Home
  • E-mailSylvia.Varland@uib.no
  • Phone+47 55 58 66 93
  • Visitor Address
    Department of Biomedicine, Building for Basic Biological Research (BBB), 6th floor
    Jonas Lies vei 91
    5009 Bergen
  • Postal Address
    Postboks 7803
    5020 Bergen

Dr. Sylvia Varland obtained a Ph.D. in Molecular Biology from University of Bergen in 2016. She received a personal mobility grant fellowship from the Research Council of Norway and was on a two year research stay in the Boone and Andrews lab at the Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada. She currently works in the Arnesen Lab at Department of Biomedicine, University of Bergen, Norway.

Sylvia is webmaster for arnesenlab.com

Dissemination of research findings by Sylvia Varland include

MOL399 - Master's Thesis in Molecular Biology (supervision)

MOL231 - Project in Molecular Biology

 

Sylvia Varland has previously helped teaching of

MOL100 - Introduction to Molecular Biology

MOL221 - Experimental Molecular Biology I

MOL300 - Practical Biochemistry and Molecular Biology

 

Adrian Drazic and Sylvia Varland✉.

Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes

Biosci. Rep, 2021, 41(3):BSR20202828

PubMed | PDF

 

Tarsha L Ward , Warren Tai, Sarah U Morton, Francis Impens, Petra Van Damme, Delphi Van Haver, Evy Timmerman, Gabriela Venturini, Kehan Zhang, Min Young Jang, Jon AL Willcox, Alireza Haghighi, Bruce D Gelb, Wendy K Chung, Elizabeth Goldmuntz, George Arthur Porter, Richard Lifton, Martina Brueckner, H Joseph Yost, Benoit G Bruneau, Joshua Gorham, Yuri Kim, Alexandre C Pereira, Jason Homsy, Craig C Benson, Steven R DePalma, Sylvia Varland, Christopher S Chen, Thomas Arnesen, Kris Gevaert✉, Christine E Seidman✉, and Jonathan G Seidman✉

Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency

Circ. Res. 2021, 16;128(8):1156-1169.

PubMed | PDF

 

 

Rasmus Ree*✉, Laura Kind*, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic✉, and Thomas Arnesen

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

J. Biol. Chem. 2020, 295(49), 16713–16731

PubMed | PDF

 

Sylvia Varland, Joël Vandekerckhove and Adrian Drazic✉

Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control

Trends Biochem Sci. 2019, 44(6), 502–516. 

PubMed | PDF

 

Sylvia Varland✉, Henriette Aksnes, Fedor Kryuchkov, Francis Impens, Delphi Van Haver, Veronique Jonckheere, Mathias Ziegler, Kris Gevaert, Petra Van Damme✉, and Thomas Arnesen

N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae

Mol Cell Proteomics. 2018, 17(12), 2308–2323.

PubMed | PDF

 

Rasmus Ree, Sylvia Varland, and Thomas Arnesen✉

Spotlight on protein N-terminal acetylation

Exp Mol Med. 2018, 50(7):90.

 

PubMed | PDF

 

Sylvia Varland✉ and Thomas Arnesen

Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae

BMC Res Notes. 2018, 11(1):404.

PubMed | PDF

 

Hanyin Cheng*, Avinash V. Dharmadhikari*, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F. Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E. Posey, Sarah R. Crews, Mohammad K. Eldomery, Zeynep Coban Akdemir, Andrea M. Lewis, Vernon R. Sutton, Jill A. Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A. High, Marjon A. van Slegtenhorst, Grazia M.S. Mancini, Candice R. Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E. Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J. Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S. Beighley, Raphael A. Bernier, Sébastien Küry, Mathilde Nizon, Mark A. Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S. Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J. Jongmans, Bert B.A. de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K. Rojas, Kym M. Boycott, Richard Person, Rebecca Willaert, Evan E. Eichler, R. Frank Kooy, Yaping Yang, Joseph C. Wu, James R. Lupski, Thomas Arnesen, Gregory M. Cooper, Wendy K. Chung, Jozef Gecz, Holly A.F. Stessman, Linyan Meng✉, and Gholson J. Lyon✉

Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies

Am J Hum Genet. 2018, 102(5), 985–994.

PubMed | PDF

 

Marianne Goris*, Robert S. Magin*, Håvard Foyn*, Line M. Myklebust, Sylvia Varland, Rasmus Ree, Adrian Drazic, Parminder Bhambra, Svein I. Støve, Markus Baumann, Bengt Erik Haug, Ronen Marmorstein✉ and Thomas Arnesen✉

Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80

Proc Natl Acad Sci U S A. 2018, 115(17), 4405–4410.

PubMed | PDF

 

Adrian Drazic*, Henriette Aksnes*, Michaël Marie*, Malgorzata Boczkowska, Sylvia Varland, Evy Timmerman, Håvard Foyn, Nina Glomnes, Grzegorz Rebowski, Francis Impens, Kris Gevaert, Roberto Dominguez, and Thomas Arnesen✉

NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

Proc Natl Acad Sci U S A. 2018, 115(17), 4399–4404.

PubMed | PDF

 

Sylvia Varland*, Line M. Myklebust*, Siri Øfsthus Goksøyr, Nina Glomnes, Janniche Torsvik, Jan Erik Varhaug, and Thomas Arnesen✉

Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30

Gene. 2018, 644, 2737.

PubMed | PDF 

 

Sylvia Varland*, Camilla Osberg*, and Thomas Arnesen✉

N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects

Proteomics. 2015, 15(14), 23852401

PubMed | PDF

 

 

 

* shared first authorship, ✉ correspondence // Updated March 6, 2021.

 

 

Academic article
  • Show author(s) 2020. PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin. Journal of Biological Chemistry. 16713-16731.
  • Show author(s) 2018. Truncating variants in NAA15 are associated with variable levels of intellectual disability, autism spectrum disorder, and congenital anomalies. American Journal of Human Genetics. 985-994.
  • Show author(s) 2018. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proceedings of the National Academy of Sciences of the United States of America. 4405-4410.
  • Show author(s) 2018. NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proceedings of the National Academy of Sciences of the United States of America. 4399-4404.
  • Show author(s) 2018. N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular & Cellular Proteomics. 2309-2323.
  • Show author(s) 2018. Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae. BMC Research Notes.
  • Show author(s) 2018. Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30. Gene. 27-37.
Lecture
  • Show author(s) 2015. Metabolic Regulation of N-Terminal Acetylation in Saccharomyces cerevisiae.
Academic lecture
  • Show author(s) 2020. Exploring N-terminal acetyltransferases using functional genomics.
  • Show author(s) 2018. Protein N-terminal acetylation: when the start matters.
Reader opinion piece
  • Show author(s) 2016. Forskere og modellorganismer i skjønn forening. NBS-nytt. 34-36.
Masters thesis
  • Show author(s) 2012. Investigating Potential Functional Effects of Glucose- Dependent Dynamic N-Terminal Acetylation in Saccharomyces cerevisiae.
Doctoral dissertation
  • Show author(s) 2016. Regulation of protein N-terminal acetylation.
Poster
  • Show author(s) 2019. NAA80 – a novel regulator of cytoskeleton dynamics.
  • Show author(s) 2019. Mechanism of actin N-terminal acetylation by NAA80-profilin.
  • Show author(s) 2018. N-terminal acetylation of actin by NAA80 impacts cell migration.
  • Show author(s) 2018. Discovery of NAA80 as actin’s N-terminal acetyltransferase – a novel regulator of cytoskeleton dynamics.
  • Show author(s) 2018. Actin Acetylation.
  • Show author(s) 2018. A Yeast Model for Genetic Variants in Human NAA15 associated with Autism Spectrum Disorder.
  • Show author(s) 2016. Dynamic aspects of protein N-terminal acetylation in response to changes in nutrient availability.
  • Show author(s) 2015. The N-terminal acetyltransferase NatC has a role in cellular stress response in yeast.
  • Show author(s) 2015. Metabolic Regulation of Protein N-terminal Acetylation.
  • Show author(s) 2012. GLUCOSE DEPENDENT DYNAMIC N-TERMINAL ACETYLATION IN SACCHAROMYCES CEREVISIAE.
  • Show author(s) 2012. Dynamicity and functional implications of N-terminal acetylation in S. cerevisiae.
Academic literature review
  • Show author(s) 2019. Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control . TIBS -Trends in Biochemical Sciences. Regular ed.. 1-15.
  • Show author(s) 2018. Spotlight on protein N-terminal acetylation. Experimental and Molecular Medicine. 13 pages.
  • Show author(s) 2015. N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects. Proteomics. 2385-2401.

More information in national current research information system (CRIStin)

Sylvia Varland is the project manager for the NFR funded project "NatFUGE: Exploring N-terminal acetyltransferases with FUnctional GEnomics".

Twitter