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Bergen Epilepsy Research Group (BERG)
The SCAN-AED research team

Yuelian Sun, MD PhD

Associated professor at Department of Neurology, Department of Clinical Medicine, Aarhus University.

Research interests:

She has been working on reproductive epidemiology for more than 20 years including research on pre- and perinatal factors for short-term and long-term outcomes in offspring such as congenital malformation, neurological or neuropsychiatric disorders (cerebral palsy, epilepsy, ADHD, autism, cognition), cancer, and injury. She has investigated a series of pre- and perinatal risk factors for epilepsy in childhood and early adulthood including maternal diseases (infertility, infection and fever, pre-eclampsia), maternal life style factors (binge drinking and diet), maternal medication during pregnancy (antibiotics for cystitis, antidepressant), perinatal factors (Apgar score, birth weight, gestational age,  neonatal hyperbilirubinemia), and factors in early life (breastfeeding, vaccination). In recent years, she is focusing on safety of medication used during pregnancy and interested in applying case-only designs in epidemiological research.

 

Selected publications:

Sun Y, Pedersen LH, Wu CS, Petersen I, Sørensen HT, Olsen J. Antidepressant use during pregnancy and risk of congenital heart defects: a case-time-control study. Pharmacoepidemiol Drug Saf (Accepted)

 

Christensen J, Pedersen LH, Sun Y, et al. Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring. JAMA network open 2019;2(1):e186606.

 

Mao Y, Ahrenfeldt LJ, Christensen K, Wu CS, Christensen J, Olsen J, Sun Y. Risk of epilepsy in opposite-sex and same-sex twins: a twin cohort study. Biology of Sex Differences. 2018;9(1):21

 

Elkjær LS, Bech BH, Sun Y, Laursen TM, Christensen J. Association Between Prenatal Valproate Exposure and Performance on Standardized Language and Mathematics Tests in School-aged Children. JAMA Neurol. 2018 Feb 19. doi: 10.1001/jamaneurol.2017.5035. [Epub ahead of print]

 

Mao Y, Pedersen LH, Christensen J, Vestergaard M, Zhou W, Olsen J, Sun Y. Prenatal exposure to antidepressants and risk of epilepsy in childhood. Pharmacoepidemiology and drug safety 2016;25(11):1320-30.

 

Maimburg RD, Olsen J, Sun Y. Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. Epilepsy research 2016;124:67-72.

 

Sun Y, Wu CS, Olsen J. Trimethoprim use before pregnancy and risk of congenital malformation: reanalyzed using a case-crossover design and a case-time-control design. Pharmacoepidemiol Drug Saf 2014;10:1076-83. (Honorable mention of The Ronald D. Mann Best Paper Award)

 

Sun Y, Christensen J, Olsen J. Childhood epilepsy and maternal antibodies to microbial and tissue antigens during pregnancy. Epilepsy Res 2013;107(1-2):61-74.

 

Wu CS, Pedersen LH, Miller JE, Sun Y, Streja E, Uldall P, Olsen J. Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy. PloS one 2013;8(2):e57552.

 

Miller JE, Pedersen LH, Sun Y, Olsen J. Maternal Use of Cystitis Medication and Childhood Epilepsy in a Danish Population-based Cohort. Paediatr Perinat Epidemiol 2012;26:589-95.

 

Sun Y, Christensen J, Hviid A, Li J, Vedsted P, Olsen J, Vestergaard M. Risk of Febrile Seizures and Epilepsy after Vaccination with Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b. JAMA 2012;307:823-31.

 

Sun Y, Vestergaard M, Christensen J, Olsen J. Breastfeeding and Risk of Epilepsy in Childhood: A Birth Cohort Study. J Pediatr 2011;158:924-9.

 

Sun Y, Vestergaard M, Christensen J, Olsen J. Prenatal exposure to elevated maternal body temperature and risk of epilepsy in childhood: a population-based pregnancy cohort study. Paediatr Perinat Epidemiol 2011;25:53-9.

 

Sun Y, Vestergaard M, Christensen J, Olsen J, Olsen SF. Intake of marine n-3 fatty acids during pregnancy and risk for epilepsy in the offspring: a population-based cohort study. Epilepsy Res 2010;91:267-72.

 

Sun Y, Strandberg-Larsen K, Vestergaard M, Christensen J, Nybo Andersen, AM, Gronbaek M, Olsen J. Binge drinking during pregnancy and risk of seizures in childhood: a study based on the Danish National Birth Cohort. Am J Epidemiol 2009;169:313-22.

 

Sun Y, Vestergaard M, Christensen J, Nahmias AJ, Olsen J. Prenatal exposure to maternal infections and epilepsy in childhood: A population-based cohort study. Pediatrics 2008;121:E1100-E1107.

 

Wu CS, Sun Y, Vestergaard M, Christensen J, Ness RB, Haggerty CL, Olsen J. Preeclampsia and risk for epilepsy in offspring. Pediatrics 2008;122:1072-8.

 

Sun Y, Vestergaard M, Pedersen CB, Christensen J, Basso O, Olsen J. Gestational age, birth weight, intrauterine growth, and the risk of epilepsy. Am.J Epidemiol. 2008;167:262-70.

 

Sun Y, Vestergaard M, Christensen J, Zhu JL, Bech BH, Olsen J. Epilepsy and febrile seizures in children of treated and untreated subfertile couples. Hum Reprod 2007;22:215-20.

 

Sun Y, Vestergaard M, Pedersen CB, Christensen J, Olsen J. Apgar scores and long-term risk of epilepsy. Epidemiology 2006;17:296-301.