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Night shift work is associated with sleep problems and multiple other negative health effects. Prolonged wakefulness induces deficits in brain functions, which affects alertness, performance and mood. My PhD-project is a translational project and involves simulating night-shift work in both rats and humans. I aim to investigate how night-shift work affects waking function and cognitive performance during work, and subsequent sleep. I will also investigate how different light interventions during simulated night-shifts will affect the brains' processing capasity and how it may impact daytime sleep.
- 2017. No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 11:70: 1-12. doi: 10.3389/fncir.2017.00070
- 2016. A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms. 32: 48-63. doi: 10.1177/0748730416675460
- 2016. Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. Nutrients. 8:712: 1-13. doi: 10.3390/nu8110712
No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex. Marti AR, Patil S, Mrdalj J, Meerlo P, Skrede S, Pallesen S, Pedersen TT, Bramham CR, Grønli J. Frontiers in Neural Circuits, 2017 11(70). doi: 10.3389/fncir.2017.00070.
A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Grønli J, Meerlo P, Pedersen TT, Pallesen S, Skrede S, Marti AR, Wisor JP, Murison R, Henriksen TEG, Rempe MJ, Mrdalj J. J Biol Rhythm, 2017 Feb;32(1):48-63. doi: 10.1177/0748730416675460.
Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shift work. A rat model. Marti AR, Meerlo P, Grønli J, van Hasselt SJ, Mrdalj J, Pallesen S, Pedersen TT, Henriksen TEG, Skrede S.Nutrients, 2016 Nov 8;8(11). doi:10.3390/nu8110712