s) 2015. cAMP-dependent Protein Kinase A (PKA) - Mediated c-Myc degradation is dependent on the relative proportion of PKA-I and PKA-II isozymes. Molecular Pharmacology. 469-476.
  • Show author(s) 2015. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 7313-7323.
  • Show author(s) 2015. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of Enzyme Inhibition and Medicinal Chemistry. 180-188.
  • Show author(s) 2015. B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. Journal of Clinical Investigation. 3051-3062.
  • Show author(s) 2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
  • Show author(s) 2014. Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. Proteomics. 1971-1976.
  • Show author(s) 2014. New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 108-115.
  • Show author(s) 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
  • Show author(s) 2014. Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics.
  • Show author(s) 2014. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 2036-2053.
  • Show author(s) 2014. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
  • Show author(s) 2014. 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 2646-2655.
  • Show author(s) 2013. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
  • Show author(s) 2013. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
  • Show author(s) 2013. Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer.
  • Show author(s) 2013. DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PLOS ONE. 12 pages.
  • Show author(s) 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
  • Show author(s) 2013. Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid-induced maturation of acute promyelocytic leukemia cells. Molecular Pharmacology. 1057-1065.
  • Show author(s) 2012. The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 3000-3009.
  • Show author(s) 2012. Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLOS ONE.
  • Show author(s) 2012. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PLOS ONE. 11 pages.
  • Show author(s) 2011. The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLOS ONE. 10 pages.
  • Show author(s) 2011. The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 489-501.
  • Show author(s) 2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
  • Show author(s) 2011. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
  • Show author(s) 2011. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death and Differentiation. 11 pages.
  • Show author(s) 2010. UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity. PLOS ONE. 13 pages.
  • Show author(s) 2010. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2659-2672.
  • Show author(s) 2010. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
  • Show author(s) 2010. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry. 14062-14070.
  • Show author(s) 2010. A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem. 1594-1599.
  • Show author(s) 2009. POSTMan (POST-translational modification analysis), a software application for PTM discovery. Proteomics. 1400-1406.
  • Show author(s) 2009. Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
  • Show author(s) 2009. Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. Journal of Proteomics & Bioinformatics. 244-245.
  • Show author(s) 2009. Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
  • Show author(s) 2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
  • Show author(s) 2008. cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. Journal of Biological Chemistry. 7196-7205.
  • Show author(s) 2008. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Molecular and Cellular Biology. 3804-3816.
  • Show author(s) 2008. Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. Journal of Biological Chemistry. 22723-22736.
  • Show author(s) 2008. Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. Blood. 2866-2877.
  • Show author(s) 2007. LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Molecular Cancer.
  • Show author(s) 2007. Cyclic adenosine 3 ',5 '-monophosphate(cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells. Endocrinology. 4612-4622.
  • Show author(s) 2006. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 21500-21511.
  • Show author(s) 2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
  • Show author(s) 2005. Substrate enhances the sensitivity of type I protein kinase a to cAMP. Journal of Biological Chemistry. 13279-13284.
  • Show author(s) 2005. Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 294-306.
  • Show author(s) 2005. A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 252-260.
  • Show author(s) 2004. cAMP protects neutrophils against TNF?-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). Journal of Leukocyte Biology. 641-647.
  • Show author(s) 2004. Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. Blood. 2775-2782.
  • Show author(s) 2004. Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia. 1989-1996.
  • Show author(s) 2003. cAMP effector mechanisms. Novel twists for an "old" signaling system. FEBS Letters. 121-126.
  • Show author(s) 2003. cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. Journal of Biological Chemistry. 35394-35402.
  • Show author(s) 2003. Search for new cyclic AMP-binding proteins. FEBS Letters. 103-107.
  • Show author(s) 2003. Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells. Chemistry and Biology. 609-618.
  • Show author(s) 2003. Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. Journal of Biological Chemistry. 38548-38556.
  • Show author(s) 2003. Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Molecular Biology of the Cell. 3292-3304.
  • Show author(s) 2002. Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 197-210.
  • Show author(s) 2002. Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. Journal of Biological Chemistry. 2804-2811.
  • Show author(s) 2002. Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses. Journal of Hematotherapy & Stem Cell Research. 469-481.
  • Show author(s) 2002. A Novel Extraneuronal Role for Cylin-dependent Protein Kinase 5 (CDK5), Modulation of cAMP-induced apoptosis in rat leukemia cells. Journal of Biological Chemistry. 20783-20793.
  • Show author(s) 2001. Establishment of okadaic acid resistant cell clones using a cDNA expression library. Cell Death and Differentiation. 754-766.
  • Show author(s) 2001. Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environmental Toxicology. 225-233.
  • Show author(s) 2001. Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. International Journal of Occupational Medicine and Environmental Health. 335-344.
  • Show author(s) 2001. Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 139-140.
  • Show author(s) 2000. Membrane permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorganic & Medicinal Chemistry Letters. 571-573.
  • Show author(s) 2000. Ectopic expression of Bcl-2 switches over nuclear signalling for cAMP-inducd apoptosis to granulocytic differentiation. Cell Death and Differentiation. 1081-1089.
  • Show author(s) 2000. Apoptosemekanismen - mulige vinklinger for kreftbehandling. Tidsskrift for Den norske legeforening. 61.
  • Show author(s) 2000. An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon. 347-360.
  • Show author(s) 2000. 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry. 8803-8812.
  • Show author(s) 1999. cAMP induces co-translational modification of proteins in IPC-81 cells. Biochemical Journal. 369-377.
  • Show author(s) 1999. Ultrarapid apoptosis inducted by phosphatase inhibitors. Cell Death Differ. Cell Death and Differentiation. 1099-1108.
  • Show author(s) 1999. An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon. 347-360.
  • Show author(s) 1998. Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon. 1101-1114.
  • Show author(s) 1998. Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation. 660-668.
  • Show author(s) 1998. A number of morphologically distinct types of regulated (apoptotic) cell death can be induced in leukemia cells, depending on the nature and intens the death-inducing agent. (invited review). Scanning microscopy.
  • Show author(s) 1997. Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 43-45.
  • Show author(s) 1997. Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 4373-4383.
  • Show author(s) 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • Show author(s) 1997. Fas/APO-1 (CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP. Biochemical and Biophysical Research Communications - BBRC. 20-25.
  • Show author(s) 1996. Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis. Experientia. 963-967.
  • Show author(s) 1994. Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cells. Proc Nat Acad Sci U S A Biol Sci. 8428-8432.
  • Show author(s) 1994. Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. Journal of Cell Science, Supplement. 3363-3377.
  • Show author(s) 1994. Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 834-840.
  • Show author(s) 1994. Apoptotic Cell Death analyzed at the molecular level by two-dimensional gel electrophoresis. Electrophoresis. 503-510.
  • Show author(s) 1994. (Rp)- and (Sp)-8-pideridino-cAMP@<S@> discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase type I and II. European Journal of Biochemistry (EJB). 1089-1094.
  • Show author(s) 1994. (Rp)- and (Sp)-8-pideridino 3', 5'-(cyclic)thiophosphates discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase typeI and II. European Journal of Biochemistry (EJB). 1089-1094.
  • Show author(s) 1993. The genetic subtypes of cAMP-dependent protein kinase - functionally different or redundant? Biochimica et Biophysica Acta. 249-258.
  • Show author(s) 1993. Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis. FEBS Letters. 16-20.
  • Show author(s) 1993. Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemic (IPC-81) cells. Exp Cell Res. 157-161.
  • Show author(s) 1993. Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 293-301.
  • Show author(s) 1993. Exogenous substrate stimulate autodephosphorylation of cyclic-AMP-dependent protein kinase II. Biochemical Journal. 497-503.
  • Show author(s) 1993. Elevated cAMP gives short-term inhibition and long-term stimulation of hepatocyte DNA replication: Roles of the cAMP-dependent protein kinase subunits. Journal of Cellular Physiology. 160-170.
  • Show author(s) 1993. Apoptotisk celledød. NBS-nytt. 6-12.
  • Show author(s) 1993. Anti-apoptotic effect of heterozygously expressed mutant RI (Ala%3%3%6 ->Asp) subunit of cAMP-kinase I in a rat leukaemia cell line. Journal of Biological Chemistry. 8332-8340.
  • Show author(s) 1992. cAmp-dependent protein kinase type I mediates the inhibitory effects of cAMP on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • Show author(s) 1992. Phenylatanine modulates positively the cAMP-dependant phosphorylation and modulates negatively the vasopressin-and okadeic acid-induced phosphorylation of phenylalanine 4-monoxygenase in intact rat hepatocytes. European Journal of Biochemistry (EJB). 161-170.
  • Show author(s) 1992. Phenylalanine modulates differently the phosphorylation of phenylalanine 4-monooxygenase in intact rat hepatocytes exposed to cAMP and Ca2+-elevating agents. European Journal of Biochemistry (EJB). 161-170.
  • Show author(s) 1992. Differential expression of cAMPkinase subunits is correlated with growth in rat mammary carcinmas and uterus. British Journal of Cancer. 1022-1029.
  • Show author(s) 1992. Derivatives of 1-_b-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimick the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'phosphate (cGMP). Carbohydrate Research. 217-235.
  • Show author(s) 1992. Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • Show author(s) 1991. The protein phosphatase inhibator okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Experimental Cell Research. 237-246.
  • Show author(s) 1991. Supramolecular complexes of cAMP-dependent protein kinase isozymes in bovine adrenal cortex and medulla. Biochemical Society Transactions. 1163-1165.
  • Show author(s) 1991. Restricted effusion of the type 2 isoform of cAMP dependent protein kinase in rat hepatocytes permabilized by digitonin. Biochemical Society Transactions. 1161-1162.
  • Show author(s) 1991. Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. Journal of Cellular Physiology. 73-80.
  • Show author(s) 1991. Mutations that alter the charge of type I regulatory subunit and modify activation properties of cAMP-kinase from S49-mouse lymphoma cells. Journal of Biological Chemistry. 3547-3553.
  • Show author(s) 1991. Hormonial activation of gene transcription in rat-transformed NIH 3T3 cells overexpressing the R2a and R2b subunits of the cAMP dependent protein kinase. Journal of Biological Chemistry. 23074-23082.
  • Show author(s) 1991. High-molecular-mass complexes of the regulatory subunits of cyclic AMP-dependent protein kinase. Biochemical Society Transactions. 1163-1165.
  • Show author(s) 1988. Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth. Proceedings of the National Academy of Sciences of the United States of America. 6319-6233.
Popular scientific lecture
  • Show author(s) 2002. Bioprospektering.
  • Show author(s) 2002. Apoptose - kommersielle aspekter.
Academic lecture
  • Show author(s) 2009. SMALL-RING MACROLACTAMS WITH ACYL SIDE CHAIN: NEW INSIGHTS INTO THE BIOSYNTHESIS AND ITS EVOLUTION.
  • Show author(s) 2004. cAMP protects neutrophils against TNFa-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • Show author(s) 2004. Development of a sensitive PP2A binding assay for microcystin and nodularin.
  • Show author(s) 2003. cAMP-dependent protein kinase signaling. A potential drug target.
  • Show author(s) 2003. cAMP induced protein phosphorylation in acute myelogenous leukemia cells.
  • Show author(s) 2003. cAMP effector mechanisms. Novel twists for an "old" signalling system.
  • Show author(s) 2003. Proteomics. Possibilities and role of PROBE unit.
  • Show author(s) 2003. Protein kinases involved in leukemia cell apoptosis.
  • Show author(s) 2003. PROBE. Progress report and visions for proteomics.
  • Show author(s) 2003. Identification of phosphorylated targets in ultrarapidly induced apoptosis.
  • Show author(s) 2003. Apoptosisd methodology. Clinical aspects.
  • Show author(s) 2003. Apoptosis. mechanistic and clinical aspects.
  • Show author(s) 2002. cAMP signalling related to apoptosis.
  • Show author(s) 2002. cAMP protects neutrophils against TNF_-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • Show author(s) 2002. cAMP and okadaic acid induced apoptosis.
  • Show author(s) 2002. The cAMP-binding site of EPAC-1.
  • Show author(s) 2002. Regulated cell death.
  • Show author(s) 2002. New apoptosis-modulating substances from marine microalgae.
  • Show author(s) 2002. Cyclin-dependent protein kinases and cell death.
  • Show author(s) 2002. Cell death induced by natural compounds. The significance of distinct phenotypes.
  • Show author(s) 2002. Bioactive compounds from cyanobacteria.
  • Show author(s) 2002. Apoptose. Klinisk relevans og metodikk.
  • Show author(s) 2001. Use of retroviral expression in the elucidation of PKA in cell signaling and apoptosis pathways.
  • Show author(s) 2001. Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • Show author(s) 2001. Cell death in HeLa cells.
  • Show author(s) 2001. 3-Thia fatty acid induces mitochondrial alterations and triggers apoptosis in cancer cells.
  • Show author(s) 1998. Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
  • Show author(s) 1998. Membranpermeable und bioaktivierbare Analoga von cGMP als Aktivatoren von Apoptosis in IPC-81 Leukämiezellen,.
  • Show author(s) 1998. Marine cyanobacteria as a source for bioactive (apoptosis-modifying) compounds with potential as cell biology reagents and drugs.
  • Show author(s) 1998. Distinct apoptotic death forms. Distinct pathways and functions?
  • Show author(s) 1993. Signal-induced Apoptosis in Myeloid Leukemia. Apoptosis or Programmed Cell Death. From Basic Research to Clinical Application.
  • Show author(s) 1993. "Cyclic AMP dependent protein kinase and phosphatase inhibitors induces different phenotypic forms of cell death.".
  • Show author(s) 1989. Characterization and hormonal regulation of cAMP-dependent protein kinase in rat Sertoli cells.
Feature article
  • Show author(s) 1999. cAMP inhibits translation by inducing Ca2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells. FEBS Letters. 97-101.
  • Show author(s) 1998. Injected cytochrome c induces apoptosis. Nature. 449-450.
Doctoral dissertation
  • Show author(s) 2017. Exchange Proteins directly Activated by cAMP (Epac): Physiological roles and Regulation of expression .
  • Show author(s) 2015. Cell death induction by free and encapsulated cancer drug candidates.
  • Show author(s) 2007. New lessons from an "old" drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia.
  • Show author(s) 1980. Binding proteins for cyclic AmP in mammalian tissues : some aspects of their interaction with cyclic AMP and their use in competitive binding assays for cyclic AMP.
Interview
  • Show author(s) 2002. Giftalger tar livet av kreftceller.
  • Show author(s) 2002. Celledødsbødler fra havet.
  • Show author(s) 2002. "Nobelprisen i Medisin 2002".
Academic chapter/article/Conference paper
  • Show author(s) 2009. Cyclic nucleotide analogs.
  • Show author(s) 2007. Serine/Threonine Protein Phosphatases in Apoptosis. 16 pages.
  • Show author(s) 2004. Cyclic Nucleotide Analogs as Tools to investigate Cyclic Nucleotide Signalling. 6 pages.
  • Show author(s) 1996. Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate.
  • Show author(s) 1991. Criteria used to judge that a cellular response is mediated by cAMP. 12 pages.
Abstract
  • Show author(s) 2013. Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 322-322.
  • Show author(s) 2012. Microvascular permeability in the absence of Epac1 activity. The FASEB Journal. 1 pages.
  • Show author(s) 2008. Cyclic nucleotide analogs as probes for signaling pathways. Naunyn-Schmiedeberg's Archives of Pharmacology. 31-31.
  • Show author(s) 2006. Camp-dependent protein kinase. European Journal of Pharmaceutical Sciences. S4-S5.
  • Show author(s) 2006. A staurosporine story: Indolocarbazole orthoamides and fluorinated analogs of LY333531. European Journal of Pharmaceutical Sciences. S3-S3.
  • Show author(s) 2006. 14-3-3 proteins as substrates for cAMP-dependent protein kinase. European Journal of Pharmaceutical Sciences. S27-S27.
Poster
  • Show author(s) 2012. Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect.
  • Show author(s) 2010. Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3.
  • Show author(s) 2009. The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
  • Show author(s) 2007. Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets.
  • Show author(s) 2003. Myeloid leukemia cell differentiation by bcl-2 and camp involves induction of ccaat/enhancer binding protein ? (c/ebp?), nuclear accumulation of c/ebp?, and direct interaction between bcl-2 and c/ebp?
  • Show author(s) 2002. Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins- Development of a sensitive in vitro assay.
  • Show author(s) 2002. Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins - development of a sensitive in vitro bioassay.
  • Show author(s) 2002. Effects of a new bioactive substance from a marine microalga on mammalian cells.
  • Show author(s) 2002. Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase. Development of a new compound selective for EPAC 1 activation.
  • Show author(s) 2002. Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase.
  • Show author(s) 2001. TWO NOVEL APOPTOSIS-MODULATION SUBSTANCES ISOLATED FROM MARINE MICRO-ALGAE.
  • Show author(s) 2001. New apoptosis-modulating substances from marine microalgae.
  • Show author(s) 2001. Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • Show author(s) 2001. Differential Affinities of C-subunit Isozymes of the cAMP-Dependent Protein Kinase for Pseudosubstrates and Substrates.
  • Show author(s) 2001. Development of a sensitive in vitro bioassay for diarrhetic shellfish poisoning (DSP) toxins.
  • Show author(s) 2001. Comparison of the cAMP binding sites of EPAC-1 and cAMP kinase.
Academic literature review
  • Show author(s) 2015. Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. Marine Drugs. 6505-6520.
  • Show author(s) 2011. The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. Current Topics in Medicinal Chemistry. 1393-1405.
  • Show author(s) 2011. The 14-3-3 proteins in regulation of cellular metabolism. Seminars in Cell and Developmental Biology. 713-719.

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