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The Research Group of Immunology and Rheumatology

The Dendritic Cell Group

The overall aim of our research is to further unravel the mechanisms by which dendritic cells modulate T cell responses, both in autoimmunity as well as tumour immuni­ty.Our results will lead to a better under­standing of the cellular mechanisms involved in antigen presentation, T cell stimulation and tolerance induction, thereby revealing new tools for diagnosis and targets for therapy of patients with cancer, autoimmune and infectious diseases as well as patients undergoing stem cell transplantation.Thus, it might lead to an increased survival and better quality of life for patients.

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Projects and current members within the group

Richard Davies (PhD fellow): Signaling cascades and immunological networks in autoimmune diseases

The aim of his study is to explore and compare signaling networks in unstimulated and stimulated immune cells (B cells, T cells, monocytes) from patients with primary Sjögren’s syndrome in order to analyze the signaling cascades activated by for instance various TLR ligands in these patients using single cell phospho-flow. The obtained results will help to gain insights in possible misdirected signaling pathways in patients with autoimmune diseases and thus support the development of new diagnostic tools and improve current therapies.

Dag Heiro Yi (medical student of the research line – “forskerlinjestudent”): Improving dendritic cell-based immunotherapy

Dag’s project focuses on improving the quality of dendritic cells (DCs) used in immunotherapy by using different maturation stimuli in combination with OK432. OK432 is a penicillin killed Streptococcus pyogenes preparation which has shown promising results in immunotherapy so far. Dag’s analyses focus on phenotype, cytokine production and T cell stimulatory capacity of the generated DC populations.

Anders Krogh Aarebrot (medical student of the research line - "forskerlinjestudent"): Monitoring and improving treatment of psoriasis

In this project we want to combine phosphoflow as well as clinical and biological investigations with the overall aim of gaining insights to psoriasis treatment and deepening understanding of disease pathophysiology.