Yenan Bryceson's picture

Yenan Bryceson

  • E-mailYenan.Bryceson@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2024). Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children. Journal of Experimental Medicine (JEM).
  • Show author(s) (2024). Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19. Journal of Clinical Immunology.
  • Show author(s) (2023). Viral host range factors antagonize pathogenic SAMD9 and SAMD9L variants. Experimental Cell Research.
  • Show author(s) (2023). Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs. Science immunology.
  • Show author(s) (2023). SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency. Science Signaling. 20 pages.
  • Show author(s) (2023). Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer. Signal Transduction and Targeted Therapy. 2 pages.
  • Show author(s) (2023). Human skin-resident CD8<sup>+</sup> T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a. Immunity. 1285-1302.
  • Show author(s) (2023). Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8<sup>+</sup> T cells. Science immunology. eabn0484.
  • Show author(s) (2022). Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity. Journal of Allergy and Clinical Immunology. 388-399.e4.
  • Show author(s) (2022). Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency. Journal of Experimental Medicine (JEM). 26 pages.
  • Show author(s) (2022). Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding. Journal of Clinical Immunology. 1685-1695.
  • Show author(s) (2021). X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Science immunology.
  • Show author(s) (2021). The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation. Science immunology.
  • Show author(s) (2021). RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis. Blood. 2033-2045.
  • Show author(s) (2021). Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Science immunology. 17 pages.
  • Show author(s) (2021). Hobit identifies tissue-resident memory t cell precursors that are regulated by eomes. Science immunology.
  • Show author(s) (2021). Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy. Cell Stem Cell.
  • Show author(s) (2021). Adult-Onset Ataxia with Neuropathy and White Matter Abnormalities Due to a Novel SAMD9L Variant. Neurology: Genetics.
  • Show author(s) (2020). Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. European Journal of Immunology. 694-702.
  • Show author(s) (2020). Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity. PLoS Biology. 1-33.
  • Show author(s) (2020). Diagnostic challenges for a novel SH2D1A mutation associated with X-linked lymphoproliferative disease. Pediatric Blood & Cancer. 1-5.
  • Show author(s) (2020). Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets. Frontiers in Immunology.
  • Show author(s) (2019). Progressive impairment of NK cell cytotoxic degranulation is associated with TGF-β1 deregulation and disease progression in pancreatic cancer. Frontiers in Immunology.
  • Show author(s) (2019). Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease. NPJ GENOMIC MEDICINE. 1-7.
  • Show author(s) (2019). Determination of essential phenotypic elements of clusters in high-dimensional entities—DEPECHE. PLOS ONE. 1-15.
  • Show author(s) (2019). A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function. Journal of Experimental Medicine (JEM). 2778-2799.
  • Show author(s) (2018). The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in t cells from patients with SLE. Annals of the Rheumatic Diseases. 1070-1077.
  • Show author(s) (2018). Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment? Scandinavian Journal of Immunology. 1-7.
  • Show author(s) (2018). Screening for Wiskott-Aldrich syndrome by flow cytometry. Journal of Allergy and Clinical Immunology. 333-335.e8.
  • Show author(s) (2018). Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. British Journal of Dermatology. 371-380.
  • Show author(s) (2018). NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nature Immunology. 1083-1092.
  • Show author(s) (2018). Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets. Science immunology.
  • Show author(s) (2018). ARID5B regulates metabolic programming in human adaptive NK cells. Journal of Experimental Medicine (JEM). 2379-2395.
  • Show author(s) (2018). A RAB27A 5' untranslated region structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation. Journal of Allergy and Clinical Immunology. 317-321.e8.
  • Show author(s) (2017). Unperturbed cytotoxic lymphocyte phenotype and function in myalgic encephalomyelitis/chronic fatigue syndrome patients. Frontiers in Immunology. 1-15.
  • Show author(s) (2017). Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. Scandinavian Journal of Immunology. 491-502.
  • Show author(s) (2017). Natural killer cell biology illuminated by primary immunodeficiency syndromes in humans. Clinical Immunology. 29-42.
  • Show author(s) (2017). Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia. Leukemia. 1108-1116.
  • Show author(s) (2017). High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors. eLIFE.
  • Show author(s) (2017). Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms. Blood. 2266-2279.
  • Show author(s) (2017). Differences in granule morphology yet equally impaired exocytosis among cytotoxic T cells and NK cells from Chediak-Higashi syndrome patients. Frontiers in Immunology.
  • Show author(s) (2017). CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin. Immunity. 287-300.
  • Show author(s) (2017). Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells. Blood. 1927-1939.
  • Show author(s) (2017). Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs. Blood. 1940-1946.
  • Show author(s) (2016). The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer. Current Topics in Microbiology and Immunology. 225-243.
  • Show author(s) (2016). Reduced potency of cytotoxic T lymphocytes from patients with high-risk myelodysplastic syndromes. Cancer Immunology and Immunotherapy. 1135-1137.
  • Show author(s) (2016). Diversification and functional specialization of human NK cell subsets. Current Topics in Microbiology and Immunology. 63-93.
  • Show author(s) (2016). CD56dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT. Leukemia. 456-463.
  • Show author(s) (2015). Targeted high-throughput sequencing for genetic diagnostics of hemophagocytic lymphohistiocytosis. Genome Medicine.
  • Show author(s) (2015). Incidence and clinical presentation of primary hemophagocytic lymphohistiocytosis in Sweden. Pediatric Blood & Cancer. 346-352.
  • Show author(s) (2015). Functional anti-CD94/NKG2A and anti-CD94/NKG2C autoantibodies in patients with systemic lupus erythematosus. Arthritis & Rheumatology. 1000-1011.
  • Show author(s) (2015). Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function. Immunity. 443-456.
  • Show author(s) (2014). Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. Journal of Experimental Medicine (JEM). 1079-1091.
  • Show author(s) (2014). Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation. Cancer Immunology and Immunotherapy. 627-641.
  • Show author(s) (2013). Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. Blood. 1411-1418.
  • Show author(s) (2013). Development of classical Hodgkin's lymphoma in an adult with biallelic STXBP2 mutations. Haematologica. 760-764.
  • Show author(s) (2013). Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production. Blood. 1345-1356.
  • Show author(s) (2021). Editorial: Membrane Trafficking in Immunology - How Membrane Transport and Exocytosis Defects Underlie Immunodeficiencies. Frontiers in Immunology.
  • Show author(s) (2020). Editorial: Molecular and Cellular Pathways in NK Cell Development. Frontiers in Immunology.
Reader opinion piece
  • Show author(s) (2013). Novel deep intronic and missense UNC13D mutations in familial haemophagocytic lymphohistiocytosis type 3. British Journal of Haematology. 415-418.
Letter to the editor
  • Show author(s) (2022). Studying severe long COVID to understand post-infectious disorders beyond COVID-19. Nature Medicine. 879-882.
  • Show author(s) (2021). Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis. Journal of Allergy and Clinical Immunology. 96-98.
  • Show author(s) (2019). Microdeletion of 7p12.1p13, including IKZF1, causes intellectual impairment, overgrowth, and susceptibility to leukaemia. British Journal of Haematology. 354-357.
  • Show author(s) (2015). Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency. Journal of Allergy and Clinical Immunology. 1638-1641e5.
  • Show author(s) (2014). Combined newborn screening for familial hemophagocytic lymphohistiocytosis and severe T- and B-cell immunodeficiencies. Journal of Allergy and Clinical Immunology. 226-228.e7.
Doctoral dissertation
  • Show author(s) (2019). Systemic inflammation in psoriasis: Circulating immune cells and cytokines.
  • Show author(s) (2019). Corrigendum: Unperturbed cytotoxic lymphocyte phenotype and function in myalgic encephalomyelitis/chronic fatigue syndrome patients. Frontiers in Immunology.
Academic literature review
  • Show author(s) (2022). Neuroinflammation Associated With Inborn Errors of Immunity. Frontiers in Immunology.
  • Show author(s) (2022). Human genetic and immunological determinants of critical COVID-19 pneumonia. Nature. 587-598.
  • Show author(s) (2022). Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia? Scandinavian Journal of Immunology.
  • Show author(s) (2021). Genetics and pathophysiology of haemophagocytic lymphohistiocytosis. Acta Paediatrica. 2903-2911.
  • Show author(s) (2018). Natural killer cells in inflammation and autoimmunity. Cytokine & growth factor reviews. 37-46.
  • Show author(s) (2018). HLH: Genomics illuminates pathophysiological diversity. Blood. 5-7.
  • Show author(s) (2017). Natural killer cell-mediated immunosurveillance of human cancer. Seminars in Immunology. 20-29.
  • Show author(s) (2016). Natural killer cell memory in context. Seminars in Immunology. 368-376.
  • Show author(s) (2016). Epigenetic Regulation of Adaptive NK Cell Diversification. Trends in immunology. 451-461.
  • Show author(s) (2014). Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity. Experimental Cell Research. 10-17.
  • Show author(s) (2014). NK cell development and function - Plasticity and redundancy unleashed. Seminars in Immunology. 114-126.

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