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Tomas Mikal Lind Eagan's picture

Tomas Mikal Lind Eagan

Professor, Research group leader for the Bergen Respiratory Research group and Senior Consultant and Section leader for research at the Department of Thoracic Medicine, Haukeland University Hospital
  • E-mailTomas.Eagan@uib.no
  • Visitor Address
    3 etg Sentralblokken, Lungefløyen
    Jonas Lies Vei 65
    5021 Bergen
    Room 
    3077
  • Postal Address
    Postboks 7804
    5020 Bergen

Respiratory Medicine to the medical students at the University of Bergen in MED4, MED5, MED6, MED11 and MED12

  • Show author(s) (2023). Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections. Clinical Infectious Diseases. 1361-1371.
  • Show author(s) (2023). Impaired Lung Function in Extremely Preterm-Born Adults in Their Fourth Decade of Life. American Journal of Respiratory and Critical Care Medicine. 493-495.
  • Show author(s) (2022). The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis. Microbiome. 11 pages.
  • Show author(s) (2022). The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease . PLOS ONE.
  • Show author(s) (2022). Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort. Pathogens.
  • Show author(s) (2022). Factors associated with coronary heart disease in COPD patients and controls. PLOS ONE. 1-17.
  • Show author(s) (2022). Comparison of nutritional risk screening with NRS2002 and the GLIM diagnostic criteria for malnutrition in hospitalized patients. Scientific Reports. 9 pages.
  • Show author(s) (2022). Clinical information predicting severe obstructive sleep apnea: A cross-sectional study of patients waiting for sleep diagnostics. Respiratory Medicine.
  • Show author(s) (2022). A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease. PLOS ONE. 15 pages.
  • Show author(s) (2021). The pulmonary mycobiome—A study of subjects with and without chronic obstructive pulmonary disease. PLOS ONE. 16 pages.
  • Show author(s) (2021). Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable? BMC Pulmonary Medicine. 1-12.
  • Show author(s) (2021). Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4. BMC Genomics. 15 pages.
  • Show author(s) (2021). Characteristics of 24-hour ambulatory blood pressure monitoring in a COVID-19 survivor. Future Cardiology. 1321-1326.
  • Show author(s) (2021). CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test. Respiratory Medicine. 8 pages.
  • Show author(s) (2020). The airway microbiota and exacerbations of COPD. European Respiratory Journal Open Research (ERJ Open Research). 1-10.
  • Show author(s) (2020). One Year Change in 6-Minute Walk Test Outcomes is Associated with COPD Prognosis. COPD: Journal of Chronic Obstructive Pulmonary Disease. 662-671.
  • Show author(s) (2020). Levels of proteinase 3 and neutrophil elastase in plasma, BAL and biopsies in COPD. European Respiratory Journal.
  • Show author(s) (2020). Incremental costs of COPD exacerbations in GOLD stage 2+ COPD in ever-smokers of a general population. Respiratory Medicine: X. 1-7.
  • Show author(s) (2020). ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF. BMJ Open Respiratory Research.
  • Show author(s) (2020). Complications and discomfort after research bronchoscopy in the MicroCOPD study. BMJ Open Respiratory Research.
  • Show author(s) (2020). Coagulation markers as predictors for clinical events in COPD. Respirology (Carlton South. Print). 1-10.
  • Show author(s) (2020). Changes in the induced sputum proteome during COPD exacerbations. European Respiratory Journal.
  • Show author(s) (2019). The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease. PLOS ONE. 1-17.
  • Show author(s) (2019). Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients. PLOS ONE. 1-18.
  • Show author(s) (2019). Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study. Respiratory Medicine. 81-88.
  • Show author(s) (2019). Motivation and response rates in bronchoscopy studies. Multidisciplinary Respiratory Medicine. 1-9.
  • Show author(s) (2019). Laboratory contamination in airway microbiome studies. BMC Microbiology. 1-13.
  • Show author(s) (2019). Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 224-233.
  • Show author(s) (2019). Alterations in sputum inflammatory markers during exacerbations for COPD patients with different stable state levels. European Respiratory Journal.
  • Show author(s) (2018). Tidal Expiratory Flow Limitation: A new method for evaluating pulmonary function in elderly and patients with Chronic Obstructive Pulmonary Disease .
  • Show author(s) (2018). Lung hyperinflation and functional exercise capacity in patients with COPD - a three-year longitudinal study. BMC Pulmonary Medicine. 9 pages.
  • Show author(s) (2018). Guideline adherence in hospital recruited and population based COPD patients. BMC Pulmonary Medicine. 1-9.
  • Show author(s) (2017). The association of tidal EFL with exercise performance, exacerbations, and death in COPD. The International Journal of Chronic Obstructive Pulmonary Disease. 2179-2188.
  • Show author(s) (2017). Static hyperinflation and decline in functional capacity in COPD patients. European Respiratory Journal.
  • Show author(s) (2017). Repeated desaturation in 6 minute walk test increases risk for mortality in COPD patients.
  • Show author(s) (2017). Protected sampling is preferable in bronchoscopic studies of the airway microbiome. European Respiratory Journal Open Research (ERJ Open Research).
  • Show author(s) (2017). Median regression spline modeling of longitudinal FEV1 measurements in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients. PLOS ONE. 1-13.
  • Show author(s) (2017). Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD. European Respiratory Journal. 1-10.
  • Show author(s) (2017). Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients. Respiratory Research. 1-9.
  • Show author(s) (2017). Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease. European Respiratory Journal. 1-12.
  • Show author(s) (2017). A pilot study of hot-wire, ultrasonic and wedge-bellows spirometer inter- and intra-variability. BMC Research Notes.
  • Show author(s) (2016). Vitamin D and antimicrobial peptides in COPD. Results from the Bergen COPD Cohort Study.
  • Show author(s) (2016). Self-reported influenza vaccination and protective serum antibody titers in a cohort of COPD patients. Respiratory Medicine. 53-59.
  • Show author(s) (2016). Respiratory timing and dynamic hyperinflation during incremental exercise in patients with COPD. European Respiratory Journal.
  • Show author(s) (2016). Participation in research bronchoscopy: a literature review. European Clinical Respiratory Journal.
  • Show author(s) (2016). Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD patients. European Respiratory Journal. 82-91.
  • Show author(s) (2016). Macrophage migration inhibitory factor, a role in COPD. American Journal of Physiology - Lung cellular and Molecular Physiology. L1-L7.
  • Show author(s) (2016). Longitudinal changes in Peak Oxygen Uptake in Chronic Obstructive Pulmonary Disease (COPD) Patients with Dynamic Hyperinflation and/or Tidal Expiratory Flow Limitation.
  • Show author(s) (2016). Incidence of utilization- and symptom-defined COPD exacerbations in hospital- and population-recruited patients. The International Journal of Chronic Obstructive Pulmonary Disease. 2099-2108.
  • Show author(s) (2016). Expert opinion of mediastinal lymph node positions from an intrabronchial view. BMC Pulmonary Medicine.
  • Show author(s) (2016). Diffusion capacity and CT measures of emphysema and airway wall thickness – relation to arterial oxygen tension in COPD patients. European Clinical Respiratory Journal.
  • Show author(s) (2016). Complications and discomfort of bronchoscopy: a systematic review. European Clinical Respiratory Journal. 9 pages.
  • Show author(s) (2016). Change in Pulmonary Diffusion Capacity in a General Population Sample over 9 Years. European Clinical Respiratory Journal. 9 pages.
  • Show author(s) (2016). Associations between obstructive lung disease and symptoms of obstructive sleep apnoea in a general population. Clinical Respiratory Journal. 31-39.
  • Show author(s) (2015). Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD. PLOS ONE.
  • Show author(s) (2015). Variability of within-breath reactance in COPD patients and its association with dyspnoea. European Respiratory Journal. 625-634.
  • Show author(s) (2015). Serial measurements of arterial oxygen tension are associated with mortality in COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease. 287-294.
  • Show author(s) (2015). Peak oxygen uptake and breathing pattern in COPD patients – a four year longitudinal study.
  • Show author(s) (2015). Peak oxygen uptake and breathing pattern in COPD patients - a four-year longitudinal study. BMC Pulmonary Medicine.
  • Show author(s) (2014). The Bergen COPD microbiome study (MicroCOPD): rationale, design, and initial experiences. European Clinical Respiratory Journal.
  • Show author(s) (2014). Productivity losses in chronic obstructive pulmonary disease: a population-based survey. BMJ Open Respiratory Research. 1-8.
  • Show author(s) (2014). Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study. PLOS ONE.
  • Show author(s) (2014). Predictors for PaO2 and hypoxemic respiratory failure in COPD-A three-year follow-up. COPD: Journal of Chronic Obstructive Pulmonary Disease. 531-538.
  • Show author(s) (2014). Physical activity and longitudinal change in 6-min walk distance in COPD patients. Respiratory Medicine. 86-94.
  • Show author(s) (2014). Paraneoplastic Hu and CRMP5 antibodies are present in smokers without cancer or neurological disease. Respirology (Carlton South. Print). 730-734.
  • Show author(s) (2014). Mortality In COPD Patients With Increased Intrabreath Reactance.
  • Show author(s) (2014). Longitudinal change in peak oxygen uptake in COPD patients .
  • Show author(s) (2014). Longitudinal change in peak oxygen uptake in COPD patients .
  • Show author(s) (2014). Interleukin-18 levels in induced sputum of stable and exacerbated COPD patients. European Respiratory Journal.
  • Show author(s) (2014). Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy. BMC Pulmonary Medicine.
  • Show author(s) (2014). Flow limitation during resting breathing is associated with reduced exercise capability in COPD.
  • Show author(s) (2014). Dynamic hyperinflation and respiratory timing during incremental exercise in patients with chronic obstructive pulmonary disease .
  • Show author(s) (2014). Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients. Respiratory Research.
  • Show author(s) (2014). Airway obstruction, dynamic hyperinflation, and breathing pattern during incremental exercise in COPD patients. Physiological Reports.
  • Show author(s) (2013). Slope and curvature of the relationship between ventilation and tidal volume in COPD patients.
  • Show author(s) (2013). Reference values for within-breath pulmonary impedance parameters in asymptomatic elderly. Clinical Respiratory Journal. 245-252.
  • Show author(s) (2013). Non-response in telephone surveys of COPD patients does not introduce bias. Journal of Telemedicine and Telecare. 40-44.
  • Show author(s) (2013). Insomnia symptoms, objectively measured sleep, and disease severity in chronic obstructive pulmonary disease outpatients. Sleep Medicine. 1328-1333.
  • Show author(s) (2013). Comparison of 2011 and 2007 global initiative for chronic obstructive lung disease guidelines for predicting mortality and hospitalization. American Journal of Respiratory and Critical Care Medicine. 51-59.
  • Show author(s) (2013). Can intra-breath variations of reactance predict dyspnea?
  • Show author(s) (2012). The prevalence of undiagnosed renal failure in a cohort of COPD patients in western Norway. Respiratory Medicine. 361-366.
  • Show author(s) (2012). TNF-alpha is associated with loss of lean body mass only in already cachectic COPD patients. Respiratory Research. 10 pages.
  • Show author(s) (2012). Recommendations for epidemiological studies on COPD. European Respiratory Journal. 1278-1279.
  • Show author(s) (2012). Predictors for longitudinal change in 6-Minute Walk Distance in COPD patients.
  • Show author(s) (2012). Longitudinal Variability Of Expiratory Flow Limitation (EFL) In COPD Patients And Healthy Smokers Detected Non-invasively By Impulse Oscillometry.
  • Show author(s) (2012). Hu antibodies are present in smokers with chronic obstructive pulmonary disease without cancer or neurological disease. Journal of Neuroimmunology. 21-22.
  • Show author(s) (2012). Explained variance for blood gases in a population with COPD. Clinical Respiratory Journal. 72-80.
  • Show author(s) (2012). Exacebation history in COPD patients with and without expiratory flow limitation (EFL).
  • Show author(s) (2012). Different COPD disease characteristics are related to different outcomes in the 6-minute walk test. COPD: Journal of Chronic Obstructive Pulmonary Disease. 227-234.
  • Show author(s) (2012). Daytime respiratory symptoms are associated with obstructive sleep apnoea syndrome. Journal of Sleep Research. 229-230.
  • Show author(s) (2012). Chronic obstructive pulmonary disease is associated with low levels of vitamin D. PLOS ONE. 8 pages.
  • Show author(s) (2012). Association of exposure to environmental tobacco smoke in childhood with chronic obstructive pulmonary disease and respiratory symptoms in adults. Respirology (Carlton South. Print). 499-505.
  • Show author(s) (2011). Recommendations for epidemiological studies on COPD. European Respiratory Journal. 1261-1277.
  • Show author(s) (2011). High prevalence of respiratory symptoms during air travel in patients with COPD. Respiratory Medicine. 50-56.
  • Show author(s) (2011). Expiratory flow limitation (EFL) detected non-invasively as a phenotypic characteristic of COPD.
  • Show author(s) (2011). Comorbidity of Asthma With ADHD. Journal of Attention Disorders. 564-571.
  • Show author(s) (2011). Adult attention deficit hyperactivity disorder is associated with asthma. BMC Psychiatry. 7 pages.
  • Show author(s) (2011). A randomised trial of endobronchial ultrasound guided sampling in peripheral lung lesions. Lung Cancer. 219-225.
  • Show author(s) (2011). 6 minutts gangtest hos KOLS-pasienter.
  • Show author(s) (2010). Systemic mannose-binding lectin is not associated with chronic obstructive pulmonary disease. Respiratory Medicine. 283-290.
  • Show author(s) (2010). Systemic inflammatory markers in chronic obstructive pulmonary disease – results from the Bergen COPD Cohort Study. European Respiratory Journal. 540-548.
  • Show author(s) (2010). Socioeconomic risk factors for lung function decline in a general population. European Respiratory Journal. 480-487.
  • Show author(s) (2010). Significance of endobronchial lesion appearance in the diagnostic value of different endoscopic techniques Response. Respiratory Medicine. 1387-1387.
  • Show author(s) (2010). Respiratory symptoms in adults are related to impaired quality of life, regardless of asthma and COPD: results from the European community respiratory health survey. Health and Quality of Life Outcomes.
  • Show author(s) (2010). Reference values for resistance and reactance measures from Impuls Oscillometry in healthy elderly.
  • Show author(s) (2010). Quantitative computed tomography measures of emphysema and airway wall thickness are related to respiratory symptoms. American Journal of Respiratory and Critical Care Medicine. 353-359.
  • Show author(s) (2010). Neutrophil Gelatinase-Associated Lipocalin A Biomarker in COPD. Chest. 888-895.
  • Show author(s) (2010). In-flight respiratory symptoms and pre-flight characteristics in patients with COPD.
  • Show author(s) (2010). Body composition and plasma levels of inflammatory biomarkers in COPD. European Respiratory Journal. 1027-1033.
  • Show author(s) (2010). Air travel habits in patients with COPD.
  • Show author(s) (2009). Within-day repeatability and signal to noise ratio for IOS parameters and FEV1 in smokers with and without COPD.
  • Show author(s) (2009). Systemic mannose-binding lectin is not associated with chronic obstructive pulmonary disease. Respiratory Medicine. 283-290.
  • Show author(s) (2009). Quantitative CT Measures of Emphysema and Airway Wall Thickness Are Related to Respiratory Symptoms. American Journal of Respiratory and Critical Care Medicine.
  • Show author(s) (2009). Occupational exposure and incidence of respiratory disorders in a general population. Scandinavian Journal of Work, Environment and Health. 454-460.
  • Show author(s) (2009). Cost minimization analysis for combinations of sampling techniques in bronchoscopy of endobronchial lesions. Respiratory Medicine. 888-894.
  • Show author(s) (2008). Respiratory symptoms, COPD severity, and health related quality of life in a general population sample. Respiratory Medicine. 399-406.
  • Show author(s) (2008). Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques. BMC Pulmonary Medicine.
  • Show author(s) (2007). JEM-based occupational exposure assessment and incidence of respiratory disorders in a community sample.
  • Show author(s) (2007). Changes in Respiratory Symptoms and Health-Related Quality of Life. Chest. 1890-1897.

More information in national current research information system (CRIStin)

 

 

The Bergen COPD Microbiome Study (MicroCOPD)

The study aims to characterize the airways microbiome in patients with COPD, compared with healthy adults.

Secondary motives are to assess different bronchoscopic sampling techniques, to compare the microbiome within the lungs (upper versus lower airways, left versus right lung), the stability of the microbiome, and to study the impact of tobacco smoking and composition of the lower airways microbiome on development of COPD.

The pilot study was performed spring of 2012, data collection was performed 213-2015.16Sr DNA sequencing was performed in-house on the Illumina MiSeq platform. Several research papers have been published from this study, and already three bright PhD students (Einar Marius Martinsen, Christine Drengenes and Elise Leiten) have finalized their PhD projects with data from this study. Several more are underway.

The lung microbiome in interstitial lung disease Study (MicroILD)

This is an extension of the MicroCOPD study, with the aim to characterize the airways microbiome in patients undergoing evaluation for interstitial lung diseases. Data collection was performed 2014-2016, and 70 patients with ILDs were included, and papers on IPF and sarcoidosis have been published.

The lung microbiome in lung cancer study (MicroLC)

The final extension of the MicroCOPD study is per August 2023 in its pilot phase. We aim to examine how the pulmonary and gut microbiome influences risk of lung cancer, influence on treatment response and risk of treatment-related side effects.

The Bergen GeneCOPD follow-up study (GenKOLS follow-up)

The first Bergen GeneCOPD study was performed in 2002/04, where 500 COPD patients and healthy controls were assessed with a CT scan, lung function testing and clinical data, and gene wide association studies were performed. In 2014 the follow-up started, aiming to include 250 patients and 400 controls. The primary study question is the assessment of longitudinal change in COPD assessed by CT thorax, secondary motive is to assess risk factors for comorbid coronary heart disease. 

The Bergen COPD Cohort Study (BergenCOPD)

The study started in 2006 and ended in 2014. More than 400 COPD patients and 300 healthy controls were included, and most were attempted followed until the end of 2014, with annual clinical examinations.

The main research question was to search for predictors of later advers outcomes such as mortality, exacerbation frequency, development of cachexia and lung function decline. Almost 40 research papers are published from this study, and data from this study have been part of a number of PhD theses (Louise Persson, Eirunn Waatevik, Bernt Aarli, Bente Frisk, Marie Waatevik, Gunnar Husebø, Solveig Tangedal)