Home
  • E-mailSylvia.Varland@uib.no
  • Phone+47 55 58 66 93
  • Visitor Address
    Department of Biomedicine, Building for Basic Biological Research (BBB), 6th floor
    Jonas Lies vei 91
    5009 Bergen
  • Postal Address
    Postboks 7803
    5020 Bergen

Dr. Sylvia Varland obtained a Ph.D. in Molecular Biology from University of Bergen in 2016. She received a personal mobility grant fellowship from the Research Council of Norway and was on a two year research stay in the Boone and Andrews lab at the Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada. She currently works in the Arnesen Lab at Department of Biomedicine, University of Bergen, Norway.

Sylvia is webmaster for arnesenlab.com

Dissemination of research work by Sylvia Varland includes

MOL231 - Project in Molecular Biology

 

Sylvia Varland has previously helped teaching of

MOL100 - Introduction to Molecular Biology

MOL221 - Experimental Molecular Biology I

MOL300 - Practical Biochemistry and Molecular Biology

 

Rasmus Ree*, Laura Kind*, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, and Thomas Arnesen. "PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin"  JBC. 2020, September.

PubMed | PDF

Sylvia Varland, Joël Vandekerckhove and Adrian Drazic. "Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control". Trends Biochem Sci. 2019 Jun;44(6):502-516. 

PubMed | PDF

Sylvia Varland**, Henriette Aksnes, Fedor Kryuchkov, Francis Impens, Delphi Van Haver, Veronique Jonckheere, Mathias Ziegler, Kris Gevaert, Petra Van Damme**, and Thomas Arnesen. "N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae". Mol Cell Proteomics. 2018;17(12):2308-2323.

PubMed | PDF 

Rasmus Ree, Sylvia Varland, and Thomas Arnesen. "Spotlight on protein N-terminal acetylation". Exp Mol Med. 2018;27;50(7):90.

PubMed | PDF

Sylvia Varland** and Thomas Arnesen. “Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae". BMC Res Notes. 2018;22;11(1):404.

PubMed | PDF

Hanyin Cheng*, Avinash V. Dharmadhikari*, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F. Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E. Posey, Sarah R. Crews, Mohammad K. Eldomery, Zeynep Coban Akdemir, Andrea M. Lewis, Vernon R. Sutton, Jill A. Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A. High, Marjon A. van Slegtenhorst, Grazia M.S. Mancini, Candice R. Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E. Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J. Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S. Beighley, Raphael A. Bernier, Sébastien Küry, Mathilde Nizon, Mark A. Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S. Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J. Jongmans, Bert B.A. de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K. Rojas, Kym M. Boycott, Richard Person, Rebecca Willaert, Evan E. Eichler, R. Frank Kooy, Yaping Yang, Joseph C. Wu, James R. Lupski, Thomas Arnesen, Gregory M. Cooper, Wendy K. Chung, Jozef Gecz, Holly A.F. Stessman, Linyan Meng, and Gholson J. Lyon. "Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies”. Am J Hum Genet. 2018;102(5):985-994.

PubMed | PDF

Marianne Goris*, Robert S. Magin*, Håvard Foyn*, Line M. Myklebust, Sylvia Varland, Rasmus Ree, Adrian Drazic, Parminder Bhambra, Svein I. Støve, Markus Baumann, Bengt Erik Haug, Ronen Marmorstein and Thomas Arnesen. "Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80". Proc Natl Acad Sci U S A. 2018;115(17):4405-4410.

PubMed | PDF

Adrian Drazic*, Henriette Aksnes*, Michaël Marie*, Malgorzata Boczkowska, Sylvia Varland, Evy Timmerman, Håvard Foyn, Nina Glomnes, Grzegorz Rebowski, Francis Impens, Kris Gevaert, Roberto Dominguez and Thomas Arnesen. "NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility".  Proc Natl Acad Sci U S A. 2018;115(17):4399-4404.

PubMed | PDF

Sylvia Varland*, Line M. Myklebust*, Siri Øfsthus Goksøyr, Nina Glomnes, Janniche Torsvik, Jan Erik Varhaug, and Thomas Arnesen. “Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30”. Gene. 2018;644:27-37.

PubMed | PDF 

Sylvia Varland*, Camilla Osberg*, and Thomas Arnesen. “N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects”. Proteomics. 2018; 15(14):2385-401.

PubMed | PDF

 

* contributed equally ** corresponding // Updated September 28, 2020.

 

Academic article
  • 2018. Truncating variants in NAA15 are associated with variable levels of intellectual disability, autism spectrum disorder, and congenital anomalies. American Journal of Human Genetics. 985-994.
  • 2018. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proceedings of the National Academy of Sciences of the United States of America. 4405-4410.
  • 2018. NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proceedings of the National Academy of Sciences of the United States of America. 4399-4404.
  • 2018. N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular & Cellular Proteomics. 2309-2323.
  • 2018. Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae. BMC Research Notes.
  • 2018. Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30. Gene. 27-37.
Lecture
  • 2015. Metabolic Regulation of N-Terminal Acetylation in Saccharomyces cerevisiae.
Academic lecture
  • 2020. Exploring N-terminal acetyltransferases using functional genomics.
  • 2018. Protein N-terminal acetylation: when the start matters.
Reader opinion piece
  • 2016. Forskere og modellorganismer i skjønn forening. NBS-nytt. 34-36.
Masters thesis
  • 2012. Investigating Potential Functional Effects of Glucose- Dependent Dynamic N-Terminal Acetylation in Saccharomyces cerevisiae.
Doctoral dissertation
  • 2016. Regulation of protein N-terminal acetylation.
Poster
  • 2019. NAA80 – a novel regulator of cytoskeleton dynamics.
  • 2019. Mechanism of actin N-terminal acetylation by NAA80-profilin.
  • 2018. N-terminal acetylation of actin by NAA80 impacts cell migration.
  • 2018. Discovery of NAA80 as actin’s N-terminal acetyltransferase – a novel regulator of cytoskeleton dynamics.
  • 2018. Actin Acetylation.
  • 2018. A Yeast Model for Genetic Variants in Human NAA15 associated with Autism Spectrum Disorder.
  • 2016. Dynamic aspects of protein N-terminal acetylation in response to changes in nutrient availability.
  • 2015. The N-terminal acetyltransferase NatC has a role in cellular stress response in yeast.
  • 2015. Metabolic Regulation of Protein N-terminal Acetylation.
  • 2012. GLUCOSE DEPENDENT DYNAMIC N-TERMINAL ACETYLATION IN SACCHAROMYCES CEREVISIAE.
  • 2012. Dynamicity and functional implications of N-terminal acetylation in S. cerevisiae.
Academic literature review
  • 2019. Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control . 1-15.
  • 2018. Spotlight on protein N-terminal acetylation. 13 pages.
  • 2015. N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects. 2385-2401.

More information in national current research information system (CRIStin)

Sylvia Varland is the project manager for the NFR funded project "NatFUGE: Exploring N-terminal acetyltransferases with FUnctional GEnomics"

Twitter