Tie-Jun Shi's picture

Tie-Jun Shi

Postdoctoral Fellow
  • E-mailTiejun.Shi@uib.no
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
  • Tyrosine hydroxylase expression and brain disorders
  • Neuropathic pain caused by nerve injury
Academic article
  • Show author(s) (2021). The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase. Nature Communications. 15 pages.
  • Show author(s) (2020). G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury . Journal of Pain Research. 419-429.
  • Show author(s) (2020). Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury. Scientific Reports.
  • Show author(s) (2019). Phenylalanine hydroxylase variants interact with the co-chaperone DNAJC12. Human Mutation. 483-494.
  • Show author(s) (2019). A preliminary study on DRGs and spinal cord of a galanin receptor 2-EGFP transgenic mouse. Neuropeptides.
  • Show author(s) (2017). Neuronal plasticity of trigeminal ganglia in mice following nerve injury. Journal of Pain Research. 349-357.
  • Show author(s) (2017). Neuronal plasticity in trigeminal ganglia of mouse following nerve injury. Journal of Pain Research. 349-357.
  • Show author(s) (2017). Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice. Journal of Pain Research. 2079-2087.
  • Show author(s) (2016). PEGylated cationic hybrid bicellar nanodisc for efficient siRNA delivery. RSC Advances. 113745-113753.
  • Show author(s) (2016). How Far Have We Come in the Field of Nerve Regeneration After Trigeminal Nerve Injury? Current Oral Health Reports. 309-313.

More information in national current research information system (CRIStin)

Selected Publications:
  • Xu Z-Q, Shi T-J and Hökfelt T (1996). Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos. Proc. Natl. Acad. Sci. USA, Vol. 93: 14901-14905.

  • Zhang X, Shi T-J, Holmberg K, Landry M, Huang W-J, Xiao H-S, Ju G and Hökfelt T (1997). Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia. Proc. Natl. Acad, Sci, USA, 94: 729-734.

  • Shi T-J, Holmberg K, Xu Z-Q, Steinbusch H, Vente J D and Hökfelt T (1997). Effect of peripheral nerve injury on cGMP and nitric oxide synthase expression in rat dorsal root ganglia: Time course and coexistence. Pain, 78:171-180.

  • Shi T-J, Cui J-G, Meyerson B, Linderoth B and Hökfelt T (1999). Expression of neuropeptide Y and galanin mRNA in rat dorsal root ganglia in four peripheral nerve injury models. Neuroscience, 93: 741-757.

  • Shi T-J, Winzer-Serhan U, Leslie F and Hökfelt T (2000) Distribution and regulation of a2-adrenergic receptors in rat dorsal root ganglia. Pain, 84: 319-330.

  • Shi T-J, Tandrup T, Bergman T, Xu Z-Q and Hökfelt T (2001) Effect of peripheral nerve injury on neuron number and peptide expression in mouse dorsal root ganglia. Neurosciene, 105: 249-263.

  • Shi T-J, Hua X-Y, Lu X-Y, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh, Bartfai T and Hökfelt T (2006) Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci, 23:627-36.

  • Shi T-J, Li J-Y, Dahlström A, Pedrazzini T and Hökfelt T (2006) Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers. Neuroscience, 140:293-304.

  • Brumovsky P, Shi T-J , Landry M, Villar MJ, Hökfelt T (2007) Neuropeptide tyrosine and pain. Trends Pharmacol Sci. 28:93-102。

  • Shi T-J, Liu SX, Hammarberg H, Watanabe M, Xu ZQ, Hökfelt T(2008)Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc Natl Acad Sci U S A. 105:20004-8.

  • Shi T-J, Xiang Q, Zhang M-D, Tortoriello G, Hammarberg H, Mulder J, Fried K, Wagner L, Josephson A, Uhlén M, Harkany T, Hökfelt T (2012). Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human. Mol Pain. 29:80.

  • Shi T-J, Zhang M-D, Zeberg H, Nilsson J, Grünler J, Liu S-X, Xiang Q, Persson J, Fried KJ, Catrina SB, Watanabe M, Arhem P, Brismar K, Hökfelt T (2013). Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model. Proc. Natl. Acad. Sci. USA, 110: 690-5.

  • Shi T-J, Xiang Q, Zhang MD, Barde S, Kai-Larsen Y, Fried K, Josephson A, Glück L, Deyev SM, Zvyagin AV, Schulz S, Hökfelt T (2014). Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain. Mol. Pain, 13: 10:12.

  • Lyu C, Mulder J, Barde S, Sahlholm K, Zeberg H, Nilsson J, Århem P, Hökfelt T, Fried K, Shi T-J (2015) G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy. Mol Pain, 11:44.

  • Lynds R, Lyu C, Lyu G, Shi X-Q, Rosen A, Mustafa K and Shi T-J (2017) Neuronal plasticity of trigeminal ganglia in mice following nerve injury. J of Pain Res, 10:349-357.

  • Tyrosine hydroxylase deficiency and brain disorder
  • Phenylalanine hydroxylase deficiency and PKU