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Stein Ove Døskeland

Professor
  • E-mailStein.Doskeland@uib.no
  • Phone+47 55 58 63 76
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Aasebø, Elise; Berven, Frode; Bartaula-Brevik, Sushma; Stokowy, Tomasz; Hovland, Randi; Vaudel, Marc; Døskeland, Stein Ove; Mc Cormack, Emmet; Batth, Tanveer S; Olsen, Jesper V; Bruserud, Øystein; Selheim, Frode; Hernandez-Valladares, Maria. 2019. Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia. bioRxiv - the preprint server for biology.
  • Åsrud, Kathrine Sivertsen; Pedersen, Line; Aesoy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit. 2019. Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. 1-17.
  • Gucek, Alenka; Gandasi, Nikhil R.; Omar-Hmeadi, Muhmmad; Bakke, Marit; Doskeland, Stein Ove; Tengholm, Anders; Barg, Sebastian. 2019. Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis . eLIFE.
  • Bjørnstad, Ronja; Aesoy, Reidun; Bruserud, Øystein; Brenner, Annette; Giraud, Francis; Dowling, Tara Helen; Gausdal, Gro; Moreau, Pascale; Doskeland, Stein Ove; Anizon, Fabrice; Herfindal, Lars. 2019. A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 567-578.
  • Wangen, Rebecca; Aasebø, Elise; Trentani, Andrea; Doskeland, Stein Ove; Bruserud, Øystein; Selheim, Frode; Hernandez-Valladares, Maria. 2018. Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome. International Journal of Molecular Sciences. 1-11.
  • Kleppe, Rune; Jonassen, Inge; Doskeland, Stein Ove; Selheim, Frode. 2018. Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. International Journal of Molecular Sciences. 1-21.
  • Curry, Fitz-Roy E.; Taxt, Torfinn; Rygh, Cecilie Brekke; Pavlin, Tina; Bjørnstad, Ronja; Doskeland, Stein Ove; Reed, Rolf K. 2018. Epac1−/− mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast‐enhanced magnetic resonance imaging with contrast agents of different molecular weights. Acta Physiologica. 1-14.
  • Prandina, Anthony; Herfindal, Lars; Radix, Sylvie; Rongved, Pål; Doskeland, Stein Ove; Le Borgne, Marc; Perret, Florent. 2018. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of enzyme inhibition and medicinal chemistry (Print). 370-375.
  • Aesoy, Reidun; Muwonge, Haruna; Sivertsen Åsrud, Kathrine; Sabir, Misbah; Witsø, Solveig Lund; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Høivik, Erling Andre; Doskeland, Stein Ove; Bakke, Marit. 2018. Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLOS ONE.
  • Viktorsson, Elvar Örn; Grøthe, Bendik Melling; Aesoy, Reidun; Sabir, Misbah; Snellingen, Simen; Åstrand, Ove Alexander Høgmoen; Prandina, Anthony; Bonge-Hansen, Tore; Doskeland, Stein Ove; Herfindal, Lars; Rongved, Pål. 2017. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 2285-2293.
  • Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; kristiansen, k; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove. 2017. Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 441-452.
  • Nygaard, Gyrid; Herfindal, Lars; Sivertsen Åsrud, Kathrine; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Oveland, Eystein; Berven, Frode; Myhren, Lene Elisabeth; Høivik, Erling Andre; Lunde, Turid Helen Felli; Bakke, Marit; Doskeland, Stein Ove; Selheim, Frode. 2017. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
  • Edland, Ravn Fritdtjov; Wergeland, Anita; Kopperud, Reidun Kristin; Sivertsen åsrud, Kathrine; Høivik, Erling Andre; Witsø, Solveig Lund; Æsøy, Reidun; Madsen, Lise; Kristiansen, K; Bakke, Marit; Doskeland, Stein Ove; Jonassen, Anne K. 2016. Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutrition & Metabolism. 1-11.
  • Liu, Qingyuan; Nguyen, Eric; Doskeland, Stein Ove; Ségal-Bendirdjian, Evelyne. 2015. cAMP-dependent Protein Kinase A (PKA) - Mediated c-Myc degradation is dependent on the relative proportion of PKA-I and PKA-II isozymes. Molecular Pharmacology. 469-476.
  • Giraud, Francis; Bourhis, Marion; Ebrahimi, Edris; Herfindal, Lars; Roy Choudhury, Romi; Bjørnstad, Ronja; Doskeland, Stein Ove; Anizon, Fabrice; Moreau, Pascale. 2015. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 7313-7323.
  • Bouaziz, Zouhair; Issa, Samar; Gentili, Jacques; Gratz, Andreas; Bollacke, Andre; Kassack, Matthias; Jose, Joachim; Herfindal, Lars; Gausdal, Gro; Doskeland, Stein Ove; Mullié, Catherine; Sonnet, Pascal; Desgrouas, Camille; Taudon, Nicolas; Valdameri, Glaucio; Di Pietro, Attilio; Baitiche, Milad; Le Borgne, Marc. 2015. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of enzyme inhibition and medicinal chemistry (Print). 180-188.
  • Houge, Gunnar; Haesen, Dorien; Vissers, Lisenka E.L.M.; Mehta, Sarju; Parker, Michael J.; Wright, Michael; Vogt, Julie; McKee, Shane; Tolmie, John L.; Cordeiro, Nuno; Kleefstra, Tjitske; Willemsen, Marjolein H.; Reijnders, Margot R.F.; Berland, Siren; Hayman, Eli; Lahat, Eli; Brilstra, Eva H.; Van Gassen, Koen L.I.; Zonneveld-Huijssoon, Evelien; De Bie, Charlotte I.; Hoischen, Alexander; Eichler, Evan E.; Holdhus, Rita; Steen, Vidar Martin; Doskeland, Stein Ove; Hurles, Matthew E.; FitzPatrick, David R.; Janssens, Veerle. 2015. B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. Journal of Clinical Investigation. 3051-3062.
  • Nygaard, Gyrid; Herfindal, Lars; Kopperud, Reidun Kristin; Aragay, Anna M.; Holmsen, Holm A; Doskeland, Stein Ove; Kleppe, Rune; Selheim, Frode. 2014. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
  • Aasebø, Elise; Vaudel, Marc; Mjaavatten, Olav; Gausdal, Gro; van der Burgh, Arthur Edward Emiel; Gjertsen, Bjørn Tore; Doskeland, Stein Ove; Bruserud, Øystein; Berven, Frode; Selheim, Frode. 2014. Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. Proteomics. 1971-1976.
  • Giraud, Francis; Bourhis, Marion; Nauton, Lionel; Théry, Vincent; Herfindal, Lars; Doskeland, Stein Ove; Anizon, Fabrice; Moreau, Pascale. 2014. New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 108-115.
  • Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Doskeland, Stein Ove. 2014. Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
  • Myhren, Lene Elisabeth; Nilssen, Ida Mostrøm; Nicolas, Valérie; Doskeland, Stein Ove; Barratt, Gillian; Herfindal, Lars. 2014. Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics.
  • Liu, Liwei; Herfindal, Lars; Jokela, Jouni; Shishido, Tania Keiko; Wahlsten, Matti; Doskeland, Stein Ove; Sivonen, Kaarina. 2014. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 2036-2053.
  • Sletta, Håvard; Degnes, Kristin Fløgstad; Herfindal, Lars; Klinkenberg, Geir; Fjærvik, Espen; Zahlsen, Kolbjørn; Brunsvik, Anders; Nygaard, Gyrid; Aachmann, Finn Lillelund; Ellingsen, Trond Erling; Doskeland, Stein Ove; Zotchev, Sergey. 2014. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
  • Liu, Liwei; Jokela, Jouni; Herfindal, Lars; Wahlsten, Matti; Sinkkonen, Jari; Permi, Perttu; Fewer, David P.; Doskeland, Stein Ove; Sivonen, Kaarina. 2014. 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 2646-2655.
  • Herfindal, Lars; Nygaard, Gyrid; Kopperud, Reidun Kristin; Krakstad, Camilla; Doskeland, Stein Ove; Selheim, Frode. 2013. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
  • Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Doskeland, Stein Ove; Selheim, Frode; Herfindal, Lars. 2013. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
  • Herfindal, Lars; Myhren, Lene Elisabeth; Gjertsen, Bjørn Tore; Doskeland, Stein Ove; Gausdal, Gro. 2013. Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer.
  • Høivik, Erling Andre; Witsø, Solveig Lund; Bergheim, Inger Riise; Xu, Yunjian; Jakobsson, Ida; Tengholm, Anders; Doskeland, Stein Ove; Bakke, Marit. 2013. DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PLOS ONE. 12 pages.
  • Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frederic; ROUHEE, NAZANIN; McCormack, Emmet ; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Doskeland, Stein Ove. 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
  • Nguyen, Eric; Gausdal, Gro; Varennes, Jacqueline; Pendino, Frederic; Lanotte, Michel; Doskeland, Stein Ove; Ségal-Bendirdjian, Evelyne. 2013. Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid-induced maturation of acute promyelocytic leukemia cells. Molecular Pharmacology. 1057-1065.
  • Oftedal, Linn Silje Wathne; Myhren, Lene Elisabeth; Jokela, Jouni; Gausdal, Gro; Sivonen, Kaarina; Doskeland, Stein Ove; Herfindal, Lars. 2012. The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 3000-3009.
  • Jokela, Jouni; Oftedal, Linn Silje Wathne; Herfindal, Lars; Permi, Perttu; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina. 2012. Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLOS ONE.
  • Jia, Bingbong; Madsen, Lise; Petersen, Rasmus Koefoed; Techer, Nathalie; Kopperud, Reidun Kristin; Ma, Tao; Doskeland, Stein Ove; Ailhaud, Gérard; Wang, Jinfu; Amri, EZ-Zoubir; Kristiansen, Karsten. 2012. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PLOS ONE. 11 pages.
  • Dao, Khanh Kim; Pey, Angel L.; Gjerde, Anja Underhaug; Teigen, Knut; Byeon, In-Ja L.; Doskeland, Stein Ove; Gronenborn, Angela M.; Martinez, Aurora. 2011. The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLOS ONE. 10 pages.
  • Oftedal, Linn Silje Wathne; Skjærven, Kaja Helvik; Coyne, Rosie Theresa; Edvardsen, Bente; Rohrlack, Thomas; Skulberg, Olav; Doskeland, Stein Ove; Herfindal, Lars. 2011. The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 489-501.
  • Herfindal, Lars; Myhren, Lene Elisabeth; Kleppe, Rune; Krakstad, Camilla; Selheim, Frode; Jokela, Jouni; Sivonen, Kaarina; Doskeland, Stein Ove. 2011. Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
  • Jensen, Baard Olav; Kleppe, Rune; Kopperud, Reidun Kristin; Nygård, Gyrid; Doskeland, Stein Ove; Holmsen, Holm A; Selheim, Frode. 2011. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
  • Huseby, Sjur; Gausdal, Gro; Keen, Thomas Jeffrey; Kjærland, Endre; Krakstad, Camilla; Myhren, Lene Elisabeth; Brønstad, Kirsten Marie; Kunick, Conrad; Schwede, Frank; Genieser, Hans-Gottfried; Kleppe, Rune; Doskeland, Stein Ove. 2011. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death and Differentiation. 11 pages.
  • Madsen, Lise; Pedersen, Lone M; Lillefosse, Haldis Haukås; Fjaere, Even; Brønstad, Ingeborg; Hao, Qin; Petersen, Rasmus Kofoed; Hallenborg, Philip; Ma, Tao; De Matteis, Rita; ARAUJO, HERNANDEZ PEDRO W; Mercader, Josep; Bonet, M Louisa; Hansen, Jacob B; Cannon, Barbara; Nedergaard, Jan; Wang, Jun; Cinti, Saverio; Voshol, Peter; Doskeland, Stein Ove; Kristiansen, Karsten. 2010. UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity. PLOS ONE. 13 pages.
  • Oftedal, Linn Silje Wathne; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Doskeland, Stein Ove; Herfindal, Lars. 2010. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2659-2672.
  • Jensen, Baard Olav; Kleppe, Rune; Kopperud, Reidun Kristin; Nygård, Gyrid; Doskeland, Stein Ove; Holmsen, Holm A; Selheim, Frode. 2010. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
  • Byeon, In-Ja L.; Dao, Khanh Kim; Jung, Jinwon; Keen, Thomas Jeffrey; Leiros, Ingar; Doskeland, Stein Ove; Martinez, Aurora; Gronenborn, Angela M. 2010. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry. 14062-14070.
  • Jokela, Jouni; Herfindal, Lars; Wahlsten, Matti; Permi, Perttu; Selheim, Frode; Vasconçelos, Vitor M.; Doskeland, Stein Ove; Sivonen, Kaarina. 2010. A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem. 1594-1599.
  • Arntzen, Magnus Øverlie; Osland, Christoffer Leif; Raa, Christopher Rasch-Olsen; Kopperud, Reidun Kristin; Doskeland, Stein Ove; Lewis, Aurelia; D Santos, Clive. 2009. POSTMan (POST-translational modification analysis), a software application for PTM discovery. Proteomics. 1400-1406.
  • Prestegard, Siv Kristin; Oftedal, Linn Silje Wathne; Coyne, Rosie Theresa; Nygård, Gyrid; Skjærven, Kaja Helvik; Knutsen, Gjert; Doskeland, Stein Ove; Herfindal, Lars. 2009. Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
  • Birkeland, Even; Nygaard, G; Oveland, Eystein; Mjaavatten, Olav; Ljones, M; Doskeland, Stein Ove; Krakstad, Camilla; Selheim, Frode. 2009. Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. Journal of Proteomics & Bioinformatics. 244-245.
  • Jørgensen, Hanne; Degnes, Kristin; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander; Herfindal, Lars; Bruheim, Per; Klinkenberg, Geir; Bredholt, Harald; Nygård, Gyrid; Doskeland, Stein Ove; Ellingsen, Trond E.; Zotchev, Sergey B. 2009. Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
  • Herfindal, Lars; Kasprzykowski, Franciszek; Schwede, Frank; Lankiewicz, Leszek; Fladmark, Kari Espolin; Lukomska, Joanna; Wahlsten, Matti; Sivonen, Kaarina; Grzonka, Zbigniew; Jastorff, Bernd; Doskeland, Stein Ove. 2009. Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
  • Madsen, Lise; Pedersen, Lone Møller; Liaset, Bjørn; Ma, Tao; Petersen, Rasmus Kofoed; van den Berg, Sjoerd; Pan, Jie; Müller-Decker, Karin; Dülsner, Erik D.; Kleemann, Robert; Kooistra, Teake; Doskeland, Stein Ove; Kristiansen, Karsten. 2008. cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. Journal of Biological Chemistry. 7196-7205.
  • Petersen, Rasmus Kofoed; Madsen, Lise; Pedersen, Lone Møller; Hallenborg, Philip; Hagland, Hanne; Viste, Kristin; Doskeland, Stein Ove; Kristiansen, Karsten. 2008. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Molecular and Cellular Biology. 3804-3816.
  • Madsen, Lise; Petersen, Rasmus Kofoed; Steffensen, Knut R.; Pedersen, Lone Møller; Hallenborg, Philip; Ma, Tao; Frøyland, Livar; Doskeland, Stein Ove; Gustafsson, Jan-Åke; Kristiansen, Karsten. 2008. Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. Journal of Biological Chemistry. 22723-22736.
  • Gausdal, Gro; Gjertsen, Bjørn Tore; McCormack, Emmet Martin; Van Damme, Petra; Hovland, Randi; Krakstad, Camilla; Bruserud, Øystein; Gevaert, Kris; Vandekerckhove, Joel; Doskeland, Stein Ove. 2008. Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. Blood. 2866-2877.
  • Huang, Tien-Sheng; Myklebust, Line Merethe; Kjærland, Endre; Gjertsen, Bjørn Tore; Pendino, Frederic; Bruserud, Øystein; Doskeland, Stein Ove; Lillehaug, Johan. 2007. LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Molecular Cancer.
  • Dremier, Sarah; Milenkovic, Milutin; Blancquaert, Sara; Dumont, Jacques E.; Doskeland, Stein Ove; Maenhaut, Carine; Roger, Pierre P. 2007. Cyclic adenosine 3 ',5 '-monophosphate(cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells. Endocrinology. 4612-4622.
  • Dao, Khanh Kim; Teigen, Knut; Kopperud, Reidun Kristin; Hodneland, Erlend; Schwede, Frank; Mellgren, Anne Elisabeth Christensen; Martinez, Aurora; Doskeland, Stein Ove. 2006. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 21500-21511.
  • Krakstad, Camilla; Herfindal, Lars; Gjertsen, Bjørn Tore; Bøe, Roald; Vintermyr, Olav Karsten; Fladmark, Kari Espolin; Doskeland, Stein Ove. 2006. CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
  • Viste, Kristin; Kopperud, Reidun; Christensen, Anne Elisabeth; Doskeland, Stein Ove. 2005. Substrate enhances the sensitivity of type I protein kinase a to cAMP. Journal of Biological Chemistry. 13279-13284.
  • Selheim, Frode; Herfindal, Lars; Martins, Rosario; Vasconcelos, Vitor; Doskeland, Stein Ove. 2005. Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 294-306.
  • Herfindal, Lars; Selheim, Frode; Oftedal, Linn Silje Wathne; Wahlsten, Matti; Sivonen, Kaarina; Doskeland, Stein Ove. 2005. A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 252-260.
  • Krakstad, Camilla; Christensen, Anne Elisabeth; Døskeland, Stein Ove. 2004. cAMP protects neutrophils against TNF?-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). Journal of Leukocyte Biology. 641-647.
  • Jensen, BO; Selheim, Frode; Døskeland, Stein Ove; Gear, AR; Holmsen, Holm A. 2004. Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. Blood. 2775-2782.
  • Gausdal, Gro; Gjertsen, Bjørn Tore; Fladmark, Kari Espolin; Demol, H.; Vandekerckhove, Joel; Døskeland, Stein Ove. 2004. Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia. 1989-1996.
  • Kopperud, Reidun; Krakstad, Camilla; Selheim, Frode; Døskeland, Stein Ove. 2003. cAMP effector mechanisms. Novel twists for an "old" signaling system. FEBS Letters. 121-126.
  • Christensen, Anne Elisabeth; Selheim, Frode; de Rooij, Johan; Dremier, Sarah; Schwede, Frank; Dao, Khanh Kim; Martinez, Aurora; Maenhaut, Carine; Bos, Johanes L.; Genieser, H.-G.; Døskeland, Stein Ove. 2003. cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. Journal of Biological Chemistry. 35394-35402.
  • Dremier, Sarah; Kopperud, Reidun; Døskeland, Stein Ove; Dumont, Jaques; Maenhaut, C. 2003. Search for new cyclic AMP-binding proteins. FEBS Letters. 103-107.
  • Tronstad, Karl Johan; Gjertsen, Bjørn Tore; Krakstad, Camilla; Berge, Kjetil; Brustugun, Odd Terje; Døskeland, Stein Ove; Berge, Rolf Kristian. 2003. Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells. Chemistry and Biology. 609-618.
  • Rehmann, Holger; Schwede, Frank; Døskeland, Stein Ove; Wittinghofer, Alfred; Bos, Johannes. 2003. Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. Journal of Biological Chemistry. 38548-38556.
  • Sandal, Tone; Aumo, Linda; Hedin, Lars Flemming; Gjertsen, Bjørn Tore; Døskeland, Stein Ove. 2003. Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Molecular Biology of the Cell. 3292-3304.
  • Bruserud, Øystein; Glenjen, Nils; Gjertsen, Bjørn Tore; Herfindal, Lars; Døskeland, Stein Ove. 2002. Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 197-210.
  • Fladmark, Kari Espolin; Brustugun, Odd Terje; Mellgren, Gunnar; Krakstad, Camilla; Bøe, Roald; Vintermyr, Olav Karsten; Schulman, Howard; Døskeland, Stein Ove. 2002. Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. Journal of Biological Chemistry. 2804-2811.
  • Gjertsen, Bjørn Tore; Øyan, Anne Margrete; Marzolf, Bruz; Hovland, Randi; Gausdal, Gro; Døskeland, Stein Ove; Dimitrov, Krassen; Golden, Allison; Kalland, Karl-Henning; Hood, Leroy; Bruserud, Øystein. 2002. Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses. Journal of Hematotherapy & Stem Cell Research. 469-481.
  • Sandal, Tone; Stapnes, Camilla; Kleivdal, Hans Torstein; Lars, Hedin; Døskeland, Stein Ove. 2002. A Novel Extraneuronal Role for Cylin-dependent Protein Kinase 5 (CDK5), Modulation of cAMP-induced apoptosis in rat leukemia cells. Journal of Biological Chemistry. 20783-20793.
  • Sandal, Tone; Ahlgren, Ragnhild; Lillehaug, Johan; Døskeland, Stein Ove. 2001. Establishment of okadaic acid resistant cell clones using a cDNA expression library. Cell Death and Differentiation. 754-766.
  • Mankiewicz, J; Tarczynska, M; Fladmark, Kari Espolin; Døskeland, Stein Ove; Walter, Z; Zalewski, M. 2001. Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environmental Toxicology. 225-233.
  • Mankiewitcz, J; Walter, Z; Tarczynska, M; Zalewski, M; Fladmark, Kari Espolin; Døskeland, Stein Ove. 2001. Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. International Journal of Occupational Medicine and Environmental Health. 335-344.
  • Selheim, Frode; Herfindal, Lars; Knutsen, Gjert; Holmsen, Holm; Døskeland, Stein Ove. 2001. Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 139-140.
  • Schwede, F; Brustugun, Odd Terje; Zorn-Kruppa, M; Døskeland, Stein Ove; Jastorff, B. 2000. Membrane permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorganic & Medicinal Chemistry Letters. 571-573.
  • Seite, P; Ruchaud, S; Hillion, J; Gendron, MC; Bruland, O; Segal-Bendirdjian, E; Døskeland, Stein Ove; Lillehaug, Johan R; Lanotte, M. 2000. Ectopic expression of Bcl-2 switches over nuclear signalling for cAMP-inducd apoptosis to granulocytic differentiation. Cell Death and Differentiation. 1081-1089.
  • Døskeland, Stein Ove; Gjertsen, Bjørn Tore. 2000. Apoptosemekanismen - mulige vinklinger for kreftbehandling. Tidsskrift for Den norske legeforening. 61.
  • Serres, Margrethe Hauge; Fladmark, Kari Espolin; Døskeland, Stein Ove. 2000. An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon. 347-360.
  • Schwede, F; Christensen, Anne Elisabeth; Liauw, S; Hippe, T; Kopperud, Reidun; Jastorff, B; Døskeland, Stein Ove. 2000. 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry. 8803-8812.
  • Hovland, Randi; Døskeland, Anne Paulus; Eikhom, Thor S; Robaye, B; Døskeland, Stein Ove. 1999. cAMP induces co-translational modification of proteins in IPC-81 cells. Biochemical Journal. 369-377.
  • Fladmark, Kari Espolin; Brustugun, Odd Terje; Hovland, Randi; Bøe, Ragnar; Gjertsen, Bjørn Tore; Zhivotovsky, B; Døskeland, Stein Ove. 1999. Ultrarapid apoptosis inducted by phosphatase inhibitors. Cell Death Differ. Cell Death and Differentiation. 1099-1108.
  • Serres, Margrethe Hauge; Fladmark, Kari Espolin; Døskeland, Stein Ove. 1999. An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon. 347-360.
  • Fladmark, Kari Espolin; Serres, Margrethe Hauge; Larsen, Nina Lied; Yasumoto, T.; Aune, T.; Døskeland, Stein Ove. 1998. Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon. 1101-1114.
  • Brustugun, Odd Terje; Fladmark, Kari Espolin; Døskeland, Stein Ove; Orrenius, S.; Zhivotovsky, B. 1998. Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation. 660-668.
  • Cressey, Lill Irene; Benoit, G.; Døskeland, Stein Ove; Lanotte, M. 1998. A number of morphologically distinct types of regulated (apoptotic) cell death can be induced in leukemia cells, depending on the nature and intens the death-inducing agent. (invited review). Scanning microscopy.
  • Lund, Johan; Bakke, Marit; Mellgren, Gunnar; Morohashi, K.; Døskeland, Stein Ove. 1997. Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 43-45.
  • Mellgren, Gunnar; Bruland, T; Døskeland, A.P; Flatmark, Torgeir; Vintermyr, Olav Karsten; Døskeland, Stein Ove. 1997. Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 4373-4383.
  • Fladmark, Kari Espolin; Gjertsen, Bjørn Tore; Molven, Anders; Mellgren, Gunnar; Vintermyr, Olav Karsten; Døskeland, Stein Ove. 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • Fladmark, Kari Espolin; Gjertsen, Bjørn Tore; Døskeland, Stein Ove; Vintermyr, Olav Karsten. 1997. Fas/APO-1 (CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP. Biochemical and Biophysical Research Communications - BBRC. 20-25.
  • Houge, Gunnar; Døskeland, Stein Ove. 1996. Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis. Experientia. 963-967.
  • Ruchaud, S.; Duprez, E.; Gendron, M. C.; Houge, G.; Geniester, H. G.; Jastorff, B.; Døskeland, Stein Ove; Lanotte, M. 1994. Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cells. Proc Nat Acad Sci U S A Biol Sci. 8428-8432.
  • Gjertsen, Bjørn Tore; Cressey, L. I.; Ruchaud, S.; Houge, G.; Lanotte, M.; Døskeland, Stein Ove. 1994. Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. Journal of Cell Science, Supplement. 3363-3377.
  • Jensen, P. H.; Cressey, L.; Gjertsen, Bjørn Tore; Madsen, P.; Mellgren, Gunnar; Hokland, P.; Gliemann, J.; Døskeland, Stein Ove; Lanotte, M.; Vintermyr, Olav Karsten. 1994. Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 834-840.
  • Robay, B.; Døskeland, Anne Paulus; Riviera-Lopez, S.; Døskeland, Stein Ove; Dumont, J. 1994. Apoptotic Cell Death analyzed at the molecular level by two-dimensional gel electrophoresis. Electrophoresis. 503-510.
  • Øgreid, D.; Dostmann, W.; Geniester, H. -G.; Niemannn, P.; Døskeland, Stein Ove; Jastorrf, B. 1994. (Rp)- and (Sp)-8-pideridino-cAMP@<S@> discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase type I and II. European Journal of Biochemistry (EJB). 1089-1094.
  • Øgreid, D.; Dostmann, W.; Geniester, H. -G.; Niemannn, P.; Døskeland, Stein Ove; Jastorrf, B. 1994. (Rp)- and (Sp)-8-pideridino 3', 5'-(cyclic)thiophosphates discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase typeI and II. European Journal of Biochemistry (EJB). 1089-1094.
  • Døskeland, Stein Ove; Maronde, E.; Gjertsen, Bjørn Tore. 1993. The genetic subtypes of cAMP-dependent protein kinase - functionally different or redundant? Biochimica et Biophysica Acta. 249-258.
  • Houge, G.; Døskeland, Stein Ove; Bøe, Ragnar; Lanotte, M. 1993. Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis. FEBS Letters. 16-20.
  • Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore; Lanotte, M.; Døskeland, Stein Ove. 1993. Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemic (IPC-81) cells. Exp Cell Res. 157-161.
  • Mellgren, Gunnar; Vintermyr, Olav Karsten; Bøe, Ragnar; Døskeland, Stein Ove. 1993. Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 293-301.
  • Gjertsen, Bjørn Tore; Fauske, B.; Døskeland, Stein Ove. 1993. Exogenous substrate stimulate autodephosphorylation of cyclic-AMP-dependent protein kinase II. Biochemical Journal. 497-503.
  • Vintermyr, Olav Karsten; Bøe, Ragnar; Bruland, T.; Houge, G.; Døskeland, Stein Ove. 1993. Elevated cAMP gives short-term inhibition and long-term stimulation of hepatocyte DNA replication: Roles of the cAMP-dependent protein kinase subunits. Journal of Cellular Physiology. 160-170.
  • Houge, G.; Døskeland, Stein Ove; Gjertsen, Bjørn Tore. 1993. Apoptotisk celledød. NBS-nytt. 6-12.
  • Gjertsen, Bjørn Tore; Duprez, E.; Bernard, O.; Lanotte, M.; Døskeland, Stein Ove. 1993. Anti-apoptotic effect of heterozygously expressed mutant RI (Ala%3%3%6 ->Asp) subunit of cAMP-kinase I in a rat leukaemia cell line. Journal of Biological Chemistry. 8332-8340.
  • Skålhegg, B. S.; Landmark, B.; Døskeland, Stein Ove; Hansson, V.; Lea, T.; Jahnsen, T. 1992. cAmp-dependent protein kinase type I mediates the inhibitory effects of cAMP on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • Døskeland, Anne Paulus; Vintermyr, Olav Karsten; Flatmark, Torgeir; Cotton, R. G. H.; Døskeland, Stein Ove. 1992. Phenylatanine modulates positively the cAMP-dependant phosphorylation and modulates negatively the vasopressin-and okadeic acid-induced phosphorylation of phenylalanine 4-monoxygenase in intact rat hepatocytes. European Journal of Biochemistry (EJB). 161-170.
  • Døskeland, Anne Paulus; Vintermyr, Olav Karsten; Flatmark, Torgeir; Cotton, R. G. H.; Døskeland, Stein Ove. 1992. Phenylalanine modulates differently the phosphorylation of phenylalanine 4-monooxygenase in intact rat hepatocytes exposed to cAMP and Ca2+-elevating agents. European Journal of Biochemistry (EJB). 161-170.
  • Houge, G.; Cho-Chung, Y.-S.; Døskeland, Stein Ove. 1992. Differential expression of cAMPkinase subunits is correlated with growth in rat mammary carcinmas and uterus. British Journal of Cancer. 1022-1029.
  • Genieser, H. G.; Winkler, E.; Butt, E.; Zorn, M.; Schulz, S.; Iwitzki, F.; Störmann, R.; Jastorff, B.; Døskeland, Stein Ove; Øgreid, D.; Ruchaud, S.; Lanotte, M. 1992. Derivatives of 1-_b-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimick the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'phosphate (cGMP). Carbohydrate Research. 217-235.
  • Skalhegg, B. S.; Landmark, Brynjar Fowels; Doskeland, Stein Ove; Hansson, Vidar; Lea, T; Jahnsen, Tore. 1992. Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • Bøe, Ragnar; Gjertsen, Bjørn Tore; Houge, G.; Vintermyr, Olav Karsten; Lanotte, M.; Døskeland, Stein Ove. 1991. The protein phosphatase inhibator okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Experimental Cell Research. 237-246.
  • Haavik, Jan; Fauske, B.; Flatmark, Torgeir; Døskeland, Stein Ove. 1991. Supramolecular complexes of cAMP-dependent protein kinase isozymes in bovine adrenal cortex and medulla. Biochemical Society Transactions. 1163-1165.
  • Vintermyr, Olav Karsten; Dao, Khanh Kim; Døskeland, Stein Ove. 1991. Restricted effusion of the type 2 isoform of cAMP dependent protein kinase in rat hepatocytes permabilized by digitonin. Biochemical Society Transactions. 1161-1162.
  • Lanotte, M.; Riviere, J. B.; Hermouet, S.; Houge, G.; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore; Døskeland, Stein Ove. 1991. Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. Journal of Cellular Physiology. 73-80.
  • Steinberg, R. A.; Gorrman, K. B.; Øgreid, D.; Døskeland, Stein Ove; Weber, I. T. 1991. Mutations that alter the charge of type I regulatory subunit and modify activation properties of cAMP-kinase from S49-mouse lymphoma cells. Journal of Biological Chemistry. 3547-3553.
  • Otten, A.; Parenteau, L. A.; Døskeland, Stein Ove; McKnight, G. S. 1991. Hormonial activation of gene transcription in rat-transformed NIH 3T3 cells overexpressing the R2a and R2b subunits of the cAMP dependent protein kinase. Journal of Biological Chemistry. 23074-23082.
  • Haavik, Jan; Fauske, B.; Flatmark, Torgeir; Døskeland, Stein Ove. 1991. High-molecular-mass complexes of the regulatory subunits of cyclic AMP-dependent protein kinase. Biochemical Society Transactions. 1163-1165.
  • Ally, S.; Tortora, G.; Clair, T.; Grieco, D.; Merlo, G.; Katsaros, D.; Øgreid, Dagfinn; Doskeland, Stein Ove; Jahnsen, Tore; Cho-Chung, Y. S. 1988. Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth. Proceedings of the National Academy of Sciences of the United States of America. 6319-6233.
Popular scientific lecture
  • Døskeland, Stein Ove. 2002. Bioprospektering.
  • Døskeland, Stein Ove. 2002. Apoptose - kommersielle aspekter.
Academic lecture
  • Zotchev, Sergey; Jørgensen, Hanne; Degnes, Kristin F.; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander; Herfindal, L.; Bruheim, Per; Klinkenberg, Geir; Bredholt, Harald; Nygård, G.; Døskeland, Stein O.; Ellingsen, Trond Erling. 2009. SMALL-RING MACROLACTAMS WITH ACYL SIDE CHAIN: NEW INSIGHTS INTO THE BIOSYNTHESIS AND ITS EVOLUTION.
  • Krakstad, Camilla; Christensen, Anne Elisabeth; Døskeland, Stein Ove. 2004. cAMP protects neutrophils against TNFa-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • Kleivdal, Hans; Kristiansen, Sven inge; Døskeland, Stein Ove; Goksøyr, Anders. 2004. Development of a sensitive PP2A binding assay for microcystin and nodularin.
  • Døskeland, Stein Ove. 2003. cAMP-dependent protein kinase signaling. A potential drug target.
  • Kjærland, Endre; Hovland, Randi; Kleppe, Rune; Fladmark, Kari Espolin; Døskeland, Stein Ove. 2003. cAMP induced protein phosphorylation in acute myelogenous leukemia cells.
  • Kopperud, Reidun; Krakstad, Camilla; Selheim, Frode; Døskeland, Stein Ove. 2003. cAMP effector mechanisms. Novel twists for an "old" signalling system.
  • Døskeland, Stein Ove. 2003. Proteomics. Possibilities and role of PROBE unit.
  • Døskeland, Stein Ove. 2003. Protein kinases involved in leukemia cell apoptosis.
  • Døskeland, Stein Ove. 2003. PROBE. Progress report and visions for proteomics.
  • Fladmark, Kari Espolin; Vintermyr, Olav Karsten; Vandekerckhove, Joel; Døskeland, Stein Ove. 2003. Identification of phosphorylated targets in ultrarapidly induced apoptosis.
  • Døskeland, Stein Ove. 2003. Apoptosisd methodology. Clinical aspects.
  • Døskeland, Stein Ove. 2003. Apoptosis. mechanistic and clinical aspects.
  • Døskeland, Stein Ove. 2002. cAMP signalling related to apoptosis.
  • Krakstad, Camilla; Christensen, Anne Elisabeth; Døskeland, Stein Ove. 2002. cAMP protects neutrophils against TNF_-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • Døskeland, Stein Ove. 2002. cAMP and okadaic acid induced apoptosis.
  • Christensen, Anne Elisabeth; Kopperud, Reidun; Ole-Kristian Hess, Nilsen; de Rooij, Johan; Dao, Khanh Kim; Bos, Johannes; Døskeland, Stein Ove. 2002. The cAMP-binding site of EPAC-1.
  • Døskeland, Stein Ove. 2002. Regulated cell death.
  • Herfindal, Lars; Selheim, Frode; Knutsen, Gjert; Døskeland, Stein Ove. 2002. New apoptosis-modulating substances from marine microalgae.
  • Døskeland, Stein Ove. 2002. Cyclin-dependent protein kinases and cell death.
  • Døskeland, Stein Ove. 2002. Cell death induced by natural compounds. The significance of distinct phenotypes.
  • Fladmark, Kari Espolin; Herfindal, Lars; Døskeland, Stein Ove; Knutsen, Gjert; Rivero, A; Eriksson, J.E.; Wahlsten, M; Sivonen, K; Valle, R; Vasconcelos, V; Webb, P; Lord, J; Schwede, F; Jastorff, B; Genieser, H.G.; Lankiewicz, L.; Kasprzykowski, F.; Graslund, A; Langel, U; Törnroos, Karl Wilhelm; Villa-Moruzzi, E. 2002. Bioactive compounds from cyanobacteria.
  • Døskeland, Stein Ove. 2002. Apoptose. Klinisk relevans og metodikk.
  • Kleivdal, Hans Torstein; Kjærland, Endre; Døskeland, Stein Ove. 2001. Use of retroviral expression in the elucidation of PKA in cell signaling and apoptosis pathways.
  • Sandal, Tone; Ahlgren, Ragnhild; Lillehaug, Johan; Døskeland, Stein Ove. 2001. Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • Krakstad, Camilla; Døskeland, Stein Ove. 2001. Cell death in HeLa cells.
  • Tronstad, Karl Johan; Gjertsen, Bjorn Tore; Berge, Kjetil; Brustugun, Odd Terje; Døskeland, Stein Ove; Berge, Rolf Kristian. 2001. 3-Thia fatty acid induces mitochondrial alterations and triggers apoptosis in cancer cells.
  • Brustugun, Odd Terje; Fladmark, Kari Espolin; Mellgren, Gunnar; Bøe, Ragnar; Zhivotovsky, B.; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore; Døskeland, Stein Ove. 1998. Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
  • Schwede, F.; Brustugun, Odd Terje; Zorn-Kruppa, M.; Døskeland, Stein Ove; Jastorff, B. 1998. Membranpermeable und bioaktivierbare Analoga von cGMP als Aktivatoren von Apoptosis in IPC-81 Leukämiezellen,.
  • Fladmark, Kari Espolin; Eriksson, J.; Sivonen, K.; Lord, J.; Jastorff, B.; Gräslund, A.; Villa-Moruzzi, E.; Døskeland, Stein Ove. 1998. Marine cyanobacteria as a source for bioactive (apoptosis-modifying) compounds with potential as cell biology reagents and drugs.
  • Døskeland, Stein Ove; Fladmark, Kari Espolin; Krakstad, Camilla; Brustugun, Odd Terje. 1998. Distinct apoptotic death forms. Distinct pathways and functions?
  • Døskeland, Stein Ove; Gjertsen, Bjørn Tore; Houge, G.; Lanotte, M. 1993. Signal-induced Apoptosis in Myeloid Leukemia. Apoptosis or Programmed Cell Death. From Basic Research to Clinical Application.
  • Gjertsen, Bjørn Tore; Cressey, L. I.; Houge, G.; Lanotte, M.; Døskeland, Stein Ove. 1993. "Cyclic AMP dependent protein kinase and phosphatase inhibitors induces different phenotypic forms of cell death.".
  • Landmark, Brynjar Fowels; Eskild, Winnie; Doskeland, Stein Ove; Skålhegg, Bjørn Steen; Lohmann, Susanne; Walter, Ulrich; Hansson, Vidar; Jahnsen, Tore; Beebe, Stephen. 1989. Characterization and hormonal regulation of cAMP-dependent protein kinase in rat Sertoli cells.
Feature article
  • Hovland, Randi; Eikhom, Thor S; Proud, CG; Cressey, Lill Irene; Lanotte, M; Døskeland, Stein Ove. 1999. cAMP inhibits translation by inducing Ca2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells. FEBS Letters. 97-101.
  • Zhivotovsky, B.; Orrenius, S.; Brustugun, Odd Terje; Døskeland, Stein Ove. 1998. Injected cytochrome c induces apoptosis. Nature. 449-450.
Doctoral dissertation
  • Muwonge, Haruna. 2017. Exchange Proteins directly Activated by cAMP (Epac): Physiological roles and Regulation of expression .
  • Myhren, Lene Elisabeth. 2015. Cell death induction by free and encapsulated cancer drug candidates.
  • Gausdal, Gro. 2007. New lessons from an "old" drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia.
  • Doskeland, Stein Ove. 1980. Binding proteins for cyclic AmP in mammalian tissues : some aspects of their interaction with cyclic AMP and their use in competitive binding assays for cyclic AMP.
Interview
  • Døskeland, Stein Ove; Hafstad, Anne. 2002. Giftalger tar livet av kreftceller.
  • Døskeland, Stein Ove. 2002. Celledødsbødler fra havet.
  • Døskeland, Stein Ove. 2002. "Nobelprisen i Medisin 2002".
Academic chapter/article/Conference paper
  • Christensen, Anne Elisabeth; Viste, Kristin; Doskeland, Stein Ove. 2009. Cyclic nucleotide analogs.
  • Gausdal, Gro; Krakstad, Camilla; Herfindal, Lars; Doskeland, Stein Ove. 2007. Serine/Threonine Protein Phosphatases in Apoptosis.
  • Christensen, Anne Elisabeth; Døskeland, Stein Ove. 2004. Cyclic Nucleotide Analogs as Tools to investigate Cyclic Nucleotide Signalling. 6 pages.
  • Brustugun, Odd Terje; Mellgren, Gunnar; Gjertsen, Bjørn Tore; Bjerkvig, Rolf; Døskeland, Stein Ove. 1996. Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate.
  • Døskeland, Stein Ove; Bøe, Ragnar; Bruland, T.; Vintermyr, Olav Karsten; Jastorff, B.; Lanotte, M. 1991. Criteria used to judge that a cellular response is mediated by cAMP.
Abstract
  • Myhren, Lene Elisabeth; Nilsen, IM; Nicolas, Valerie; Doskeland, Stein Ove; Barratt, Gillian; Herfindal, Lars. 2013. Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 322-322.
  • Karlsen, Tine Veronica; Kopperud, Reidun Kristin; Liden, Åsa; Brekke, Cecilie; Reed, Rolf K.; Doskeland, Stein Ove. 2012. Microvascular permeability in the absence of Epac1 activity. The FASEB Journal. 1 pages.
  • Poppe, Heiko; Rybalkin, Sergei D.; Rehmann, Holger; Hinds, Thomas R.; Christensen, Anne Elisabeth; Schwede, Frank; Genieser, Hans-Gottfried; Bos, Johanes L.; Doskeland, Stein Ove; Beavo, Joseph A.; Butt, Elke. 2008. Cyclic nucleotide analogs as probes for signaling pathways. Naunyn-Schmiedeberg's Archives of Pharmacology. 31-31.
  • Kjærland, Endre; Viste, Kristin; Kleppe, Rune; Døskeland, Stein Ove. 2006. Camp-dependent protein kinase. European Journal of Pharmaceutical Sciences. S4-S5.
  • Jochum, Anne; Lamouille, Thierry; Døskeland, Stein Ove; Parker, Peter; Goekjian, Peter. 2006. A staurosporine story: Indolocarbazole orthoamides and fluorinated analogs of LY333531. European Journal of Pharmaceutical Sciences. S3-S3.
  • Kjærland, Endre; D Santos, Clive; Døskeland, Stein Ove; Kleppe, Rune. 2006. 14-3-3 proteins as substrates for cAMP-dependent protein kinase. European Journal of Pharmaceutical Sciences. S27-S27.
Poster
  • Fouillet, Bruno; Nacereddine, Abdelhamid; Larsen, Nina Lied; Bouaziz, Zouhair; Herfindal, Lars; Marminon, Christelle; Bollacke, Andre; Doskeland, Stein Ove; Le Borgne, Marc. 2015. Indeno[1,2-b]indole derivatives as protein kinase CK2 inhibitors: comparison of in silico models for Tox prediction.
  • Herfindal, Lars; Myhren, Lene Elisabeth; Nilssen, Ida Mostrøm; Nicolas, Valerie; Doskeland, Stein Ove; Barratt, Gillian. 2012. Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect.
  • Herfindal, Lars; Myhren, Lene Elisabeth; Kleppe, Rune; Krakstad, Camilla; Selheim, Frode; Doskeland, Stein Ove. 2010. Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3.
  • Jørgensen, Hanne; Degnes, Kristin F.; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander; Herfindal, Lars; Bruheim, Per; Klinkenberg, Geir; Bredholt, Harald; Nygård, Gyrid; Døskeland, Stein O.; Ellingsen, Trond Erling; Zotchev, Sergey. 2009. The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
  • Kleppe, Rune; Selheim, Frode; Doskeland, Stein Ove. 2007. Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets.
  • Sandal, Tone; Krakstad, Camilla; Ånensen, Nina; Gjertsen, Bjørn Tore; Døskeland, Stein Ove; Hedin, Lars Flemming. 2003. Myeloid leukemia cell differentiation by bcl-2 and camp involves induction of ccaat/enhancer binding protein ? (c/ebp?), nuclear accumulation of c/ebp?, and direct interaction between bcl-2 and c/ebp?
  • Huang, Tien-Sheng; Bjørndal, Bodil; Fladmark, Kari Espolin; Døskeland, Stein Ove; Bruserud, Øystein; Lanotte, Michel; Lillehaug, Johan. 2003. Differential Expression of Splicing factor SR proteins and Their phosphorylation in Cell Stress leading to Apoptosis.
  • Ibsen, M.W.; Kristiansen, C.I.; Nilsen, M.V.; Kleivdal, H; Fladmark, Kari Espolin; Døskeland, Stein Ove; Nguyen, L; Aune, T.; Goksøyr, A. 2002. Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins- Development of a sensitive in vitro assay.
  • Ibsen, Margrethe; Kristiansen, Sven Inge; Nilsen, Mona V.; Kleivdal, Hans; Fladmark, Kari; Døskeland, Stein Ove; Nguyen, L.; Aune, Tore; Goksøyr, Anders. 2002. Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins - development of a sensitive in vitro bioassay.
  • Fladmark, Kari Espolin; Vintermyr, Olav; Vandekerckhove, Joel; Døskeland, Stein Ove. 2002. Phosphorylated targets in ultrarapidly induced apoptosis.
  • Herfindal, Lars; Selheim, Frode; Aursland, Kjetil; Krakstad, Camilla; Knutsen, Gjert; Døskeland, Stein Ove. 2002. Effects of a new bioactive substance from a marine microalga on mammalian cells.
  • Christensen, Anne Elisabeth; Kopperud, Reidun; de Rooij, Johan; Ole-Kristian Hess, Nilsen; Dao, Khanh Kim; Schwede, Frank; Genieser, Hans-Gottfried; Bos, Johannes; Døskeland, Stein Ove. 2002. Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase. Development of a new compound selective for EPAC 1 activation.
  • Christensen, Anne Elisabeth; de Rooij, Johan; Kopperud, Reidun; Ole-Kristian Hess, Nilsen; Dao, Khanh Kim; Schwede, Frank; Bos, Johannes; Genieser, Hans-Gottfried; Døskeland, Stein Ove. 2002. Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase.
  • Herfindal, Lars; Krakstad, Camilla; Selheim, Frode; Wahlsten, Matti; Knutsen, Gjert; Sivonen, Kaarina; Døskeland, Stein Ove. 2001. TWO NOVEL APOPTOSIS-MODULATION SUBSTANCES ISOLATED FROM MARINE MICRO-ALGAE.
  • Herfindal, Lars; Selheim, Frode; Knutsen, Gjert; Døskeland, Stein Ove. 2001. New apoptosis-modulating substances from marine microalgae.
  • Sandal, Tone; Ahlgren, Ragnhild; Lillehaug, Johan; Døskeland, Stein Ove. 2001. Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • Beebe, Stephen; Christensen, Anne Elisabeth; Kopperud, Reidun; Brønstad, Kirsten; Zhang, Weiquing; Døskeland, Stein Ove. 2001. Differential Affinities of C-subunit Isozymes of the cAMP-Dependent Protein Kinase for Pseudosubstrates and Substrates.
  • Ibsen, Margrethe; Fladmark, Kari; Døskeland, Stein Ove; Nguyen, L.; Aune, Tore; Goksøyr, Anders. 2001. Development of a sensitive in vitro bioassay for diarrhetic shellfish poisoning (DSP) toxins.
  • Christensen, Anne Elisabeth; Dao, Khanh Kim; Ole-Kristian Hess, Nilsen; de Rooij, Johan; Bos, Johannes; Døskeland, Stein Ove. 2001. Comparison of the cAMP binding sites of EPAC-1 and cAMP kinase.
  • Serres, M.H.; Fladmark, Kari Espolin; Knutsen, Gjert; Døskeland, Stein Ove. 1997. Detedtion of toxins from marine cyanobacteria based on their affinity for protein phosphatase 2A and their ability to induce apoptosis in salmon hepatocytes.
  • Cressey, L. I.; Gjertsen, Bjørn Tore; Døskeland, Stein Ove. 1993. Morphometrical and morphological characterization of cell death induced by cAMP dependent protein kinase in rat myeloid leukemia cell line.
Academic literature review
  • Kleppe, Rune; Herfindal, Lars; Doskeland, Stein Ove. 2015. Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. 6505-6520.
  • Kleppe, Rune; Krakstad, Camilla; Selheim, Frode; Kopperud, Reidun Kristin; Doskeland, Stein Ove. 2011. The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. 1393-1405.
  • Kleppe, Rune; Martinez, Aurora; Doskeland, Stein Ove; Haavik, Jan. 2011. The 14-3-3 proteins in regulation of cellular metabolism. 713-719.

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