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  • E-mailSylvia.Varland@uib.no
  • Visitor Address
    Department of Biomedicine, Building for Basic Biological Research (BBB), 6th floor
    Jonas Lies vei 91
    5009 Bergen
  • Postal Address
    Postboks 7803
    5020 Bergen

Dr. Sylvia Varland obtained a Ph.D. in Molecular Biology from University of Bergen in 2016. She received a personal mobility grant fellowship from the Research Council of Norway and was on a two year research stay in the Boone and Andrews lab at the Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada. She currently works in the Arnesen Lab at Department of Biomedicine, University of Bergen, Norway.

Sylvia Varland, Joël Vandekerckhove and Adrian Drazic. "Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control". Trends Biochem Sci. 2019 Jun;44(6):502-516. 

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Sylvia Varland**, Henriette Aksnes, Fedor Kryuchkov, Francis Impens, Delphi Van Haver, Veronique Jonckheere, Mathias Ziegler, Kris Gevaert, Petra Van Damme**, and Thomas Arnesen. "N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae". Mol Cell Proteomics. 2018;17(12):2308-2323.

PubMed | PDF 

Rasmus Ree, Sylvia Varland, and Thomas Arnesen. "Spotlight on protein N-terminal acetylation". Exp Mol Med. 2018;27;50(7):90.

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Sylvia Varland** and Thomas Arnesen. “Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae". BMC Res Notes. 2018;22;11(1):404.

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Hanyin Cheng*, Avinash V. Dharmadhikari*, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F. Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E. Posey, Sarah R. Crews, Mohammad K. Eldomery, Zeynep Coban Akdemir, Andrea M. Lewis, Vernon R. Sutton, Jill A. Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A. High, Marjon A. van Slegtenhorst, Grazia M.S. Mancini, Candice R. Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E. Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J. Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S. Beighley, Raphael A. Bernier, Sébastien Küry, Mathilde Nizon, Mark A. Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S. Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J. Jongmans, Bert B.A. de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K. Rojas, Kym M. Boycott, Richard Person, Rebecca Willaert, Evan E. Eichler, R. Frank Kooy, Yaping Yang, Joseph C. Wu, James R. Lupski, Thomas Arnesen, Gregory M. Cooper, Wendy K. Chung, Jozef Gecz, Holly A.F. Stessman, Linyan Meng, and Gholson J. Lyon. "Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies”. Am J Hum Genet. 2018;102(5):985-994.

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Marianne Goris*, Robert S. Magin*, Håvard Foyn*, Line M. Myklebust, Sylvia Varland, Rasmus Ree, Adrian Drazic, Parminder Bhambra, Svein I. Støve, Markus Baumann, Bengt Erik Haug, Ronen Marmorstein and Thomas Arnesen. "Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80". Proc Natl Acad Sci U S A. 2018;115(17):4405-4410.

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Adrian Drazic*, Henriette Aksnes*, Michaël Marie*, Malgorzata Boczkowska, Sylvia Varland, Evy Timmerman, Håvard Foyn, Nina Glomnes, Grzegorz Rebowski, Francis Impens, Kris Gevaert, Roberto Dominguez and Thomas Arnesen. "NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility".  Proc Natl Acad Sci U S A. 2018;115(17):4399-4404.

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Sylvia Varland*, Line M. Myklebust*, Siri Øfsthus Goksøyr, Nina Glomnes, Janniche Torsvik, Jan Erik Varhaug, and Thomas Arnesen. “Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30”. Gene. 2018;644:27-37.

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Sylvia Varland*, Camilla Osberg*, and Thomas Arnesen. “N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects”. Proteomics. 2018; 15(14):2385-401.

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* contributed equally ** corresponding // Updated June 13, 2019.

 

Journal articles
  • Varland, Sylvia; Vandekerckhove, Joel; Drazic, Adrian. 2019. Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control. TIBS -Trends in Biochemical Sciences. Regular ed.. 1-15. doi: 10.1016/j.tibs.2018.11.010
  • Cheng, Hanyin; Dharmadhikari, Avinash V.; Varland, Sylvia; Ma, Ning; Domingo, Deepti; Kleyner, Robert; Rope, Alan F.; Yoon, Margaret; Stray-Pedersen, Asbjørg; Posey, Jennifer E.; Crews, Sarah R.; Eldomery, Mohammad K.; Akdemir, Zeynep Coban; Lewis, Andrea M.; Sutton, Vernon R.; Rosenfeld, Jill A.; Conboy, Erin; Agre, Katherine; Xia, Fan; Walkiewicz, Magdalena; Longoni, Mauro; High, Frances A.; van Slegtenhorst, Marjon A.; Mancini, Grazia M.S.; Finnila, Candice R.; van Haeringen, Arie; den Hollander, Nicolette; Ruivenkamp, Claudia A.; Naidu, Sakkubai; Mahida, Sonal; Palmer, Elizabeth E.; Murray, Lucinda; Lim, Derek; Jayakar, Parul; Parker, Michael J.; Giusto, Stefania; Stracuzzi, Emanuela; Romano, Corrado; Beighley, Jennifer S.; Bernier, Raphael A.; Küry, Sébastien; Nizon, Mathilde; Corbett, Mark A.; Shaw, Marie; Gardner, Alison; Barnett, Christopher; Armstrong, Ruth; Kassahn, Karin S.; Van Dijck, Anke; Vandeweyer, Geert; Kleefstra, Tjitske; Schieving, Jolanda; Jongmans, Marjolijn J.; De Vries, Bert; Pfundt, Rolph; Kerr, Bronwyn; Rojas, Samantha K.; Boycott, Kym M.; Person, Richard; Willaert, Rebecca; Eichler, Evan E.; Kooy, R. Frank; Yang, Yaping; Wu, Joseph C.; Lupski, James R.; Arnesen, Thomas; Cooper, Gregory M.; Chung, Wendy K.; Gecz, Jozef; Stessman, Holly A.F.; Meng, Linyan; Lyon, Gholson J. 2018. Truncating variants in NAA15 are associated with variable levels of intellectual disability, autism spectrum disorder, and congenital anomalies. American Journal of Human Genetics. 102: 985-994. doi: 10.1016/j.ajhg.2018.03.004
  • Drazic, Adrian; Aksnes, Henriette; Marie, Michael Bruno Eric; Boczkowska, Malgorzata; Varland, Sylvia; Timmerman, Evy; Foyn, Håvard; Glomnes, Nina; Rebowski, Grzegorz; Impens, Francis; Gevaert, Kris; Dominguez, Roberto; Arnesen, Thomas. 2018. NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proceedings of the National Academy of Sciences of the United States of America. 115: 4399-4404. doi: 10.1073/pnas.1718336115
  • Goris, Marianne; Magin, Robert S.; Foyn, Håvard; Myklebust, Line Merethe; Varland, Sylvia; Ree, Rasmus Moen; Drazic, Adrian; Bhambra, Parminder Kaur; Støve, Svein Isungset; Baumann, Markus; Haug, Bengt Erik; Marmorstein, Ronen; Arnesen, Thomas. 2018. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proceedings of the National Academy of Sciences of the United States of America. 115: 4405-4410. Published 2018-03-26. doi: 10.1073/pnas.1719251115
  • Ree, Rasmus Moen; Varland, Sylvia; Arnesen, Thomas. 2018. Spotlight on protein N-terminal acetylation. Experimental and Molecular Medicine. 50. 13 pages. doi: 10.1038/s12276-018-0116-z
  • Varland, Sylvia; Aksnes, Henriette; Kryuchkov, Fedor; Impens, Francis; Haver, Delphi Van; Jonckheere, Veronique; Ziegler, Mathias; Gevaert, Kris; Damme, Petra Van; Arnesen, Thomas. 2018. N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular & Cellular Proteomics. 17: 2309-2323. Published 2018-12-01. doi: 10.1074/mcp.RA118.000982
  • Varland, Sylvia; Arnesen, Thomas. 2018. Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae. BMC Research Notes. 11. Published 2018-06-22. doi: 10.1186/s13104-018-3513-4
  • Varland, Sylvia; Myklebust, Line Merethe; Goksøyr, Siri Øfsthus; Glomnes, Nina; Torsvik, Janniche; Varhaug, Jan Erik; Arnesen, Thomas. 2018. Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30. Gene. 644: 27-37. doi: 10.1016/j.gene.2017.12.019
  • Varland, Sylvia. 2016. Forskere og modellorganismer i skjønn forening. NBS-nytt. 40: 34-36.
  • Varland, Sylvia; Osberg, Camilla; Arnesen, Thomas. 2015. N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects. Proteomics. 15: 2385-2401. doi: 10.1002/pmic.201400619
Reports and theses
  • Varland, Sylvia. 2016. Regulation of protein N-terminal acetylation. University of Bergen.
  • Varland, Sylvia. 2012. Investigating Potential Functional Effects of Glucose- Dependent Dynamic N-Terminal Acetylation in Saccharomyces cerevisiae. Universitetet i Bergen, Bergen. 103 pages.

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