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Yenan Bryceson

Professor
  • E-mailYenan.Bryceson@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Theorell, Axel; Bryceson, Yenan; Theorell, Jakob. 2019. Determination of essential phenotypic elements of clusters in high-dimensional entities—DEPECHE. PLOS ONE. 14: 1-15. doi: 10.1371/journal.pone.0203247
  • Theorell, Jakob; Bileviciute-Ljungar, Indre; Tesi, Bianca; Schlums, Heinrich; Johnsgaard, Mette Sophie; Asadi-Azarbaijani, Babak; Strand, Elin Bolle; Bryceson, Yenan. 2019. Corrigendum: Unperturbed cytotoxic lymphocyte phenotype and function in myalgic encephalomyelitis/chronic fatigue syndrome patients. Frontiers in Immunology. 10. doi: 10.3389/fimmu.2019.00350
  • Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Davies, Richard Allan; Bader, Lucius; Holmes, Timothy; Gavasso, Sonia; Bryceson, Yenan; Jonsson, Roland; Sandvik, Lene Frøyen; Appel, Silke. 2018. Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. British Journal of Dermatology. 179: 371-380. doi: 10.1111/bjd.16269
  • Chiang, Samuel C.C.; Vergamini, Sue M; Husami, Ammar; Neumeier, Lisa; Quinn, Kathryn; Ellerhorst, Teresa; Sheppard, Linda; Gifford, Carrie; Buchbinder, David; Joshi, Avni; Ifversen, Marianne; Kleiner, Gary I; Bussel, James B.; Chandrakasan, Shanmuganathan; Pesek, Robert D; Pozos, Tamara; Rose, Melissa J; Scurlock, Amy M; Zhang, Kejian; Bryceson, Yenan; Bleesing, Jack; Marsh, Rebecca A. 2018. Screening for Wiskott-Aldrich syndrome by flow cytometry. Journal of Allergy and Clinical Immunology. 142: 333-335.e8. doi: 10.1016/j.jaci.2018.04.017
  • Cichocki, Frank; Wu, Cheng-Ying; Zhang, Bin; Felices, Martin; Tesi, Bianca; Tuininga, Katie; Dougherty, Phillip; Taras, Emily; Hinderlie, Peter; Blazar, Bruce R.; Bryceson, Yenan; Miller, Jeffrey S. 2018. ARID5B regulates metabolic programming in human adaptive NK cells. Journal of Experimental Medicine. 215: 2379-2395. doi: 10.1084/jem.20172168
  • Hagberg, Niklas; Joelsson, Martin; Leonard, Dag; Reid, Sarah; Eloranta, Maija-Leena; Mo, John; Nilsson, Magnus K.; Syvänen, Ann-Christine; Bryceson, Yenan; Rönnblom, Lars. 2018. The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in t cells from patients with SLE. Annals of the Rheumatic Diseases. 77: 1070-1077. doi: 10.1136/annrheumdis-2017-212794
  • Jelencic, Vedrana; Sestan, Marko; Kavazovic, Inga; Lenartic, Maja; Marinovic, Sonja; Holmes, Tim D.; Prchal-Murphy, Michaela; Lisnic, Berislav; Sexl, Veronika; Bryceson, Yenan; Wensveen, Felix M; Polic, Bojan. 2018. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nature Immunology. 19: 1083-1092. doi: 10.1038/s41590-018-0209-9
  • Solberg, Silje Michelsen; Sandvik, Lene Frøyen; Eidsheim, Marianne; Jonsson, Roland; Bryceson, Yenan; Appel, Silke. 2018. Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment? Scandinavian Journal of Immunology. 88:e12725: 1-7. doi: 10.1111/sji.12725
  • Tesi, Bianca; Bryceson, Yenan. 2018. HLH: Genomics illuminates pathophysiological diversity. Blood. 132: 5-7. doi: 10.1182/blood-2018-05-845818
  • Tesi, Bianca; Rascon, Jelena; Chiang, Samuel C.C.; Burnyte, Birute; Löfstedt, Alexandra; Fasth, Anders; Heizmann, Miriam; Juozapaite, Sandra; Kiudeliene, Rosita; Kvedaraite, Egle; Miseviciene, Valdone; Muleviciene, Audrone; Muller, Martha-Lena; Nordenskjöld, Magnus; Matuzeviciene, Reda; Samaitiene, Ruta; Speckmann, Carsten; Stankeviciene, Sigita; Zekas, Vytautas; Voss, Matthias; Ehl, Stephan; Vaiciene-Magistris, Nerija; Henter, Jan-Inge; Meeths, Marie; Bryceson, Yenan. 2018. A RAB27A 5' untranslated region structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation. Journal of Allergy and Clinical Immunology. 142: 317-321.e8. doi: 10.1016/j.jaci.2018.02.031
  • Wu, Chuanfeng; Espinoza, Diego A; Koelle, Samson J; Yang, Di; Truitt, Lauren; Schlums, Heinrich; Lafont, Bernard A; Davidson-Moncada, Jan K; Lu, Rong; Kaur, Amitinder; Hammer, Quirin; Li, Brian; Panch, Sandhya; Allan, David A; Donahue, Robert E; Childs, Richard W; Romagnani, Chiara; Bryceson, Yenan; Dunbar, Cynthia E. 2018. Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets. Science immunology. 3. doi: 10.1126/sciimmunol.aat9781
  • Zitti, Beatrice; Bryceson, Yenan. 2018. Natural killer cells in inflammation and autoimmunity. Cytokine & growth factor reviews. 42: 37-46. doi: 10.1016/j.cytogfr.2018.08.001
  • Cheuk, Stanley; Schlums, Heinrich; Gallais Serezal, Irene; Martini, Elisa; Chiang, Samuel C.C.; Marquardt, Nicole; Gibbs, Anna; Detlofsson, Ebba; Introini, Andrea; Forkel, Marianne; Höög, Charlotte M.; Tjernlund, Annelie; Michaëlsson, Jakob; Folkersen, Lasse; Mjösberg, Jenny M.; Blomqvist, Lennart; Ehrström, Marcus; Ståhle, Mona; Bryceson, Yenan; Eidsmo, Liv. 2017. CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin. Immunity. 46: 287-300. doi: 10.1016/j.immuni.2017.01.009
  • Chiang, Samuel C.C.; Wood, Stephanie M.; Tesi, Bianca; Akar, Himmet Haluk; Al-Herz, Waleed; Ammann, Sandra; Belen, Fatma Burcu; Caliskan, Umran; Kaya, Zuhre; Lehmberg, Kai; Patiroglu, Turkan; Tokgoz, Huseyin; Unuvar, Aysegul; Introne, Wendy J; Henter, Jan-Inge; Nordenskjöld, Magnus; Ljunggren, Hans-Gustaf; Meeths, Marie; Ehl, Stephan; Krzewski, Konrad; Bryceson, Yenan. 2017. Differences in granule morphology yet equally impaired exocytosis among cytotoxic T cells and NK cells from Chediak-Higashi syndrome patients. Frontiers in Immunology. 8. doi: 10.3389/fimmu.2017.00426
  • Corat, Marcus A F; Schlums, Heinrich; Wu, Chuanfeng; Theorell, Jakob; Espinoza, Diego A; Sellers, Stephanie E; Townsley, Danielle M; Young, Neal S; Bryceson, Yenan; Dunbar, Cynthia E; Winkler, Thomas. 2017. Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs. Blood. 129: 1940-1946. doi: 10.1182/blood-2016-08-734285
  • Davies, Richard Allan; Hammenfors, Daniel; Bergum, Brith; Jakobsen, Kjerstin; Solheim, Magne; Vogelsang, Petra; Brun, Johan G; Bryceson, Yenan; Jonsson, Roland; Appel, Silke. 2017. Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. Scandinavian Journal of Immunology. 86: 491-502. doi: 10.1111/sji.12622
  • Ilander, Mette; Olsson-Strömberg, Ulla; Schlums, Heinrich; Guilhot, Joëlle; Brück, Oscar; Lähteenmäki, Hanna; Kasanen, Tiina; Koskenvesa, Perttu; Söderlund, Stina; Höglund, Martin; Markevärn, Berit; Själander, Anders; Lotfi, Kourosh; Dreimane, Arta; Lübking, Anna; Holm, Elena; Björeman, Mats; Lehmann, Sören; Stenke, Leif; Ohm, Lotta; Gedde-Dahl, Thobias; Majeed, Mohammed Waleed; Ehrencrona, Hans; Koskela, Satu; Saussele, Susanne; Mahon, François-Xavier; Porkka, Kimmo; Hjorth-Hansen, Henrik; Bryceson, Yenan; Richter, Johan; Mustjoki, Satu. 2017. Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia. Leukemia. 31: 1108-1116. doi: 10.1038/leu.2016.360
  • Malmberg, Karl-Johan; Carlsten, Mattias; Björklund, Andreas; Sohlberg, Ebba; Bryceson, Yenan; Ljunggren, Hans-Gustaf. 2017. Natural killer cell-mediated immunosurveillance of human cancer. Seminars in Immunology. 31: 20-29. doi: 10.1016/j.smim.2017.08.002
  • Marcais, Antoine; Marotel, Marie; Degouve, Sophie; Koenig, Alice; Fauteux-Daniel, Sebastien; Drouillard, Annabelle; Schlums, Heinrich; Viel, Stephane; Besson, Laurie; Allatif, Omran; Blery, Mathieu; Vivier, Eric; Bryceson, Yenan; Thaunat, Olivier; Walzer, Thierry. 2017. High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors. eLIFE. 6. doi: 10.7554/eLife.26423
  • Schlums, Heinrich; Jung, Moonjung; Han, Hongya; Theorell, Jakob; Bigley, Venetia; Chiang, Samuel C.C.; Allan, David S J; Davidson-Moncada, Jan K; Dickinson, Rachel E; Holmes, Tim; Hsu, Amy P; Townsley, D.; Winkler, Thomas; Wang, Weixin; Aukrust, Pål; Nordøy, Ingvild; Calvo, Katherine R.; Holland, Steve; Collin, Matthew; Dunbar, Cynthia E; Bryceson, Yenan. 2017. Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells. Blood. 129: 1927-1939. doi: 10.1182/blood-2016-08-734236
  • Tesi, Bianca; Davidsson, Josef; Voss, Matthias; Rahikkala, Elisa; Holmes, Timothy; Chiang, Samuel C.C.; Komulainen-Ebrahim, Jonna; Gorcenco, Sorina; Nilsson, Alexandra Rundberg; Ripperger, Tim; Kokkonen, Hannaleena; Bryder, David; Fioretos, Thoas; Henter, Jan-Inge; Möttönen, Merja; Niinimäki, Riitta; Nilsson, Lars; Pronk, Cornelis Jan; Puschmann, Andreas; Qian, Hong; Uusimaa, Johanna; Moilanen, Jukka; Tedgård, Ulf; Cammenga, Jörg; Bryceson, Yenan. 2017. Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms. Blood. 129: 2266-2279. doi: 10.1182/blood-2016-10-743302
  • Theorell, Jakob; Bileviciute-Ljungar, Indre; Tesi, Bianca; Schlums, Heinrich; Johnsgaard, Mette Sophie; Asadi-Azarbaijani, Babak; Strand, Elin Bolle; Bryceson, Yenan. 2017. Unperturbed cytotoxic lymphocyte phenotype and function in myalgic encephalomyelitis/chronic fatigue syndrome patients. Frontiers in Immunology. 8:723: 1-15. doi: 10.3389/fimmu.2017.00723
  • Voss, Matthias; Bryceson, Yenan. 2017. Natural killer cell biology illuminated by primary immunodeficiency syndromes in humans. Clinical Immunology. 177: 29-42. doi: 10.1016/j.clim.2015.11.004
  • Cichocki, Frank; Cooley, Sarah; Davis, Zachary; DeFor, Todd E.; Schlums, Heinrich; Zhang, Bin; Brunstein, Claudio G.; Blazar, Bruce R.; Wagner, John; Diamond, Don J.; Verneris, Michael R.; Bryceson, Yenan; Weisdorf, Daniel J.; Miller, Jeffrey S. 2016. CD56dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT. Leukemia. 30: 456-463. doi: 10.1038/leu.2015.260
  • Cichocki, Frank; Schlums, Heinrich; Theorell, Jakob; Tesi, Bianca; Miller, Jeffrey S.; Ljunggren, Hans-Gustaf; Bryceson, Yenan. 2016. Diversification and functional specialization of human NK cell subsets. Current Topics in Microbiology and Immunology. 395: 63-93. doi: 10.1007/82_2015_487
  • Cichocki, Frank; Verneris, Michael R.; Cooley, Sarah; Bachanova, Veronika; Brunstein, Claudio G.; Blazar, Bruce R.; Wagner, John; Schlums, Heinrich; Bryceson, Yenan; Weisdorf, Daniel J.; Miller, Jeffrey S. 2016. The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer. Current Topics in Microbiology and Immunology. 395: 225-243. doi: 10.1007/82_2015_445
  • Holmes, Timothy; Bryceson, Yenan. 2016. Natural killer cell memory in context. Seminars in Immunology. 28: 368-376. doi: 10.1016/j.smim.2016.05.008
  • Sand, Kristoffer; Theorell, Jakob; Bruserud, Øystein; Bryceson, Yenan; Kittang, Astrid Marta Olsnes. 2016. Reduced potency of cytotoxic T lymphocytes from patients with high-risk myelodysplastic syndromes. Cancer Immunology and Immunotherapy. 65: 1135-1137. doi: 10.1007/s00262-016-1865-y
  • Tesi, Bianca; Schlums, Heinrich; Cichocki, Frank; Bryceson, Yenan. 2016. Epigenetic Regulation of Adaptive NK Cell Diversification. Trends in immunology. 37: 451-461. doi: 10.1016/j.it.2016.04.006
  • Hagberg, Niklas; Theorell, Jakob; Hjorton, Karin; Spee, Pieter; Eloranta, Maija-Leena; Bryceson, Yenan; Rönnblom, Lars. 2015. Functional anti-CD94/NKG2A and anti-CD94/NKG2C autoantibodies in patients with systemic lupus erythematosus. Arthritis & Rheumatology. 67: 1000-1011. doi: 10.1002/art.38999
  • Meeths, Marie; Horne, Annacarin; Sabel, Magnus; Bryceson, Yenan; Henter, Jan-Inge. 2015. Incidence and clinical presentation of primary hemophagocytic lymphohistiocytosis in Sweden. Pediatric Blood & Cancer. 62: 346-352. doi: 10.1002/pbc.25308
  • Schlums, Heinrich; Cichocki, Frank; Tesi, Bianca; Theorell, Jakob; Béziat, Vivien; Holmes, Tim D.; Han, Hongya; Chiang, Samuel C.C.; Foley, Bree; Mattsson, Kristin; Larsson, Stella; Schaffer, Marie; Malmberg, Karl-Johan; Ljunggren, Hans-Gustaf; Miller, Jeffrey S.; Bryceson, Yenan. 2015. Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function. Immunity. 42: 443-456. doi: 10.1016/j.immuni.2015.02.008
  • Tesi, Bianca; Lagerstedt-Robinson, Kristina; Chiang, Samuel C.C.; Bdira, Eya Ben; Abboud, Miguel; Belen, Burcu; Devecioglu, Omer; Fadoo, Zehra; Yeoh, Allen E.J.; Erichsen, Hans Christian; Möttönen, Merja; Akar, Himmet Haluk; Hästbacka, Johanna; Kaya, Zuhre; Nunes, Susana; Patiroglu, Turkan; Sabel, Magnus; Saribeyoglu, Ebru Tugrul; Tvedt, Tor Henrik Anderson; Unal, Ekrem; Unal, Sule; Unuvar, Aysegul; Meeths, Marie; Henter, Jan-Inge; Nordenskjöld, Magnus; Bryceson, Yenan. 2015. Targeted high-throughput sequencing for genetic diagnostics of hemophagocytic lymphohistiocytosis. Genome Medicine. 7:130. doi: 10.1186/s13073-015-0244-1
  • Tesi, Bianca; Sieni, Elena; Neves, Conceicao; Romano, Francesca; Cetica, Valentina; Cordeiro, Ana Isabel; Chiang, Samuel; Schlums, Heinrich; Galli, Luisa; Avenali, Stefano; Tondo, Annalisa; Canessa, Clementina; Henter, Jan-Inge; Nordenskjöld, Magnus; Hsu, Amy P; Holland, Steven M; Neves, Joao F; Azzari, Chiara; Bryceson, Yenan. 2015. Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency. Journal of Allergy and Clinical Immunology. 135: 1638-1641e5. doi: 10.1016/j.jaci.2014.11.030
  • Borte, Stephan; Meeths, Marie; Liebscher, Inés; Krist, Kerstin; Nordenskjöld, Magnus; Hammarström, Lennart; von Döbeln, Ulrika; Henter, Jan-Inge; Bryceson, Yenan. 2014. Combined newborn screening for familial hemophagocytic lymphohistiocytosis and severe T- and B-cell immunodeficiencies. Journal of Allergy and Clinical Immunology. 134: 226-228.e7. doi: 10.1016/j.jaci.2014.04.026
  • Cichocki, Frank; Schlums, Heinrich; Li, Hongchuan; Stache, Vanessa; Holmes, Timothy; Lenvik, Todd R.; Chiang, Samuel C.C.; Miller, Jeffrey S.; Meeths, Marie; Anderson, Stephen K.; Bryceson, Yenan. 2014. Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. Journal of Experimental Medicine. 211: 1079-1091. doi: 10.1084/jem.20131131
  • Cichocki, Frank; Sitnicka, Ewa; Bryceson, Yenan. 2014. NK cell development and function - Plasticity and redundancy unleashed. Seminars in Immunology. 26: 114-126. doi: 10.1016/j.smim.2014.02.003
  • Meeths, Marie; Chiang, Samuel C.C.; Löfstedt, Alexandra; Müller, Martha-Lena; Tesi, Bianca; Henter, Jan-Inge; Bryceson, Yenan. 2014. Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity. Experimental Cell Research. 325: 10-17. doi: 10.1016/j.yexcr.2014.03.014
  • Theorell, Jakob; Gustavsson, Anna-Lena; Tesi, Bianca; Sigmundsson, Kristmundur; Ljunggren, Hans-Gustaf; Lundbäck, Thomas; Bryceson, Yenan. 2014. Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation. Cancer Immunology and Immunotherapy. 63: 627-641. doi: 10.1007/s00262-014-1539-6
  • Chiang, Samuel C.C.; Theorell, Jakob; Entesarian, Miriam; Meeths, Marie; Mastafa, Monika; Al-Herz, Waleed; Frisk, Per; Gilmour, Kimberly C.; Ifersen, Marianne; Langenskiöld, Cecilia; Machaczka, Maciej; Naqvi, Ahmed; Payne, Jeanette; Perez-Martinez, Antonio; Sabel, Magnus; Unal, Ekrem; Unal, Sule; Winiarski, Jacek; Nordenskjöld, Magnus; Ljunggren, Hans-Gustaf; Henter, Jan-Inge; Bryceson, Yenan. 2013. Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production. Blood. 121: 1345-1356. doi: 10.1182/blood-2012-07-442558
  • Cohnen, André; Chiang, Samuel C.C.; Stojanovic, Ana; Schmidt, Hendrik; Claus, Maren; Saftig, Paul; Janssen, Ottmar; Cerwenka, Adelheid; Bryceson, Yenan; Watzl, Carsten. 2013. Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. Blood. 122: 1411-1418. doi: 10.1182/blood-2012-07-441832
  • Entesarian, Miriam; Chiang, Samuel CC; Sclums, Heinrich; Meeths, Marie; Chan, Mei-Yoke; Mya, Soe-Nwe; Soh, Shui-Yen; Nordenskjöld, Magnus; Henter, Jan-Inge; Bryceson, Yenan. 2013. Novel deep intronic and missense UNC13D mutations in familial haemophagocytic lymphohistiocytosis type 3. British Journal of Haematology. 162: 415-418. doi: 10.1111/bjh.12371
  • Machaczka, Maciej; Klimkowska, Monika; Chiang, Samuel C.C.; Meeths, Marie; Muller, Martha-Lena; Gustafsson, Britt; Henter, Jan-Inge; Bryceson, Yenan. 2013. Development of classical Hodgkin's lymphoma in an adult with biallelic STXBP2 mutations. Haematologica. 98: 760-764. doi: 10.3324/haematol.2012.073098

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