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Torgils Fossen

Professor
  • E-mailTorgils.Fossen@uib.no
  • Phone+47 55 58 34 63
  • Visitor Address
    Realfagbygget, Allégt. 41
  • Postal Address
    Postboks 7803
    5020 BERGEN
Academic article
  • 2020. Flavonoids and other phenolics in herbs commonly used in Norwegian commercial kitchens. Food Chemistry. 1-8.
  • 2019. Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L. Phytochemistry. 67-77.
  • 2019. Bumblebee death associated with Tilia x europaea L. Biochemical Systematics and Ecology. 16-23.
  • 2019. A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae). Heliyon. 1-13.
  • 2018. The N-Terminus of the HIV-1 p6 Gag Protein Regulates Susceptibility to Degradation by IDE. Viruses. 1-23.
  • 2017. Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism. Tetrahedron. 3866-3877.
  • 2017. Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. PLOS ONE. 1-29.
  • 2017. Non-Polar Natural Products from Bromelia laciniosa, Neoglaziovia variegata and Encholirium spectabile (Bromeliaceae). Molecules.
  • 2017. Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry. 646-657.
  • 2016. Toxic aromatic compounds from fruits of Narthecium ossifragum L. Phytochemistry. 76-85.
  • 2016. The prolyl isomerase pin1 promotes the herpesvirus-induced phosphorylation-dependent disassembly of the nuclear lamina required for nucleocytoplasmic egress. PLoS Pathogens. 30 pages.
  • 2016. New Polyfunctional Phragmalin Limonoids from Neobeguea mahafalensis. Planta Medica. 1087-1095.
  • 2016. Glutamic acid residues in HIV-1 p6 regulate virus budding and membrane association of gag. Viruses.
  • 2015. pUL69 of human cytomegalovirus recruits the cellular protein arginine methyltransferase 6 via a domain that is crucial for mRNA export and efficient viral replication. Journal of Virology. 9601-9615.
  • 2015. The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects. Biochemical Pharmacology. 1-15.
  • 2015. Pseudoaeruginosins, nonribosomal peptides in nodularia spumigena. ACS Chemical Biology. 725-733.
  • 2015. Growing with dinosaurs: natural products from the Cretaceous relict Metasequoia glyptostroboides Hu & Cheng - a molecular reservoir from the ancient world with potential in modern medicine. Phytochemistry Reviews. 35 pages.
  • 2015. First identification of natural products from the African medicinal plant Zamioculcas zamiifolia - A drought resistant survivor through millions of years. Fitoterapia. 280-285.
  • 2014. The first flavonoid isolated from Bromelia laciniosa (Bromeliaceae). Journal of Medicinal Plants Research. 558-563.
  • 2014. Reversible ketomethylene-based inhibitors of human neutrophil proteinase 3. Journal of Medicinal Chemistry. 9396-9408.
  • 2014. Mutation of the highly conserved ser-40 of the HIV-1 p6 gag protein to phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of gag. Viruses. 3738-3765.
  • 2014. Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry. 4759-4769.
  • 2014. Balticidins A-D, antifungal hassallidin-like lipopeptides from the Baltic Sea cyanobacterium Anabaena cylindrica Bio33. Journal of natural products. 1287-1296.
  • 2014. 6-Carboxydihydroresveratrol 3-O-β-glucopyranoside - A novel natural product from the Cretaceous relict Metasequoia glyptostroboides. Fitoterapia. 109-114.
  • 2013. Novel GHB-derived natural products from European mistletoe (Viscum album). Pharmaceutical Biology. 981-986.
  • 2013. Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures. Biochimica et Biophysica Acta - Proteins and Proteomics. 568-582.
  • 2013. HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein. Biochimica et Biophysica Acta - Biomembranes. 816-823.
  • 2012. Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-alpha binding. Journal of General Virology. 1756-1768.
  • 2012. Novel aminoalkaloids from European mistletoe (Viscum album L.). Phytochemistry Letters. 677-681.
  • 2012. HIV-1 p6-Another viral interaction partner to the host cellular protein cyclophilin A. Biochimica et Biophysica Acta - Proteins and Proteomics. 667-678.
  • 2012. A new protolimonoid from Capuronianthus mahafalensis. Fitoterapia. 901-906.
  • 2011. The Host-Pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains. BMC Structural Biology. 16 pages.
  • 2011. Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly. Retrovirology. 16 pages.
  • 2010. The intriguing Cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding. BMC Structural Biology. 15 pages.
  • 2010. Flavone C-Glycosides from seeds of Fenugreek, Trigonella foenum-graecum L. Journal of Agricultural and Food Chemistry. 7211-7217.
  • 2009. Structural properties of anthocyanins: Rearrangement of C-Glycosyl-3-deoxyanthocyanidins in acidic aqueous solutions. Journal of Agricultural and Food Chemistry. 6668-6677.
  • 2009. C-glycosylanthocyanidins synthesized from C-glycosylflavones. Phytochemistry. 278-287.
  • 2008. The flavonoids of tomatoes. Journal of Agricultural and Food Chemistry. 2436-2441.
  • 2008. Synthesis of full length PB1-F2 influenza A virus proteins from 'Spanish flu' and 'bird flu'. Journal of Peptide Science. 954-962.
  • 2007. Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein. Journal of Biological Chemistry. 353-363.
  • 2007. Reactivity of anthocyanins and pyranoanthocyanins. Studies on aromatic hydrogen-deuterium exchange reactions in methanol. Journal of Agricultural and Food Chemistry. 8261-8268.
  • 2007. Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo. Journal of Virology. 9572-9576.
  • 2007. Onions: A source of unique dietary flavonoids. Journal of Agricultural and Food Chemistry. 10067-10080.
  • 2007. Molar Absorptivities and Reducing Capacity of Pyranoanthocyanins and Other Anthocyanins. Journal of Agricultural and Food Chemistry. 10591-10598.
  • 2007. Covalent anthocyanin-flavone dimer from leaves of Oxalis triangularis. Phytochemistry. 552-562.
  • 2007. Anthocyanin 3-galactosides from Cornus alba 'Sibirica' with glucosidation of the B-ring. Phytochemistry. 640-645.
  • 2006. Preparative isolation and NMR characterization of carboxypyranoanthocyanins. Journal of Agricultural and Food Chemistry. 3572 -3577.
  • 2006. Characterization of Hemiacetal Forms of Anthocyanidin 3-O-b-Glycopyranosides. Journal of Agricultural and Food Chemistry. 9340-9346.
  • 2005. Solution structure of the human immunodeficiency virus type 1 p6 protein. Journal of Biological Chemistry. 42515-42527.
  • 2005. Isolation and identification of flavonoids, including flavone rotamers, from the herbal drug Crataegi folium cum flore (hawthorn). Phytochemical Analysis. 334-341.
  • 2005. Flavone C-glycosides from leaves of Oxalis triangularis. Journal of Agricultural and Food Chemistry. 10057-10060.
  • 2005. Acylated anthocyanins from leaves of Oxalis triangularis. Phytochemistry. 1133-1140.
  • 2004. Dimeric anthocyanins from strawberry (Fragaria ananassa) consisting of pelargonidin 3-glucoside covalently linked to four flavan-3-ols. Phytochemistry. 1421-1428.
  • 2004. Anthocyanin from strawberry (Fragaria ananassa) with the novel aglycone, 5-carboxypyranopelargonidin. Phytochemistry. 405-410.
  • 2003. Structural characterization of the HIV-1 Vpr N terminus - Evidence of cis/trans-proline isomerism. Journal of Biological Chemistry. 43188-43201.
  • 2003. Anthocyanins with 4'-glucosidation from red onion, Allium cepa. Phytochemistry. 1367-1374.
  • 2003. Anthocyanins from red onion, Allium cepa, with novel aglycon. Phytochemistry. 1217-1220.
  • 2003. Anthocyanins from flowers of the orchids Dracula chimaera and D. cordobae. Phytochemistry. 783-787.
  • 2003. Anthocyanins from a Norwegian potato cultivar. Food Chemistry. 433-437.
  • 2002. Anthocyanins of grasses. Biochemical Systematics and Ecology. 855-864.
  • 2001. Cyanidin 3-(6"-acetylgalactoside) and other anthocyanins from reddish leaves of the water lily, Nymphaea alba. Journal of Horticultural Science & Biotechnology. 213-215.
  • 2001. Anthocyanins from maize, Zea mays, and reed canarygrass, Phalaris arundinacea. Journal of Agricultural and Food Chemistry. 2318-2321.
  • 2000. Covalent anthocyanin-flavonol complexes from flowers of chive, Allium schoenoprasum. Phytochemistry. 317-323.
  • 2000. Colour and stability of the six common anthocyanidin 3-glucosides in aqueous solutions. Food Chemistry. 101-107.
  • 2000. Anthocyanins from tubers and shoots of the purple potato. Journal of Horticultural Science & Biotechnology. 360-363.
  • 1999. Flavonoids from blue flowers of Nymphaea caerulea. Phytochemistry. 1133-1137.
  • 1999. Delphinidin 3'-galloylgalactosides from blue flowers of Nymphaea caerulea. Phytochemistry. 1185-1188.
  • 1999. Cyanidin 3-(2'',3''-digalloylglucoside) from red leaves of Acer platanoides. Phytochemistry. 1697-1700.
  • 1999. Anthocyanin pigments of tulips. Phytochemistry. 1687-1692.
  • 1998. Petunidin 3-O-a-rhamnopyranoside-5-O-b-glucopyranoside and other anthocyanins from flowers of Vicia villosa. Journal of Agricultural and Food Chemistry. 4568-4570.
  • 1998. Myricetin 3-rhamnopyranosyl (1-6) galactoside from Nymphaea x marliacea. Phytochemistry. 1997-2000.
  • 1998. Flavonoids from red onion (Allium cepa). Phytochemistry. 281-285.
  • 1998. Cyanidin 3-(6"-succinyl-b-glucopyranoside) and other anthocyanins from Phragmites australis. Phytochemistry. 1065-1068.
  • 1998. Color and stability of pure anthocyanins influenced by pH including the alkaline region. Food Chemistry. 435-440.
  • 1998. Anthocyanins from flowers and leaves of Nympaea x marliacea cultivars. Phytochemistry. 823-827.
  • 1997. Malonylated anthocyanins of garilc Allium sativum. Food Chemistry. 215-217.
  • 1997. Acylated anthocyanins from leaves of the water lily, Nympaea x marliacea. Phytochemistry. 353-357.
  • 1996. Unusual substitution pattern of anthocyanins containing aliphatic acids. Polyphenols Communications. 11-12.
  • 1996. Characteristic Anthocyanin Pattern from Onions and other Allium spp. Journal of Food Science. 703-706.
  • 1996. Characteristic Anthocyanin Pattern from Onions and other Allium spp. Journal of Food Science. 703-706.
  • 1995. Anthocyanins with unusual acylation pattern from stem of Allium victorialis. Phytochemistry. 1809-1812.
Report
  • 2017. Assessment of the potential connection between Tilia trees and bumblebee Death. Opinion of the Panel on Alien organisms and trade in endangered species (CITES) of the Norwegian Scientific Committee for Food Safety. 2017:15. 2017:15. .
Lecture
  • 2016. The Nobel Prize in Medicine 2015.
  • 2013. PB1-F2 –Structural signatures of highly pathogenic influenza viruses.
Popular scientific lecture
  • 2016. Planter er medisin. Dialogbasert omvisning med kjemikeren, legen og botanikeren om både tradisjonelle og nye medisinplanter.
  • 2000. Farger i naturen.
Academic lecture
  • 2018. Nytt potensielt virkestoff fra urgammel iransk medisinplante.
  • 2017. Rome –en unik kilde til nye antileukemi naturprodukter.
  • 2016. Alpha-helix 2 of the multifunctional regulatory protein pUL69 mediates Pin1-interaction and its phosphorylation is required for efficient multiplication of human cytomegalovirus.
  • 2015. Mutations of viral proteins –and their structural consequences.
  • 2015. Characterization of increasingly complex bioactive natural products.
  • 2012. Two NLS sequences within the cytomegaloviral protein kinase pUL97 regulate the nuclear import of both isoforms through the classical importin α/β pathway.
  • 2012. The intriguing host–pathogen interaction of human cyclophilin A and HIV-1 Vpr: prolyl cis/trans isomerisation catalysis and specific binding.
  • 2012. The Host-Pathogen interaction of Human Cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains.
  • 2012. Recent advances in structural investigations of viral proteins.
  • 2011. The intriguing Host-Pathogen interaction of Human Cyclophilin A and HIV-1 Vpr.
  • 2008. Hydrogen-deuterium exchange rates of various anthocyanin classes as basis for reactivity studies.
  • 2007. Biological functionality of anthocyanins expressed through structure details.
  • 2007. Analysis of Flavonoids in bulbs of Allium cepa.
  • 2006. Solution structure of the Human Immunodeficiency Virus type 1 p6 protein.
  • 2006. Characterization of novel flavonoids from leaves of Oxalis triangularis including equilibrium forms of a covalent anthocyanin-flavone C-glycoside.
  • 2006. Characterization of novel flavonoid classes by NMR spectroscopy.
  • 2005. The anthocyanins: A review on occurence, chemistry and properties during the last decade.
  • 2005. Structure of the multifunctional HIV-1 protein p6.
  • 2003. Structure and interaction studies of HIV-1 proteins. Multidimensional NMR of 15N-labelled full-length Vpr.
  • 1999. Stability of anthocyanins in alkaline media. 1st. International Congress on Pigments in Food Technology.
  • 1998. Colour and stability of pure anthocyanins in aqueous solutions at high pH values.
  • 1996. Antocyaner i løkplanter.
  • 1996. Anthocyanins with unusual acylation pattern from Allium species.
Masters thesis
  • 2017. Effekt av utvalgte unike naturstoffer på celleviabilitet og sårtilheling i nevroendokrine PC12 celler med særlig fokus på Annexin A2.
Popular scientific article
  • 1998. Flavonoidar i planter - Forsvar og kommunikasjon. Naturen.
  • 1998. Antocyaner i mat. Kjemi. 14-16.
Doctoral dissertation
  • 2017. Characterization of bioactive natural products from edible, medicinal and toxic plants.
  • 2007. Isolation, identification and properties of pyranoanthocyanins and anthocyanin forms.
  • 1998. Chemical studies of acylated anthocyanins and other flavonoids isolated from plants. -.
Academic chapter/article/Conference paper
  • 2006. Spectroscopic Techniques Applied to Flavonoids. 76 pages.
  • 2000. Beskrivelse av den trolig eldste norske påskeliljekultivar, basert på kjemiske, morfologiske og cytologiske undersøkelser. 4 pages.
Encyclopedia article
  • 2003. Characterization of anthocyanins by NMR. 1-24. In:
    • 2003. Current Protocols in Food Analytical Chemistry.
Poster
  • 2017. Zamioculcas zamiifolia –an ancient African medicinal plant with undeserved bad reputation?
  • 2017. The secondalpha-helix within pUL69 contains pUL97-phosphorylation sites that critically affect Pin1-mediated isomerization and efficient multiplication of HCMV.
  • 2017. Novel complex polyfunctional phragmalin limonoids from the Madagascar medicinal plant Neobeguea mahafalensis.
  • 2017. Non-polar natural products from the drought resistant Brazilian medicinal plants Bromelia laciniosa, Neoglaziovia variegata and Encholirium spectabile (Bromeliaceae).
  • 2017. Balticidins A−D, Structurally complex antifungal Lipopeptides from the Baltic Sea Cyanobacterium Anabaena cylindrica Bio33.
  • 2016. Peptidyl-prolyl isomerase Pin1 is an important effector in the phosphorylation-triggered reorganization of the nuclear lamina during herpesvirus nuclear egress.
  • 2016. Glutamic acid residues in HIV-1 p6 regulate virus budding and membrane association of gag.
  • 2015. Motifs in HIV-1 p6 Gag that regulate ubiquitination and membrane association of Gag.
  • 2015. Cellular isomerase Pin1 promotes the phosphorylation-triggered disassembly of the nuclear lamina during nuclear egress of alpha-, beta- and gamma-herpesviruses.
  • 2014. Phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of herpesviruses.
  • 2013. A novel natural product from the dinosaur-age tree Metasequoia glyptostroboides.
  • 2012. The intriguing host–pathogen interaction of human cyclophilin A and HIV-1 Vpr.
  • 2012. Specification of the HCMV pUL97 isoforms: differences in subcellular localization and functionality.
  • 2012. Serine-40 in HIV-1 p6 regulates Gag ubiquitinylation in an L-domain independent manner.
  • 2012. Novel aminoalkaloids from European Mistletoe.
  • 2011. The Intriguing Cyclophilin A-HIV-1 Vpr Interaction: Prolyl cis/trans Isomerisation Catalysis and Specific Binding.
  • 2008. Reactivity studies by NMR on anthocyanins occurring in fruits and berries.
  • 2007. The impact of anthocyanin purity in antioxidant measurements.
  • 2007. Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein.
  • 2007. Proline 35 of HIV-1 Vpr regulates incorporation in virus particles and is required for replication in macrophages.
  • 2007. Analysis of anti-p6 antibodies in HIV-1 infected individuals.
  • 2006. Structure, folding, and oligomerization of PB1-F2, a pro-apoptotic inluenza A virus protein.
  • 2006. Solution structure of the Human Immunodeficiency Virus type 1 p6 protein.
  • 2006. NMR characterization of various forms of anthocyanin 3-glucosides in deuterated methanolic solutions with and without acid.
  • 2006. Characterization of 5-carboxypyranoanthocyanins.
  • 2006. Anthocyanin 3-galactosides with glucosyl moieties on the B-ring from Cornus alba ‘Sibirica’.
  • 2005. Nutritional aspects of anthocyanin pigments.
  • 2005. Flavonoids from the herbal drug “Crataegi folium cum flore”, hawthorn.
  • 2004. Covalently linked anthocyanin-flavanol dimers.
  • 2004. Characterization of Pyranoanthocyanins.
  • 2001. Chive, a specialised flavonoid producer.
  • 2000. Anthocyanins from grasses.
  • 1999. Analysis of covalent anthocyaninflavonol complexes from flowers of chives Allium schoenoprasum.
  • 1997. Anthocyasins of some bluish flowers (<EM>Lupinus, Echium</EM> and <EM>Echium</EM> and <EM>Vicia</EM> spp).
Academic literature review
  • 2007. Onions: A source of unique dietary flavonoids. 10067-10080.

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