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Tomasz Tadeusz Kantyka's picture

Tomasz Tadeusz Kantyka

Postdoctoral fellow, Post-doc/Researcher
  • E-mailTomasz.Kantyka@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen

Coordinator and lecturer at MEDMET-1

B. Wladyka, A. J. Kozik, M. Bukowski, A. Rojowska, T. Kantyka, G. Dubin, A. Dubin, alpha1-Antichymotrypsin inactivates staphylococcal cysteine protease in cross-class inhibition. Biochimie 93, 948-953 (2011); published online EpubMay (10.1016/j.biochi.2011.01.014).

E. Frohlich, T. Kantyka, K. Plaza, K. H. Schmidt, W. Pfister, J. Potempa, S. Eick, Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis. Molecular oral microbiology 28, 192-203 (2013); published online EpubJun (10.1111/omi.12015).

J. Fischer, Z. Wu, T. Kantyka, M. Sperrhacke, O. Dimitrieva, Y. Koblyakova, K. Ahrens, N. Graumann, H. Baurecht, K. Reiss, J. M. Schroder, E. Proksch, U. Meyer-Hoffert, Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury. The Journal of investigative dermatology 134, 1305-1312 (2014); published online EpubMay (10.1038/jid.2013.502).

J. Koziel, D. Bryzek, A. Sroka, K. Maresz, I. Glowczyk, E. Bielecka, T. Kantyka, K. Pyrc, P. Svoboda, J. Pohl, J. Potempa, Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis. Journal of immunology 192, 5363-5372 (2014); published online EpubJun 1 (10.4049/jimmunol.1303062).

O. Laugisch, A. Wong, A. Sroka, T. Kantyka, J. Koziel, K. Neuhaus, A. Sculean, P. J. Venables, J. Potempa, B. Moller, S. Eick, Citrullination in the periodontium--a possible link between periodontitis and rheumatoid arthritis. Clinical oral investigations 20, 675-683 (2016); published online EpubMay (10.1007/s00784-015-1556-7).

N. Gruba, E. Bielecka, M. Wysocka, A. Wojtysiak, M. Brzezinska-Bodal, K. Sychowska, M. Kalinska, M. Magoch, A. Pecak, K. Falkowski, M. Wisniewska, L. Sasiadek, K. Plaza, E. Kroll, A. Pejkovska, M. Rehders, K. Brix, G. Dubin, T. Kantyka, J. Potempa, A. Lesner, Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity. International journal of molecular sciences 20,  (2019); published online EpubMar 28 (10.3390/ijms20071557).

M. Kaminska, A. Aliko, A. Hellvard, E. Bielecka, V. Binder, A. Marczyk, J. Potempa, N. Delaleu, T. Kantyka, P. Mydel, Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis. Journal of periodontology,  (2018); published online EpubDec 2 (10.1002/JPER.18-0179).

T. Kantyka, T. Latendorf, O. Wiedow, J. Bartels, R. Glaser, G. Dubin, J. M. Schroder, J. Potempa, U. Meyer-Hoffert, Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage. Biological chemistry 390, 1313-1320 (2009); published online EpubDec (10.1515/BC.2009.136).

G. Dubin, J. Stec-Niemczyk, M. Kisielewska, K. Pustelny, G. M. Popowicz, M. Bista, T. Kantyka, K. T. Boulware, H. R. Stennicke, A. Czarna, M. Phopaisarn, P. S. Daugherty, I. B. Thogersen, J. J. Enghild, N. Thornberry, A. Dubin, J. Potempa, Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln. Journal of molecular biology 379, 343-356 (2008); published online EpubMay 30 (10.1016/j.jmb.2008.03.059).

K. Plaza, M. Kalinska, O. Bochenska, U. Meyer-Hoffert, Z. Wu, J. Fischer, K. Falkowski, L. Sasiadek, E. Bielecka, B. Potempa, A. Kozik, J. Potempa, T. Kantyka, Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins. The Journal of biological chemistry 291, 18753-18764 (2016); published online EpubSep 2 (10.1074/jbc.M116.722942).

T. Kantyka, J. Potempa, Human SCCA serpins inhibit staphylococcal cysteine proteases by forming classic "serpin-like" covalent complexes. Methods in enzymology 499, 331-345 (2011)10.1016/B978-0-12-386471-0.00016-X).

K. Pyrc, A. Milewska, T. Kantyka, A. Sroka, K. Maresz, J. Koziel, K. A. Nguyen, J. J. Enghild, A. D. Knudsen, J. Potempa, Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage. Infection and immunity 81, 55-64 (2013); published online EpubJan (10.1128/IAI.00830-12).

T. Kantyka, J. Fischer, Z. Wu, W. Declercq, K. Reiss, J. M. Schroder, U. Meyer-Hoffert, Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides 32, 1187-1192 (2011); published online EpubJun (10.1016/j.peptides.2011.03.009).

T. Kantyka, K. Plaza, J. Koziel, D. Florczyk, H. R. Stennicke, I. B. Thogersen, J. J. Enghild, G. A. Silverman, S. C. Pak, J. Potempa, Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence. Biological chemistry 392, 483-489 (2011); published online EpubMay (10.1515/BC.2011.044).

M. Potempa, J. Potempa, T. Kantyka, K. A. Nguyen, K. Wawrzonek, S. P. Manandhar, K. Popadiak, K. Riesbeck, S. Eick, A. M. Blom, Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. PLoS pathogens 5, e1000316 (2009); published online EpubFeb (10.1371/journal.ppat.1000316).

U. Meyer-Hoffert, Z. Wu, T. Kantyka, J. Fischer, T. Latendorf, B. Hansmann, J. Bartels, Y. He, R. Glaser, J. M. Schroder, Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. The Journal of biological chemistry 285, 32174-32181 (2010); published online EpubOct 15 (10.1074/jbc.M109.091850).

M. Kalinska, U. Meyer-Hoffert, T. Kantyka, J. Potempa, Kallikreins - The melting pot of activity and function. Biochimie 122, 270-282 (2016); published online EpubMar (10.1016/j.biochi.2015.09.023).

S. Eick, M. Puklo, K. Adamowicz, T. Kantyka, P. Hiemstra, H. Stennicke, A. Guentsch, B. Schacher, P. Eickholz, J. Potempa, Lack of cathelicidin processing in Papillon-Lefevre syndrome patients reveals essential role of LL-37 in periodontal homeostasis. Orphanet journal of rare diseases 9, 148 (2014); published online EpubSep 27 (10.1186/s13023-014-0148-y).

N. Mallorqui-Fernandez, S. P. Manandhar, G. Mallorqui-Fernandez, I. Uson, K. Wawrzonek, T. Kantyka, M. Sola, I. B. Thogersen, J. J. Enghild, J. Potempa, F. X. Gomis-Ruth, A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. The Journal of biological chemistry 283, 2871-2882 (2008); published online EpubFeb 1 (10.1074/jbc.M708481200).

A. Y. Karim, M. Kulczycka, T. Kantyka, G. Dubin, A. Jabaiah, P. S. Daugherty, I. B. Thogersen, J. J. Enghild, K. A. Nguyen, J. Potempa, A novel matrix metalloprotease-like enzyme (karilysin) of the periodontal pathogen Tannerella forsythia ATCC 43037. Biological chemistry 391, 105-117 (2010); published online EpubJan (10.1515/BC.2010.009).

T. Kantyka, L. N. Shaw, J. Potempa, Papain-like proteases of Staphylococcus aureus. Advances in experimental medicine and biology 712, 1-14 (2011)10.1007/978-1-4419-8414-2_1).

E. Bielecka, C. Scavenius, T. Kantyka, M. Jusko, D. Mizgalska, B. Szmigielski, B. Potempa, J. J. Enghild, E. R. Prossnitz, A. M. Blom, J. Potempa, Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity. The Journal of biological chemistry 289, 32481-32487 (2014); published online EpubNov 21 (10.1074/jbc.C114.617142).

O. Laugisch, M. Schacht, A. Guentsch, T. Kantyka, A. Sroka, H. R. Stennicke, W. Pfister, A. Sculean, J. Potempa, S. Eick, Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid. Molecular oral microbiology 27, 45-56 (2012); published online EpubFeb (10.1111/j.2041-1014.2011.00631.x).

T. Kantyka, N. D. Rawlings, J. Potempa, Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function. Biochimie 92, 1644-1656 (2010); published online EpubNov (10.1016/j.biochi.2010.06.004).

P. Kulig, T. Kantyka, B. A. Zabel, M. Banas, A. Chyra, A. Stefanska, H. Tu, S. J. Allen, T. M. Handel, A. Kozik, J. Potempa, E. C. Butcher, J. Cichy, Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. Journal of immunology 187, 1403-1410 (2011); published online EpubAug 1 (10.4049/jimmunol.1002352).

H. F. R. Jentsch, N. Arnold, V. Richter, J. Deschner, T. Kantyka, S. Eick, Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight. Journal of periodontal research 52, 1050-1057 (2017); published online EpubDec (10.1111/jre.12476).

J. Smagur, K. Guzik, M. Bzowska, M. Kuzak, M. Zarebski, T. Kantyka, M. Walski, B. Gajkowska, J. Potempa, Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages. Biological chemistry 390, 361-371 (2009); published online EpubApr (10.1515/BC.2009.042).

M. Jusko, J. Potempa, T. Kantyka, E. Bielecka, H. K. Miller, M. Kalinska, G. Dubin, P. Garred, L. N. Shaw, A. M. Blom, Staphylococcal proteases aid in evasion of the human complement system. Journal of innate immunity 6, 31-46 (2014)10.1159/000351458).

T. Kantyka, K. Pyrc, M. Gruca, J. Smagur, K. Plaza, K. Guzik, S. Zeglen, M. Ochman, J. Potempa, Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung. Journal of innate immunity 5, 251-260 (2013)10.1159/000345417).

T. Goulas, D. Mizgalska, I. Garcia-Ferrer, T. Kantyka, T. Guevara, B. Szmigielski, A. Sroka, C. Millan, I. Uson, F. Veillard, B. Potempa, P. Mydel, M. Sola, J. Potempa, F. X. Gomis-Ruth, Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase. Scientific reports 5, 11969 (2015); published online EpubJul 1 (10.1038/srep11969).

M. Kalinska, T. Kantyka, D. C. Greenbaum, K. S. Larsen, B. Wladyka, A. Jabaiah, M. Bogyo, P. S. Daugherty, M. Wysocka, M. Jaros, A. Lesner, K. Rolka, N. Schaschke, H. Stennicke, A. Dubin, J. Potempa, G. Dubin, Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C. Biochimie 94, 318-327 (2012); published online EpubFeb (10.1016/j.biochi.2011.07.020).

  • Aliko, Ardita; Kaminska, Marta; Falkowski, Katherine; Bielecka, Ewa; Benedyk-Machaczka, Malgorzata; Malicki, Stanislaw; Koziel, Joanna; Wong, Alicia; Bryzek, Danuta; Kantyka, Tomasz Tadeusz; Mydel, Piotr Mateusz. 2019. Discovery of novel potential reversible peptidyl arginine deiminase inhibitor. International Journal of Molecular Sciences. 20. doi: 10.3390/ijms20092174
  • Jonsson, Maria Karolina; Kantyka, Tomasz Tadeusz; Falkowski, Katherine; Aliko, Ardita; Aga, Anna-Birgitte; Lillegraven, Siri; Sexton, Joseph; Fevang, Bjørg-Tilde Svanes; Mydel, Piotr Mateusz; Haavardsholm, Espen A. 2019. Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis. Scandinavian Journal of Rheumatology. 9 pages. doi: 10.1080/03009742.2019.1641216
  • Jentsch, Holger F.R.; Arnold, N.; Richter, V.; Deschner, James; Kantyka, Tomasz Tadeusz; Eick, Sigrun. 2017. Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight. Journal of Periodontal Research. 52: 1050-1057. doi: 10.1111/jre.12476

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